Researchers used CRISPR and AI to identify two novel drug targets for psoriasis: the oxytocin receptor and ALOX5 enzyme. Topical gels containing these compounds reduced inflammation in mice as effectively as widely used injected therapies, offering a promising new approach to treating moderate-to-severe disease.
According to a new study published in PLOS One, people with a history of criminal legal involvement have higher odds of visiting an emergency department, particularly for substance use and mental health reasons. The authors conclude that CLI history should be recognized as a social determinant of health shaping patterns of ED use.
A recent study reveals that over 90% of the Mar Menor's key nutrients degrading the ecosystem come from recirculated underground flows, not traditional sources like streams or groundwater. This discovery highlights a previously overlooked pathway of contamination and its impact on eutrophication episodes.
The Spanish University System (SUE) saw a 95% increase in publications from public universities between 2015 and 2024, with a record year of 74,846 publications in 2021. This growth is attributed to improved faculty productivity, with public universities exceeding one article per faculty member.
Researchers modeled key physical characteristics of biological tools to understand their diversity, finding that shape affects trade-offs between efficiency and resistance. The analysis revealed optimal cone shapes for puncture tools, including those resembling scorpion's stingers and shark teeth.
Researchers have discovered fragments as small as 5cm in size in geosynchronous orbit, shedding light on their behavior and highlighting the need for more accurate surveys to mitigate damage to expensive satellites.
A study by HSE University found that younger users and those in Moscow and St Petersburg are more likely to fact-check information online. The researchers also discovered that middle- and high-income users are more likely to question the accuracy of content they encounter, highlighting digital inequality.
A new international paper argues that science alone is not enough to protect coral reefs, which are disappearing at an unprecedented rate due to climate change and human activities. The authors propose using artistic expression and creative design to inspire public awareness and meaningful action for coral reef conservation.
Researchers have developed a new tool to screen genes involved in human development at unprecedented scale and speed. The method, using organoids from human pluripotent stem cells, revealed new insights into human brain development, including the role of ZIC2, SOX11, and ZNF521 genes.
In California's human-dominated landscape, gray wolves predominantly feed on cattle, followed by mule deer and small mammals. This dietary composition suggests that coexisting with humans may be complex for wolf populations.
New research has identified genetic mutations involved in congenital cerebral ventriculomegaly, a condition where brain fluid-filled ventricles swell due to hydrocephalus. The study links CCV to neurodevelopmental disorders and positions it as an early neuroimaging correlate of autism risk.
The partnership aims to identify and develop quantum materials that will power the next generation of computing, sensing, and energy technologies. By combining world-class researchers from Rice University and Max Planck Society, the collaboration seeks to accelerate discovery and create lasting global impact in sustainability and energ...
A SUTD study reveals that factors beyond temperature affect comfort at home. Residents who spent more time outdoors reported greater comfort without air-conditioning, while closed windows and blocked airflow contributed to warmer rooms. Practical advice is needed to help households understand these influences and make informed decisions.
Researchers develop a new strategy for producing negative thermal expansion (NTE) materials, enabling safer and more efficient synthesis. The approach combines reverse coprecipitation with oxidation in a single step, eliminating the need for harsh chemicals and reducing environmental impact.
A new study explores an FMQA-based optimization framework for RNA design, revealing that encoding matters in achieving optimal results. The approach identifies high-quality RNA sequence candidates with relatively few evaluations, outperforming competing methods.
A new study from the University of Copenhagen shows that exercise plays a crucial role in improving cardiovascular health even after significant weight loss. Participants who exercised developed healthier blood vessels and lower inflammation compared to those who relied on medication alone.
Scientists at Hackensack Meridian Health's CDI Lab published two companion papers explaining the 'exhaustion' of key immune cells. The first paper identified Id proteins as determinants of exhausted CD8+ T cell fate, while the second paper revealed CTCF's role in dynamic enhancer activation and invariant barriers.
The WAG-H5-2#2508 demonstrated accuracy within stated uncertainties, closely matching manufacturer specifications and rivaling established laser gravimeters. Its long-term stability was also confirmed, enabling continuous, unattended monitoring and supporting hybrid gravity observation networks.
Chikungunya fever is caused by the Chikungunya virus, transmitted by Aedes mosquitoes. Traditional Chinese medicine offers promising integrative treatments, particularly for acute symptoms and chronic polyarthralgia. A holistic response to CHIKV requires combining standard care with evidence-based TCM.
Two research teams from Rice University and Houston Methodist are awarded grants to study protective effects of metal nanoclusters against radiation-induced skin injuries and explore the role of m6A in leukemia cell growth. The collaboration aims to improve cancer care and outcomes through innovative, interdisciplinary proposals.
Researchers from Universitat Oberta de Catalunya found that robot adoption increases productivity in Spanish SMEs, especially smaller firms with fewer workers and less innovation. However, introducing robots does not directly translate into increased international business activity, as regional specialization plays a key role.
Understanding plant microbiome interactions could transform crop production and improve sustainability. Researchers are exploring how plants shape their microbial partners to acquire nutrients, defend against disease, and respond to environmental stresses.
Researchers developed an AI assistant called ChatHEA to guide the discovery of new catalysts for clean energy technologies. The team screened and evaluated 100 five-element high-entropy alloy catalysts, finding that FeCoCuPtIr showed excellent oxygen reduction activity and durability.
Researchers from Institute of Science Tokyo have created a compact 300-GHz-band 4×4 bi-directional phased-array transceiver in 65-nm CMOS, achieving significant advancements in 6G wireless communication. The transceiver operates over 240–270 GHz and consumes only 26 mW per element.
Encellin reports non-fibrotic engraftment and host vascularization in Phase 1 trial participants, building on interim results. The findings support the company's approach to deliver cell therapy safely and durably without immunosuppression.
Research on ocean acidification's impact on cephalopod brains reveals a 49% reduction in brain volume compared to controls. The greatest reductions were found in visual information-interpretation regions, correlating with significant feeding behavior changes.
Hawaii's songless crickets have rapidly evolved to overcome reproductive challenges caused by lack of courtship songs. Non-singing males develop faster than wild-type males, allowing them to seek out female mates using alternative methods.
A recent study by Oregon State University suggests that animals don't necessarily flee in search of better breathing conditions when exposed to wildfire smoke. Instead, they may shift their behavior to reduce the negative impacts of smoke inhalation.
A collaborative research team led by HKU Dentistry has mapped noma incidence risk across 296 local government areas in Nigeria, revealing previously unrecognised high-risk areas. The study provides a comprehensive small-area assessment of noma risk in Nigeria and offers implications for public health.
New study redefines the existence of necks in fish and amphibians, identifying functionally distinct anatomical regions. The project aims to build new definitions that apply more widely across all major vertebrate groups.
Research on burying beetles found that heat stress leads to an increase in same-sex mounting, contradicting initial assumptions. The study suggests a possible trade-off between heat-protection and social communication cuticular hydrocarbons may be involved.
A new study reveals that summer concurrent hot and dry events in China intensify due to different physical driving mechanisms in western and east-central regions. Western China's trends are driven by anthropogenic warming, while east-central China's hazards stem from coupled monsoon decline, drought amplification, and heat feedback.
Researchers developed an aerated hydrogel that allows air to pass through while maintaining its water content. This breakthrough enables longer-lasting products, such as breathable bandages, implants, and wearable sensors, with improved skin comfort and reduced sweat buildup.
A study by John Innes Centre researchers reveals that inner tissues play a crucial role in shaping plant organs, contradicting the widespread assumption that external layers control growth. By analyzing cell division orientation and gene editing techniques, they discovered genes affecting stem thickness in Arabidopsis.
This cohort study of 38,535 singletons found that birth weight decile was associated with early-life growth patterns. The use of birth weight decile group may help identify high-risk children missed by conventional thresholds.
Scientists at CUNY ASRC successfully amplify electromagnetic waves by simulating ultrafast rotation, recreating Penrose-Zel'dovich process. This breakthrough enables experimental studies of extreme rotational dynamics and opens new avenues for wireless communications and optics applications.
A new study by researchers at the University of California, Santa Cruz, reveals that multipotent progenitors, 'parent' blood cells, protect blood cell production and function from aging effects. The findings confirm the safety of bone marrow transplants from older donors.
Researchers at UC San Diego successfully performed two surgeries using teleoperated humanoid robots, called Surgie, which have real potential for amplifying access to critical surgeries. The compact robots can be deployed in remote areas and are easier to use than specialized robotic systems.
Depression is associated with a greater tendency to be reinforced by social rewards on Twitter, contrary to laboratory-based findings of blunted reinforcement learning in depression. This suggests potential mechanisms linking social media use to worse mental health outcomes.
Between 2003 and 2024, annual US deaths caused by law enforcement increased significantly, with non-Hispanic Black males experiencing the highest mortality rates. Firearms were responsible for more than 87% of these deaths, highlighting persistent racial disparities in the US.
Scientists identified 81 previously unrecognized cancer-driving genes in basal-like breast cancer, a subset with poor outcomes. The discovery expands understanding of chromosomal rearrangements and opens possibilities for targeted therapy.
A new paper by MIT Professor Areg Danagoulian describes his idea for a satellite-based sensor system that can detect neutrons generated by high-energy protons colliding with radioactive material. The system could detect nuclear weapons with 99% accuracy, even in low-Earth orbit.
Researchers developed a method to analyze compounds pulled in cupping jars, detecting changes in 13 volatile compounds before and after treatment. These findings suggest that cupping therapy may have measurable physiological effects, which can be studied with modern analytical techniques.
A new strategy makes stem cell transplants safer by replacing chemotherapy-based treatment with targeted antibodies that recognize specific markers on blood-forming stem cells. This approach allows for less toxic treatment and could enable chemotherapy-free or chemotherapy-sparing transplantation approaches.
The Journalism Science Alliance has selected 25 new projects, receiving nearly €1 million in funding, to promote science-based investigative journalism worldwide. The projects, led by journalists and scientists from 24 countries, will benefit from expert mentoring, training, and networking opportunities.
Researchers from Penn, NYU, and the Linguistic Data Consortium create virtual patients with adjustable psychiatric symptoms to simulate real-world conversations. The STELLAR platform aims to augment clinician training practices with essential conversation scenarios.
The study demonstrated sustained improvements in disease features in mouse models with effects lasting throughout their lifespan. Genespire's approach has the potential to translate into human health as a single-administration treatment for patients with MMA.
The ORIGIN project aims to reduce development timelines for sustainable, fermentation-based ingredients from 5-7 years to 2-3 years. By combining AI, biotechnology, and fermentation, the project will address scientific and technological challenges to produce high-value natural ingredients.
A cohort study of nearly 20,000 NFL players revealed that players are dying of dementia and Parkinson’s disease at much higher rates than the general population. The study found a fourfold increase in neurodegenerative mortality among NFL players compared to the general population.
A survey of Illinois emergency departments found that many hospitals lack pediatric mental health specialists and struggle with timely access to evaluation by a mental health professional. The study proposes practical solutions, such as investing in mental health staffing, therapeutic activities, and real-time bed tracking to improve c...
Scientists have identified the genetics of caddisflies' evolutionary superpower, which involves a gene that produces a main protein in silk. The study found remarkable heterogeneity in those genes among individuals from two nearby wild populations, highlighting how nature modifies this bioadhesive material while preserving its performa...
A recent study published in Nature Communications has identified a clear link between the composition of gut bacteria and frailty in older women. The research found that lower gut bacterial diversity and impaired function are associated with increased vulnerability to disease, falls, functional impairment, and death.
Researchers developed a low-cost electrochemical sensor to detect dopamine levels in artificial human tears. The technology could support the development of new tools for monitoring Parkinson's disease and other conditions linked to atypical dopamine levels.
The Robotic Surgery Center at KU Ansan Hospital has introduced the Da Vinci 5 robotic system, expanding its precision surgical capabilities. With its advanced features and ergonomic design, the system is expected to enhance patient safety and clinical outcomes.
A first-of-its-kind randomized controlled trial demonstrates rapid metabolic improvements with a ketogenic diet compared to diet-as-usual, leading to correlations between ketone levels and reduced blood glucose and depression symptoms. The study also shows sustained metabolic improvements alongside significant reductions in schizophren...
Researchers found that hatchery-raised fall Chinook salmon exposed to noise were less likely to complete the journey to the ocean and back. However, when raised in a quiet environment, they were more likely to return than those raised with ambient or continuous white noise.
A Korean University research team has created a new brain implant that enables precise control of neural activity using temperature, opening possibilities for advanced brain–computer interfaces and treatments for neurological disorders.
A global analysis of childhood diets over nearly 30 years reveals that children worldwide consume low amounts of essential nutrients found in fruits, vegetables, nuts, and legumes. In contrast to many other countries, the US sees a decline in consumption of these foods from infancy to adolescence.
A new study finds that fully virtual applied behavior analysis (ABA) services delivered by a Board Certified Behavior Analyst (BCBA) are a feasible alternative to traditional in-person therapy. Children with autism who received focused ABA services showed improvements in adaptive skills, behavior outcomes, and family quality of life.
Researchers develop a comprehensive framework to predict drilling instability in backfilled ground, considering strength differences and asymmetry. The proposed design criterion aims to reduce inclined drilling deviations by at least 10 millimeters per meter of depth.