Researchers have discovered a new class of high-Tc superconductors among 5d transition-metal-oxides, with the highest Tc recorded at 17.8 K in ReO3. The discovery is attributed to the synergistic mechanism of pressure-enhanced orbital hybridization and oxygen-lattice-dominated electron-phonon coupling.
Researchers challenged the double water bulge model by analyzing tidal data from satellite observations. They found that only 56.84% of locations experienced low tides and 43.16% experienced high tides, contradicting the physical existence of two water bulges.
Climate change is altering the distribution of cropland nitrogen pollution in China, with emerging hotspots shifting from the south to the north. Nitrogen accumulation in soils and increased rainfall are key drivers of this shift.
Researchers at the Max Planck Institute for Chemistry have developed a new method to reconstruct daily seawater temperatures over a four-month period from single rhodoliths. The approach combines three-dimensional X-ray imaging with geochemical analyses and an algorithm to merge data from multiple branches into a continuous timeline.
A new study found that folic acid works with the enzyme ALDH1L1 to produce retinoic acid, a critical developmental signal for the nervous system. Folic acid's protective effect is lost when ALDH1L1 is disrupted, supporting its role in preventing neural tube defects.
A high-throughput ceramic processing method using cellulose nanofiber dispersions enables rapid exploration of dielectric materials. The researchers identified a dielectric ceramic with excellent temperature stability, demonstrating its potential in advanced functional materials.
In a rat model of ischemic stroke, administering rapamycin immediately after blood flow restoration reduced brain damage and improved neurological recovery. The drug's protective effects extend beyond improving circulation, suggesting additional biological mechanisms that could be targeted to improve stroke recovery.
Researchers created a programmable DNA nanodevice that penetrates lipid membranes using mechanical motion, delivering molecular cargo into synthetic cells. The device enables active control of membrane transport in space and time.
A 304-million-year-old warming event could inform scientists about rapidly changing Earth conditions. A small temperature spike led to a larger one from melting permafrost, with global sea surface temperatures rising by over 7 degrees Celsius.
The €6 million 'BabyIAXO' magnet system at the University of Bonn will search for the axion, a particle that could explain a long-standing problem in the Standard Model of particle physics. The project's success would provide proof of the axion's existence and solve the 'strong CP problem'.
Researchers found that meaning in life and healthy digital habits are strong predictors of better mental health outcomes. These factors can be strengthened through interventions, regardless of religious affiliation.
Researchers develop new CAR-T engineering strategies to address the barriers of solid tumors, including tumor access, targeting specificity, cellular resilience, and patient physiological context. The approaches aim to build cellular fitness and overcome immunosuppressive signals, with promising results in clinical trials.
A statewide study of Mississippi's public universities found that nearly 1 in 4 students gamble, with 7% showing signs of a gambling problem. Students with gambling problems are more likely to report mental health concerns.
The University of Louisville's MD-PhD program has received a federal designation and funding, enabling it to amplify its curriculum and increase the number of physician-researchers trained. The National Institutes of Health (NIH) has designated UofL's program as an elite Medical Scientist Training Program.
Researchers at CERN's Large Hadron Collider have made a groundbreaking discovery that challenges the long-standing theory of how gluons behave inside atomic nuclei. The study, led by University of Kansas physicist Daniel Tapia Takaki, used incoherent J/ψ photonuclear production to probe the underlying gluon structure with unprecedented...
Researchers have discovered that proteins released from mitochondria can activate the immune system in a similar way to invading bacteria. Elevated levels of mitochondrial proteins were found circulating in the bloodstream even when no live bacteria were present, leading to excessive inflammation.
Researchers develop pangenome-guided breeding strategy to combine beneficial genes and traits for higher yields and stress tolerance in crops. The approach identifies and reintroduces lost genetic variants from wild species, resulting in improved seed size and high-altitude adaptability.
The DOE has committed funding for UNITY-3, a cutting-edge breeding blanket test facility at ORNL, with Kyoto Fusioneering relocating its US headquarters to Tennessee. This partnership establishes a shared commercial-scale testing infrastructure to validate critical systems and train digital twins of breeding blanket concepts.
Researchers at Kaunas University of Technology have created a more stable interface between the different layers of perovskite solar cells, improving their efficiency and operational lifetime. The new concept enables large-area modules to be coated with a uniform layer, allowing for practical application testing.
Researchers developed a novel imaging approach called SANDI to study microstructural brain abnormalities associated with Huntington's disease. The model revealed differences in cell density and size, correlating with disease progression and motor performance.
The Marcus Foundation has awarded $28.7 million to advance a clinical trial testing a stem cell-based therapy designed to regenerate damaged heart tissue after a heart attack. Researchers aim to develop approaches that could reduce or eliminate the need for immunosuppressive drugs.
New research articles published in The Journal of Nuclear Medicine explore intensified PSMA-targeted therapy for advanced prostate cancer, as well as novel approaches to targeted radiopharmaceutical therapy. Studies also investigate radiation doses from PSMA-targeted therapy and their relationship with treatment outcomes, while others ...
Researchers at TU Wien and University of California San Diego have discovered a new quantum regime of coherent X-ray generation with higher energies, breaking the conventional energy cutoff limit. The effect is attributed to the interaction between two electrons in helium atoms, which release their energy simultaneously.
Recent studies from the University of Gothenburg found that nicotine use is associated with symptoms of anxiety, depression, and other mental health problems in adolescents. Girls are particularly vulnerable to these effects, including increased risk of worsening sleep problems, low mood, and difficulties concentrating.
A new study identifies a parasite-specific protein TgPRO that helps Toxoplasma manage oxidative stress and energy production in crowded cells. The findings point to a possible therapeutic strategy: inhibiting pathways controlled by TgPRO could make the parasite more vulnerable to antiparasitic drugs.
The US FDA has cleared Eve, the first self-balancing personal exoskeleton, enabling eligible adults with spinal cord injury to walk and perform daily activities hands-free. Participants reported improvements in health status, psychological well-being, and quality of life, demonstrating substantial clinical relevance.
A global study of 68 specialist music programs across 25 countries reveals a spectrum of approaches to supporting musically gifted children. The research highlights the need for balancing artistic excellence with genuine care for children, with some programs prioritizing institutional prestige over child well-being.
New research at Aston University shows that mānuka honey's effectiveness against disease-causing bacteria cannot be attributed solely to its sugar content and methylglyoxal levels. The study identified additional bioactive compounds responsible for the antimicrobial activity, which may lead to the development of more effective honey-de...
A team of researchers has developed a new way to study heart valve disorders by creating miniature, working models of the heart. The models, called assembloids, were grown from pluripotent adult stem cells and can be used to simulate various types of valve disorders, including mitral valve prolapse.
Vasanthi Jayaraman has been elected President-elect of the Biophysical Society, while Harpreet Singh will serve as Secretary. The election results also include four members elected to Council for three-year terms.
A new study published in Diabetes Care found that older adults with type 2 diabetes are at a higher fracture risk, but bone loss alone does not explain this increased risk. Researchers used a novel bone imaging device to analyze cortical and trabecular bone density, microarchitecture, and strength, and found that changes in these areas...
A McGill University-led study recommends cold-climate cities expand electric bus fleets and implement slow charging to optimize operations and reduce energy consumption. The approach aims to eliminate diesel reliance and minimize operating costs, making transit systems more cost-effective and eco-friendly.
A hybrid lifestyle program showed potential benefits for cardiometabolic health among adherent participants with obesity, but failed to achieve significant weight loss. The study suggests further investigation into the program's effects on metabolic health.
Researchers developed a computational framework called DANDELION to identify disease-driving genes in complex diseases like asthma. The study found that protein palmitoylation plays a key role in driving the disease, revealing a potential new target for future therapies.
Researchers develop two virtual culturally grounded interventions to address substance use among urban American Indian and Alaska Native emerging adults. The studies show reduced substance use, including cannabis and alcohol consumption, as well as social connections with tribal communities.
A new international study defines clinical obesity as a significant predictor of increased disease burden, operative risk, and cardiovascular risk in patients undergoing metabolic bariatric surgery. The study found that the majority of patients met criteria for clinical obesity, while a minority had preclinical obesity.
Researchers at Murdoch Children's Research Institute have developed a powerful platform to test and advance new treatments for childhood heart diseases. The breakthrough involves creating lab-grown heart valve tissues that closely resemble human body valves, providing a promising approach for regenerative medicine.
Patients with severe traumatic brain injury in resource-limited settings are at higher risk of mortality. The study highlights the need for improved acute and postdischarge care to reduce mortality rates.
Researchers at NUS engineered baker's yeast to sense and respond to red and blue light, enabling dynamic control over cellular behavior. The breakthrough uses optogenetics to deliver complex instructions without repeated chemical inducers.
Integrating improvisational theatre, mindfulness meditation, and board games into the classroom can help stabilize—and even improve—students' mental health. The most anxious participants showed a protective effect, with self-efficacy remaining stable.
Researchers developed a novel method to probe how mirror-image materials structure acts like a microscopic filter, influencing electron separation and movement. The approach allows for faster testing of promising materials for spintronics and optoelectronics technologies.
A study by King's College London has identified two types of white blood cells linked to survival outcomes for patients with melanoma. Effective immunotherapy treatment is associated with efficient B and T cell responses, while immature or poorly functioning B cell populations predict poorer outcomes.
Taylor & Francis introduces Plain Language Reviews to make technical information accessible to non-specialists. These open-access articles summarize multiple peer-reviewed articles on a single topic, empowering readers with complete understanding.
A multidisciplinary project combines computer modeling, particle science, and pharmaceutical science to create more effective inhalers for people who can't inhale deeply. Researchers found that improved designs can reduce deposition in the mouth and throat, increase penetration of particles into the lungs.
A new theory proposes that critical illness arises from loss of physiological coordination, not just organ failure. The Entropic Critical Illness Theory views living organisms as open systems with a continuous need to regulate entropy.
Researchers identified recurring metabolic changes associated with blood-brain barrier disruption, including disrupted glutamate and glutamine metabolism. These findings suggest that characteristic patterns of metabolic changes may be used to detect brain damage in the future.
Researchers found molecular signs of changes in the blood of people exposed to air pollution, detectable years before diagnosis with lung cancer. The study suggests potential biomarkers for early detection and prevention strategies.
A UCD study evaluates 43 studies on financial habits and mental illness, revealing significant gaps in current research. Objective financial data is rarely used, and traditional statistical methods dominate the field.
Researchers developed a full-color near-eye display using stacked holographic gratings, improving brightness and power efficiency. The new design enables lightweight, energy-efficient augmented reality glasses with clear virtual images in bright environments.
Researchers found that individuals who prefer sweet tastes are less willing to tolerate uncertainty, leading them to choose smaller immediate rewards. This suggests a different mechanism underlying impulsivity than previously thought.
Researchers from the University of Missouri discovered that the ratio of large and small stars in distant galaxies depends on their environment, potentially altering how scientists estimate galaxy mass and age. This breakthrough could lead to more accurate estimates and a better understanding of the universe's history.
Scientists at Cancer Research UK Scotland Institute and University of Glasgow identify a new pathway for delivering antisense oligonucleotides (ASOs) into cells, enhancing the effectiveness of ASO-based therapy for pancreatic cancer and other diseases. The researchers found that ASOs enter cells via endocytosis and bind to specific rec...
Researchers found that middle-aged individuals with a higher frequency of nocturnal micro-awakenings are more genetically prone to develop Alzheimer’s disease. In contrast, younger adults did not show this association. The study suggests that sleep analysis could complement existing tools for early identification and prevention.
A new study published in JACC suggests that waist circumference and waist-to-hip ratio provide critical information about cardiovascular risk, even among people with a normal BMI. Individuals with elevated central adiposity were associated with higher risks for most outcomes, regardless of their weight status.
A new clinical trial at HonorHealth Research Institute uses a vaccine-based on immune system dendritic cells to fight advanced melanoma. The vaccine has shown promising results in treating refractory and unresectable cases of the disease, with a 10-fold increase in immune response.
A new survey finds that opposition to local data centers has risen sharply among US adults, with 61% opposing construction in their areas. Meanwhile, views on artificial intelligence remain stable, with 39% expressing concerns about its impact.
Researchers identified seven proteins in the blood that can help diagnose Alzheimer's disease more accurately, improving treatment choices and future research. The new blood-based tests provide a clearer picture of the disease, allowing for earlier detection and better patient outcomes.
A new analysis tool helps municipalities identify areas with insufficient tree cover, enabling targeted interventions to improve livability and reduce heat exposure. The tool provides a granular diagnostic approach, allowing cities to prioritize infrastructure investments and greening initiatives where they are needed most.
A new framework, Tripartite Reactions to Emotions theory, explains how emotional posts and reviews influence perceptions of products and authors' own feelings. The theory reveals three distinct psychological reactions: pushing people toward and away from a product or brand, sometimes simultaneously.
A protein known for sensing cellular stress also acts as a cholesterol sensor in specialized immune cells, enabling them to process dying cells and maintain immune homeostasis. IRE1's removal leads to cholesterol accumulation, negatively affecting cell survival and immune function.