In a groundbreaking study, researchers found that transplanted neural stem cells slow ALS disease onset and progression by producing protective molecules and reducing inflammation. The treatment improves motor function and prolongs survival in ALS mice, offering new hope for treating this devastating disease.
Scientists from the Danish Stem Cell Center found that stem cells grow better in three-dimensional environments, leading to improved insulin-producing cell development. This discovery holds promise for improving diabetes treatment with cell therapy.
Researchers have created a new stem-like state of adult epithelial cells, which exhibit attributes favoring regenerative medicine. These cells do not express genes found in embryonic stem cells and induced pluripotent stem cells, making them stable and less prone to forming tumors.
A University of Cincinnati research team isolated and grew lung cancer stem cells in a preclinical model, offering a new avenue for investigating immunotherapy options that specifically target stem cells. This breakthrough could lead to the development of novel therapies targeting these cells and improving treatment outcomes.
Researchers at Boston University developed a novel technique to produce human induced pluripotent stem cells (iPSCs) from peripheral blood, offering an ethical alternative to embryonic stem cells. The method has been published in JoVE and provides a valuable resource for studying rare genetic disorders.
Researchers investigated the use of stem cells in treating equine tendon injuries. Bone marrow-derived mesenchymal stem cells and adipose-derived stem cells showed promise in strengthening tendons after injury, while umbilical cord blood-derived stem cells may offer even greater potential for tendon regeneration.
Researchers successfully grew and sorted induced pluripotent stem cells for use in cartilage repair and studying osteoarthritis. The breakthrough uses adult stem cells converted into embryonic-like stem cells to produce cartilage tissue.
The partnership enables the publication of high-quality stem cell research in an open-access venue, promoting outreach and quality in the field. Stem Cell Reports will feature various article types and allow authors to retain full copyright over their work.
A recent study has revealed the existence of a rare sub-group of activated immune cells that act as bodyguards to protect stem cells from premature differentiation. These macrophage cells secrete prostaglandins, which delay differentiation and preserve the youthful state of the stem cells.
A two-year clinical trial found no survival difference between patients receiving peripheral blood stem cells and bone marrow stem cells from unrelated donors. However, peripheral blood stem cell transplants were associated with a higher incidence of chronic graft-versus-host disease (GVHD).
Researchers at Mayo Clinic have developed a way to detect and eliminate potentially troublemaking stem cells, making stem cell therapy safer. The new approach uses a chemotherapeutic agent that selectively damages the DNA of the stem cells, efficiently killing the tumor-forming cells without affecting healthy ones.
Researchers at Moffitt Cancer Center have discovered that microRNA miR-214 plays a critical role in regulating ovarian cancer stem cell properties. The study found that miR-214 induces the expression of a stem cell transcription factor (Nanog), leading to chemoresistance and potentially serving as a therapeutic target for ovarian cancer.
Researchers identify FGF2 as a protein that stimulates cells to divide and activates dormant stem cells, leading to muscle depletion. By administering an FGF2 inhibitor, they halted the decline in muscle stem cells in mice.
Scientists have developed a new video protocol to isolate brain tumor initiating stem cells from primary brain tumors, allowing for quick and efficient analysis of target cells. This approach has been effectively used to identify similar stem cells in leukemia patients.
The Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research at Albert Einstein College of Medicine hosted its first stem cell institute symposium, showcasing the latest research on induced pluripotent stem cells and hematopoietic stem cells. The event featured four presentations by renowned speakers fr...
Researchers have elucidated how muscle stem cells colonize niches for efficient growth and repair. They found that these stem cells weaken when located outside their muscle fiber niches, leading to weakened muscles. The Notch signaling pathway plays a crucial role in preventing differentiation of stem cells into muscle cells.
Researchers at the Stowers Institute for Medical Research discovered that planarian stem cells, known as neoblasts, can mobilize and rebuild tissues lost to amputation. The team found that these stem cells remain pluripotent even in fully mature animals and migrate to the site of injury when needed.
Researchers at Michigan Medicine have discovered the crucial role of Mof in preserving stem cells' ability to become any type of cell. By regulating DNA access, Mof enables stem cells to maintain their 'stem-ness' and differentiate into specialized cells.
Researchers at Duke University Health System have found that mesenchymal stem cells can prevent post-traumatic arthritis in mice with fractures. The study suggests that these stem cells alter the balance of inflammation and regeneration in knee joints, thereby preventing the development of osteoarthritis.
Researchers at Sanford-Burnham Medical Research Institute have discovered a molecule that converts stem cells into heart cells, potentially replacing diseased or damaged tissue in heart disease patients. The molecule, ITD-1, blocks TGFϐ signaling, allowing stem cells to differentiate into cardiomyocytes.
Researchers from IMIM have deciphered the role of β-catenin in generating haematopoietic stem cells, which can be used to treat leukaemia patients without compatible donors. The study lays the foundation for laboratory-generated stem cells that can improve transplant quality and quantity.
Modified human stem cells helped enhance the activity of an enzyme called telomerase, which elongates telomere length. This technique increased telomere length and activity, as well as increasing cardiac stem cell proliferation, vital steps in combating heart failure.
A new study published in the journal Stem Cell reveals an antibody developed by researchers can detect stem cells in organs like the liver and pancreas. This breakthrough helps understand tissue regeneration and cancer diagnosis and treatment.
Researchers found two key epigenetic regulating genes that govern cell-fate determination of human bone marrow stem cells. The discovery may allow stem cells to differentiate specifically into bone cells while inhibiting fat cell differentiation, paving the way for therapies in regenerative medicine and osteoporosis treatment.
Scientists have reprogrammed amniotic fluid cells into a more versatile state similar to embryonic stem cells. The findings suggest that stem cells derived from donated amniotic fluid could be stored in banks and used for therapies, providing a viable alternative to the limited embryonic stem cells currently available.
Researchers at the University of Maryland School of Medicine have discovered that adult stem cells from bone marrow can transform into cells of other organs, such as the heart, brain, and pancreas. This breakthrough has significant implications for treating diseases like diabetes, Parkinson's, and Alzheimer's.
A Johns Hopkins University team found a protein molecule, p190RhoGAP, that regulates cardiac stem cells to form healthy heart tissue or blood vessels. By altering its levels, the researchers were able to improve the effectiveness of stem cell therapy in treating heart attack patients.
Richard Alley, a renowned geoscientist, has been recognized by the US News STEM Leadership Hall of Fame for his groundbreaking work in the field. He will receive the award on June 29 at U.S. News STEM Solutions 2012 in Dallas, Texas.
Stem cells in the developing embryo give rise to adult nephrons, but unlike skin and gut, kidneys can't build new ones. FGF9 and FGF20 proteins maintain the embryonic kidney's stem cell niche, which is crucial for future research on growing kidney stem cells in the lab.
A study by UT Southwestern Medical Center researchers has identified a protein receptor on cancer cells that induces differentiation, helping blood cancer cells grow. The receptor, called LILRB2, maintains stem cell readiness by inhibiting differentiation and preserving self-renewal.
Researchers discovered an anti-psychotic drug, thioridazine, that selectively targets and exhausts cancer stem cells, leading to improved survival rates in leukemia patients. The compound works by encouraging cancer stem cells to differentiate into less threatening cell types.
Researchers at McMaster University have discovered a drug, thioridazine, that kills cancer stem cells in humans while avoiding toxic side effects of conventional treatments. The study holds promise for new strategies and discovery pipelines for developing anticancer drugs.
Stem cells, essential building blocks of life, gradually lose their ability to maintain tissues and organs as they age. Researchers at the Salk Institute found that the stem cell niche's biological events contribute to this decline, but also discovered a mechanism to reverse it by increasing expression of Imp.
Researchers identified a cell surface protein ganglioside GD2 that flags breast cancer stem cells as potent tumor-generating cells. A small molecule drug triptolide inhibits GD3 synthase, essential to GD2 production, and stymies cancer growth in preclinical tests.
Researchers at NYSCF have successfully grown compact bone tissue using human embryonic stem cells, which can be used to repair and replace damaged bone in patients. The breakthrough could lead to personalized bone grafts that avoid immune rejection.
Researchers from Brazil and Korea used human immature dental pulp stem cells to create induced pluripotent stem cells, showing promising characteristics for therapeutic applications. The studies suggest that dental stem cells may be a valuable alternative source for regenerative medicine, including tooth regeneration and repair.
Researchers from the University of Minnesota have effectively treated muscular dystrophy in mice using human stem cells derived from a new process that makes the production of human muscle cells efficient and effective. The study outlines a strategy for developing a rapidly dividing population of skeletal myogenic progenitor cells, set...
Researchers at UCLA identified new genetic components controlling neural stem cell adhesion and proliferation, crucial for normal nervous system development. The study's findings could lead to a better understanding of birth defects and disorders like autism, as well as the formation of brain tumors.
A molecular pathway that controls the retention and release of brain stem cells has been identified. The discovery reveals that this pathway is critical for the adhesion of stem cells to their niche and for stem cell maintenance, suggesting a new idea in understanding stem cell regulation.
Researchers suggest that stem cells have intrinsic capacities for self-maintenance and evasion of differentiation. By analyzing current properties and characteristics of stem cells, the 'by default' hypothesis proposes that stem cells exist due to factors that repress cellular signals for specialization.
Researchers have developed a new type of human stem cell called endodermal progenitor cells, which can differentiate into multiple cell types, including functioning pancreatic beta cells. The cells show promise for modeling human diseases and may offer a potential source for future diabetes treatments.
A combination approach therapy targeting β-catenin pathway may stamp out CML for good. Leukemia stem cells are vulnerable to treatments aiming at this pathway, unlike normal blood stem cells.
Researchers have developed a unique suspension technique for growing stem cells, eliminating the need for surface growth and increasing efficiency. This breakthrough has the potential to make cost-effective large-scale stem cell manufacturing possible, which could lead to new treatments for heart disease.
Researchers at NIH have discovered how arsenic exposure can turn normal stem cells into cancer stem cells, spur tumor growth. This finding suggests that cancer may be a stem-cell-based disease and has implications for understanding carcinogenesis.
Scientists have discovered a new paradigm for immunotherapy against cancer by priming antibodies and T cells with cancer stem cells. The study found that purified cancer stem cells strengthened the potency of antibodies and T cells that selectively targeted cancer stem cells.
The University of Bonn team has successfully derived brain stem cells directly from connective tissue in mice, which can reproduce and be converted into various types of brain cells. This method is faster, safer, and associated with a lower risk of tumors compared to existing approaches.
Researchers have developed a new method to induce somatic stem cells directly from fully differentiated skin cells. This breakthrough reduces the risk of tumor formation and increases their therapeutic potential for tissue regeneration.
Researchers at UGA created the first blueprint of how stem cells respond to external signaling molecules. The finding reconciles years of conflicting results and enables precise control over stem cell differentiation into specific cell types.
Scientists at Whitehead Institute have made a breakthrough in understanding planarian stem cells, discovering genes that regulate two main functions: differentiation and renewal. The study, published in Cell Stem Cell, provides insights into the molecular mechanisms underlying regenerative medicine.
Researchers have developed a synthetic version of the essential protein Oct4, which enhances the effect of genes needed for stem cells. This breakthrough enables more efficient generation and maintenance of stem cells, with potential applications in regenerative medicine and disease treatment.
Research identifies SIRT1 as a key enzyme protecting leukemia stem cells from stress and driving cancer recurrence. Inhibiting SIRT1 selectively reduces CML stem cell survival and growth, offering a potential therapeutic target for treatment resistance.
Researchers at UCLA's Jonsson Comprehensive Cancer Center found that radiation treatment converts normal breast cancer cells into treatment-resistant stem cells. These induced breast cancer stem cells have a 30-fold increased ability to form tumors, undermining the effectiveness of radiation therapy.
A novel technique enhances bone growth by guiding stem cells to the bone surface, increasing bone density and preventing age-related bone loss. The study successfully tested this approach in mice with osteoporosis, paving the way for human trials.
Scientists have identified endothelial and perivascular cells as the key creators of the niche that nurtures haematopoietic stem cells. This discovery could lead to increased safety and effectiveness of bone marrow transplantation by replicating signals that promote blood-forming stem cell expansion.
Researchers successfully converted stem cells from umbilical cords into oligodendrocytes, critical cells that insulate nerves in the brain and spinal cord. The breakthrough offers new hope for treating spinal cord injuries and multiple sclerosis by injecting healthy oligodendrocytes into the body.
A Penn State research team has discovered a compound produced from fish oil that targets and kills leukemia stem cells, potentially leading to a cure for the disease. The compound, D12-PGJ3, selectively activates a gene in leukemia stem cells that programs their own death.
Researchers have developed a therapy using FT1050 that improves stem cell engraftment in umbilical cord blood transplant recipients, allowing for faster recovery and reduced complications. The treatment accelerates the process of stem cells taking root in patients, resulting in improved outcomes.
A team led by Nancy Speck at the University of Pennsylvania School of Medicine has discovered a molecular marker for hematopoietic stem cells, providing insights into their origin and development. This finding could help manipulate embryonic stem cells to generate new blood cells for therapy in leukemia patients
Researchers found that newly derived human embryonic stem cell lines have a better molecular signature than established lines, indicating higher quality and potentially better performance in disease modeling. The study suggests that maintaining the original state of X chromosome inactivation could be crucial for achieving optimal results.
Researchers from UCLA's cancer and stem cell centers have successfully engineered blood stem cells to create cancer-killing T-cells that seek out and attack human melanoma. The approach could lead to a sustained immune response, potentially protecting against cancer recurrence.