A new analysis of nearly half a million cells from dozens of pancreatic tumors reveals how tumor evolution, subtype transitions, and microenvironment interactions shape the disease. Genetic reconfiguration within a tumor enables cancer cells to transition between subtypes, making them more vulnerable to immune attack.
A five-year research program will explore new ways to understand and control light in complex environments, helping launch a new chapter for UCF's Townes Laser Institute. The program combines traditionally separate fields to investigate systems capable of characterizing and adapting to a complex optical environment.
A new species, Dianjunus rex, has been discovered in Chinese forests, producing vertical fruiting bodies up to 50 cm high and weighing up to 2.2 kg. The fungus represents a new family, Dianjunaceae, which arose around 65 million years ago, shortly after the mass extinction of the dinosaurs.
Bruce Arians, a renowned coach and mentor, has been selected for the 2027 Paul 'Bear' Bryant Heart of a Champion Award. The American Heart Association honors his exceptional contributions to college football and the community, recognizing his resilience and commitment to helping others.
A new study found that children living in areas with higher levels of lithium in drinking water were more likely to be diagnosed with Wolff-Parkinson-White syndrome, a rare heart condition. Lithium levels in California were associated with a 71% greater odds of diagnosis compared to lower levels.
A recent FAU study found that Hawaiian corals respond differently to ocean heat, with thermal tolerance varying among species and environmental conditions. The study reveals that some corals, such as P. compressa from cooler waters, exhibit higher thermal tolerance than others, like M. capitata from warmer environments.
Researchers developed an AI model, SPACER, that analyzes gene activity to understand immune cell recruitment to tumors. The tool reveals that local signals attract immune cells and mucins create physical barriers to keep them away, with potential implications for cancer therapies and autoimmune disorders.
Researchers from Waseda University successfully controlled the motion of magnetic skyrmions using optical skyrmions, a topological pattern in light. The study provides a new framework for controlling magnetic skyrmions with light, opening routes for optomagnonics and spintronics technologies.
Researchers have developed a human stem-cell model that recreates early immune-cell development and shows how a single progenitor population can give rise to specialized macrophages across different organs. The model provides a platform to study how these processes change in disease, and how they might eventually be harnessed therapeut...
Researchers developed a new model that accounts for age-related changes in color vision, guiding lighting designs that make it easier for older adults to perceive colors. The model estimated how easily a person would distinguish similar colors based on illumination light's spectrum and age-adjusted sensitivities of the eye's three cone...
The agreement enables participating institutions to publish open access in Frontiers' full journal portfolio without individual author costs, streamlining budget planning and reducing administrative burdens. Institutions can join the agreement before the end of 2026, with early joiners gaining access to FAIR² Data Management offering.
The study found that disrupting PLA2G15 reduced stress-induced cellular senescence in mouse kidney cells while altering the composition of phospholipids involved in lysosomal function. This suggests a possible connection between lipid metabolism, mitochondrial pathways, and kidney aging.
This theme issue explores innovative research on engagement as a primary outcome, investigating psychosocial factors, novel measurement strategies, and real-world innovations. JMIR Publications seeks research that contributes to the field's evolving understanding of engagement to build more sustainable, user-centered health technologies.
A Southwest Research Institute (SwRI)-led team has developed an improved model for predicting solar events by incorporating activity on the far side of the Sun. The new model provides a more accurate map of the entire surface of the Sun, helping scientists to better understand and forecast solar activity.
Researchers found that bacteria species can thrive in copper-rich environments, with some species resistant to copper concentrations above 70 milligrams per liter. The study aims to target molecular pathways that help bacteria express copper-resistant genes to develop more effective antifouling coatings.
A new study found that a consumer smartwatch can accurately identify adults with moderate-to-severe obstructive sleep apnea, with a 94% accuracy rate. The Samsung Galaxy Watch demonstrated high sensitivity and specificity, making it a potential screening tool for this common sleep disorder.
Researchers identified three key particles that contribute to heart disease risk after 'bad' cholesterol is lowered, including triglyceride-rich lipoprotein and lipoprotein(a). The study suggests that measuring or targeting these particles may improve prevention alongside existing treatments.
Researchers found that specific combinations of TP53 and CDKN2A mutations activate cGAS-STING-mediated immunity, delaying oral cancer progression. The immune activation was associated with delayed progression to invasive oral cancer.
A study by UNIGE scientists shows that a vegan diet can alter liver metabolism within days, affecting glucose production and ammonia elimination. The discovery highlights the pivotal role of the GDH enzyme in regulating these processes.
Researchers developed a method to adapt adult-trained AI models for pediatric use, addressing critical gaps in medical AI for children. The method, trained on adult data, outperformed adult models trained on pediatric data from a single hospital at 29 of 30 sites, even when tested on new images.
A recent study by Virginia Tech found that the Upper Basin is experiencing rapid groundwater losses, with surface-water shortages increasingly affecting groundwater as well. Groundwater depletion in the Upper Basin accelerated after 2019, with a loss of approximately 4.6 trillion gallons during the 2020-2022 drought.
A new study by Ohio State University researchers found that 'internal focalization' in literature can promote forgiveness of both fictional and real-life characters. By giving readers access to a character's inner thoughts, this technique elicits empathy and forgiveness, suggesting stories may be a prescription for better emotional hea...
Researchers developed a new AI search framework, CMS-NAS, to predict epileptic seizures with improved accuracy and efficiency. The framework balances prediction performance and model size, achieving state-of-the-art results on public datasets.
A study by UMass Amherst finds that women are 37% more likely to be promoted to CEO in companies with separate divisions, where their results are measurable and comparable to other executives. This structural change may help address the significant gender gap in CEO positions, currently holding women to less than 10% of top jobs.
Research teams at ETH Zurich have solved the puzzle of nuclear envelope assembly, showing that Torsin-1A and CLCC1 complexes work together to enable membrane fusion. This finding offers a new therapeutic approach for primary dystonia, a rare movement disorder affecting about six in 100,000 people worldwide.
The authors propose a 'Discovery Compact' that includes predictable, multi-year funding, support for the scientific workforce, and translation research policy to accelerate discovery-to-application. The compact also emphasizes government anticipatory governance, scientific integrity, and public accountability.
Families of children with B-cell acute lymphoblastic leukemia (B-ALL) experience substantial and lasting challenges, including household employment changes and marital status changes, beginning early after diagnosis. These challenges persist throughout treatment and have significant financial, social, and emotional impacts on families.
ACLM launches a new medical school curriculum and an updated food-as-medicine course to help medical schools meet federal and state nutrition education requirements. The curriculum provides 40 hours of nutrition instruction and a longitudinal educational experience that helps students understand how nutrition influences chronic disease.
Juvmo, a Parkinson's disease drug, has been approved by the FDA and offers a new treatment option for patients, potentially reducing side effects. The drug's unique mechanism of action provides relief from motor symptoms, and its approval marks a significant milestone in the research of UVA Health scientists.
Women with PMOS/PCOS may be at higher risk for Alzheimer's disease and dementia due to metabolic comorbidities like insulin resistance and obesity. The condition's impact on brain health and memory could be related to common health issues that often occur alongside PMOS.
A survey of 15-year-olds worldwide suggests that boys' underperformance may be due to negative attitudes towards academic effort, with larger gaps in more developed countries. Boys are less likely to agree that trying hard is important, and their responses correlate with individual academic performance, especially in reading.
A recent study reveals that devaluation is the primary factor driving the academic gender gap, with 38% of women experiencing devaluation compared to 16% of men. The study, which surveyed over 10,000 academics, found that devaluation was the most strongly associated factor with women considering leaving or leaving academia altogether.
Researchers compared Sjögren's syndrome-associated bronchiectasis to non-associated cases, exploring demographic, clinical, and microbiologic characteristics. The study aimed to provide insights into the intersection of bronchiectasis and NTM disease, with potential implications for treatment and management.
A new study has linked exposure to the safer plastic additive DINCH during pregnancy to lighter and smaller newborns. Higher levels of DINCH in the urine of pregnant women resulted in a 27-gram reduction in newborn birth weight, highlighting potential risks of chemical additives on fetal development.
A $13.3 million randomized clinical trial is testing whether weekly semaglutide can reduce alcohol and opioid use, and reduce justice involvement among adults with alcohol and opioid use disorder. The study aims to improve employment, health, and housing outcomes among participants, and will enroll up to 1,200 adults with the conditions.
A new report from Digital Science raises concerns about the adequacy of U.S. research security policies for short-term researchers, finding nearly half held U.S. affiliations for 24 months or less. The report proposes a risk-calibrated approach to strengthen research security without restricting international collaboration.
A study published in Menopause Journal found that physical activity, such as walking and yoga, can reduce depressive symptoms and improve quality of life during menopause. The review of 12 randomized controlled trials revealed that aerobic-based exercise and mind-body activities had strong effects on psychological symptoms.
Researchers analyzed nearly half a million cells from dozens of patients' tumors to understand how pancreatic cancer cells continuously evolve over time. The study found that specific genetic changes, such as increased activity of the MYC gene, enable cancer cells to resist therapy and spread rapidly.
A new mechanism of plasma turbulence in the solar wind was discovered, revealing a clear structure in unstructured space plasma. The findings, published in The Astrophysical Journal Letters, show that turbulent magnetic fields exhibit a clear reversal of magnetic field rotation sense over a certain wavelength.
The Safe Social Media Act aims to protect children's physical and mental health through digital safety rules and a regulator. The proposed act includes a Digital Safety and Data Protection Commission and temporarily restricts accounts for children under 16 until platforms meet enforceable standards.
A 100-year study of UK Good Housekeeping magazine recipes reveals a narrowing of seafood options to just five species: cod, haddock, tuna, salmon, and prawns. The study, led by Dr Ruth Thurstan, shows how decades of changes in fish supply and trade influenced domestic cooking habits.
A study published in the Canadian Medical Association Journal found that 5% of practising physicians report disabilities, with mental health, visual, and mobility disabilities being the most common. The research emphasizes the importance of accessible work environments and equitable policies to promote the well-being and retention of p...
A recent study identified a protein in the placenta involved in vascular development, challenging previous beliefs about its function. The protein, soluble platelet-derived growth factor receptor beta, plays a role in infant vascular development and may affect maternal health.
Jie Zhuang, a University of Tennessee professor of soil science, is among nine international SSSA Fellows recognized for his contributions to soil science and research. He has received numerous awards and is a Fellow with the American Association for the Advancement of Science (AAAS).
Stanford researchers have developed a novel material designed to address the challenges of glycine-based, electrified medical devices. The material, engineered with a novel process, maintains piezoelectric performance for 60 days, a significant improvement over previous versions. The team aims to test the material in more extreme envir...
A study by CU Anschutz researchers has found a possible link between the APOE4 gene, fat in the brain, and inflammation, which may help explain how genetic risk factors for Alzheimer's disease affect the brain. The study suggests that the ApoE protein can change how brain immune cells handle fat and trigger inflammation.
A large study led by Oregon State University found that brain cancer risk increases with exposure to elevated concentrations of radon, a known lung carcinogen. The research, published in Neuroepidemiology, suggests that residential radon exposure may contribute to the overall burden of central nervous system cancers.
DNA vaccines deliver genetic instructions encoding selected antigens, stimulating humoral and cellular immune responses. Emerging technologies, including artificial intelligence and synthetic biology, may further broaden the platform's capabilities.
The new AI models can predict scenarios of aerosol concentrations and cloud properties, separating the aerosol effect from meteorological factors. The project aims to improve climate predictions and extreme weather forecasts, helping American communities prepare for and protect against climate-related challenges.
The critical zone, a thin layer of soil, groundwater, bedrock, and vegetation, supports nearly all life on the planet and is degrading due to human activities and climate change. A career geologist, Paul Doss, advocates for a bigger role in understanding ecosystems.
Researchers explore targeting mitochondria to treat triple-negative breast cancer, a form of breast cancer with limited treatment options. Mitochondrial dysfunction may contribute to chemoresistance, and disrupting mitochondrial dynamics could lead to cancer-cell death.
UChicago researchers successfully created a 2D topological insulator using the 'carpet' growth method, a technique that produces uniform-thickness films of bismuth telluride. The material exhibits near-lossless energy transmission, with potential applications in electronics and quantum computing. The researchers used molecular beam epi...
Piezo channels play a crucial role in orthodontic treatment by detecting mechanical pressure and translating it into biological activity. Piezo-targeted therapies may provide new opportunities for more precise orthodontic care.
The EP4 receptor is a key regulator of inflammation and a promising therapeutic target for various inflammatory diseases. Targeting this receptor could provide more precise approaches to controlling inflammation, offering safer and more targeted treatments.
A new review highlights FTO's complex role in gastrointestinal cancers, influencing tumor growth, metastasis, and treatment resistance. FTO-targeting approaches may complement immunotherapy, raising possibilities for combination treatment strategies.
Long non-coding RNAs (lncRNAs) regulate cancer treatment resistance by altering gene expression, interacting with microRNAs and proteins, and influencing chromatin. LncRNAs such as MALAT1, HOTAIR, and PVT1 have been associated with pathways that can help cancer cells withstand treatment.
A team of researchers at Penn State has developed a new type of soft computer using water-based droplets, connected by membranes, to process information in wet environments. The networks, inspired by the human brain, can sense and process ions with lower energy cost than silicon chips, and demonstrate temporal computing capabilities,
Researchers created a small soft robot called BeetleBot that combines artificial muscles, a camera, and tactile sensors to perform tasks like gripping objects and avoiding obstacles. The robot uses bidirectional feedback to connect user control with sensory information, enabling practical tasks to be carried out.
The University of Oklahoma will continue its life-saving weather research with a $220M 5-year renewal from NOAA, marking its fifth decade of partnership. Researchers will focus on severe weather phenomena, forecast improvements, and societal impacts, providing innovative forecasts that reduce extreme weather impacts.
A new ice sheet model developed by UC Irvine and NASA JPL projects Thwaites Glacier's melting will contribute up to 30mm sea level rise by 2100, even without additional climate warming. The model factors in a 4-6km grounding zone, predicting accelerated detachment and ice flow.