A new gene catalogue provides comprehensive insights into premature aging disorders, highlighting the central role of genome maintenance and DNA repair pathways. The catalogue organizes genetic and clinical information for 56 syndromes and 160 distinct clinical entities, offering a valuable framework for future research.
Researchers found that faces presented behind observers are perceived as more emotionally intense than those in front. This 'behind-enhancement bias' is observed even when participants view the face via a virtual mirror without turning around. The study suggests a spatially modulated perceptual bias related to processing of emotionally...
Researchers found associations between BRCA1/2 pathogenic variants and four types of cancer: thyroid, bladder, skin, and head and neck. Pathogenic variants in BRCA1 increase thyroid cancer risk, while BRCA2 increases risk for bladder, head and neck, and skin cancers.
A community-based point-of-care HCV RNA testing program was feasible and led to a high percentage of same-day treatment for American Indian and Alaska Native participants. The study supports expanding point-of-care HCV RNA testing and integrated treatment to advance HCV elimination.
The American Gastroenterological Association has announced its 2026 recognition prize recipients, including Hashem El-Serag for the Julius Friedenwald Medal for his exceptional service to the field and AGA. Dr. El-Serag is an internationally recognized physician-scientist known for pioneering epidemiologic research on hepatocellular ca...
A notable minority of US youth and young adults, particularly those facing structural disadvantages and mental health distress, engage in intentional online searches for gun-related harm. Public health strategies combining digital interventions with structural reforms offer promise to reduce gun-related harm among vulnerable populations.
Researchers found that active mitochondria keep dendritic cells ready to respond by maintaining key internal processes. Disrupting this balance alters DNA methylation patterns at regulatory regions, enabling rapid gene activation.
Researchers proposed a dynamically expandable learning framework for interactive trajectory prediction to enable models to adapt to evolving traffic environments. The approach effectively mitigates catastrophic forgetting and maintains stable predictions for critical interaction scenarios across multiple learning stages.
Scientists have pioneered a way to make integrated circuits for light by depositing complex patterns of specialized materials onto silicon wafers. This advance could provide a big boost for emerging technologies such as artificial intelligence, quantum computers, and optical atomic clocks.
A new study found that AI applications enhance consumer understanding of skin conditions by increasing accuracy and confidence. However, imperfect guessing accuracy remains, highlighting the need for further design improvements to facilitate better comprehension.
A massive study of ancient DNA from nearly 16,000 people across over 10,000 years in West Eurasia reveals that natural selection has shaped modern human genomes more than previously thought. Many gene variants linked to health and complex traits have been selected since farming began.
An international team of scientists has established a formal scientific definition for 'Blue Zones', a term previously used to describe places where people live the longest. The new criteria capture two key benchmarks: unusually strong longevity after age 70 and high odds of reaching 100, conditional on surviving to 70.
Researchers developed MitoCatch, a system that targets disease-affected cells with healthy mitochondria. The innovation enables efficient cell type-specific mitochondrial delivery, improving survival of damaged neurons in vitro and retinal ganglion cells in vivo.
Researchers developed a novel approach to personalize travel behavior analysis without centralizing sensitive user data. The IPC-FM framework achieves high accuracy and adapts quickly to new users, offering a customizable solution for individual mobility needs.
Researchers identified a CRISPR variant that distinguishes tumor DNA from healthy DNA and selectively cuts the former. This method relies on methyl groups attached to DNA, which are altered in cancer cells.
A study from Columbia University Mailman School of Public Health found that Epstein-Barr virus and a specific immune-related gene interact to shape disease risk. The research identified a key interaction between the human HLA allele HLA-A*11:01 and a viral variant in the EBV gene EBNA3B, elevating nasopharyngeal cancer risk.
Researchers at Boston Children's Hospital have identified a mechanism for immune cells to recycle defective or autoreactive antibodies by editing their genes. The new process uses an enzyme called RAG to swap out light chains with nearby new ones, often making them non-defective and functional.
Scientists have tracked oxygen spillover in catalysts using environmental transmission electron microscopy and observed bulk oxygen spillover for the first time in Ru/rutile-TiO2 catalysts. The research provides new approaches for utilizing catalyst bulk, enabling it to contribute to mass transfer during catalytic reactions.
The JAMA+ Trials platform provides a comprehensive online space for clinical trial research, featuring multimedia content and tailored resources. Recent trials published across multiple JAMA Network journals are highlighted on the platform.
Researchers developed a platform called PerturbFate to map genetic variations and identify common control points driving changes in cell behavior. The study shows that targeting these shared regulatory nodes can lead to combination therapies for complex diseases like cancer, with potential applications beyond melanoma drug resistance.
A large DRUP trial reveals that existing targeted cancer therapies can deliver profound and durable benefits, even in heavily pretreated or rare cancers. About one-third of patients responded to treatment or had stable disease for at least four months.
A new study developed a multi-scale dynamic driving environment to assess the impact of daily driving behavior on electric vehicle battery health. The framework uses deep reinforcement learning to optimize battery health and energy efficiency, and its results show that stable driving behavior can extend battery lifetime by approximatel...
Social media use has been linked to psychological distress and impaired functioning in some people, but the impact varies widely depending on how and why it's used. Researchers are debating how to measure social media addiction and need more rigorous studies to determine whether it should be classified as a clinical disorder.
A new study introduces the diameter-transformed fluidized bed (DTFB) reactor, which addresses national demands for upgraded automotive gasoline quality and advanced heterogeneous catalytic reactions. The DTFB platform achieves precise selectivity control for complex catalytic reactions in a single fluidized bed.
Researchers propose a novel latency-aware trajectory prediction framework, LatenAux, empowered by a consolidated auxiliary learning paradigm. The framework transforms latency from a hindrance into an opportunity for improved performance. Extensive experiments validate its effectiveness and superiority.
KEPT, an AI system, combines video understanding with a memory of similar past scenes to help self-driving cars predict their own short-term path more safely. The system uses a fast and lightweight retrieval module to reduce prediction errors and potential collisions.
Researchers from China Mobile Research Institute and ZGC Institute outline a comprehensive analysis of cooperative integrated sensing and communication (ISAC), a key paradigm for sixth-generation mobile information networks. The study presents real-world field trial results, demonstrating the technology's feasibility in various setups.
A study in Engineering explores a novel strategy for multi-user edge computing systems to maximize robot swarm lifetime. By exploiting correlation among distributed data sources, the approach reduces communication overhead and energy drain, extending swarm operation by up to 650%.
A new artificial intelligence framework called SS-MA-PPO treats mandatory lane-change control as a coordinated multi-agent problem, enabling CAVs to effectively coordinate with surrounding vehicles. The framework consistently delivered the best performance in terms of delay, waiting time, fuel consumption, and stop-and-go frequency.
The report highlights a critical implementation gap in digital mental health tools, which struggle to reach the masses due to inadequate infrastructure. The industry has excelled in creating evidence-based tools and AI systems, but fails to deliver them at population scale without proper systems in place.
The award recognizes the book's significant contributions to research, teaching, business, and industry in the field of optics and photonics. The authors, Thomas Luhmann, Stuart Robson, Stephen Kyle, and Jan Böhm, are renowned experts in photogrammetry and 3D imaging.
Researchers developed a simple, 15-minute test to measure melatonin levels using fluorescent nanoparticles and smartphone-based readers. This technology can aid in monitoring circadian rhythms, crucial for shift workers and space operations.
Researchers at Case Western Reserve University will use AI and machine learning to analyze over 1,800 potential genes that have been identified as suitable new targets for treating Alzheimer's disease. The goal is to deliver a prioritized list of genetically validated drug targets to pharmaceutical developers and clinicians.
Researchers at KAUST have discovered that depleted oil fields can be used to store hydrogen in a safe and efficient manner. This method involves incorporating hydrogen into carbon-based molecules called Liquid Organic Hydrogen Carriers (LOHCs), which can then be stored underground and extracted to recover residual oil.
The Cancer Dependency Map Consortium is launching Phase 3 to expand its research beyond cancer vulnerabilities to investigate resistance and surface targets. The consortium aims to develop novel oncology targets and biomarkers for the next generation of cancer therapies.
Researchers at Northwestern University have developed a single-step process to turn methane into methanol without high heat and pressures. The method harnesses tiny bursts of plasma to break the chemical bonds in methane, producing a cleaner-burning fuel for ships and industrial boilers.
A survey found 84% of primary care patients are unfamiliar with Alzheimer's blood tests, but 85% would take one if recommended. Patients value education and ease of use, and express concerns about test reliability and cost.
Researchers develop fluoride-engineered perovskite nanocrystal glass for high-efficiency, full-color emission and ultra-high-resolution holographic displays. The glass matrix enables stable and efficient photoluminescence of PNCs, driving the creation of high-quality dynamic displays.
The organization welcomes Craig Bower, Allison Hirsch Hadar, Susan Johnson, Andrew Schillaci, and Ed Warshauer to its Board of Trustees, succeeding outgoing members. These new leaders join a mission primed for global impact, signaling a reinforced commitment to accelerating safe, effective, and targeted therapies.
A recent study found that academic burnout is associated with increased internet gaming and depression in Chinese adolescents. The study highlights the importance of targeted prevention strategies, including mental health check-ups, counseling sessions, stress management programs, and attentional bias modification training.
Intensifying ocean eddies are amplifying climate extremes in key coastal ecosystems by redistributing heat and nutrients. This process enhances productivity in some areas while trapping heat closer to the surface, leading to rapid warming and altered regional weather patterns.
Engineers at Northwestern University developed artificial neurons that generate realistic electrical signals to activate living brain cells. This breakthrough paves the way for brain-machine interfaces and neuroprosthetics, as well as more efficient brain-like computing systems.
A new study by Cornell University suggests that animal and human waste could meet 102% of nitrogen and 50% of phosphorus needs for US agriculture, reducing reliance on synthetic fertilizers. However, implementation challenges such as processing and transport need to be addressed to unlock this potential.
A new study reveals that cancer cells may begin escaping therapy much earlier, triggered by a stress response that drives them into a temporary drug-tolerant state. Researchers identified an early molecular trigger: NF-κB, which acts as a regulator of cellular stress and survival.
A new blood test identifies African Americans carrying high-risk APOL1 variants at risk of developing kidney failure years before clinical symptoms appear. The test uses circulating protein markers linked to kidney injury and fibrosis, outperforming existing clinical prediction tools.
A large-scale study linked loneliness to an increased risk of degenerative heart valve disease, including aortic valve stenosis and mitral valve regurgitation. Researchers say addressing loneliness could help delay disease progression and reduce the clinical and economic burden of valvular heart disease.
An international team of researchers used AI to create tiny 'smart' proteins that detect chosen targets, opening the way to low-cost biosensors. The protein switches can work inside living cells and generate electrical signals, making them suitable for various sensing technologies.
Researchers found that nearly half of Prairie lakes, wetlands, and reservoirs may be degraded by decades of urea use, which increases growth of microscopic plants and drains essential oxygen out of ponds. Sustainable sources of water are threatened due to agricultural impacts, drainage of wetlands, and climate change.
A study by Ebenbuild confirms strong predictive performance of patient-specific lung digital twins, validated against clinical imaging data. The model's accuracy was demonstrated through a correlation coefficient of 0.95 with experimental data, enabling locally resolved predictions of aerosol deposition at the individual patient level.
The SWIFTT platform uses Copernicus Sentinel satellite data and machine learning models to identify tree health changes, detect anomalies, and predict threats like spruce bark beetle outbreaks and wildfires. Foresters can access timely alerts, prioritize inspections, and coordinate clearing of dead wood to protect forests.
Leading women physicists from India will share their stories of navigating biases and creating practical strategies for advancing equity and inclusion in science. The webinar highlights the real-world impact of physics research and its societal benefits.
The University of Chicago's Data Science Institute is developing AI-based forecasting technology to support farmers and citizens worldwide. The project aims to deliver forecasts that inform decision-making on agriculture, public health, and extreme heat avoidance.
A growing number of fungi are becoming resistant to medication, posing serious risks for patients with weakened immune systems. A five-step plan aims to monitor and prevent the rise of resistant fungi through awareness, surveillance, infection prevention and control, optimized use, and investments.
Researchers at Osaka Metropolitan University developed a new AI-powered snake-like robot that optimizes its movement using deep reinforcement learning. The robot's 'rolling motion' achieves twice the travel speed per unit of power consumption compared to traditional slithering motion, making it more efficient on flat surfaces.
A study found that AI models trained on large amounts of registry data can identify individuals at higher risk of melanoma. The most advanced model distinguished individuals with a 33% probability of developing melanoma in about 73% of cases.
A Virginia Tech student's discovery of a rare, ancient meat-eating dinosaur sheds light on the evolution and spread of dinosaurs during the Jurassic period. The species, Ptychotherates bucculentus, had massive cheekbones and a short snout, indicating constant evolution in early dinosaurs.
According to new research, over 66 million Americans use AI tools or chatbots for physical or mental healthcare information or advice. Most turn to AI to supplement their healthcare experiences, using it before or after seeing a doctor. AI usage is driven by various factors, including wanting answers quickly, additional information, an...
Researchers at Stockholm Environment Institute developed a new method to identify and reduce risks of violating Sámi rights linked to industrial projects on traditional lands. The method highlights significant risks to human rights, particularly for the Gabna Sámi reindeer herding community.
Researchers propose an agnostic biosignature that detects life on a population level by analyzing patterns of planetary traits and spatial relationships. This method prioritizes reliability over completeness, minimizing false positives even if it misses some life-bearing planets.
A high-precision Human Immune Aging Clock (HIAC) has been developed to quantify immunosenescence and identify actionable intervention targets. The study identified RUNX1 as a functional 'brake' on T-cell senescence, and found that individuals with decelerated immune aging displayed a more youthful immune profile.