Researchers identified two cell signals that can guide stem cells to repair eye damage, increasing their survival and function after transplantation. The study's findings offer a promising approach to restoring eyesight by modifying stem cells with enhanced chemokine receptors.
Researchers used genome-wide profiling to study the epigenetic landscape of human stem cells, revealing important information about gene regulation. They found differences in chromatin structures between long-term and short-term stem cells, which could improve understanding of cancer cell behavior and stem cell therapy.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have created a drug that can lure stem cells to damaged tissue, improving treatment efficacy for neurological disorders. The discovery could expand the use of stem cell therapies to new conditions such as heart disease or arthritis.
The study uses large datasets to examine representation of sexual minorities in STEM fields. Men in same-sex couples are less likely to complete a STEM degree or work in a STEM occupation compared to heterosexual men. However, women in same-sex couples are more likely to work in a STEM field than women in different-sex couples.
Researchers discovered that stem cells have smaller and weaker centromeres compared to differentiated cells. This finding highlights a possible mechanism for the errors in cell division that limit the potential of stem cells in regenerative medicine.
Researchers found that a protein called Rictor plays a key role in regulating stem cell metabolism, which can help prevent hair loss. The study used a genetic mouse model to demonstrate that the absence of Rictor protein impaired stem cell function and led to hair loss.
Research finds that high androgen levels can cause intestinal stem cells to divide excessively and produce fewer mature epithelial cells, increasing the risk of tumor formation. The study's findings may have implications for treating or preventing colon cancers through androgen regulation.
Researchers at Tokyo Medical and Dental University identified a critical role of interferon regulatory factor-2 (IRF2) in maintaining the stemness of intestinal stem cells. IRF2-deficient mice exhibited impaired regenerative responses, highlighting its importance in preserving intestinal stem cell function.
Researchers found that the sympathetic nerve connects to hair follicle stem cells, bridging the gap between nervous system control and hair regeneration. The muscle facilitates this connection, allowing the nerve to directly regulate stem cell behavior and promote new hair growth in response to temperature changes.
Researchers found that random movements allow cells to overcome pushing forces and return to the stem cell niche. The team's findings suggest that the dynamics and geometry of tissues play a crucial role in defining stem cell number and dynamics, potentially opening new insights into organ renewal.
A new protocol enhances stem cells' ability to differentiate into adult cells, improving their quality and efficiency for therapeutic purposes. The study identified microRNA 203 as a key molecule to boost stem cell differentiation, opening doors to improved treatments for degenerative diseases.
Children's Cancer Institute researchers have discovered a new approach to treating acute myeloid leukaemia (AML) by targeting leukemia stem cells. The therapy disrupts the ability of these cells to self-renew, markedly reducing leukaemia amounts and preventing new cells from growing.
Researchers at Hong Kong University of Science and Technology discovered a key mechanism controlling muscle stem cell dormancy, involving the release of conserved introns upon activation. This discovery sheds light on the importance of Intron Retention (IR) in regulating gene expression and stem cell quiescence.
Researchers at Indiana University School of Medicine have successfully grown hairy skin from human stem cells using a 3D cell culture method. The study shows that skin generated from pluripotent stem cells can integrate into mouse skin, leading to potential applications in skin reconstruction and disease modeling.
A study published in Cell Reports reveals that human acute myeloid leukemia (AML) stem cells are dependent on the transcription factor RUNX1, which could lead to lasting remissions or even cures. The researchers used induced pluripotent stem cells from a patient with AML to recreate leukemia stem cell biology in the lab.
Researchers at the University of Sheffield have discovered ways to reduce DNA damage and mutations in pluripotent stem cells, a crucial step for regenerative medicine. The findings may allow for safer use of these cells in patients and significantly reduce the risk of genetic mutations.
Researchers mapped out how gene networks change as muscle cells mature from embryonic development to adulthood. The roadmap could lead to better methods for creating muscle stem cells from stem cells, potentially treating muscular dystrophies and sarcopenia.
A new method uses CAR-T therapy to eliminate leukemia stem cells and blood stem cells selectively, sparing mature blood cells and other tissues. The treatment is achieved through genetic modification of immune cells, which then target and destroy only the leukemic stem cells.
Researchers at the University of Illinois used nanostimulators to boost stem cells' regenerative powers, increasing blood flow and oxygen levels in ischemic limbs. The treatment showed improvements in mobility and strength, offering a promising approach for muscle repair.
Northumbria University researchers received funding to advance our understanding of the Sun's impact on planets. They developed nanostimulators that enhance stem cells' regenerative powers, showing improved muscle recovery in mice with ischemia.
Researchers discovered that microscopic alterations in stem cell niche can predict Crohn's disease recurrence. A therapeutic approach using dichloracetate (DCA) restored intestinal stem cell functionality and maintained the intestinal barrier.
Researchers have discovered that dental pulp stem cells promote neuronal growth in tissue regeneration and cancer progression, while also recruiting facial neurons. The findings open up new paths towards effective therapies against cancer using drugs that modify the communication between neurons and cancer stem cells.
Researchers at Mount Sinai have discovered a method to increase the potency of hematopoietic stem cells, which could improve bone marrow transplants. By manipulating lysosomal activity, they enhanced the potency of these stem cells by over 90-fold.
Researchers identified a molecule that maintains a healthy balance of airway basal stem cells and mature mucociliary cells, potentially leading to new treatments for lung cancer. The compound, Wnt Inhibitor Compound 1 (WIC1), has been shown to limit the proliferation of basal stem cells and restore balance in human cells.
Dr. Margaret A. Goodell, a renowned hematopoietic stem cell researcher, has been awarded the Tobias Lecture Award by the International Society for Stem Cell Research (ISSCR). Her pioneering work on epigenetic regulators of normal hematopoietic stem cell function has greatly advanced our understanding of hematologic malignancies.
Susan Solomon, CEO of The New York Stem Cell Foundation (NYSCF) Research Institute, receives the 2020 ISSCR Public Service Award for her tireless efforts to support stem cell science and researchers. NYSCF has raised over $350 million for stem cell research projects.
Researchers at Baylor College of Medicine have identified a new mechanism that contributes to adult bone maintenance and repair. Periosteal stem cells, previously poorly understood, play a major role in bone healing and respond to mechanical injury and inflammatory molecules, offering potential therapeutic applications for conditions l...
Scientists at UCLA have discovered a key protein that enables human blood stem cells to self-renew in laboratory conditions. Activating this protein, MLLT3, increases the number of blood stem cells by at least twelvefold, opening up new possibilities for treating blood disorders.
Researchers discovered tendon stem cells that can improve tendon healing and potentially avoid surgery. These stem cells compete with scar tissue precursors, suggesting a therapeutic approach to prevent fibrous scarring.
Scientists at Gladstone Institutes used a machine-learning approach to discover new ways of controlling the spatial organization of induced pluripotent stem cells. The model predicted patterns that could lead to the creation of functional organs for research or therapeutic purposes, and was found to be correct in simulating desired arr...
Researchers have discovered that dental epithelial stem cells from young mice can regenerate mammary glands and produce milk-producing cells. This breakthrough highlights the exceptional plasticity of these stem cells, which can generate not only dental tissues but also other cell populations.
Researchers found that protein GAS1 suppresses muscle stem cells' ability to build new muscles and regenerate after injury. Reversing GAS1's effect by using GDNF restores muscle stem cell function and regeneration.
A UTSA professor received a $350K NSF grant to develop survey scales for measuring STEM social capital among students. This research aims to understand the role of social networks and resources in promoting positive student outcomes in STEM.
The University of Pittsburgh has been awarded a $10 million grant to create a network of precollege programs with accreditation standards, aiming to increase racial and ethnic diversity in STEM fields. The goal is to address gaps between underrepresented students in STEM fields, ultimately leading to more diverse STEM majors and jobs.
Scientists have identified two types of gastric isthmus stem cells with different roles and characteristics in the upper and lower glands. The discovery was made through a joint research project involving South Korea, Austria, and the UK, using advanced techniques such as single-cell transcriptional analysis.
Researchers found that Id4 controls whether stem cells remain in a state of rest or enter cell division, with increasing age leading to hyperactive signaling pathway inhibiting cell division.
Research finds that ketone bodies activate Notch signaling pathway, enhancing intestinal stem cell regeneration and function. A ketogenic diet boosts stem cell proliferation and repair damaged intestinal tissue.
The study found that orthopedic, inflammatory, and pain conditions are the main types of medical conditions treated with stem cells at direct-to-consumer stem cell clinics in the Southwest. The researchers also identified differences in the degree to which listed expertise matches the medical conditions treated with stem cells.
Researchers discovered that leukemia stem cells suppress NKG2D-L proteins, evading the immune system. By inhibiting PARP1, these cells can be recognized and eliminated by NK cells.
A new study found that Slug promotes breast stem cell health by repairing DNA damage, and its deficiency is linked to increased DNA damage and decreased stem cell activity in both young and aged breast tissue. This suggests that Slug functions as a safeguard against age-related decline of breast stem cell function.
A team of scientists has identified a stem cell inducing factor called STEMIN that enables the direct conversion of leaf cells to stem cells in plants. This discovery sheds light on the molecular mechanisms underlying stem cell formation and regeneration in land plants.
A study identified Glycerol-3-phosphate dehydrogenase 1 (GPD1) as a molecular marker specific to dormant glioma stem cells. GPD1-producing cells are resistant to chemotherapy and radiation, and their activation leads to tumor relapse.
A new study published in Stem Cell Reports found that human embryonic stem cells can commit to a specific cell type within hours, rather than days, and this commitment is irreversible. The research also discovered that chromosome architecture can be remodeled locally and rapidly without dismantling the entire nucleus.
Researchers found KLF4 protein stability is critical for stem cells to specialize and become specific cell types. By preventing this breakdown, stem cells can differentiate into organs.
Research reveals SIRT1's crucial role in maintaining regenerative potential of CML leukemic stem cells and promoting leukemia development. The study suggests targeting persistent leukemic stem cells with kinase-independent metabolic alterations.
A new technique developed by researchers at the University of Illinois Chicago and the University of Pennsylvania uses stem cells and flexible implantable bone-stabilizing plates to help speed up bone healing. By mimicking embryonic conditions, this technique encourages stem cells to differentiate into cartilage and bone.
Scientists have successfully derived Expanded Potential Stem Cells (EPSCs) from both pig and human cells, offering new opportunities to study human development and regenerative medicine. These EPSCs possess developmental potency, enabling researchers to investigate pregnancy complications and develop treatments for diseases.
Researchers used single-cell RNA sequencing to identify genes expressed by each cell in the aorta, grouping them into separate populations based on gene expression profiles. This allowed for accurate distinction between stem cells and other blood vessel cells, providing key insights into their identity.
Researchers used zebrafish and human cells to determine how blood stem cells receive Wnt signaling, discovering the crucial role of the epidermal growth factor receptor. This finding may advance laboratory development of blood stem cells, potentially leading to off-the-shelf treatments for patients with blood diseases.
A new study at the University of Copenhagen found that immature intestinal cells can develop into stem cells based on their surroundings. The discovery may lead to more effective stem cell therapy for non-healing wounds and tissue repair.
Researchers from the University of Edinburgh discovered a protein that switches on an immune response in stem cells, protecting them from viruses. This finding could help develop more efficient stem cell therapies to treat diseases like Parkinson's and diabetes.
Scientists at Kyoto University have found a 'wake-up' signal that can unlock brain cells' regenerative potential. The discovery, published in Genes & Development, reveals the ebb and flow of gene expression that activates dormant neural stem cells.
Researchers at the University of Maryland School of Medicine have discovered pigment-producing stem cells that can regenerate myelin sheaths in mice, potentially treating neurodegenerative diseases like multiple sclerosis. The discovery could offer a less invasive and simpler alternative to embryonic stem cells.
Researchers have identified stem cells in hair follicles that can regenerate the myelin sheath coating neurons, potentially treating nerve injuries and demyelinating diseases like multiple sclerosis. The study found that these cells can enhance functional recovery from neuronal injury.
Researchers at Rutgers University have identified a new factor essential for maintaining stem cells in the brain and gut, whose loss contributes to anxiety and cognitive disorders. The study reveals that this gene product supports multiple types of adult stem cells, including those critical for cognitive function and intestinal renewal.
The UC Davis program aims to close the gender gap in STEM learning by providing mentors and hands-on STEM education tools to 11-year-old girls. The one-year pilot program will recruit 15,000 girls and pair them with mentors for up to 20 hours of guidance.
Researchers at Tufts University have successfully grown and maintained olfactory stem cells in culture, which can then be used to restore tissue in the nose. The discovery raises hope that future therapies could be developed to restore the sense of smell in individuals where it has been damaged by injury or degeneration.
Researchers have found that modulating blood-forming stem cells' stiffness could help drive them out of the bone marrow and into the blood, but they need to be stiff to stay put. The study, published in Cell Stem Cell, suggests that altering cell biomechanics can improve mobilization regimens for stem cell-based therapy.
Scientists identify CXCL12-expressing mesenchymal stromal cell niches as a strategy to target and eliminate treatment-resistant leukemic stem cells in chronic myelogenous leukemia. The study reveals that these niche interactions control quiescence of leukemic stem cells.
Lian's team developed a new method to differentiate stem cells into pancreatic beta cells, using small molecules that stimulate cell signaling pathways. The approach aims to create functional beta cells from stem cells for Type 1 diabetes treatment and has the potential for broad commercial impact.