Researchers from Tokyo University of Science found that short PPG signals can be used to estimate dynamical properties like determinism, predictability, and complexity with good accuracy. However, shorter signals may not be sufficient for estimating divergence.
A Japanese study reveals that policy disagreement and politicization led to the split of Japan's largest opposition party in 2017. The researchers found that traditional DIF analysis failed to capture the complexity of party positions, but a corrected version showed strong discord over defense policy.
A new study led by Tokyo University of Science researchers identifies altered gene expression and cell function changes that drive DNA damage and neoplasia in cholangiocytes exposed to 1,2-dichloropropane. The findings highlight the importance of macrophage involvement in carcinogenesis.
Researchers from Tokyo University of Science create new method for producing heterolayer coordination nanosheets with improved properties and controllability. The study expands the diversity of 2D materials, enabling potential applications in optoelectronics and renewable energy.
A team of researchers from Tokyo University of Science has developed a novel multi-proton carrier complex that shows efficient proton conductivity even at high temperatures. The resulting starburst-type metal complex acts as a proton transmitter, making it 6 times more potent than individual imidazole molecules.
A Tokyo University of Science study found that fluoride nanoparticles enhance β-sheet formation in amyloid β proteins, a common feature of Alzheimer's disease. The researchers also discovered that surrounding ions can control this process, paving the way for targeted treatments.
Researchers from Tokyo University of Science developed novel complex-peptide hybrids that induce programmed cell death in apoptosis-resistant cancer cells through paraptosis. The compounds, syn-6 and anti-6, inhibit cell death by uncoupling mitochondrial calcium uptake and inducing cytoplasmic vacuolization, leading to cell death.
A team of researchers from Tokyo University of Science has developed an efficient integrated materials synthesis system for automatic discovery of new functional magnetic materials. Using artificial intelligence and computational science, they identified promising materials five times more efficiently than traditional trial-and-error a...
Researchers at Tokyo University of Science have developed a fast and facile synthesis method for antibacterial amino acid Schiff base copper complexes using microwave irradiation. The new technique produces high-purity products with promising antimicrobial activity, overcoming the challenge of long synthesis times.
A novel single-cell RNA sequencing technique, TAS-Seq, has been developed to provide higher-precision data than current methods. The new method detects more genes and identifies highly variable genes, making it a sensitive high-throughput scRNA method.
Researchers use machine learning to automatically analyze Reflection High-Energy Electron Diffraction (RHEED) data, enabling faster and more efficient discovery of new materials. The study focused on surface superstructures in thin-film silicon surfaces and identified optimal synthesis conditions using non-negative matrix factorization.
A research team from Tokyo University of Science has developed a new method to create copolymers with different metal species, which have potential uses in catalysis and drug discovery. The technique allows for controlling the composition of metal species in the resulting polymer.
A team of scientists at Tokyo University of Science has successfully produced hydrogen peroxide using spent coffee grounds and tea leaf residue. The new method, which is simple, cost-effective, and environmentally friendly, opens up new applications for unused biomass resources.
Researchers from Tokyo University of Science discovered that bony fish head cartilage contains abundant proteoglycans, including aggrecan, with similar CS structures to salmon nasal cartilage. This finding reveals the potential of sturgeon as an alternative source of CSPGs for health food formulations.
Researchers found phosphatidylinositol bisphosphate (PIP2) essential for epithelial cell-cell adhesion and maintaining cellular identity. PIP2 regulates epithelial properties by recruiting Par3 to the plasma membrane, facilitating the formation of adherens junctions and preventing epithelial-mesenchymal transformation.
Researchers at Tokyo University of Science propose two new search strategies to reduce the computational cost of rebalancing in bicycle-sharing systems. The approaches focus on finding feasible solutions more efficiently and redefine the problem to minimize solving time.
Researchers discover that type 1 TPCs encode SV channels in plant vacuoles, while type 2 TPCs likely encode distinct ion channels. This study provides functional and evolutionary insights into the TPC family in plants, shedding light on their role in plant growth and defence mechanisms.
Researchers from Tokyo University of Science have designed a tunable physical reservoir device based on dielectric relaxation at an electrode-ionic liquid interface. The system can store and process analog signals, enabling real-time processing of signals in living environments.
Researchers at Tokyo University of Science identify brain regions and signaling pathways involved in fear extinction via delta receptor activation. The study suggests a potential therapeutic agent for post-traumatic stress disorders by suppressing fearful memories.
Researchers studied peptide bond formation between tRNA molecules and a ribosomal RNA segment, revealing the potential for minihelices to bind to the primordial peptidyl transferase center. The study suggests that functional interactions between tRNA and PTC could have been 'revised' in evolution.
A study by Tokyo University of Science researchers has demonstrated that a computationally-light model can simulate complex brain cell responses, including periodic and quasi-periodic responses. The Izhikevich neuron model was found to be capable of reproducing both types of responses at lower computational cost.
Researchers at Tokyo University of Science discovered that disulfiram inhibits FROUNT protein and chemokine signaling pathways, reducing anxiety levels in mice. The study suggests a potential breakthrough anti-anxiety medication with safe and effective treatment for elderly patients suffering from anxiety and insomnia.
A study by Tokyo University of Science researchers used WCNs with increasing n values to find features of language that cannot be analyzed using existing WCNs. They found important features in networks with more than three co-occurrences, independent of text data.
Researchers develop a new method to reconstruct the states of complex nonlinear systems based on time series data. The approach optimizes reconstruction parameters by focusing on the geometric structure of attractors, resulting in improved accuracy.
Researchers from Tokyo University of Science analyzed usage patterns of bicycles in four major US cities to improve bicycle sharing system efficiency. They found temporal patterns and similarities between weekdays and weekends, contradicting previous studies.
Researchers discover medusavirus undergoes four stages of maturation within host cells, with unique particle structures and DNA-protein exchange mechanisms. The findings provide new insights into giant viruses' biology and behavior.
Researchers developed a new reading method for SOT-RAMs that can nullify the readout disturbance, reducing it by at least 10 times. The method involves creating a bi-directional read path, cancelling out the disturbances produced by spin currents.
Researchers discovered that plant volatile signals can warn neighboring plants of herbivore attacks, activating defense genes and increasing resistance. The team found epigenetic mechanisms, including histone acetylation, play a key role in this process.
Researchers have identified a novel enzyme that catalyzes the formation of glycosidic bonds in complex sugar moieties. The discovery provides fresh insights into carbohydrate metabolism and offers a breakthrough for the synthesis of sugar chains, which play key roles in various biological processes.
Scientists discovered that a gene family regulates plant immune response, with some genes promoting defense and others inhibiting it. The research has implications for sustainable agriculture and food security.
Researchers propose a disaggregation strategy to estimate power consumption of individual electrical facilities, improving accuracy over traditional methods. The new approach uses linear regression residuals and clustered daily routines to provide more accurate estimations for workdays and holidays.
Researchers identified eight new microorganisms that cleave ether bonds in the lignin-based compound-2-phenoxyacetophenone. These discoveries could enhance our understanding of the carbon cycle and facilitate biotechnological applications for lignin commercialization.
Researchers at Tokyo University of Science have discovered a method to improve the crystallinity of coordination nanosheets by mixing two metal ion solutions. This approach results in higher crystallinity and improved performance in devices such as electronics and batteries. The findings open a new pathway for tuning the functional pro...
A new bacterial strain, Noda2021, belonging to Candidatus phylum Dependentiae has been isolated and sequenced, revealing its genetic material and potential ecological significance. This discovery sheds light on the diversity of microorganisms in Japan's microbiological hotspots.
Researchers at Tokyo University of Science have developed bionanoparticles derived from corn that selectively target and inhibit the growth of cancer cells, inducing tumor necrosis factor-α release. These findings suggest a novel, economical, and safe anti-cancer therapy approach.
Researchers have discovered a streamlined two-step synthesis strategy to produce neoechinulin B and its derivatives, exhibiting strong anti-HCV and anti-SARS-CoV-2 activities. The novel process utilizes a piperazine-2,5-dione derivative and tetra-n-butylammonium fluoride (TBAF) as key reagents.
A new bilateral tumor model was demonstrated to be useful for investigating the relationship between T-cell repertoire and cancer immunotherapy's therapeutic effects. The study found that T-cell profiles of both tumors were almost identical, indicating a similar anti-tumor response in a single mouse.
Researchers from Tokyo University of Science developed a high-quality crystalline interface using quasi-homo-epitaxial growth, which eliminated mobility issues and enabled spontaneous electron transfer. This breakthrough could lead to highly efficient flexible solar cells and wearable electronic devices.
A study published in Allergy reveals the importance of PU.1 transcription factor in regulating CCL17 gene expression, which contributes to allergic diseases. The research found that suppressing PU.1 can reduce inflammation in asthmatic mice, paving the way for novel treatments.
Scientists at Tokyo University of Science have developed a novel polymer-based hydrogel that can prevent postoperative pancreatic fistulae, a frequent complication of pancreatic surgery. The Exceval hydrogel shows great promise for clinical applications due to its adjustable properties and high absorption abilities.
Researchers at Tokyo University of Science have developed a novel light-based method for rapidly racemizing chiral sulfoxides, a crucial step in producing desired enantiomers. This breakthrough utilizes photocatalysts to achieve rapid racemization under moderate conditions, bypassing the need for high temperatures previously required.
A study by Tokyo University of Science researchers identifies a novel regulatory axis targeting dendritic cell activity, suppressing autoimmune disease symptoms and bone loss. They discovered DCIR binds to glycoproteins on macrophages and osteoclasts, reducing inflammation and immune responses.
Researchers at Tokyo University of Science have reported the first-ever observation of long-range ferromagnetic order in icosahedral quasicrystals. The discovery was made using conventional X-ray diffraction, magnetic susceptibility, and specific heat measurements.
A team of scientists from Tokyo University of Science has developed a machine learning-based tool to predict thermoacoustic oscillations in engines. The tool uses dynamical systems theory and can classify combustion into three states, identifying pressure fluctuations that indicate future combustion oscillations.
A new study found that unique names increased in Japan between 2004 and 2018, with a greater rate of change for girls than boys. This suggests that parents increasingly valued their daughters' uniqueness and independence, highlighting sex differences in sociocultural changes.
Researchers develop an algorithm to find optimal or near-optimal solutions in the space of 'infeasible solutions' to speed up search, alleviating traffic congestion and improving city living. A novel solution to a combinatorial optimization problem in bicycle sharing systems is proposed.
Researchers from Tokyo University of Science developed a computationally quick approach to predict molten droplet solidification on a solid surface. The model simulates the solidification process by considering the droplet behavior and heat transfer between the hotter droplet and cooler surface, replicating experiments with high accuracy.
A recent study published in Frontiers in Immunology found that opioids can control gut immune responses, reduce colonic inflammation, and even promote the growth of regulatory T cells. The findings suggest that KNT-127 could be a promising therapeutic option for inflammatory bowel disease.
Researchers at Tokyo University of Science discover that vicarious social defeat can cause psychological stress in mice, leading to depression and decreased neurogenesis. The study sheds light on the pathophysiology of depression and may lead to the development of novel antidepressants.
Scientists from Tokyo University of Science and NIMS Japan have evaluated the irreversibility of LixWO3 thin films. They found that irreversible Li+ trapping and Li2WO4 formation are different processes, with proportions of 7.7% and 50.9%, respectively.