A new glioblastoma model called Core2Edge has been developed to study the invasive front and direct assessment of new drug candidates in human tissue. The model combines glioblastoma organoids with human brain tissue, allowing for the tracking of tumor cell spread and the visualization of fine structures.
A team of surgeons used robot-assisted stereotactic surgery to treat a patient with multiple deep brain abscesses, achieving complete resolution and rapid neurological recovery. The minimally invasive strategy reduced surgical trauma and accelerated healing.
A multidisciplinary consensus updates treatment guidance for prolactinomas, emphasizing early recognition, individualized management strategies, and advanced imaging. The recommendations cover screening, assessment, diagnosis, treatment, and long-term monitoring to improve patient outcomes and quality of life.
New research has identified genetic mutations involved in congenital cerebral ventriculomegaly, a condition where brain fluid-filled ventricles swell due to hydrocephalus. The study links CCV to neurodevelopmental disorders and positions it as an early neuroimaging correlate of autism risk.
A young woman's quality of life and ability to walk were restored after a specialized procedure at Semmelweis University. The laparoscopic removal of a rare, benign tumor of neurological origin in the lesser pelvis, known as a schwannoma, was performed using intraoperative electrophysiological monitoring.
Researchers developed a novel gene therapy platform that successfully restored muscle function in preclinical models of Duchenne muscular dystrophy by delivering full-length mRNA of the DMD gene via engineered extracellular vesicles. The treatment showed improved muscle strength, endurance, and function without serious side effects.
Researchers find that limiting methionine in the diet destabilizes DNA organization and leads to cancer cell death and increased animal survival. The study proposes a new connection between diet, gene regulation, and cancer growth, opening possibilities for treating aggressive brain tumors.
A multicenter clinical trial found that implanting collagen tiles during brain surgery improved tumor control and lowered the risk of recurrence by 12.1% compared to current standard of care. Patients treated with tile-based radiation therapy (TBRT) had a median overall survival of 42.5 months, more than double the 17.6 months seen wit...
A nationwide study has compared two surgical approaches for treating Chiari malformation and syringomyelia, finding no difference in complication rates and clinical outcomes. Patients who underwent the more invasive procedure had greater improvement in their syringomyelia symptoms.
Researchers develop tailored revascularization approach for moyamoya disease, improving circulation while minimizing complications. The technique, called STAPC, uses vessel diameter, blood-flow dynamics, and recipient brain arteries to guide surgical decisions.
A new NYU Langone Health study found that e-bike and scooter crashes are now accounting for nearly 7% of trauma patients admitted to NYC hospitals, with traumatic brain injuries on the rise. The study also highlights the importance of improved urban infrastructure and helmet use to prevent these injuries.
A recent study led by Cedars-Sinai Health Sciences University found that the same brain neurons are activated when people perceive and imagine objects. The research provides a detailed understanding of the neural mechanism underlying visual perception and creation of mental images in the human brain.
The study found that concrete words activated regions of the brain responsible for sensory experiences and language, while abstract words relied more heavily on language-related areas. The team also discovered that multiple brain regions communicated with each other to process both concrete and abstract words.
A new medical technology development initiative, DBS Lead Lock, aims to refine deep brain stimulation lead fixation for improved precision and efficiency. The project, in collaboration with the Marshall Advanced Manufacturing Center, is currently in prototype development.
Blocking two key 'don't eat me signals' in cancer cells heightens the immune response and sensitizes tumors to immunotherapy in glioblastoma models. Researchers found that simultaneously blocking CD47 and CD24 improved immunotherapy response, allowing macrophages to better recognize and attack cancer cells.
The Brain Trauma Foundation has updated its guidelines for the care of patients with penetrating traumatic brain injury (pTBI) with new evidence-based recommendations and treatment algorithms. The guidelines aim to balance complexity with convenience for use during emergencies, providing practical flowcharts for clinicians.
Researchers identified blood-based biomarkers that can help distinguish patients with glioblastoma who are most likely to live longer from novel treatment with an engineered oncolytic virus. The study found that adding an immune booster increased survival times and improved immunological fitness.
The new intraoperative MRI technology enables real-time functional scans during neurosurgery, allowing doctors to detect complications and tailor their approach. This innovation saves time, labor, and improves safety and recovery for patients.
Researchers discovered Chlamydia pneumoniae can cause inflammation, nerve cell death and cognitive decline in Alzheimer's disease. The study suggests targeting chronic bacterial infection may represent a new treatment strategy.
A recent study published in The Lancet Neurology found that patients with acute ischemic stroke who experience prolonged transfer times are more likely to leave the hospital with significant disability. The study of over 20,000 patients highlighted the need for shorter transfer times to improve patient outcomes.
JMIR Publications' JMIR Neurotechnology journal now accepts submissions on novel technological advances for neurological disorders. Researchers can submit review articles exploring emerging technologies, such as neurofeedback, neurosurgery, and brain-machine interfaces.
A study highlights how social media is transforming neurosurgical education, collaboration, and case consultations globally. Platforms like Neurosurgery Cocktail have democratized neurosurgical knowledge, supporting high-level discourse among experts.
Researchers developed a new 3D surface scanning approach for precise brain surgery, outperforming CT scans in accuracy. The system eliminates radiation exposure and provides real-time guidance to surgeons.
Researchers developed a noninvasive approach using nasal drops to deliver potent tumor-fighting medicine to the brain, boosting the immune response and eradicating glioblastoma tumors in mice. The nano-sized medicine successfully activated the STING pathway and armed the immune system to fight the cancer.
Research using brain-computer interface reveals tirzepatide's temporary suppression of brain activity involved in 'food noise' in a patient with severe obesity, calling for further investigation. The medication, originally developed to manage Type 2 diabetes, may have potential in treating impulse control disorders like binge eating di...
Researchers created BraDiPho, a 3D atlas of brain connections, combining clinical neuroscience, artificial intelligence, and neuroanatomy. The tool facilitates precise identification of white matter connections, opening up new therapeutic perspectives for neurological diseases.
A new contactless optical-tracking registration method has been developed to simplify robot-guided SEEG surgery, reducing positioning errors and procedure time. The study demonstrates the accuracy and ease of use of this technique, making it a promising innovation in neurosurgery.
A new, fully degradable cranial clamp made from poly-L-lactic acid has been developed to address traditional fixation system drawbacks. The study compared its performance to Aesculap CranioFix through laboratory tests and a clinical trial involving 90 patients, showing improved safety and healing outcomes.
A team of Pitt engineers has created self-powered spinal implant technology capable of transmitting real-time data from inside the body. The innovation utilizes new human-developed composites known as metamaterials to harvest energy and transmit signals wirelessly.
A study led by Julie Pilitsis, MD, PhD, found a possible connection between chronic pain and eosinophilia, a white blood cell condition, in patients undergoing spinal cord stimulation or implanted pain medicine pumps. The study suggests that eosinophilia may be an immune biomarker for chronic pain.
The UTHealth Houston Novel Treatments for Acute Brain Injury Institute focuses on improving care for patients with acute brain injuries through research, clinical expertise, education, and community outreach. The institute aims to advance pharmaceutical and device therapies and train the next generation of neurocritical care experts.
Researchers developed a multi-analyte test that accurately identifies brain cancers using small samples of cerebrospinal fluid, offering a promising new tool for guiding clinical decision-making. The test combines multiple biological markers and demonstrates high sensitivity and specificity in detecting central nervous system cancers.
The Ellen Siow Professorship aims to advance education and research in neuro-oncology, specifically glioblastoma. This will drive the development of innovative programmes and interventions, fostering progress that benefits people in Singapore and beyond.
The Congress of Neurological Surgeons has issued its first comprehensive guidelines on the care of adults with functioning pituitary adenomas (FPA), a prevalent and complex condition. The guidelines mark a pivotal step in standardizing care, optimizing patient outcomes, and promoting multidisciplinary coordination.
The new book Spinal Surgery Biomechanics: Principles for Residents offers a comprehensive exploration of core biomechanical concepts essential for mastering spinal surgical procedures. It bridges the gap between theory and practice, providing a biomechanical framework that supports surgical planning and patient safety.
The Cirrus Resting State fMRI Software uses AI technology to rapidly map the brain and identify sensitive areas controlling critical functions. The technology, developed at WashU Medicine, enables more precise neurosurgeries with improved accuracy and accessibility for patients.
Researchers at Stanford Medicine have mapped brain activity underlying emotional responses to mild unpleasant sensory experiences. Shared features between human and mouse brains may help understand driving forces behind neuropsychiatric disorders. The study's findings could unveil new insights into the mechanisms of emotional regulation.
Researchers developed a gene therapy that can target the airway and lungs using a nasal spray, outperforming previous versions in preclinical models. The innovative tool, AAV.CPP.16, showed promise for treating respiratory diseases like pulmonary fibrosis and viral infections.
Dr. Edward F. Chang's pioneering research has revealed how the human brain encodes speech sounds and movements, leading to the development of a successful speech neuroprosthesis that restores communication in paralyzed individuals. His work combines high-precision neurosurgery with advanced neuroscience and brain mapping.
Researchers discovered a novel line of communication between metastatic medulloblastoma and leptomeningeal fibroblasts, facilitating recruitment and reprogramming to support tumor growth. Disrupting this communication may offer a potential treatment opportunity for this devastating disease.
Researchers at UT Health San Antonio have discovered a way to delay or even block recurrence of the deadliest brain cancer after radiation by targeting senescent cells with experimental 'senolytic' drugs. This approach shows promise in preventing tumor growth and improving patient survival.
A new AR navigation system for EVD placement shows improved accuracy and reduced complications compared to the freehand technique. The system enables precise 3D guidance and real-time feedback during drilling, reducing errors and improving outcomes.
A study published in the Journal of Neurosurgery found that surgery can alleviate psychiatric distress and improve cognitive function in patients with Chiari Malformation type 1. Nearly 90% of patients showed improvements in cognitive function or psychiatric symptoms, with many reporting a significant reduction in brain fog.
The Neuro-Oncology Translational Research Training Program aims to bridge laboratory discoveries and clinical applications in neuro-oncology, targeting glioblastoma and brain metastases. The program provides predoctoral and postdoctoral trainees with cutting-edge lab experience and mentorship across multiple disciplines.
Scientists at EPFL and Università San Raffaele have found a way to address muscle spasticity in patients with incomplete spinal cord injury by using high-frequency electrical stimulation. This treatment gives paralyzed patients access to rehabilitation protocols, overcoming muscular stiffness and spasms.
Researchers found a common cause and potential treatment for 'smooth brain' disorders like lissencephaly, identifying dysregulation in the mTOR pathway. The study suggests a single treatment approach could benefit patients across the lissencephaly spectrum.
Researchers uncover human hippocampal CA3 region's unique neural connectivity and synaptic properties. The team found that the human CA3 network codes information efficiently to maximize associations and memory storage, with sparser connections and more reliable synapses compared to mouse models.
Research published online in Journal of Neurology Neurosurgery & Psychiatry found that cutting early life exposure to parental smoking may lower the risk of developing MS in those who are genetically predisposed. The study also showed an interplay between genetic and environmental risk factors for MS, associated with certain aspects of...
A new OHSU study reveals that the human ability to conceptualize numbers is rooted deep within the brain, specifically in the putamen region. This finding has significant implications for improving learning among math-challenged individuals and for neurosurgical interventions.
A new treatment combination of surgery and embolization for subdural hematomas has been shown to reduce the risk of follow-up surgeries. The procedure, which blocks specific blood vessels, resulted in a 4% recurrence rate compared to 11% without embolization.
A new study published in the New England Journal of Medicine found that blocking the artery supplying the brain covering reduced re-operations for chronic subdural hematomas by threefold. The EMBOLISE trial followed 400 participants and showed a significant reduction in recurrence rates with a simple, minimally invasive procedure.
Researchers have identified three distinct subtypes of Chiari type-1 malformations with distinct characteristics, enabling physicians to develop treatment protocols for patients. The study used artificial intelligence to analyze data from over 1,200 patients and identified patterns that can inform medical decision making.
Researchers developed an AI-powered model called FastGlioma that can detect residual tumor tissue with high accuracy in 10 seconds. The technology outperformed conventional methods, reducing the risk of missed tumors by nearly 75%. This innovation could change the field of neurosurgery and minimize reliance on radiographic imaging.
A study published in Nature reveals that astrocytes, star-shaped brain cells, play a crucial role in storing and retrieving memories. Researchers found that these non-neuronal cell types work closely with groups of neurons called engrams to regulate the formation and recall of memories.
A study found that stereotactic radiosurgery (SRS) achieved high rates of tumor control for patients with Koos grade I vestibular schwannomas. The procedure also reduced the risk of cranial dysfunction, tinnitus, and vestibular dysfunction compared to observation alone.
A new study by UT Health San Antonio reveals that BRCA1 plays a crucial role in promoting error-free DNA repair through the activation of end resection enzymes. This understanding sheds light on the tumor suppressor function of BRCA1 and has important implications for breast and other cancers.
A study published in Science Advances has identified key characteristics of multiply recurrent meningiomas (MRMs), a highly aggressive form of brain tumor. Researchers found that MRMs are more numerous, larger and more common in men than women, with increased chromosomal instability and DNA methylation.
Researchers at Duke University Medical Center found that Black men with metastatic prostate cancer have the greatest survival benefit from sipuleucel-T immunotherapy, possibly due to a genetic variant that encourages an inflammatory response. The study could lead to targeted treatment for patients who will benefit most
A new scoring system helps doctors predict which patients will likely become seizure-free after minimally invasive epilepsy surgery. The model is based on eight clinical factors and has been shown to outperform other predictive models in predicting seizure freedom.