Articles tagged with Fgf Pathway
A team at The University of Osaka has identified a signaling molecule called FGFR3 and a pathway called CREB as key in regulating bone growth. Cells carrying the genetic mutation associated with achondroplasia accumulate in the resting zone and show abnormal behaviors, which included abnormal patterns of division and migration.
Scientists found that tumor-promoting fibroblasts attract nerve fibers through a vicious cycle of signaling and neurotransmitter release. This cycle promotes pre-cancerous growth and pulls in more nerve fibers, leading to a self-reinforcing loop. Disrupting this cycle may lead to new therapies for pancreatic cancer.
Scientists have found a way to effectively 'intercept' pancreatic cancer by targeting the KRAS and FGFR2 genes. This approach slows tumor formation and reduces the number of 'early versions' of cancer in the pancreas. Researchers believe this therapy could be a game-changer for patients with a family history of pancreatic cancer.
Researchers from Korea University have developed a groundbreaking technique to transform fibroblasts into mature cardiomyocytes, holding promise for regenerative medicine in treating cardiovascular disease. The method combines fibroblast growth factor 4 (FGF4) with vitamin C to accelerate cell maturation and enhance function.
A new study found that fibroblast growth factor 21 (FGF21) is an independent predictor of all-cause mortality in older adults. The Polsenior2 study revealed that middle and high FGF21 levels were associated with increased mortality risk, particularly when adjusted for age, co-morbidities, and blood parameters.
A new study reveals FGF18 as a key inducer of hepatic stellate cell proliferation and liver fibrosis. FGF18 levels are dramatically elevated in fibrotic livers, and its overexpression induces liver fibrosis in mice.
Researchers have discovered that embryonic stem cells are guided by a complex interplay of signaling molecules to determine their cell type. The study found that fibroblast growth factor (FGF) acts as an antagonist of the signal molecule BMP, influencing cell differentiation and fate.
Researchers found that dietary saturated/trans fats, but not cholesterol, can trigger hepatic angiogenesis and lymphangiogenesis in mice, leading to the promotion of hepatic tumors. This process is driven by the JNK-HIF1α-VEGF-C axis.
Researchers found that severe asthma patients produce growth factors that block corticosteroids from working, leading to frequent breathing problems. This discovery may lead to new treatments targeting these growth factors to improve outcomes for patients with severe asthma.
Researchers discovered that a hormone called FGF21 suppresses alcohol consumption in primates by altering neural transmission in the brain. This finding provides a mechanism for a liver-to-brain endocrine feedback loop to protect the liver from damage and may lead to potential treatment options for alcohol use disorder.
Biologists at St Petersburg University studied mechanisms of regeneration of marine animals and found that suppression of FGF protein activity disrupts the ability of Alitta virens to restore lost body segments. Similar proteins are found in humans, suggesting potential therapeutic approaches for regenerative medicine.
The study, published in Genes and Development, reveals the role of signaling pathways in regulating cell behavior, including proliferation, death, and migration. The research team identified new signaling outputs that function independently of established FGF signal transduction pathways, particularly in cell adhesion.
Researchers found that fibroblast growth factor 1 repairs damaged perineuronal nets in the brain, a critical response required for sustained diabetes remission. The discovery sheds light on the intricate biology of the brain's response to the protein and may lead to more effective diabetes treatments.
Scientists at CNIC discover a system providing cells with positional information about their location in developing organs. The study shows that malfunctioning of this system causes congenital malformations and may explain the effects of thalidomide, a drug inducing limb defects.
Researchers have discovered that physical forces, such as centrifugal force, play a crucial role in enhancing cell-to-cell attachment and increasing tissue stiffness during embryonic development. The study reveals that the FGF receptor/Erk2 signaling pathway is essential for this process.
The study reveals how fibroblast growth factor 23 (FGF23) signals to cells through its receptor and alpha-Klotho, reversing previous conjecture on alpha-Klotho's anti-aging role. The findings also shed light on kidney disease leading to heart hypertrophy.
Research at Kanazawa University identifies FGF signaling as essential for gyri formation in the cerebral cortex, enabling large-scale neuron development and brain functions. The study uses a ferret model to analyze genome-level interactions, revealing the importance of FGF signaling in gyrus formation.
Researchers at the University at Buffalo have discovered a common genomic pathway that may be responsible for schizophrenia. By studying skin cells from four adults with schizophrenia, they found a dysregulated gene program that affects over 1,000 genes and can lead to the development of the disease.
Researchers at Tokyo Institute of Technology identified fgf20a and fgf3/10a as major fibroblast growth factor ligands involved in fin regeneration. Fgf signalling acts directly on fin ray mesenchyme to form a blastema, promoting cell proliferation and tissue recovery.
Researchers at Osaka University found that smoking habits change the levels of α-klotho and FGF-21 in blood serum, which are linked to aging. These changes suggest a metabolic disorder and may contribute to accelerated aging in smokers.
A new study found that people with depression have higher levels of a brain protein called FGF9, which can be a target for developing new antidepressants. The research also showed that artificially increasing FGF9 levels in rats led to depression-like behavior changes.
UC San Diego researchers use a statistical tool to determine the optimal media composition for growing human pluripotent stem cells (hPSCs), reducing variability and improving reproducibility. The findings aim to create a standard for hPSC cultures, enabling laboratories worldwide to access consistent results.
Researchers have found that local implants of autologous adipose tissue-derived cells resulted in significant pain reduction and healing within two to seven weeks for all patients with long-lasting, non-healing digital ulcers. The treatment showed promise as an alternative to traditional therapies.
Researchers found that mice lacking specific vascular system proteins developed normally but healed poorly from injuries. Increasing FGF signaling may improve wound healing, while inhibiting it in the eye could help patients with age-related macular degeneration or diabetic retinopathy.
Researchers found functional electrical stimulation can promote endogenous neural precursor cell proliferation and improve motor function in rats with acute cerebral infarction. The treatment also enhanced expression of basic fibroblast growth factor and epidermal growth factor.
Researchers found that Noggin accelerates and increases the differentiation of neural precursors, outperforming basic fibroblast growth factor (bFGF). Noggin's greater effect was observed in inducing neural precursor differentiation from human embryonic stem cells.
Researchers have identified fibroblast growth factor 18 (FGF18) as a predictive marker for poor overall survival in ovarian cancer patients. The study found that overexpression of the FGF18 gene is associated with enhanced tumor blood vessel formation and expression of cancer-promoting cytokines.
Researchers found that basic fibroblast growth factor protects the spinal cord by reducing calcitonin gene-related peptide and acetylcholinesterase expression in damaged motor neurons. This suggests a potential therapeutic application for treating spinal cord injuries.
Researchers have developed a new bio-mimicking therapeutic that can stabilize bFGF, allowing for its potential use in treating skin wounds and accelerating the healing process. The stable conjugate has been shown to function like normal bFGF to trigger the same signaling pathways involved in wound healing.
A study in Cell Communication and Signaling reveals an extensive interactome of over 500 novel interactions between SH2 domains and phosphotyrosine peptides. The researchers identified six general classes of SH2 domain specificity, which may control the selectivity of individual domains.
Researchers have developed a new and effective way to regrow blood vessels, potentially bypassing surgery and repairing damaged vessels through injection of a lipid-incased substance. This method has shown promise in treating chronic myocardial ischemia disease, affecting up to 27 million patients in the US.
Scientists have developed a method to deliver growth factor to regrow blood vessels, which could lead to revolutionary heart disease treatment. The research, published in PNAS, uses a novel delivery system that increases the activity and stability of growth factor.
Patients with elevated FGF-23 levels had a higher risk of end-stage renal disease and death, even at early stages of chronic kidney disease. The association was found across different estimated glomerular filtration rates (GFR) categories.
Researchers at URMC discovered a defect in cellular pathways regulating bone formation at the stem cell level, leading to premature closure of skull sutures and craniosynostosis. This finding sheds light on the complex system controlling stem cell fate and has implications for understanding skeletal disorders and cancer.
A team of researchers has created a new in vitro model for studying the effects of light on wound healing. They found that exposure to blue-violet light increases mitochondrial activity, cell proliferation, and growth factor secretion in human epidermal keratinocytes. These results suggest that blue light may be useful in enhancing epi...
Researchers at Washington University School of Medicine found that a growth factor gene plays a critical role in palate development, suggesting a new target for preventing and treating cleft palate. The study's findings could lead to the development of drugs that activate or inhibit the gene to ensure normal palate growth.
A new study reveals that nerve-cell transplants can promote nurturing growth factors, promoting the healing of an injured nervous system. The transplants helped brain-damaged rats fully recover their cognitive function, including learning and memory.
Researchers at the University of Pittsburgh have identified an enzyme inhibitor that increases cardiac progenitor cells and influences heart development in zebrafish. The findings have broad implications for understanding heart development and improving treatments for damaged or diseased tissues.
A study by University of Utah researchers reveals that interaction between Wnt and Fgf growth factor signaling pathways is crucial for proper collective cell migration. Proper division of labor between the two pathways enables cells to migrate directionally, but defects in these interactions may lead to cancer progression.
Fibroblasts, key cells in wound healing, transform into powerful contractile cells through a mechanical process. This new understanding could help prevent fibrosis and improve tissue engineering by controlling the rigidity of cell cultures.
The Pourquié Lab has demonstrated the crucial role of fibroblast growth factor (FGF) in somitogenesis, a process required for vertebrae formation. The study successfully characterized and verified FGF signaling's importance during this process, providing new insights into the clock and wavefront explanation of somitogenesis.
University of Iowa researchers have discovered new genetic mutations associated with non-syndromic cleft lip and palate, a common form of the condition. The findings may eventually help clinicians predict a family's risk of having more children with the condition.
The study found that activating hedgehog signals in adult mouse hearts increased blood vessel density, offering an alternative to invasive procedures. The researchers believe a drug treatment targeting hedgehog signaling could provide substantial benefit to patients with ischemic heart disease and myocardial infarctions.
Researchers have identified a link between the fibroblast growth factor system and major depressive disorder, with those treated with SSRIs showing smaller changes. The study's findings offer new insights into the biological mechanisms underlying mood disorders and potential avenues for targeted therapeutics.
Researchers have discovered a chemical messenger called fibroblast growth factor 18 (FGF 18) that regulates bone development in growing embryos. FGF 18 appears to coordinate both the lengthening and hardening of bones, which may lead to new understanding of diseases such as achondroplasia and osteoporosis.
Researchers have found that PR39 promotes angiogenesis by blocking the degradation of a key transcription factor, HIF-1alpha. The newly formed vessels were fully functional in mice studies, offering a promising tool for treating coronary artery disease and peripheral vascular disease.
Researchers at Duke University have demonstrated that two naturally occurring growth factors significantly improved the ability of severed nerve fibers to reconnect with high accuracy. The study could lead to new strategies for improving peripheral nerve repair procedures in humans.