Articles tagged with Cell Transplantation
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Researchers at Karolinska Institutet found that only viable neurons survive in the developing nervous system, while immature ones die. This discovery challenges the long-standing neurotrophic theory and could lead to new treatments for neurological diseases like Parkinson's.
Researchers at the University of Pennsylvania have developed a method to transplant healthy lung cells into injured mice, improving blood-oxygen levels and promoting lung regeneration. The technique, using specialized alveolar type-two cells, showed promise in treating various models of lung injury.
Scientists found that mutations in mitochondrial DNA can induce an immune response, leading to the rejection of stem cell transplants. The study used hybrid stem cells with nuclear and mitochondrial DNA from different sources and showed that even a single mitochondrial mutation can trigger an immune response.
A new study by University of Minnesota researchers demonstrates the ability to induce lasting immune tolerance in transplanted cells and organs without long-term use of anti-rejection drugs. This achievement opens up possibilities for a cure for type 1 diabetes.
Researchers developed a scaffold microrobot that precisely delivers cells to target tissues, increasing treatment safety and efficiency. The technology minimizes cell loss in the body and can be controlled wirelessly using an external magnetic field.
Researchers at Stanford Medicine developed an antibody treatment that enables mice to accept haploidentical hematopoietic stem cell transplants without immunosuppression. This breakthrough could transform the treatment of immune disorders and increase organ availability for transplantation.
Researchers developed a blood test to track transplanted stem cells' effectiveness by analyzing exosomes, tiny cellular components secreted into the recipient's blood. The test showed promising results in repairing damaged heart muscle cells, paving the way for new treatments for various diseases.
Researchers found that transplanting human bone marrow-derived endothelial progenitor cells into mice with ALS-like symptoms improved motor function and slowed disease progression. The treatment repaired damage to the blood-spinal cord barrier, leading to increased motor neuron survival and reduced capillary leakage.
Researchers have made a breakthrough in understanding antibody-mediated rejection, a major challenge in organ transplantation. They discovered the critical amino acids and binding site of alloantibodies on HLA molecules, providing new avenues for developing therapies to prevent or treat this type of rejection.
Researchers have found no rebound of HIV in two patients who stopped taking their medication after receiving stem cell transplants, providing crucial insights into the potential mechanisms of cure. The transplanted donor cells had a gene defect that made it difficult for HIV to infect cells, offering new hope for developing a cure.
Scientists have developed a new technique using CRISPR-Cas9 gene editing to create pluripotent stem cells that can avoid rejection by the immune system. These 'universal' stem cells can be manufactured more efficiently than individualized cells and bring promise to regenerative medicine.
Researchers have discovered a molecular approach to prevent organ rejection while maintaining the ability to fight infections. By blocking coronin 1 in T cells, these immune cells suppress immune response to transplanted organs but continue to control viral and bacterial infections.
A recent USC-Stanford study reveals that successfully transplanted stem cells exhibit 'extreme behavior' due to radiation and chemotherapy, whereas healthy cells produce blood and immune cells more evenly. The research also shows that certain stem cells become dormant or biased towards producing specific immune cells.
Researchers at Texas A&M University have made a breakthrough in treating epilepsy by using stem cell-derived neurons to stop seizures and improve cognitive function. The study showed that transplanted human GABAergic neurons formed synapses with host excitatory neurons and were directly involved in controlling seizures.
Researchers identified genetic changes that enable tumor cells to evade immune detection after stem cell transplant. Telomere length is linked to risk of death from high-dose chemotherapy in MDS patients.
Researchers at Columbia University Irving Medical Center found that circulating white blood cells from donors contain matured cells that educate recipients' immune system to be tolerant of donated tissues. The study suggests new strategies for managing organ transplantation and reducing immunosuppression.
Researchers from UCI School of Medicine have found that neurons in blind rats' brains function normally after receiving fetal retinal cell transplants. The study reveals the potential for retinal transplants to treat retinal degeneration in people.
Researchers found that relapsed leukemia cells have reduced expression of genes involved in immune recognition, making them invisible to the immune system. Interferon gamma has been shown to turn back on these hidden immune markers, suggesting a potential therapeutic approach for AML patients who relapse after transplantation.
Researchers have found that a rare gene mutation alters brain development in mice, impairing memory and disrupting communication between nerve cells. Transplanting specific types of nerve cells into the brain improved memory problems in affected mice.
Researchers at Cincinnati Children's Hospital Medical Center describe a new method to improve the bone marrow transplant process, utilizing CASIN to mobilize higher quality donor HSCs and condition transplant recipients. This approach has potential to reduce toxicity and increase engraftment efficiency for vulnerable patients.
Researchers developed a protocol to isolate dopaminergic neurons from stem cells, improving cell-replacement therapy outcomes. The study found that transplanted cells with the contactin 2 protein exhibited better dopamine release and reduced motor symptoms in Parkinson's disease models.
Researchers discovered that afferent nerves from transplanted otic placodes form functional connections with the brainstem, allowing them to reach their target cells. The study found that these neurons rely on diffusible molecules and other guidance mechanisms to navigate the hindbrain.
Researchers have developed a new approach using synthetic hydrogel particles to educate the immune system to accept transplanted insulin-producing islets. The technique could allow for an 'off-the-shelf' therapy for type 1 diabetes without long-term immune suppression, potentially treating millions of people worldwide.
A recent study has identified monocytes as key instigators of early lung transplant failure, leading to organ rejection and death. The researchers hope their findings will lead to new therapies targeting inflammatory cells.
Dr. S. Thomas Carmichael, a UCLA neuroscientist, received the 2018 Bernard Sanberg Memorial Award for Brain Repair from ASNTR for his career-long work in stroke recovery mechanisms. His research has shown that the adult brain can form new connections after stroke and may be critical for plasticity in the recovering brain.
Doctors at the University of Illinois Hospital have cured seven adult patients with sickle cell disease using compatible donor stem cells. The new transplant protocol allows for half-matched donors, significantly increasing potential donors and improving treatment outcomes.
Researchers used adipose-derived mesenchymal stem cells to treat spinal cord injuries in rats, resulting in improved motor function and reduced damage. The study's findings suggest a promising therapeutic approach for repairing nervous tissue after injury.
Researchers at Cedars-Sinai have discovered a new way to treat amyotrophic lateral sclerosis (ALS) by transplanting altered neural cells into the brain. Laboratory rats that received the transplants lived 8 percent longer and were free of paralysis 10 percent longer than untreated animals.
Scientists have developed a new method to create more sophisticated brain-like organoid models by transplanting them into rodents, enabling longer survival and increased complexity. This breakthrough could lead to better therapies for neurological disorders, as well as the potential for human cell transplantation in the brain.
Researchers found that pairing immunosuppressive drugs with a stimulus significantly reduced T cell proliferation in renal transplant patients. This 'learned' behavior may enhance immunopharmacological treatment strategies.
Researchers found that genetically improving inhibitory interneurons and transplanting them into the brain of a mouse model with Alzheimer's disease can restore brain rhythms and cognition. This approach could lead to new treatment options for patients with Alzheimer's disease.
Researchers have developed tiny capsules that can sustain transplanted insulin-producing cells, increasing their viability and function. The capsules contain a drug that improves cell survival in low-oxygen conditions.
A new study by Duke University researchers found that stem cell transplant significantly improves survival and reduces the need for immune suppressant drugs in patients with severe scleroderma. The regimen, which includes chemotherapy and radiation, showed a highly significant benefit compared to conventional drug therapy.
Researchers discovered that a medication used to treat joint and skin conditions can help people with cancer survive by increasing the survival of transplanted blood stem cells. The drug etanercept blocks TNF-a, which kills healthy cells, allowing human blood stem cells to thrive in new hosts.
Researchers have developed tiny bilirubin-filled capsules that can improve the survival rates of transplanted pancreatic islet cells. This breakthrough has implications for treating Type 1 diabetes in both canine and human patients, with a potential treatment program for dogs that could lead to improved treatments for humans.
Researchers found that socio-demographic factors such as income level, education, and insurance status significantly impact access to stem cell transplants for patients with multiple myeloma. Higher-income Whites and Blacks, and those with private insurance, were more likely to receive the treatment.
Abatacept significantly improves survival and disease-free rates for patients with severe acute graft-versus-host disease, a life-threatening complication of stem cell transplantation. The treatment reduces the occurrence of acute GvHD from 32% to 3% in pediatric and adult patients.
Researchers at OHSU have successfully performed stem transplants on monkeys, offering a critical tool to explore the Berlin patient's unexpected cure. The findings provide hope for improving stem cell transplant outcomes for human patients with blood-related conditions.
A new chemical compound has been found to significantly improve the survival of cells during transplantation, a process used in cell-based therapies for various conditions. The antioxidant, Proxison, was tested on lab-grown cells and shown to be 10 times more effective than natural antioxidants in protecting cells from damage.
Scientists have successfully transplanted human stem cells into monkeys with Parkinson's disease, showing long-term benefits. The quality of donor cells, particularly the Dlk1 gene, played a crucial role in determining cell survival. This study brings iPS cell-based therapy closer to clinical trials.
A new study has identified Del-1, a bone marrow protein, as a potential regulator of hematopoiesis, the process by which blood cells are created. Targeting Del-1 may enhance immune cell production and improve stem cell transplants for both donors and recipients.
Scientists discovered that nonclassical monocytes play a key role in driving primary graft dysfunction after lung transplantation. Targeting these cells could lead to novel treatments and potentially prevent death.
A new hydrogel material combined with vascular endothelial growth factor (VEGF) has been shown to enhance the survival rate of transplanted insulin-producing cells in animal models. The technology could potentially treat more patients with type 1 diabetes and reduce the need for multiple donors.
Researchers at USF Health used bone marrow stem cells to repair damage to the blood-spinal cord barrier in mice with ALS, improving motor functions and nervous system conditions. The study demonstrates an early step towards pursuing stem cell therapy for potential ALS treatment.
Scientists at the Diabetes Research Institute have successfully transplanted tissue-engineered islet cells into a patient with type 1 diabetes, achieving long-term insulin independence. The omentum tissue site has been found to be a viable alternative for islet implantation, minimizing inflammatory reactions.
Transplanted fetal rat liver cells multiply and give rise to new cells in injured adult liver. This breakthrough has implications for treating liver failure without organ transplants.
Researchers at the University of Bristol have developed a technique to manufacture immortalized red blood cells, which can be cultured indefinitely and differentiated into mature red blood cells. This breakthrough could potentially provide a safe source of transfusions for people with rare blood types and areas with inadequate blood su...
A Chicagoan has become the first adult patient to be cured of congenital dyserythropoietic anemia with a novel stem cell transplant protocol. The patient, David Levy, underwent the procedure in 2014 and is now free from pain and independent.
A new drug, letermovir, has shown significant promise in preventing cytomegalovirus (CMV) infection in stem cell transplant patients, with only mild side effects and improved survival rates. The study found that 61% of patients receiving a placebo developed CMV infection, compared to 38% of those treated with letermovir.
Researchers discovered genetic mutations in TP53, RAS pathway genes, and JAK2 gene associated with shorter survival and increased relapse risk after stem cell transplant. The findings provide a guide for identifying patients most likely to benefit from a transplant, enabling personalized treatment strategies.
Researchers at Lund University successfully incorporated transplanted neurons into a stroke-injured rat brain, showing they formed normal connections with the host brain. The study used human skin cells reprogrammed to become healthy neurons and demonstrated functionality in response to touch.
Researchers used rabies viruses to visualize neural transplant integration in mouse brains, revealing region-specific connections between transplanted cells and host neurons. The approach opens new prospects for predicting and optimizing the ability of neural transplants to functionally integrate into a host nervous system.
Stem cell therapies aim to restore function in degenerative conditions, but ensuring cell survival is a major hurdle. Researchers successfully restored long-term vision in blind mice by transplanting photoreceptors derived from human stem cells and suppressing the immune response that rejects transplanted cells.
Researchers at the Krembil Research Institute have published a paper that challenges the prevailing view of vision recovery after retinal cell transplantation. They found that transplanted photoreceptor cells do not enter the recipient retina, contrary to previous interpretations.
Researchers developed a new heart imaging test that analyzes longitudinal strain to predict patient survival after stem cell transplant. The test outperformed conventional biomarkers and detected improvements before changes in traditional echocardiographic measures.
Researchers have discovered that transplanting immature interneurons into the brains of mice can help reduce fear response. The study found that these transplanted cells reactivated a juvenile-like plasticity in the mature amygdala, enhancing synaptic plasticity and modulating fear extinction behavior.
CPX-351 significantly improved 100-day mortality rates and overall survival in older untreated secondary AML patients receiving hematopoietic cell transplants. The treatment also demonstrated better median overall survival compared to standard 7+3 cytarabine and daunorubicin therapy.
Researchers at Lund University have made a significant breakthrough in producing high-quality dopamine neurons using stem cells. The study has identified key markers that correlate with successful transplantation and graft function, enabling a more accurate methods for producing dopamine cells for clinical use.
Researchers successfully integrated transplanted embryonic nerve cells into the visual cortex of adult mice, demonstrating functional connectivity and restoration of network function. This breakthrough holds promise for treating acquired brain diseases, including neurodegenerative illnesses and stroke-induced damage.
A study found that corneal cells' softness indicates their potential for stem-like activity, enabling rapid and cost-effective enrichment of limbal stem cells. This biomarker could improve clinical success rates for corneal transplant patients with naturally low limbal stem cell percentages.