Researchers at McMaster University developed a new generative AI model that designed a brand-new antibiotic in early tests, drastically speeding up drug discovery. The model generated structurally novel antibiotic candidates from a vast chemical space of 46 billion possible compounds.
A study published in Scientific Reports reveals a connection between ADHD-related traits and chronic pain, highlighting the importance of addressing ADHD in pain management. The research suggests that treating ADHD may help reduce chronic pain severity.
Researchers investigate whether micro- and nanoplastics contribute to liver disease through oxidative stress, fibrogenesis, and inflammation. They emphasize the need for increased research into plastic-induced liver injury and its potential impact on human health.
A study finds that rectal cancer mortality is increasing rapidly among adults under 45, with Hispanic and Western US populations experiencing the steepest rises. The study calls for earlier screening and increased awareness to combat this growing trend.
Researchers at NYU Langone Health found that high levels of a toxic molecule in the gut may trigger lupus nephritis. The study suggests using antibiotics as an alternative treatment instead of immunosuppressants.
Dr. Kwak's research proposes a new paradigm for robots in everyday environments, integrating perception and cognition capabilities into objects and spaces. Her work has led to practical implementations, such as educational robots and smart furniture, demonstrating the potential for human-centered robot design.
Researchers found that restoring a young microbiome can reverse features of aging in the liver, including inflammation and DNA damage. The study suggests that a healthy gut microbiome plays a key role in preventing liver cancer.
A new study suggests that eating late at night can disrupt bowel function and lead to constipation and diarrhea. Individuals who experienced high levels of chronic stress and ate more than 25% of daily calories after 9pm were more likely to report bowel problems, highlighting the impact of meal timing on gut health.
A new procedure, duodenal mucosal resurfacing, has shown promising results in preventing weight regain after GLP-1 therapy discontinuation. The study found that patients who underwent the procedure maintained over 80% of their weight loss and regained less weight compared to those who received a sham procedure.
Researchers have found that combining pembrolizumab and lenvatinib shows promise in treating recurrent clear cell ovarian and endometrial cancers with poor responses to standard treatments. The LARA trial provides encouraging responses for patients with this rare and difficult-to-treat cancer subtype.
Researchers investigated the α7 nAChR-PARP1 axis as a therapeutic target for Parkinson's disease. The study found that activating α7 nAChRs suppresses PARP1 activity, reducing neurotoxicity and improving motor function in mouse models. This discovery provides a scientific foundation for developing novel therapies targeting this axis.
Researchers have developed a novel approach to fabricate high-performance nanophotonic devices with record-breaking ultra-deep nanohole waveguides. The technique enables the creation of nanostructures with extreme depth-to-diameter ratios, overcoming long-standing limitations in single-pulse nanolithography.
The review highlights key considerations for selecting an optimal drug target, including therapeutic hypothesis, druggability and safety, commercial tractability, and combination value. AI's capacity to process complex multimodal data enables researchers to navigate biological complexity and uncover disease-associated targets.
A novel nickel-based Pickering emulsion catalyst enables gram-scale synthesis of high-purity benzaldehyde with co-produced hydrogen, offering a sustainable alternative to traditional fine chemical synthesis. The synergistic effect of photon-heteroatom jointly promoted redox cycling accelerates the dehydrogenation reaction.
A new study reveals that nurse-delivered models of care can effectively manage common sleep problems like insomnia and OSA, but designing services with patients and staff is critical. The review found strong potential for GP nurses to deliver treatments like CBTi and support patients on CPAP machines.
Researchers developed a compact metasurface polarimeter for cancer tissue analysis, offering label-free imaging with reduced variability. The device's miniaturization opens the door to portable polarization-based confocal microscopy for routine histopathology screening.
A multi-institutional team has discovered a novel immune regulatory mechanism mediated by antibodies that selectively shut down overactive immune responses. The 'immune-induced TCR-like antibody' (iTab) can reduce disease severity and delay its onset in a mouse model of autoimmune disease.
Scientists have developed a novel catalyst that selectively repels chloride ions while accelerating oxygen evolution in alkaline seawater electrolysis. The optimized NiFe-LDH/Ce(OH)CO3 system delivers exceptional catalytic metrics and achieves energy efficiency of 68.59% at 500 mA cm-2.
Researchers at Saitama University discovered that mannanases, enzymes degrading glucomannan, are also essential for its synthesis in plants. The study found that Golgi-localized atypical mannanases play a crucial role in preventing aggregation of growing glucomannan chains.
A study from the University of Oregon found that heavy drinking takes a toll on college students' cognition, with impaired memory, attention, and decision-making. The research tracked participants over several weeks, revealing a link between alcohol consumption and cognitive lapses.
Researchers found that consumers are willing to pay more for glass wine bottles, with Gen Z willing to spend $35.38. Providing sustainability information about packaging can influence willingness to pay, with a significant discount relative to glass packaging.
A machine learning approach improves how roaring behaviour can be studied by detecting long-distance roaring based solely on acceleration data. The algorithm works reliably with both male and female lions, even with mixed signals when walking while roaring.
A new Northern White Rhino embryo has been successfully produced, boosting hopes for the species' survival. The BioRescue Consortium's work has also underscored the importance of public engagement, communication, and ethical reflection in wildlife conservation.
A Swedish study found that children adopted into families with better home environments showed improved adult psychosocial outcomes, including lower criminal convictions and higher educational achievements. The benefits also extended into the next generation, with offspring displaying modestly higher psychosocial functioning.
The consortium aims to forge actionable drug development solutions for patients living with AATD by collaborating on endpoints, biomarkers, and clinical trial design. AIRNA brings RNA editing expertise to the consortium's efforts to accelerate drug development for alpha-1 antitrypsin deficiency.
In England, 13,386 patients waited at least three days for A&E treatment in 2025, with numbers spending a whole day in emergency departments increasing by a third since 2023. The prolonged waits are causing harm to patients nationwide, with some saying they'd rather die at home.
A Swedish study of siblings found that adopted children who grew up in more favourable family environments had lower risks of mental health issues, criminality, and social problems. These benefits extended to the next generation, with adopted children's offspring displaying higher functioning and lower risks.
A new study analyzing nearly 100 travellers' diaries reveals that turnpiking improved road conditions, reducing danger and speeding up journeys. The toll-funded system made a major contribution to the Industrial Revolution by reducing freight rates and enabling faster stagecoach travel.
Doctors should exercise caution when commenting on public figures' mental health, as diagnoses require direct assessment. The BMJ opinion article explores ethical tensions and the importance of professional standards in such cases.
The new fiber probe can track three key biomarkers - glucose, lactate, and ethanol - simultaneously, providing a more complete picture of metabolic health. This innovation offers faster, real-time sensing technologies for clinicians to respond rapidly to evolving metabolic crises.
A new UBC study maps climate change's impact on Canada's environment, revealing regions with high unpredictability and lower biodiversity. The team identified over 2.7 million square kilometres of unprotected land that could strengthen the country's conservation network.
Scientists found that specific genetic sequences, known as HAQERs, have a significant impact on human language abilities. These regions evolved before humans and Neanderthals diverged and are thought to be responsible for the development of modern human language.
A new $15 million research network will investigate the causes and treatments of heart valve disease, which affects over 80 million people worldwide. The American Heart Association hopes to develop early warning signs and diagnosis methods to expand treatment options and improve quality of life for patients.
Research from the University of Texas at Austin finds that consumers pay up to $170 extra per vehicle when buying a used car with nearly identical mileage but one digit off, due to left-digit bias. This phenomenon can result in higher prices for cars just below round numbers like 20,000 or 50,000.
Paxlovid helps vaccinated adults recover faster from COVID-19, but does not reduce hospital admissions or deaths. The drug significantly reduces viral load and side effects, making it a valuable treatment option for higher-risk patients.
Penn State professor Greg Fosco emphasizes the importance of parental monitoring, autonomy-supportive parenting, and fostering a sense of purpose in teenagers' lives. Research suggests that when adolescents perceive a stable relationship with their parents, their well-being suffers, while having a sense of purpose is linked to lower su...
A study from the University of São Paulo reveals that neurodegenerative processes extend beyond the central nervous system, affecting various targets throughout the body. The researchers identified over 9,000 autoantibodies linked to immune status, neurological damage, and symptoms specific to each disease.
A new model predicts that the selection of a single follicle for maturation during human pregnancy is entirely random, contrary to prior theories. The model suggests that once one follicle is selected, estradiol levels start rising, causing FSH levels to fall below the threshold, and unselected follicles die off.
A team of researchers has developed a new microbial method for producing medium-chain fatty acids, which are used in various industries, including cosmetics and detergents. The breakthrough enables the use of waste materials as feedstock for fermentation, reducing reliance on palm oil.
A global trial involving 1,670 patients with intracerebral haemorrhage found that treatment with a single pill combination of three low-dose blood pressure medicines reduced the risk of another stroke by 39%. The study showed significant benefits in reducing major cardiovascular events and improving blood pressure control.
Researchers developed liquid biochar mineral complex fertilizers that significantly increase crop yields and improve nutrient efficiency. The nitrogen-enriched formulation delivered the strongest results, achieving positive nitrogen and phosphorus balances while reducing labor and cost.
Researchers found that connected habitats enhance the ability of amphibian skin microbiome to defend against diseases by increasing beneficial bacteria presence. This study highlights a critical link between environmental disturbance, microbial defenses, and disease dynamics.
The SNMMI 2026 Annual Meeting will showcase the latest scientific developments driving advances in nuclear medicine, including earlier diagnosis, personalized treatment, and improved disease management for various conditions. The meeting will feature over 150 scientific sessions, satellite symposia, and a cutting-edge exhibit hall.
A new study from Weill Cornell Medicine found that the protein caspase-5 boosts cell growth in the gut lining by amplifying Wnt signaling. This balance is crucial for maintaining a healthy intestinal lining, replacing injured cells with new ones, and preventing diseases like colorectal cancer and inflammatory bowel disease.
Scientists at St. Jude Children's Research Hospital identified a key regulatory enhancer, ecMYC E1, that drives MYC expression in pediatric medulloblastoma, a type of brain cancer with poor outcomes. Silencing this enhancer reduces MYC transcription and can be targeted to treat the disease.
A recent study published in Neurology found that people with epilepsy who experience poor sleep are at a higher risk of developing dementia compared to those without epilepsy. Optimal sleep, defined as six to eight hours per day, is associated with better cognitive function and lower dementia risk.
Researchers found that modern AI language models can distinguish between categories like commonplace, improbable and impossible events with high accuracy. The models' internal patterns, or vectors, show a correlation with human uncertainty about statement plausibility.
MSK researchers showcased innovative therapeutic advances for HER2-driven rectal and KRAS-driven pancreatic cancers, as well as a promising mRNA vaccine. CAR T cell therapies targeting uPAR showed promise in shrinking solid tumors and overcoming treatment resistance.
A study by Yokohama National University finds that work ability, inclusion, and human resource development are crucial elements for promoting disability inclusion in the workplace. The research suggests a framework to reduce barriers and promote continued success among disabled individuals.
A new study by the American Academy of Neurology found that virtual and in-person visits for new neurology patients have no significant difference in follow-up clinic visits or emergency department hospitalizations. However, some conditions like Parkinson's disease and multiple sclerosis showed a higher need for follow-up evaluations a...
The American Ornithological Society has awarded grants to six early-career researchers from Latin America and the Caribbean to study bird conservation in the region. The projects focus on endemic species and will contribute to broader efforts across the region, strengthening conservation capacity.
The Columbia University Fertility Center has been ranked #1 on Newsweek's list of America's Best Fertility Clinics for the second consecutive year. The center offers cutting-edge innovations such as HELIOS near-infrared light technology to enhance embryo development, and STAR AI-assisted method to retrieve sperm in men with azoospermia.
A recent study found that nearly 69% of former professional football players may have sleep apnea, with many cases going undiagnosed. Untreated sleep apnea is linked to worse mental, cognitive, and physical health outcomes among former athletes.
Researchers developed an electrochemical sensor to detect pancreatic cancer at low concentrations, improving accessibility and effectiveness of treatment. The device identifies CA19-9 protein, a key biomarker for the disease, allowing for early diagnosis and potentially increasing survival rates.
Researchers create model connecting nuclide signal fluctuations to progressive changes in rock structure leading to critical failure. This allows for early warning of geohazards such as landslides and avalanches.
A new NYU study analyzes hourly ridership at 10 major NYC subway stations between 2023 and 2025. Heavy rain affects peak hour travel, while extreme cold has a smaller impact, especially off-peak. The research highlights the importance of considering infrastructure, station design, and surrounding land use in transit planning.
A Princeton-led study examines the complexities of translating natural resource wealth into economic prosperity. Higher social and human capital, as well as institutional safeguards, are critical in avoiding the 'resource curse,' a phenomenon where extraction leads to limited growth and unstable institutions.
A rare case of mucinous ovarian carcinoma was reported in a postmenopausal woman, initially misdiagnosed as a pelvic abscess due to nonspecific symptoms and radiologic features. The diagnosis was confirmed after advanced imaging and tumor marker assessment. Early recognition is crucial for timely diagnosis and effective treatment of th...
The study examines the cumulative physical, cognitive and psychological demands of a Formula 1 season on team personnel. Researchers aim to develop targeted interventions to support performance, recovery and well-being in one of the world's most demanding team environments.
Researchers found that an ASO strategy boosts expression of the closely related HNRNPH1 protein, reducing symptoms of HNRNPH2-related neurodevelopmental disorder. The study provides vital mechanistic data to support advancement of this promising therapy.