A forecasting study found that the Inflation Reduction Act will save approximately $400 million on Louisiana Medicare diabetes drug costs over five years. Patients are expected to switch from non-negotiated to negotiated drugs due to lower costs, resulting in significant savings.
A cross-temporal, multinational study found that people's beliefs about women and men reflect the social roles they occupy in homes and workplaces. Stereotypes of men as assertive and ambitious and women as kinder and more caring persist despite growing female workforce participation.
A groundbreaking study from Northwestern University found that changes to the gut microbiome can change the way the brain works across different primate species. The researchers discovered patterns of gene expression associated with conditions like ADHD and schizophrenia in mice with microbes from smaller-brained primates.
A study highlights the opportunity for orthopedic surgeons to identify patients who have experienced intimate partner violence (IPV), with only 0.3% of referrals compared to 29% from emergency departments. Orthopedic teams can educate and empower patients, providing timely life-saving referrals.
A new study from GreenDrill reveals that the Prudhoe Dome ice cap melted approximately 7,000 years ago due to mild Holocene-era temperatures. This finding highlights the region's vulnerability to human-induced climate change and has significant implications for sea level rise predictions.
A newly designed mechanophore, called DAANAC, was developed to provide early warning against mechanical failure while resisting heat and UV. It features a stable and fluorescent diarylacetonitrile radical coupled to an alkoxycarbonyl radical that quenches fluorescence.
Researchers describe a new species of spider-parasitic mite found on juvenile spiders in the Butantan Institute collection in Rio de Janeiro. The larvae were collected and examined using microscopy techniques, resulting in the first description of this family in Brazil.
This study found that US youth spent more than an hour using smartphones during school hours, primarily for social media use. Objective findings from a large sample confirm previous self-report studies, highlighting the need for responsible smartphone use among adolescents.
Researchers have discovered a unique cobalt-based molecule that can function as a spin quantum bit, providing a new design strategy for molecular materials used in quantum information technologies. The molecule exhibits slow magnetic relaxation and delocalized electron spins, allowing it to stabilize the quantum state.
A University of Bonn study has shown how the fungus Ustilago maydis takes over the plant's lateral root formation function, leading to massive tissue growths that divert energy and resources from defense. The findings provide valuable insights for breeding more resistant varieties of maize.
Researchers found early medieval migrants came from the Mediterranean and Arctic Circle, with a significant spike in male migration and female mobility in the 7th-8th centuries. The study provides new evidence on the nature and scale of early medieval migration, showing that population movement was a consistent feature throughout England.
A retrospective insurance claims analysis found a high prevalence of polypharmacy among children under 15 in Côte d'Ivoire, with regional disparities evident. The study highlights the need for targeted interventions to reduce polypharmacy risks and costs across all regions.
Researchers found that ovarian cancer transforms the omentum into an environment that favors tumor spread. The study analyzed tissue samples from 15 patients and created a cell atlas of the omentum in diseased and healthy states.
A new study found that historic buildings in English cities enhance scenicness, with scores 25% higher than the average urban score. The study's findings suggest that heritage designations and architectural significance are key factors influencing scenic beauty.
A multi-center observational study found that households facing food insecurity and challenges like low social support had a significantly higher risk of long COVID. Healthy diets may protect against the risk, highlighting the need for addressing adverse social factors in disease prevention.
Researchers discovered that centimeter-long aquatic worms can spontaneously collect and organize particles in their environment through natural undulating motion. This behavior emerges from the flexibility of the worms and does not require a brain or complex interaction.
The new guidelines update past recommendations to focus on 30-year-old women with risk factors, while simplifying screening for younger and older populations. The changes aim to reduce overtreatment and improve health outcomes for cervical cancer patients.
Andreas Zeller recognized for his work on automated debugging and security testing, with a total of nine Test of Time Awards. He is one of the few researchers to receive two ERC Advanced Grants from the European Research Council.
Researchers at Columbia University developed an inhalable nanotherapy called BEAT that delivers two therapeutic proteins to the lungs to target cancer cells. The treatment showed better retention in the lungs and dramatically suppressed tumor growth compared to a systemically delivered approach.
A long-term study in Türkiye examines wolf–human interactions, revealing that conflicts cluster in areas with widespread rural livestock farming. The research highlights the impact of human-driven factors such as road networks and habitat fragmentation on conflict risk.
A large patient population study found that weight gain increases the risk of developing low back pain, with a 7% increase in risk for every BMI unit or 10 pounds over ideal weight. The study suggests maintaining a healthy weight or BMI may help avoid low back pain.
A new peer-reviewed paper by Drs. Steven N. Austad and Giovanni M. Pes validates decades of demographic research on the world's longest-lived populations, using rigorous validation criteria to confirm their exceptional human longevity.
Researchers have discovered a linear relationship between reactivity and the reciprocal of uranium concentration in thermal-spectrum molten salt reactors. This finding has significant implications for criticality calculations, fuel loading prediction, and reactivity measurement.
Researchers at Ben-Gurion University have developed a new type of plastic-like material that can be activated with light or gentle heat. The materials, known as latent monomers, remain inactive for weeks before solidifying into a durable plastic-like substance. This switchable system could give rise to hundreds of new plastic-like mate...
A recent study found a substantial COVID-19 burden in the US between October 2022 and September 2024, with adults 65 years and older particularly affected. The study's results underscore the importance of continued prevention efforts to mitigate the impact of COVID-19 on this vulnerable population.
A study led by Professor Michael Glickman and postdoctoral researcher Dr. Ajay Wagh found that brain cells transfer toxic UBB+1 protein to neighboring neurons through a mechanism involving p62, potentially accelerating Alzheimer's disease spread
Researchers have found a galaxy cluster with scorching hot gas just 1.4 billion years after the Big Bang, five times hotter than predicted, and containing three supermassive black holes that pumped energy into the surroundings. This discovery could upend current models of galaxy cluster formation and evolution.
A large-scale international study has deciphered a mechanism enabling breast cancer to metastasize to the brain. Researchers identified a specific chromosomal alteration predicting high likelihood of brain metastases and found that the absence of functional p53 gene impairs brain environment adaptation.
Researchers developed a portfolio optimization framework to maximize offshore energy production by identifying optimal locations for wind turbines and marine hydrokinetic technologies. The study found that combining these technologies in suitable locations can significantly reduce costs and increase energy stability.
Scientists develop subseasonal forecasting tools to provide timely, actionable information for governments and industries. These forecasts offer a 'sweet spot' between short-term precision and long-term planning.
Long-term ecological research faces severe threats from lack of funding, data manipulation, and political interference. The report highlights the need for institutional support to establish trustworthy facts and inform policy.
Researchers discovered that sevoflurane impairs neurogenesis and cognitive function by inhibiting fatty acid β-oxidation in neural stem/progenitor cells. Enhancing FAO activity in NSPCs attenuates sevoflurane-induced neurogenesis impairment, suggesting a new mechanism of sevoflurane neurodevelopmental toxicity.
A new study from Brown University researchers reveals that private equity firms have acquired over 500 autism therapy centers across the US, with a focus on states with high rates of autism diagnoses. The findings raise concerns about the potential impact on access to treatment and the quality of care for families seeking services.
A new platform, RootXplorer, enables accurate whole-root-system assessment of soil penetration, critical for breeding crop varieties resilient to soil compaction and drought. The system uses a standardized approach to mimic mechanical impedance and identify genotypes with contrasting tolerance to compaction.
A study applies a multi-criteria decision analysis framework to evaluate three orphan medicinal products, laronidase, emicizumab, and dimethyl fumarate, with highly consistent quantitative scores. The framework offers a transparent and multi-faceted approach to evaluating high-impact drugs for rare diseases within reimbursement systems.
Researchers at Fritz Haber Institute have made significant strides in understanding fuel-cell catalysts under industrially relevant conditions. They discovered that the rate-limiting steps and their degree of rate control change as a function of overpotential and pressure, challenging traditional views on multi-step reactions.
The January 2026 issues of four American Psychiatric Association journals feature groundbreaking research on externalizing disorders, pediatric anxiety, autism, and inflammation-related depression. The studies also explore the potential benefits of psychedelic therapy in suicide prevention.
A new approach enables efficient, real-time wheat phenology detection using compact models and knowledge distillation. The method achieves high accuracy while reducing data and computational demands, suitable for practical agricultural deployment.
Researchers discovered that nicotinic acid can dramatically reduce liver damage caused by ischemia-reperfusion injury. The compound targets damaged mitochondria, reducing markers of liver injury, suppressing inflammation, and promoting mitophagy and mitochondrial biogenesis.
A new study reveals that microplastics are impairing the oceans' ability to absorb carbon dioxide, a process crucial for regulating Earth's temperature. Microplastics also disrupt marine life, weaken the biological carbon pump, and release greenhouse gases as they degrade.
Scientists create natural surfaces with 3D nanowrinkles that control light, liquids, and living cells. The method uses laser polarization to guide the material's organization, enabling precise control over wrinkle formation and applications in bio-inspired surfaces and sensors.
Researchers created a calculator to assess multilingualism, using formulas that consider age of language acquisition and self-rated proficiency. The tool yields scores indicating language dominance and degree of multilingualism, offering a clear and transparent way to understand individual language strengths.
Researchers developed an injectable paste derived from human skin cells to restore breast volume after tumor removal, with less scarring and shorter healing time. The material promotes blood vessel growth and tissue remodeling while keeping inflammation low, making breast reconstruction safer and more accessible.
A CRISPR screen identified 331 essential genes for brain cell generation, including PEDS1 linked to a severe developmental disorder. The study provides a new approach to identifying genes involved in neurodevelopmental disorders like autism and offers insights into gene inheritance patterns.
A new clinical trial, RECIPROCAL, seeks to optimize targeted radiation therapy for men with advanced prostate cancer by adjusting treatment based on individual PSA levels. The trial aims to minimize side effects while preserving survival benefits.
Researchers at ISTA have found that the zebrafish embryo's geometry is essential for its development, guiding cell division and gene activation. The study's findings could improve IVF embryo assessments by understanding how the embryo interprets its geometry.
A new study found that a drug mimicking the hormone progesterone, megestrol, has anti-cancer activity when used with conventional anti-oestrogen treatment for women with breast cancer. This combination showed a greater decrease in tumour growth rates compared to those treated with an anti-oestrogen only.
The SHASAI project addresses cybersecurity risks in AI systems from design to real-world operation, combining secure hardware and software, risk-driven engineering, and real-world validation. The project will demonstrate its methods and tools in three diverse scenarios, supporting Europe's efforts to promote trustworthy AI.
A team of researchers successfully observed the birth and decay of a highly active solar region, known as NOAA 13664, over three solar rotations. The study provides new insights into the formation and effects of superactive regions on the sun, shedding light on their potential impact on Earth's technology and environment.
A new study from Duke University found that even mild stress before surgery can lead to delirium, uncontrolled pain, and longer hospital stays in older adults. Over 40% of patients reported moderate to high distress levels similar to those with advanced cancer.
A new synthesis of seismic research shows that AI combined with physical principles is rapidly transforming how scientists image the Earth's shallow and crustal structures. The study highlights the need for physics-guided AI frameworks that balance computational efficiency with interpretability.
Researchers have developed a new piezo-photocatalytic material that dramatically improves the removal of carbamazepine from water. The oxygen-doped MoS₂ catalyst achieves rapid and complete degradation within minutes, outperforming conventional photocatalytic approaches.
Insilico Medicine collaborates with Servier to develop novel therapeutics in oncology through AI-driven platform Pharma.AI. The partnership is focused on identifying promising targets and generating molecular structures with desired properties.
Recent advances in CAR-NK cell therapy have expanded its applicability across hematological malignancies, solid tumors, autoimmune diseases, and infectious conditions. CAR-NK cells offer a unique balance between efficacy and safety, with potential applications in cancer and immune-related diseases.
Recent advances in maternal vaccines and long-acting monoclonal antibodies have broadened the scope of RSV prevention, reducing disease burden and improving infant survival outcomes. The expert panel concludes that both strategies demonstrate strong benefit–risk profiles when used appropriately.
A team at East China Normal University directly observes femtosecond-scale quantum coherence transfer from an external laser field to microcavity exciton-polaritons. The study confirms that decoherence in the exciton reservoir is key to losing original coherence.
Researchers have developed a novel class of biomass-derived carbon dots that selectively eradicate Staphylococcus aureus in water. The nanomaterials preferentially bind to pathogen-specific cell wall components, triggering localized oxidative stress and membrane damage while sparing non-target bacteria. This approach offers a sustainab...
A new study has found that membrane filtration is a superior method for collecting submicron aerosols, including bacteria, fungi, and viruses. The research provides practical guidance for accurate airborne pathogen monitoring in hospitals, schools, and other high-risk indoor environments.
The study reveals that SMX enhances nitrous oxide emissions, which are nearly 300 times more potent than carbon dioxide. This increase occurs due to the suppression of nitrogen removal and stimulation of incomplete denitrification in sediments, leading to a significant impact on coastal ecosystems.
The study identifies profound immune dysregulation, chronic inflammation, and impaired cytotoxic function in lymphatic malformations. A Shared CD14⁺CD16⁺ Monocyte Expression Program (SMEP) is uncovered, pinpointing S100A8 as a key druggable target for therapeutic intervention.