Researchers found that girls whose mothers took paracetamol during pregnancy had smaller ovaries, fewer ovarian follicles, and lower levels of reproductive hormones at three months old. The study, published in Human Reproduction Open, suggests that foetal exposure to paracetamol may affect reproductive development, but the findings do ...
A study published in Human Reproduction found that vanillin, a common flavoring chemical in e-cigarettes, can disrupt the normal development of embryos in pregnant women who vape. High concentrations of vanillin caused cells to lose pluripotency and differentiate into endoderm, potentially leading to serious developmental issues.
A recent study found that a higher body fat percentage is linked to lower sperm counts and changes in male reproductive hormones. Men with high body fat percentages had lower semen volume, sperm concentration, and testosterone levels compared to those with normal body fat percentages.
Researchers at KAIST have developed a groundbreaking oocyte and embryo analysis technology using holotomography to predict developmental potential in IVF. This non-invasive method could revolutionize the selection of embryos for transfer, offering a more objective and quantitative approach.
The International Society for Stem Cell Research convenes its 2026 Annual Meeting in Montréal, showcasing groundbreaking discoveries and emerging clinical advances. The meeting features nearly 1,300 scientific posters and presentations spanning every area of stem cell research.
Researchers analyzed 18,396 women undergoing first IVF cycle between 2012-2021 across seven Australian fertility clinics. The study found a 68.2% cumulative live birth rate using single embryo transfer in 95.3% of cases and a multiple birth rate of just 2.9%.
Hospital admissions for miscarriage and ectopic pregnancy have increased in England over the past two decades, with persistent socioeconomic inequalities observed. Deliveries declined significantly during this period.
According to the European IVF Monitoring Consortium, over 1.15 million fertility treatment cycles were reported across Europe in 2023, resulting in the birth of 247,021 children. The growth in frozen embryo transfer (FET) was particularly notable, with FET cycles increasing by 151% compared to previous years.
A large study suggests exposure to air pollution during sperm development can impact genes associated with sperm development, chromosomal organisation and cellular quality control. Researchers identified 39 DNA methylation changes linked to air pollution mixtures, including ozone and nitrogen dioxide.
A nationwide study found substantial regional differences in sperm quality, with men in northern Spain recording the strongest semen quality. Lifestyle habits were broadly similar across regions, suggesting environmental exposures may play a role in male reproductive health.
A landmark international study found that halving patient out-of-pocket costs for fertility treatment significantly increased births achieved through ART, with a 2.67-fold increase reported. Countries with lower cost-to-baby metrics consistently achieved higher levels of ART utilisation, highlighting the importance of affordability in ...
A major new study suggests that age-related changes in the uterus may contribute to poorer pregnancy outcomes, with women aged 49 and over experiencing lower live birth rates and higher miscarriage risk despite donor-oocyte treatment. The study found that cumulative live birth rates declined substantially with age, from 80% among women...
A new Europe-wide survey found broad public support for fertility treatment and reproductive research in the UK, Netherlands, Spain, and Italy. The study suggests that public understanding and opinion on these topics continue to develop, with areas where public views are not yet settled identified.
An international team published a white paper on embryonic models based on stem cells, proposing guidelines for research and regulation. These models can mimic early human development stages, potentially aiding in understanding infertility conditions.
Eating ultra-processed foods is associated with slower embryo growth, smaller yolk sacs, and increased subfertility risk. Reducing UPF consumption around conception and pregnancy may improve fertility outcomes for both parents and embryos.
Recent discoveries have shed light on gene expression control in tumor growth, revealing the critical role of epigenetic marks and genomic imprinting. The findings have significant implications for cancer treatment, as they suggest that disrupting the tumor's access to neural signaling may halt its growth.
A study on mouse incisors reveals a cellular mechanism behind the unique decussation patterns of tooth enamel, which form the enamel's hardness through directional sliding and coordinated migration of ameloblasts. The findings provide new insights into how dental stem and progenitor cells maintain and repair enamel-forming tissues.
A new study uses three-dimensional geometric morphometric analysis to examine wrist ligament insertion sites in fossil hominids, revealing diverse locomotor behaviours and significant differences between species. The research expands palaeoanthropology methods, proposing an innovative approach to reconstructing human ancestor movement.
Researchers used light-inducible gene expression to demonstrate that gastrulation in human embryos requires an interplay between chemical cues and mechanical forces. The study found that mechanical tension fine-tunes downstream biochemical signaling pathways, leading to the formation of body axes.
A case study in CMAJ describes successful ovarian tissue preservation in a young woman with Hodgkin lymphoma, highlighting the need for improved access to fertility preservation services. The 'hub-and-spoke' model presented offers a potential solution to overcome geographical barriers and improve patient outcomes.
The journal will benefit from improved publishing infrastructure and increased visibility for its published research. Phytologia Balcanica is an international journal in plant sciences, publishing original scientific articles across various fields.
Researchers identified Phaedra1 as a gene essential for stress-induced cell death in Drosophila melanogaster. The mTOR-Zeste-Phae1 pathway controls lethal stress-dependent individual death. Suppressing this pathway increases survival rates after exposure to lethal stress.
Researchers successfully created functional ureter tissue from pluripotent stem cells, bringing them closer to developing transplantable kidneys that can produce and expel urine. The achievement is a significant step toward next-generation regenerative therapies.
A new clinical trial found that genetic testing of IVF-created embryos can improve pregnancy and live birth rates for women aged 35-42, reducing the time to conception and emotional toll of failed cycles. The study showed a 20% increase in cumulative live births with 72% success rate compared to 52% without PGT-A
A landmark 30-year study of over four million women in England found that women with endometriosis-associated infertility had a four times higher chance of conception compared to those with infertility from other causes. The study also showed that women with endometriosis may retain good reproductive potential, especially if diagnosed ...
Researchers detected microplastics in 69% of women's follicular fluid and 55% of men's seminal fluid, with PTFE being the most prevalent polymer. The study highlights the need to explore possible implications for human reproductive health and fertility.
A recent study found that women with polycystic ovary syndrome (PCOS) have embryos carrying a unique 'epigenetic memory' that could explain why the condition often runs in families. Treating affected embryos with certain inhibitors showed promise in restoring normal gene activity, suggesting a potential therapeutic avenue.
Pregnancy rates remained stable for IVF and IUI cycles in 2022, while single embryo transfer usage increased. Clinical pregnancy rates were stable, with singleton delivery rates improving to 91.5%. The use of ART rose by 15.6% despite a slight decline in total treatment cycles.
A new study reveals that women with polycystic ovary syndrome (PCOS) have a sharp reduction in the beneficial gut bacterium Parabacteroides merdae, alongside elevated levels of branched-chain amino acids. These changes may impair endometrial health and reproductive complications in women with PCOS.
A new study shows that a simple blood test taken in the first trimester of pregnancy can accurately identify women at risk of developing preeclampsia five months before clinical diagnosis. The test uses cell-free RNA, or cfRNA, to capture subtle molecular signals from multiple maternal tissues.
A new international study reveals that male partners over 45 carry significantly increased miscarriage risks and lower live birth rates even when young donor eggs are used. The study found that older paternal age is linked to genetic mutations, sperm DNA fragmentation, and epigenetic changes, impairing embryo development.
Researchers at Ruhr-University Bochum successfully produced human DNase1 in yeast cells for the first time, overcoming previous challenges. The achievement could lead to a more affordable and efficient method for manufacturing this enzyme, which is currently used to treat cystic fibrosis.
A study published in Human Reproduction found that healthy childhood diets are associated with delayed onset of menstruation, independent of body mass index (BMI) or height. The research suggests that a diet high in fruits, vegetables, and whole grains may help reduce the risk of chronic diseases such as diabetes and breast cancer.
Researchers discovered toxic zinc in glassware used for in vitro fertilization (IVF), which inhibited embryo development. By adding chelating agent EDTA or thoroughly cleaning glassware, embryotoxic effects of zinc were reduced.
Researchers at CRCHUM used single-cell RNA sequencing to study guinea pig pre-implantation development, finding striking similarities with early human embryogenesis. The discovery opens new possibilities for understanding women's infertility and developing therapeutics for healthy pregnancy.
Researchers at the University of Montreal have found that guinea pigs can serve as a reliable and robust small animal model to study human preimplantation development. The study provides new insights into the development of healthy embryos and fetuses, which could lead to improved fertility treatments and reproductive technologies.
A large study of nearly 80,000 men found that those with better semen quality lived two to three years longer than those with poorer semen quality. The research suggests that poor semen quality may be an indicator of underlying health issues, and could potentially detect early signs of disease.
A new study debunks the long-held Protura-sister hypothesis by revealing critical errors in molecular analysis. The researchers re-examined non-nucleotide sequence data and identified misinterpretations that led to the incorrect grouping of hexapod lineages.
The new guidelines provide 145 recommendations on symptoms, diagnosis, causation, sequelae, and treatment of POI. They emphasize personalized hormone therapy, prompt institution, and continuation until the usual age of menopause to prevent chronic disease and improve patient outcomes.
Women with infertility are at higher risk of developing SARD, including lupus and Sjögren's syndrome, even after accounting for pre-eclampsia and other pregnancy complications. Infertility treatments do not appear to increase this risk, suggesting that women may be undiagnosed or untreated.
Researchers used 3D technology to study key areas in brachiating primates, providing new insights into human evolution. The study confirms that early hominin species combined bipedal locomotion with arboreal locomotion similar to current bonobos.
A new AI-based system, BELA, accurately assesses IVF embryo quality by analyzing time-lapse video images and maternal age. The system generates a predictive score for euploidy or aneuploidy, offering an objective measure of embryo quality.
Researchers at Kumamoto University have achieved a groundbreaking advancement in stem cell biology by reproducing the developmental process of hematopoietic stem cells in vitro. This culture system enhances our understanding of HSC development and has the potential to be instrumental in stem cell therapy and blood disease treatments.
A large study found that women with premature ovarian insufficiency are 2.6 times more likely to have an autoimmune disorder, with some conditions increasing the risk by 26 times. The study suggests a strong link between POI and severe autoimmune diseases, highlighting the need for medical professionals to be aware of this increased risk.
A research team has successfully recreated wrinkle structures in biological tissue in vitro, revealing the mechanisms behind their formation. The study found that compressive forces and dehydration play a crucial role in wrinkle formation, mirroring aging skin effects.
Researchers found that when given accurate information about the anti-Mullerian hormone test, women had less interest in taking the test compared to those who viewed misleading online claims. The study highlights the importance of providing evidence-based information to women seeking fertility treatment.
Researchers have created a detailed 3D atlas of the African clawed frog's development, revealing key changes during metamorphosis. The atlas uses X-ray microtomography to show the transformation from tadpole to mature adult frog.
A new study has found that women with a family history of endocrine diseases, including type 2 diabetes and polycystic ovary syndrome, are at a higher risk of experiencing pregnancy loss. The study, which examined over 366,000 women in Denmark, found a significant association between endocrine disease and pregnancy loss.
A novel 3D imaging model has been introduced to identify features of blastocysts associated with successful pregnancies, potentially transforming current IVF selection methods. The study found that parameters related to size and specific features of the inner cell mass and outer layer are linked to higher pregnancy rates.
A national, register-based study of 68,738 women in Denmark reveals significant social disparities in achieving live births after assisted reproductive technology (ART) treatment. Women with higher education levels and income had a greater likelihood of success.
Data from the ESHRE European IVF Monitoring Consortium shows a 20% increase in ART treatment cycles in Europe, with steady rises in IVF and IUI usage. Pregnancy rates per transfer remained similar in 2021 and 2020 for IVF and ICSI, while frozen embryo replacement showed slightly higher rates.
A Phase 2 clinical trial demonstrated the effectiveness of OXO-001 in increasing embryo implantation, pregnancy and live birth rates among infertile women. The study showed significant improvements in biochemical, clinical and ongoing pregnancy rates, with a notable increase in live birth rates.
A new study has found that exposure to fine particulate matter prior to oocyte retrieval during IVF can reduce the odds of achieving a live birth by almost 40%. The research analysed 3,659 frozen embryo transfers and found that even in areas with excellent air quality, higher PM2.5 exposure was associated with decreased live birth rates.
A new study has found that gestational carriers experience a severe maternal morbidity rate of 7.1%, significantly higher than unassisted conceptions (2.4%) and IVF conceptions (4.6%). Gestational carriers are also at risk for postpartum haemorrhages and hypertensive disorders, which can be serious complications during pregnancy.
Men with low sperm count or none have a higher risk of developing cancer, including at younger ages, compared to fertile men. Families of azoospermic men have a significantly increased risk of five cancers, while families of oligozoospermic men have a higher risk of colon, bone and joint, and testicular cancers.
A new study emphasizes the importance of strict legal rules governing fertility treatment in the UK, warning that recent court cases could create a common law exception to informed consent. The research highlights the need for rigorous consent regimes to protect vulnerable patients from exploitation and misuse of genetic material.
A recent study published in Human Reproduction found a doubling in the chances of pregnancy miscarrying or resulting in a stillbirth following a job loss. The researchers emphasize an association between job loss and increased probability of miscarriage or stillbirth, highlighting potential socioeconomic factors.
Researchers developed a sensitive method for single-cell transcriptome analysis from tissue sections, enabling precise examination of cells with histological characteristics. The study unveiled gene expression differences in granulosa cells and revealed growth retardation in oocyte gene expression profiles.
Researchers have developed a high-resolution MRI microscope capable of capturing human embryos with a resolution of one-hundredth of a millimeter. This breakthrough enables detailed visualization and analysis of brain development and organ growth, paving the way for a high-resolution atlas of brain and other organs.
A group of biologists and ethicists suggest adding clarity to ongoing research using embryo models to refine the legal definition of human embryos. They propose a new definition that focuses on what an embryo can become rather than how it came to be, allowing for improved evaluation of models and potential future recognition as embryos.