Researchers develop molecular tool called SynTrogo, which enables selective dismantling of synaptic connections in brain circuits. By harnessing astrocytes, the system reduces synapse number while strengthening remaining connections, leading to enhanced long-term potentiation and improved memory.
A study of 153 Chilean older adults with cognitive concerns found a link between the gut microbiome's neuroactive potential and mental health status. The research suggests that alterations in the gut microbiome may contribute to depression and cognitive decline in this population.
Researchers studied the TOI-201 system, finding that the planets' orbits are tilted relative to each other, causing them to slowly change orientations. The team used multiple observational techniques to confirm the system's existence and predict future transits.
Researchers found that bacteria and cells use chemical signals to navigate their environment, while artificial particles exhibit superdiffusion and subdiffusive motion. These findings have potential applications in medicine, particularly in drug delivery.
Researchers develop Kinematic Intelligence framework to transfer skills between robots with different mechanical structures, enabling safe and predictable behavior. The approach reduces time and expertise needed to deploy robots in real-world settings.
Children's Hospital of Philadelphia (CHOP) researchers developed STRIPE, a targeted long-read RNA sequencing strategy, to reveal disease-causing genetic variants and provide molecular diagnoses for previously undiagnosed patients. The platform enables ultra-deep, full-length RNA sequencing at a practical scale, addressing the diagnosti...
A recent study found that adolescents consuming more ultra-processed foods have significantly higher odds of being overweight or obese. The study, which analyzed data from 155,000 adolescents across multiple countries, suggests that public health strategies should prioritize reducing UPF consumption among adolescents.
A study analyzing VAR decisions across 1,520 English Premier League matches found that referees overturn their original calls 95% of the time after video review. However, these decisions were not statistically linked to factors such as crowd size, score, or quarter when the call was made.
A survey of Europeans reveals widespread ignorance about fungi as food, including misunderstanding of key terms like mycoprotein. Fungal-based foods face challenges in the EU market due to lack of knowledge and misconceptions.
A novel electrode material exhibits excellent water stability, conductivity, and catalytic activity for air sterilization applications. The 0.3Co-MOF/Cu@Cu structure generates reactive oxygen species to induce bacterial death.
A new study by Lancaster University found that cognitive ability, education, and employment status are key factors influencing internet use among older adults, not age itself. The study analyzed data from over 6,000 people aged 50+ and found that most older adults in England regularly use the internet.
Scientists corrected a genetic disease of the liver in mouse models and human patient cells using gene editing, building a foundation for a potential new therapy for Zellweger spectrum disorder. The breakthrough restored function of the liver and peroxisomes, reducing toxic buildup.
A recent study from The Jackson Laboratory has identified dozens of unexpected genes strongly linked to type 2 diabetes. These genes are key to cell death and vitamin A metabolism, suggesting the disease depends on expression changes that can be targeted for treatment.
A new study found that brain activity and emotional reactivity may predict risk of readmission for patients with major depressive disorder or bipolar disorder. Participants who reacted strongly to negative emotions were at higher risk of hospitalization, suggesting a potential biomarker for identifying vulnerable individuals.
The UTHealth Houston-developed dual-payload antibody-drug conjugate technology has been acquired by Eli Lilly, marking a major step towards clinical translation. This technology delivers chemotherapy directly to tumor cells while minimizing damage to healthy tissue, offering a promising approach to cancer treatment.
A new large-scale study of over 14,000 women found that those with a longer reproductive span experienced better cognitive health, while hormone therapy use within 10 years of menopause showed no significant benefits. The results support current guidelines against hormone therapy for preventing dementia.
Researchers have developed a rapid colour-changing test to distinguish between different strains of golden staph, including those likely to be virulent and antibiotic resistant. The test uses nanozymes and short DNA molecular binders to create unique 'fingerprints' that can help separate high-risk strains from others.
A new NYU Langone Health study found that e-bike and scooter crashes are now accounting for nearly 7% of trauma patients admitted to NYC hospitals, with traumatic brain injuries on the rise. The study also highlights the importance of improved urban infrastructure and helmet use to prevent these injuries.
Researchers propose a novel brain architecture for efficient processing, integrating parallel cortical and subcortical pathways. This approach may improve decision-making tasks, suggesting current AI models are missing key brain function principles.
A new report warns that over 40% of soil-dependent species are at risk of extinction. The study highlights the importance of conserving these species for food security and mitigating global warming.
A new analytical method allows scientists to track exactly where a cancer drug accumulates inside a living cell, enabling more precise treatment design. This breakthrough uses subcellular capillary sampling and laser ablation – Inductively coupled plasma – Mass spectrometry to detect trace amounts of metal in individual cells.
High-resolution CT scans provide detailed images of mummified human remains, enabling accurate age determination and diagnosis of conditions such as osteoporosis. The analysis also sheds light on the mummification process and potential facial reconstructions of skulls.
Researchers Dr Íris Luz Batalha and Dr Maria Shchepinova from the University of Bath have been awarded funding to test new ideas in tackling global health challenges. They will develop precision-targeted therapies for antimicrobial resistance and investigate why treatments for Type 2 diabetes don't work for everyone.
A new study by the University of East London reveals that gay men's desirability shifts depending on their location and digital platforms. Queer men of colour may receive more attention abroad, but this boost is often short-lived and tied to novelty rather than lasting confidence.
A recent study by the University of Bristol found that people trying to resist their food cravings use social media content featuring indulgent treats as a substitute for eating. Dieters spent more time viewing high-calorie options and consumed less chocolate than non-dieters after being exposed to visual food content.
A study from Umeå University found that visualizing ultrasound images of atherosclerosis, combined with a motivational dialogue, increases motivation to improve lifestyle habits and take preventive medication. This results in lower estimated risk of cardiovascular disease and better development of risk factors over time.
Duracyte's technology uses an implantable device to produce therapeutic proteins continuously inside the human body, replacing injections and infusions with a single device. The device can sense biological signals, monitor tumor environments and adjust therapeutic output in real time.
Researchers developed an ovarian follicle-based angiogenesis microphysiological system that forms complex 3D vascular networks without exogenous VEGF. The platform enables direct visualization and quantitative analysis of vascular remodeling, allowing for the rapid identification of anti-angiogenic compounds with meaningful in vivo act...
A comprehensive review of indel error detection and correction techniques explores traditional model-driven approaches and emerging data-driven methods. The study highlights key challenges and future research directions, including synchronization recovery in dynamic channels and lightweight deep learning model design.
Researchers developed a new flu vaccine approach targeting specific but distinct regions of the influenza virus protein. This method broadened the immune response, leading to broader protection against various strains. The study's findings have implications for fighting other fast-changing viruses like COVID-19 and RSV.
Scientists have developed a new class of materials that can respond to external forces using their own internal energy, allowing for the creation of autonomous robots. The research demonstrates a new route to realizing active materials with multiple functions, including flexible and soft robots.
A new book co-edited by University of Kansas researcher Lisa Dieker presents a system-wide approach to address the special education workforce crisis. The volume shares strategies to attract, support, retain and lead educators of the most vulnerable student population.
Muttaburrasaurus, Australia's largest plant-eating dinosaur, had a unique toothy beak that allowed it to browse for specific leaves and seeds, and its inner ear suggests it may have walked on hind legs to crop food. The discovery also reveals a keen sense of smell, with large olfactory bulbs and complex air chambers in the nose.
A new study by NUS confirms that word-picture guessing exercises with immediate feedback significantly improve adults' ability to recall new vocabulary in a second language. The research shows that attempting an answer first, even if not fully learned yet, strengthens memory and supports lasting learning.
Researchers propose a new model explaining how cancer cells adapt to treatment resistance through a previously overlooked molecular mechanism. The model involves the family of proteins AP-1, which helps cancer cells explore different gene expression patterns until they find one that improves survival chances.
A new study reveals that birds in Hawaiian forests engage in kleptoparasitism, stealing materials from neighboring nests. The behavior, common among the scarlet I'iwi and crimson Apapane, could threaten species already under stress due to habitat loss and climate change.
Researchers propose new method to capture complex human movement in public spaces, addressing limitations of traditional approaches. By standardizing data measurement, they aim to improve crowd safety predictions and design safer spaces.
A comprehensive study found that personal values are primary drivers behind how Israelis form and maintain opinions on hostage negotiations. The research suggests that these deeply held principles provide a cognitive foundation for navigating high-stakes dilemmas.
Tiny mechanical strain can reshape graphene's electronic landscape, opening a new route for controlling quantum states in two-dimensional materials. Researchers visualize electronic states of strained regions and identify domain walls as robust one-dimensional quantum channels.
A study from Tulane University found that long-term, untreated syphilis increases the risk of serious cardiovascular issues, including stroke, heart attack, and aortic aneurysm. Adults with syphilis were more likely to develop these problems than similar patients without the infection.
The researchers developed an AI-based method that allows users to input natural language prompts about the materials they want to create and suggests optimal procedures for experiments to produce them. The method has been successfully applied to identify catalysts for turning carbon dioxide and hydrogen into carbon monoxide and water u...
Researchers tracked galaxy clusters to test gravity's strength, finding it weakens with distance as predicted by Newton and Einstein. The study confirms the existence of invisible dark matter, closing the door on alternative theories like Modified Newtonian Dynamics.
The extension of the partnership aims to refine SnapShot's performance for live manuscript submission, providing enhanced author feedback and guidance on data sharing. The collaboration also focuses on iterative product development, expanding assessment graphs to accommodate additional data policies.
Researchers found that high cholesterol absorption from the intestine increases the risk of myocardial infarctions and cardiac mortality in patients with a history of acute coronary artery events. Individuals with exceptional cholesterol absorption efficiency, which is present in about one-third of the population, are at a higher risk.
Scientists discovered a weak spot in cancer cells' editing room, which can be targeted by new treatments for aggressive cancers. By blocking the spliceosome, researchers found selectively killed RAS-expressing cells and caused mouse tumors to shrink.
A new study highlights the significant role of quality of dietary fat, rather than total amount consumed. Research reveals that palmitic acid can promote toxic bioactive lipids and low-grade inflammation, while oleic acid may have a protective effect against metabolic disorders.
Early humans at the Acheulian site of Gesher Benot Ya'aqov relied on driftwood from lakeshore environments for fuel, suggesting a practical and efficient strategy. This approach may have been a decisive factor in their choice of location.
A new study introduces Map the Giants, a pioneering citizen-science initiative to document giant coral colonies before they disappear due to global pressures. The project aims to unlock genetic secrets and traits of resilient corals, providing a validated sampling frame for future research.
Recent progress in advanced energy manufacturing highlights 3D printing's potential to redefine next-generation lithium batteries. The technology enables precise control over three-dimensional structures, improving ion-transport pathways and mechanical robustness.
A team of scientists from NTU Singapore has developed a new biochip that, when paired with Artificial Intelligence (AI), can detect quickly and accurately extremely small amounts of microRNAs. The device can cut detection time from hours to 20 minutes.
Alexandra Z. Worden, a leading expert in ocean biogeochemistry, has been awarded a Guggenheim Fellowship to deepen understanding of microbial responses to photosynthetic algae sinking to the seafloor, removing carbon dioxide from the atmosphere and impacting dark ocean communities.
The hospital is conducting a phase 2 clinical trial evaluating STAR0602, which activates the immune system to stop tumor growth across various cancers. The goal of this study is to identify safer and more effective treatments for people with advanced cancers.
Researchers developed a new AI-assisted tool called CacheMind to improve cache performance and reduce evictions. The tool uses causal reasoning to analyze fine-grained details about system behavior, enabling computer architects to identify patterns and implement fixes.
Researchers propose a new approach to secure optical communication by hiding information in the physical structure of light, making it difficult for unauthorized parties to intercept or decode. Computer simulations showed that the method can transmit information reliably without revealing it through changes in beam size or intensity.
Researchers from Shandong Second Medical University and Wuhan University identified LINC00862 as a tumor suppressor that forms a triplex-mediated transcriptional activation driving tumor suppression in HCC. The study reveals a bidirectional regulatory loop between LINC00862 and RBM47, which reinforces tumor suppression.
Researchers found that post-fire seedling establishment remained strong across key commercial species, Scots pine and birch, after combining prescribed burning with tree retention. Natural tree regeneration met or exceeded commercial standards, supporting biodiversity goals with sustainable forest management.
Researchers have finally understood why reinforced rubber is so tough and durable, with tiny particles forcing the material to fight against its own incompressibility. This breakthrough could improve tire design and lead to safer, longer-lasting products.
Researchers create living biohybrid miniature robots that solve traditional engineering trade-offs between structural rigidity and environmental adaptability. These biological engines utilize embodied intelligence to navigate complex terrains and achieve performance metrics rivaling state-of-the-art synthetics.
Scientists mapped the spread of a novel flu strain, D1.1 H5N1, through wild bird populations across North America, revealing its emergence and geographic penetration. The study shows that current human vaccine stockpiles will likely work well against both avian and human infections.
Using three-dimensional electron diffraction, researchers demonstrate that electrons can provide averaged structural information previously accessible only with X-rays. They also optimize the electron dose and develop tailored acquisition strategies to probe highly sensitive nanocrystalline structures while preserving the material.