Researchers at UC San Diego identified a key cellular pathway that drives brain degeneration in both Sanfilippo syndrome type A and Alzheimer's disease. The study reveals how the brain's immune cells respond to waste buildup, providing a novel target for drug development.
Researchers from Tohoku University and the University of Tokyo developed super exosomes that target senescent cells, improving frailty and physical performance in aged mice. The technology has potential applications in healthy aging, cognitive function, and reproductive medicine.
The Stein Institute at UC San Diego will serve as the Central Laboratory and Biorepository for the XPRIZE Healthspan Competition. The 10 finalist teams will conduct coordinated clinical trials worldwide to test their treatment approaches, aiming for a decade-long extension of human healthspan.
Researchers found that dexamethasone reduces infection-driven macrophage metabolic activity and lowers inflammatory signals, preserving the immune system's ability to control the infection. This study suggests a new approach for managing nontuberculous mycobacterial disease.
Researchers at Mount Sinai have been selected as Milestone 2 Awardee teams in XPRIZE Healthspan, a global competition that aims to develop new approaches for healthy aging. The NYC-Vita clinical trial will evaluate lifestyle and pharmaceutical interventions designed to improve immune system function and support healthier aging.
A digital training program called Measurement-based Care Training for Resilient Implementation in a Clinical Setting (METRIC) helps clinicians consistently incorporate patient-reported outcome measures into routine care. The study found that clinicians maintained positive attitudes toward measurement-based care after completing the tra...
Researchers identified distinct axonal components, including high regenerative capacity and sympathetic nerve fibers, in painful neuromas. The formation of these neuromas is associated with increased expression of pain-related neuropeptides like calcitonin gene-related peptide (CGRP) and mechanosensitive channels.
Large language models exhibit a preference for higher-quality options first, but later options when quality decreases. Models also show unique biases in name preferences, regardless of context, making them harder to predict and prevent.
A new study found that nearly all personal care and cleaning products contained at least one unlabeled chemical with known or suspected health hazards. Products marketed as 'natural' or 'non-toxic' frequently contained undisclosed chemicals linked to health harm.
Researchers argue that policymakers in Colombia can adopt a similar cooperative strategy to solve the country's current water management crisis. The pre-Hispanic field systems of La Mojana cover an astonishing 500,000 hectares and were likely built by local communities in a short period of time through cooperation.
A Kobe University study reveals that land hermit crabs are effective seed dispersers of a non-green parasitic plant. The animals scrape off fruits with their pincers, sometimes attaching them to their bodies, allowing seeds to survive passage through the digestive tract and travel significant distances.
Researchers identified a protective subtype of microglia that expands as Alzheimer's disease progresses, playing a key role in clearing harmful material from the brain. The study provides insights into how the brain's immune cells change across the lifespan and throughout Alzheimer's disease, paving the way for therapies that strengthe...
Researchers distinguish multiple fluorescent proteins with overlapping emission colors by their lifetime using fluorescence lifetime imaging microscopy (FLIM). FLIM successfully distinguishes several fluorescent proteins with overlapping color emissions within plant cells, enabling simultaneous analysis of multiple proteins.
Physicists at the University of Basel and Technical University of Munich developed a method to study the internal behavior of Wigner crystals, a fragile quantum state. By illuminating a single atomic layer of tungsten diselenide and measuring reflected light, they observed new optical features revealing collective electron dynamics.
A comprehensive review of bipolar disorder treatments has been published, identifying the most effective treatments across different age groups and mood phases. The review has been used to update clinical guidelines and provides a platform for clinicians and patients to make informed treatment decisions based on the latest evidence.
The new Wiley Registry/NIST Mass Spectral Library expands coverage to over 1.2 million spectra, enhancing the analysis of unknown chemical compounds in GC-MS workflows. This combined resource delivers high-confidence identification capabilities for leading laboratories worldwide.
A systematic review reveals that social media has only partially fulfilled its promise to democratize climate change communication. Established actors continue to shape the discussion, while climate-change skeptics gain visibility. This undermines public debate on climate change.
The study found that LVIS stent-assisted coiling provided effective aneurysm occlusion while producing measurable hemodynamic changes and maintaining procedural safety. Treatment reduced blood-flow activity within the aneurysm, with sustained improvements at 6 months.
Researchers explored how the term Busseiron, meaning 'theory of the properties of matter,' became an established discipline in Japan. The study found that its scope expanded over time, absorbing new topics and forming a durable branch of physics.
A new review article discusses how artificial intelligence can predict disease trajectories and enable precision medicine strategies for inflammatory bowel disease. AI-based systems can standardize interpretation of endoscopic images, detect mucosal healing, and support recognition of dysplasia in patients with long-standing colitis.
A new review highlights how molecular biology advances are reframing PAH as a complex vascular remodeling disease driven by endothelial dysfunction, chronic inflammation, metabolic dysregulation, and genetic susceptibility. Emerging therapies target the BMP/TGF-β pathway, growth factor signaling, and inflammatory pathways.
Researchers developed a method to predict how different types of breast cancer will respond to treatment using lab-grown mini tumors. The organoids mimicked a tumor's response to treatment and identified candidate combination therapies for cancers that don't respond to standard treatment.
NGR Oncology has appointed multiple new leadership members to various subcommittees, including Rebecca Arend as Gynecology Oncologist Vice Chair of the Translational Science Committee and Robin Lockhorst as Chair of the Pharmacy Subcommittee. David Miyamoto was also appointed Radiation Oncology Vice Chair of the Translational Science C...
Researchers from NUS CDE have developed a computational framework that reconstructs the genealogy of vernacular architecture, including Singapore's historic shophouses. The framework generates a detailed architectural 'family network' that reveals how different styles evolved and interacted over time.
Scientists have discovered a new coral species growing up to 1 meter tall on rocky outcrops in the Pacific Ocean. The bright yellow coral was found thriving in large numbers among brittle stars and has been classified into a new family, Laurinqueidae.
Researchers have developed a technique that can map protein movements over time, revealing dynamic behaviors in molecules with similar structures. This insight improves understanding of protein function and paves the way for training AI models to predict protein behavior.
Researchers found that couples who exercise together report better communication, stronger conflict resolution, and lower marital stress. Walking was the most commonly reported form of shared exercise among couples in the study, suggesting it's a simple way to create opportunities for positive interactions and conversation.
A review examines how lignin, a natural aromatic polymer, can support fertilizers, crop protection, soil improvement, and biodegradable farm materials. Lignin's unique structure-property-performance relationships make it suitable for various agricultural applications.
Researchers developed a synergistic strategy to address stability issues in wearable strain sensors. By creating a covalent co-vulcanisation network with the rubber matrix, they maintained stable sensing performance over 15,000 tensile cycles and operated reliably under harsh environmental conditions.
Researchers developed a new method to improve the fabrication of self-assembled monolayers (SAMs) through blade coating, enabling large-scale manufacturing of high-efficiency perovskite solar cells. The approach enhances device reproducibility and stability by suppressing SAM aggregation.
Researchers explore bacterial extracellular vesicles as a tool for cancer diagnosis and treatment, with potential for targeted delivery of therapeutic molecules and immunotherapy. However, consistency and safety remain major challenges in this emerging field.
A US team has created an integrated manufacturing framework to produce atomic-scale optics for next-generation light sources. The pipeline links atomic-scale fabrication and precision metrology to in-situ X-ray beam validation, achieving deterministic delivery of nanofocusing mirrors.
A multi-year strategic partnership aims to advance longevity science, understanding the connection between skin ageing and systemic health indicators. The collaboration seeks insights into how skin influences overall quality of life.
Researchers develop world's first oral microbiome-based nanomedicine to enhance immune cells' ability to attack cancer cells. The new drug, Prodrug 201, significantly increases bioavailability and effectively directs stem-like T cells into tumor sites.
A study found that coronaviruses hijack the host GBF1-ARF1-COPI pathway to utilize Golgi-derived membranes for promoting DMV formation. This mechanism was conserved across multiple coronaviruses, including SARS-CoV-2, and holds promise for therapeutic development against coronavirus infection.
The co-occurrence of biochar and microplastics in agricultural soils can alter soil carbon storage and inflate estimates of carbon sequestration. The review proposes an evidence-tiered measurement framework to accurately evaluate soil carbon storage.
Researchers developed a photocatalyst combining cellulose-derived carbon quantum dots and cadmium sulfide to improve light harvesting and electron movement. The optimized composite produced significantly more hydrogen per gram than unmodified CdS.
New research highlights the hidden threats of marine heatwaves on human health, including psychological impacts, respiratory problems, and eco-anxiety. The study calls for governments and public health agencies to treat marine heatwaves as a major public health issue.
The 100 Minds Screening Project provided over 100 free cognitive screenings to African Americans aged 60+, highlighting the need for better dementia diagnosis among older adults. The program connected participants with brain health planning information and services, aiming to address the dementia care gap within faith communities.
A KAIST research team has demonstrated for the first time that a porous material can arrange disordered gas molecules into a crystal-like structure. Using xenon as a model system, they identified a specific cobalt-based material that stabilizes xenon in a regular lattice, showcasing a breakthrough in gas crystallization.
A new analysis suggests that Oregon's voter-approved gun control measure led to a significant increase in firearm purchases, with thousands more firearms entering the state than would have otherwise. The study found that background checks surged nearly 14% before the election and then jumped 157% after the measure passed.
A lost letter from Pope Alexander II suggests that the Norman Conquest was shaped by a wider political and religious struggle, rather than just a dynastic dispute. The findings argue that England's support for one faction of the papal dispute may have given William's invasion legitimacy as a 'just war'.
A new study analyzing 11,500 US neighborhoods over a decade found that unauthorized immigration does not drive crime rates. Neighborhoods with growing undocumented populations saw greater reductions in property crime and no significant change in violent crime.
Researchers found that people's perception of technology as natural predicts their support, with a shift in framing prompting higher levels of trust and acceptance. Climate solutions like nuclear energy face resistance due to perceived unnaturalness, highlighting the need for effective communication strategies.
Researchers found that biochar produced from malt spent rootlets can sharply increase E. coli retention in sand, offering a potential route to cleaner water and productive reuse of brewery waste. Adding more biochar changes how bacteria are retained, shifting from physical trapping to direct attachment.
A randomized controlled trial found that first metatarsophalangeal joint arthrodesis significantly improves walking-related pain in patients with painful hallux rigidus. The study suggests arthrodesis as a preferred treatment option for some patients, providing a greater reduction in walking-related pain and secondary outcomes.
A new study by University of Illinois scientists reveals critically low genetic variation in one of the country's primary breeding stocks for corn, specifically grain yield in intermediate-maturity hybrids. This finding poses a significant threat to maize breeders' ability to develop high-yielding hybrids under future climate challenges.
Researchers discovered that scandium doping and coating improve the durability and performance of sodium-ion batteries by stabilizing the crystal structure and suppressing side reactions. The study found that doping improves bulk stability while coating enhances surface stability, leading to improved capacity retention and long-term cy...
Alexis Grimaud, a leading researcher in battery materials chemistry, has received the National Science Foundation CAREER Award to support his work on developing new battery materials with improved energy density and scalability. His project aims to explore complex materials that can be used as battery electrode materials.
Engineers have created a bacterium that can consume all three major sugars present in corn stalks, opening up possibilities for more efficient biomanufacturing processes. The new strain of Pseudomonas putida was developed using an automated culturing platform and can potentially be used to produce valuable molecules like indigoidine.
National Jewish Health researchers identified disease-associated gene activity in macrophages and changes in immune cell communication in lung tissue. These findings may lead to targeted therapies and improved diagnosis of pulmonary sarcoidosis.
Researchers find that targeting Trk and IGF1R pathways can delay Ewing sarcoma tumor growth, but effect is temporary. NTRK gene expression associations with patient OS were found, indicating potential biomarker value.
Scientists created a single-cell atlas of spinal neurons to understand motor coordination and recovery from injury. The study identified a small subgroup of interneurons associated with speed, clarifying their role in controlling movement.
A recent study published in the Journal of the Endocrine Society suggests a link between exposure to phthalates and elevated blood pressure during pregnancy. Pregnant women with higher levels of fragrance-associated phthalates were found to have higher systolic and diastolic blood pressure markers, increasing their risk of hypertensive...
A new study introduces a computational framework that leverages alternative splicing events to predict protein isoform functions. The framework outperforms existing approaches and provides biological insights into how splicing shapes protein function, highlighting the importance of studying proteins at the isoform level.
Researchers analyzed patient data from five clinical trials to evaluate the impact of adding hormone therapy on postoperative radiation outcomes. While traditional pathological features can identify patients at higher risk of recurrence, they do not predict treatment benefit.
Industrial-scale illegal fishing accounts for 8-15% of global marine wild capture, with impacts unevenly distributed globally. Eliminating harmful subsidies and strengthening enforcement are key to addressing the issue.
Children who prefer to play alone but feel they belong in a larger social setting are often happy and content. In contrast, those who don't value belonging or feel like they don't fit in with their peers tend to be unhappy and dissatisfied with their relationships.
Scientists discovered that turbulence in air changes the timing of odor whiffs in systematic ways, creating patterns useful to animals. This finding bridges physics and neuroscience, with potential applications in search and rescue, hazardous chemical leaks, and mimicking animal navigation behavior.
A new study has found that women with endometriosis are at a 46% higher risk of developing type 2 diabetes. The study analyzed nearly 3 million women over 25 years and suggests that chronic inflammation associated with endometriosis may play a role in metabolic health.