Articles tagged with Refraction
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers develop a new approach combining Phase Measuring Deflectometry and Shape from Polarization to accurately image specular surfaces without prior knowledge or assumptions. The single-shot method enables motion-robust measurements, pushing the limits for next-generation 3D sensors.
Researchers at Lancaster University have successfully demonstrated negative refraction using atomic arrays, eliminating the need for metamaterials. This achievement paves the way for novel technologies based on negative refraction, including perfect lenses and cloaking devices.
Researchers developed an AI model to estimate best-corrected visual acuity from fundus photographs in patients with diabetic macular edema, achieving accuracy within one to two lines on a standard chart. The study's findings support the potential of AI in clinical settings, with opportunities for further improvement.
A newly developed polarizer-embedded metalens microscope system achieves high-quality, wide-field imaging with a large depth-of-field, significantly expanding human eyesight to the microworld. The chip-scale device offers a thousand-fold reduction in volume and weight compared to traditional microscopes.
Researchers developed a lidar-based system for smart cars to recognize objects more accurately than cameras. The system uses a grid map to divide the field of view into regions containing individual objects.
A recent study published in Frontiers in Cardiovascular Medicine found that transcranial direct current stimulation (tDCS) can lower blood pressure in patients with resistant hypertension. After a single session or ten sessions, the treatment reduced peripheral and central blood pressure in some patients by up to 15 mmHg.
A study estimates that 55% of organic matter removed during wastewater treatment is refractory, leading to high greenhouse gas emissions. The researchers propose a new perspective on carbon neutrality in the industry by leaving non-toxic recalcitrant organic matter in the wastewater.
Researchers discovered a novel topological edge soliton that inherits topological protection from its linear counterpart, enabling robust and localized light beams. This breakthrough is achieved through nonlinear photorefractive lattices harnessing the valley Hall effect, without requiring an external magnetic field.
Researchers at Cornell University propose a new way to modulate metamaterials' absorptive and refractive qualities in real-time, increasing their effectiveness. This breakthrough could lead to the development of new metamaterials with improved wave absorption and scattering properties.
High-dose intranodal lymphangiography with ethiodized oil has been shown to be a safe and effective procedure for treating high-output postsurgical chylothorax, with a success rate of 83%. The procedure involved injecting higher doses of ethiodized oil, which led to resolution of symptoms in most patients.
Oak Ridge National Laboratory has developed a non-invasive air leak detection method that uses imaging technique to visualize air leaks and calculate volumetric flow. The lab also engineered a microbe to efficiently turn waste into itaconic acid, an industrial chemical used in plastics and paints. Additionally, researchers demonstrated...
Scientists have developed a new technique to manipulate nanoparticles with the same refractive properties as their background environment, overcoming a fundamental technical challenge. This breakthrough has huge potential in fields like medicine, enabling precise manipulation and measurement of microscopic objects inside cells.
Researchers at the Champalimaud Centre for the Unknown discovered a direct link between prolactin and the male refractory period is unlikely. They found that artificially increasing or blocking prolactin levels had no effect on the animals' sexual behavior, contradicting the long-held theory.
Researchers have developed a way to predict the properties of multiprincipal element alloys (MPEAs), which exhibit unique combinations of strength, ductility, and damage tolerance. The team used electron microscopy and atomistic simulations to unveil the mechanistic origins of desirable properties in MPEAs.
The RESILIENT trial found disease control in 114 out of 126 patients evaluable per protocol and progression-free survival. The study suggests that label-agnostic therapy regimens guided by Encyclopedic Tumor Analysis can offer meaningful clinical benefits for patients with relapsed refractory metastatic malignancies.
Studies in mouse models reveal that deficiencies in ADAMTS13 and complement activation contribute to thrombotic microangiopathy, a potentially deadly condition. The findings may lead to the development of novel treatment strategies for patients with refractory thrombotic microangiopathy.
A multidisciplinary health care team approach increased the likelihood of survival for patients with refractory cardiogenic shock after a heart attack, with a 75% chance of survival at 30 days compared to 50%. The study found that team decision-making and collective wisdom improved patient outcomes.
A phase III clinical trial found gilteritinib superior to standard chemotherapy in improving overall survival for patients with relapsed or refractory AML harboring a FLT3 mutation. Gilteritinib's relatively low toxicity enables outpatient management, shifting the treatment paradigm.
Researchers at UC San Diego have found that axon geometry is crucial in information flow, with a 'refraction ratio' of 0.92 indicating optimal balance between signal latency and refractory period. This discovery has implications for understanding neurological disorders like autism and developing more brain-like artificial neural networks.
PharmaMar initiates EMA re-examination process for Aplidin, a marine-derived anticancer agent targeting multiple myeloma. The re-examination procedure aims to confirm or update the negative opinion on its Marketing Authorization Application.
PharmaMar's plitidepsin demonstrated improved progression-free survival and overall survival compared to dexamethasone alone, with a significant reduction in the risk of progression. The study also showed better quality of life evolution and a novel mechanism of action that targets eEF1A2 protein.
Aplidin, an anticancer agent with no hematological toxicity, is being combined with pomalidomide, bortezomib, and dexamethasone to combat multiple myeloma. The quadruple combination study aims to increase the success rate of treatment by utilizing different mechanisms of action.
A new Finnish study found that nearly half of patients with refractory status epilepticus (RSE) recovered to baseline function within a year. The study analyzed data from a population-based cohort and showed a mortality rate of 25% for RSE patients and 36% for super-refractory status epilepticus (SRSE) patients.
A meta-analysis of three trials found that CD34+ stem cells improved exercise time by 80.5 seconds and reduced mortality by 24 months in patients with refractory angina. This therapy has been shown to be safe and effective for treating patients with limited options.
A study found that people with Down syndrome experienced nearly three times greater variability in autorefractor testing compared to a control group. This increased variability can lead to incorrect vision prescriptions and reduced chances of reaching the best possible refraction for those with Down syndrome.
The number of preschool children with visual impairment is expected to rise by 25% in the US by 2060. The majority of visual impairment will stem from simple uncorrected refractive errors.
Researchers have found that lipoprotein apheresis improves myocardial blood flow, exercise capacity, and symptoms in patients with refractory angina and high lipoprotein(a) levels. The treatment approach could provide a novel solution for these patients, who often face limited treatment options.
PharmaMar announces the start of a multicenter study evaluating plitidepsin's efficacy in patients with relapsed and refractory angioimmunoblastic T-cell lymphoma. The primary endpoint is overall response rate, while secondary endpoints include duration of response, progression-free survival, and pharmacokinetic characteristics.
A two-year clinical study found that CD34+ cells significantly reduced angina frequency in patients resistant to other therapies. The treatment demonstrated persistent improvement in angina and a trend towards decreasing major cardiac events, offering new treatment options for 'no option' patients.
A Phase I study of plitidepsin in combination with bortezomib and dexamethasone demonstrated a 56% overall response rate, including very good partial responses. The treatment was well-tolerated, with no dose-limiting toxicities, and showed clinical benefit in 72% of patients.
The US is projected to see a doubling of visual impairment and blindness cases by 2050, with the greatest burden on non-Hispanic white women and African Americans. The National Eye Institute predicts that 2.15 million non-Hispanic white women will be visually impaired by then.
The prevalence of visual impairment and blindness in the US is projected to double in the next 35 years due to an aging population. Minority groups, particularly African Americans, are at a higher risk, with Hispanic individuals experiencing a significant increase in blind rates.
The USPSTF found convincing evidence that visual acuity testing can identify refractive errors, but inadequate evidence on the benefits of screening and detection. Early treatment of refractive error, cataracts, and AMD improves or prevents loss of visual acuity, with small harms from early treatment.
A global study estimates that 101.2 million people suffer from moderate to severe visual impairment due to uncorrected refractive error (URE), while seven million are blind. The study, published in Optometry and Vision Science, suggests that providing access to affordable glasses could improve the burden of vision loss.
New study results show atezolizumab has remarkable activity in large number of patients with refractory lung cancer, regardless of treatment line. Efficacy is correlated with PD-L1 expression on tumours and immune cells.
Researchers found that nearly 60 out of 100 000 people suffer cardiac arrest outside the hospital each year and only one in ten survive. In a large study, patients with refractory cardiac arrest who were brought to the hospital with ongoing CPR had a higher survival rate compared to those resuscitated before arrival. The study's findin...
A study of 4,500 US children over 20 years identifies a single test that can predict which kids will become nearsighted by the eighth grade: a measure of their current refractive error. The research counters the notion that near work causes myopia and confirms that eight risk factors increase the likelihood of developing myopia.
A Phase 2 clinical trial demonstrates that AF-219, a selective and non-narcotic agent, significantly reduces daytime cough frequency by 75% compared to placebo. The study also shows improvements in secondary endpoints such as severity and urge to cough.
Researchers analyzed samples from the Sudbury Basin and found chondritic platinum group elements, which suggest a comet impact. The distribution of these elements indicates that the impactor was indeed a comet.
A new electroencephalography (EEG) tool has been developed to detect refractory idiopathic epilepsy in children, a condition that cannot be managed by antiepileptic drugs. The tool uses EEG classification analysis and identifies significant EEG features that distinguish refractory epilepsy from well-controlled forms.
A study of 19,849 participants found that those with vision impairment had significantly lower employment rates, especially among women and younger individuals. Poor eyesight was also associated with a higher likelihood of not working due to its impact on income.
A study published in the Journal of AAPOS found that adalimumab significantly improved anterior/posterior chamber inflammatory activity in 85.7% of pediatric patients with refractory uveitis. The biologic agent was effective in reducing inflammation and showed a reasonable side effect profile.
Researchers at the University of Pennsylvania School of Medicine found promising results in using Extracorporeal Membrane Oxygenation (ECMO) to treat select patients with refractory cardiac arrest and profound shock. The study, which included 33 patients, showed a survival rate of 21% and five patients were neurologically intact.
A study published in the European Heart Journal found that long-term outcomes in patients with advanced coronary artery disease are better than expected. The researchers analyzed data from 1,200 consecutive patients with refractory angina and found a low mortality rate of 3.9% at one year and 28.4% at nine years.
A minimally invasive procedure called VATS-LCSD has been shown to be effective in treating refractory cardiac arrhythmias in children. Almost three-quarters of symptomatic patients responded well to the treatment, with 55% becoming arrhythmia-free after sympathectomy.
A new study suggests that investing in vision care services could generate massive economic benefits, saving the global economy $202 billion each year. The proposed investment of $28 billion would provide training for eye care personnel and establish infrastructure to improve vision correction rates.
Researchers found that widely used drug gabapentin significantly improves quality of life, severity, and frequency of chronic cough in patients who have not responded to standard treatment. The study suggests gabapentin's potential as a new treatment option for refractory chronic cough.
Researchers modelled comets and asteroid particles to explain their origins and compositions. The study found that these particles could have been processed in the hot inner disk of the Solar System before traveling out to icy comets, shedding light on the puzzle of how comets acquired different rim compositions.
A new study published in the Journal of Rheumatology shows that KRYSTEXXA significantly improves pain, physical function, and health-related quality of life in adult patients with refractory chronic gout. The treatment resulted in clinically meaningful improvements in these areas compared to placebo.
A recent study found that moderate visual impairments significantly degrade drivers' ability to recognize pedestrians at night. Drivers with blurred vision recognized pedestrians 52.1% of the time, while those with cataracts only recognized them 29.9% of the time.
A recent study found that only 7% of donated recycled glasses were usable, making them twice as expensive as providing ready-made glasses. Donating recycled glasses is not a cost-effective solution to address avoidable blindness in developing countries.
A new study assesses the impact of a psychological therapy for chronic depression, targeting individuals with an emotionally over-controlled personality style. The REFRAMED study aims to provide new insights into refractory depression, a common condition that disrupts daily life.
A recent study found that pegloticase significantly reduces plasma uric acid levels and improves physical function and quality of life in patients with severe, chronic gout. The medication was effective in achieving the primary outcome in approximately 42% of patients, with significant improvements also seen in patient-reported pain.
A team of scientists has discovered a new mineral, krotite, which is believed to be one of the earliest minerals formed in our solar system. The mineral was found in an unusual inclusion embedded in a meteorite and is composed of calcium-aluminum-rich refractory material.
A study finds ranolazine effective for refractory angina, but only 59% of patients remain on the medication after one year. Adherence issues, including cost and side effects, are major concerns.
Researchers at the University of Montreal Hospital Research Centre have developed a new surgical technique to treat refractory epilepsy, with nine patients showing successful results. The innovative approach reduces risks and complications associated with previous insular surgeries.
A study by Johns Hopkins Bloomberg School of Public Health estimates that nearly 158 million people globally suffer from vision impairment due to uncorrected refractive error. This results in approximately $269 billion in productivity loss each year, with the Western Pacific region being the most affected.
The study found a 95.4% patient satisfaction rate for LASIK procedures, confirming its status as a successful elective surgery. In contrast, patients who used combined inhaled and oral steroids were found to have an elevated risk of developing cataracts, particularly posterior subcapsular cataract.
Early investigational studies show anti-tumor activity in ZOLINZA (vorinostat) and bortezomib combination for relapsed or refractory multiple myeloma. Clinical trials are underway to further evaluate this combination, offering new hope for advanced multiple myeloma patients.
The study found an ORR of 53% and CR/CRu of 20% in evaluable patients, while pooled data showed a 57% ORR and 21% CR. REVLIMID is being evaluated as a treatment option for heavily pretreated MCL patients.