Scientists uncover mechanism controlling cellular levels of tau, a protein linked to devastating neurodegenerative diseases. Overexpression of specific form of numb protein Numb-72 decreases tau levels and slows neuron loss in animal models.
A new neurocomputational model introduces a three-level information processing framework to understand brain development and cognition. The model focuses on Hebbian learning and reinforcement learning, highlighting two fundamental mechanisms for multilevel cognitive ability development in biological neural networks.
Researchers from the University of Montreal have discovered an exoplanet that could be an 'ocean planet,' completely covered by a thick layer of water. The exoplanet, TOI-1452 b, has a radius and mass similar to Earth but is believed to be rocky with a possible abundance of water.
Researchers found that forest trees with a mix of both ectomycorrhiza and arbuscular mycorrhiza had the greatest tree diversity, contradicting previous beliefs. This discovery highlights the importance of considering the coexistence of different mycorrhizal strategies in promoting plant biodiversity.
Researchers analyzed existing studies on PFAS in breast milk, finding that levels of PFOA and PFOS exceeded children's drinking water screening values by up to two orders of magnitude. The study emphasizes the need for a national breastmilk monitoring program to provide credible advice to pregnant or breastfeeding women.
A study published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association found that 12 to 14 intervention sessions can improve cognition in older adults at risk of dementia. The optimal dose was determined by analyzing data from the Multidomain Alzheimer Preventive Trial, taking into account individual characteristics su...
Researchers at Université de Montréal have created a nanoantenna to monitor the motions of proteins, offering a new method to study natural and human-designed nanotechnologies. The DNA-based fluorescent nanoantenna can detect protein conformational changes in real-time.
Scientists have identified a biomolecular condensate as the key to initiating endocytosis, a process by which cells absorb nutrients and regulate hormone sensitivity. The discovery sheds light on how membrane buckling occurs and has implications for understanding diseases such as cancers, heart disease, and neuropsychiatric disorders.
Researchers discovered that under stress conditions, proteasome molecules assemble into structures that induce cell death, a process linked to apoptosis and potentially preventing cancer. The study highlights the importance of understanding the normal functioning of cells and their connections to cancer development.
A study found that vaccination rates among Indian children improved significantly between 1992 and 2016, with a 70% drop in child mortality from vaccine-preventable diseases. However, zero-dose children remained concentrated among disadvantaged groups, including low-income households and mothers with limited education.
Researchers found that older individuals produce higher levels of protective antibodies after infection or vaccination, providing better defense against emerging variants. Antibodies from infected individuals 50+ years old reacted strongly to the Delta variant, outperforming those from vaccinated adults under 50.
A new study published in the Journal of Developmental & Behavioral Pediatrics suggests that boys who participate in sports in early childhood are less likely to experience depressive and anxiety symptoms later. The study also found that boys who exhibit higher levels of depressive and anxious symptoms during middle childhood are subseq...
Researchers developed a machine learning model that produced fewer decision-making errors than human behavior analysts. The AI system showed improved consistency and predictability in treatment decisions, with potential applications in diagnosing and treating autism, ADHD, anxiety, and depression.
A study found that white lupin plants can rejuvenate arsenic-contaminated soils by releasing compounds that bind metals, potentially offering a sustainable remediation method. The research used advanced chemical profiling to identify the root chemicals involved in this process.
An international team of scientists uses archeological digs and palaeoclimate records to study human interactions with the environment during past climate-change events. This approach can help identify tipping points in climate history and provide insights into how cultural diversity has contributed to human resilience.
A new study from Université de Montréal found that sexually diverse youths with depression are more likely to use cannabis. The study analyzed data from over 1,500 adolescent participants and found a fivefold stronger association between depressive symptoms and increased cannabis use in LGB youth.
A new study published in PNAS has identified a protein called AXL as a crucial player in hypoxia, which promotes cancer progression and resistance to treatment. By blocking the action of this protein, researchers observed improved recovery of blood vessels and revitalization of the tumour's immune environment.
A Canadian research team has identified a critical period in postnatal brain development that contributes to neurodevelopmental disorders associated with tuberous sclerosis. The study suggests that a mutation in the TSC1 gene disrupts the mTOR signaling pathway, leading to abnormal cell proliferation and synaptic connections defects.
Scientists have found a way to filter wastewater through the roots of willow trees, treating over 30 million litres of primary wastewater per hectare annually. The process produces renewable lignocellulosic biofuels and 'green' chemicals with antioxidant, anticancer, anti-inflammatory and anti-microbial properties.
Researchers have developed an observational tool to assess children up to 5 years old with a concussion. The new tool catalogues known symptoms, including headaches, memory loss, and irritability, and allows for tracking of physical, cognitive, and behavioral changes over time.
The COLCORONA study suggests that colchicine, an anti-inflammatory drug, could be used to prevent COVID-19-related complications in non-hospitalized patients with at least one risk factor for disease progression. The study's primary endpoint was the composite of death or hospitalization in patients with COVID-19.
A new study found that couple cognitive-behavioural therapy (CBT) is more effective than lidocaine in reducing women's fear of pain and improving their sexual experience. The therapy helps break the vicious cycle of fear and avoidance, allowing couples to refocus on pleasurable experiences.
Researchers have identified BMI1 as a key player in protecting neurons from DNA disorganization, a phenomenon associated with Alzheimer's disease. The discovery adds to our understanding of the fundamental mechanisms leading to the disorder and brings hope for future treatments.
Repeatedly getting angry at children leads to smaller brain structures in adolescence, according to a new study. The research found that harsh parenting practices can harm social and emotional development as well as brain structure size.
Researchers found abnormally high brain activation in individuals without diagnosed Alzheimer's but with memory concerns, suggesting a potential biomarker. Hyperactivation in certain regions increases before cognitive impairments and neuronal loss associated with the disease.
Researchers found that WASP-107b's massive gas envelope could form easily with a less massive core than previously thought, contradicting classical models of gas-giant planet formation. The discovery has significant implications for our understanding of exoplanet formation and the variety of planets in the universe.
A new study by researchers at Université de Montréal found that kindergarten readiness is associated with better academic, psychological, and health outcomes in emerging adulthood. The study, published in Pediatrics, analyzed data from over 2,000 children born between 1997 and 1998 and found that kindergarten math skills and classroom ...
A new study warns that massive African reforestation efforts could harm ecosystems, as the biomes are divided into distinct types with unique tree species. The researchers analyzed 753 sites in both environments, finding that rainfall, seasonality, and temperature are key environmental factors.
A young man suffering from severe aplastic anemia has been given a life-saving blood transplant using the UM171 molecule, which increases stem cell production and reduces immunological complications. The procedure was performed by a medical team at the Institute of Hemato-oncology and Cellular Therapy.
A new Canadian study found that girls who participate in school sports activities during middle childhood show improved behaviour and attentiveness in early adolescence. The study, led by Linda Pagani, suggests that extracurricular sports can be a positive approach to promote psychological well-being and reduce ADHD symptoms in girls.
A recent study published in Scientific Reports has found that Y chromosome genes may regulate cellular functions differently than previously thought, potentially explaining why men are more susceptible to certain diseases like Covid-19. The discovery could also provide insights into the underlying mechanisms of male health disparities.
A new Canadian study reveals that childhood sexual abuse survivors experience a higher incidence of genitourinary problems, such as urinary tract infections and pain during sex. The research also found that psychological distress is partly responsible for the physical trauma, highlighting the need for a combined approach to treatment.
T cells play a crucial role in immune response and cancer treatment. Researchers have identified key factors influencing T cell development, which can impact the body's ability to control infections or tumor growth.
A large international consortium study found over 5,000 genetic mutations affecting blood characteristics worldwide. Researchers identified specific mutations linked to increased lymphocyte levels in South Asian populations, highlighting potential risks and treatment targets.
A study by the University of Montreal has revealed the rules of synaptic plasticity, a process underlying learning and memory. The research found that dendritic spines, tiny protrusions on neurons, amplify or suppress incoming information based on its strength.
Researchers at the University of Montreal have developed a synthetic, biocompatible liquid hydrogel that promotes tissue regeneration and treats corneal perforations without transplantation. This innovative solution has the potential to help patients retain their vision and avoid blindness.
Astronomers detect exoplanet AU Mic b, about the size of Neptune, using NASA's TESS and Spitzer space telescopes. The discovery provides a unique laboratory to study planetary formation and atmospheric interactions with a young star.
A new test developed at CHU Sainte-Justine enables better management of patients with severe combined immunodeficiency (SCID) by analyzing a small volume of peripheral blood. The test uses a 3D culture system to mimic the function of a human thymus, allowing for a relatively quick response and improved treatment options.
Researchers successfully tagged telomerase with fluorescent molecules, revealing its two-step binding mode to chromosomes. The study also shows how telomerase mutation promotes tumorigenesis, offering a new target for therapeutic strategies.
Researchers at Université de Montréal have created a colorimetric test that detects changes in colour to show how maple syrup tastes, validated by analyzing 1,818 samples. The artificial tongue can distinguish between 60 categories of taste and is useful for producers.
A team of researchers has found that shocks from a nova explosion cause most of its brightness, rather than nuclear burning on the surface of the white dwarf. The study, published in Nature Astronomy, used unprecedented space observations to detect bright gamma-rays and optical data from the star V906 Carinae.
Researchers at the University of Montreal are using convalescent plasma to develop a passive immunization program for COVID-19 treatment. The program, which involves transfusing plasma from recovered patients, has shown promise in reducing mortality rates in severe viral pneumonias.
Researchers at Université de Montreal tailored a PARP inhibitor to increase its capacity to kill cancer cells, resolving a long-standing puzzle over differences between effective treatments. The new design principles could also be applied to other diseases, such as cardiovascular disease and inflammation.
Researchers at the University of Montreal developed an AI technique to better define brain sections in newborns using MRI exams. This innovation enables quick, accurate, and reliable analysis of baby brains, supporting research on brain development and neuroprotection.
A team of researchers combined genealogical information with genetic data from modern Quebecers to access the genetic profile of Quebec's historical population. The study successfully identified approximately 1.7 million individuals, but limitations in genetic coverage hindered full identification, leaving around 88% of men married bef...
Researchers at Université de Montrêl have successfully used biocatalysis to control the shapes of large ring molecules, called macrocycles. This breakthrough enables the creation of planar chiral macrocycles, which can be tailored for various applications including pharmaceuticals and electronics.
Researchers have made a major breakthrough in understanding the genetics of Down syndrome by identifying a new mechanism involved in its expression. The study found that RCAN1, a gene overexpressed in Down syndrome brains, regulates synaptic plasticity, which affects learning and memory.
Researchers at University of Montreal found that human cells scramble their membrane fat to fix holes caused by microbes, preventing cell damage. The discovery identifies a molecule, TMEM16F, that can repair these holes and protect humans from certain diseases.
A study published in Perspectives on Behavior Science found that AI models can accurately interpret behavioral data, outperforming a popular visual-aid tool. This could lead to better decision-making and tailored interventions for individuals with developmental disabilities, mental health issues or learning difficulties.
A team of researchers created the first cellular model of chronic granulomatous disease (CGD), a rare genetic condition that causes severe infections. The study's findings suggest that restoring NADPH oxidase function in defective cells could help develop new and more effective treatment strategies.