Articles tagged with Covid 19 Vaccines
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A new analysis by Cedars-Sinai investigators shows that similar levels of COVID-19 antibodies are reached over an extended period of time in different population groups. Individuals with autoimmune diseases and solid organ transplant patients experience lower long-term antibody levels.
A mathematical model predicts the long-term effectiveness of COVID-19 vaccine booster doses in various patient populations, including those with healthy immune systems and cancer patients. The model suggests that robust antibody-based responses can be achieved through booster doses, but may wane quickly in immunosuppressed individuals.
A new survey of 23 countries found that global willingness to accept a COVID-19 vaccine increased from 75.2% in 2021 to 79.1% in 2022. However, eight countries experienced an increase in hesitancy, and nearly one in eight vaccinated respondents were hesitant about receiving booster doses. The survey also revealed variations in vaccine ...
Researchers developed a CSIC vaccine that fully protects against SARS-CoV-2 infection in the brain and prevents associated brain damage. The MVA-CoV2-S vaccine candidate demonstrates sterilizing immunity and was effective even after reinfection with the virus.
A new survey of 23 countries found a 5.2% increase in COVID-19 vaccine acceptance from 2021 to 2022, but also detected increased hesitancy in several countries, particularly among younger men and women.
A study found that 6.5% of the general population in Spain hesitated to receive the COVID-19 vaccine, with younger and less educated individuals being more reluctant. In contrast, healthcare professionals showed higher vaccination rates and had fewer concerns about the vaccine's effectiveness.
A new study in Portugal's population shows that hybrid immunity from vaccination and previous SARS-CoV-2 infections confers up to 8 months of protection against omicron BA.5. The study found that protection remains high after 8 months, with a stable level of around 65%.
A study by Mass General Brigham found elevated levels of spike protein, increased cytokines, and troponin in the blood of 16 adolescents and young adults who developed myocarditis after COVID mRNA vaccination. The researchers also discovered no differences in antibody production or auto-antibodies between cases and controls.
A multicenter study found that COVID-19 vaccination following multisystem inflammatory syndrome (MIS-C) is safe, with mild reactions and no serious complications. The study included 385 patients aged 5 years or older, all of whom received at least one vaccine dose without any reports of myocarditis or MIS-C reoccurrence.
A study of 385 patients with a history of multisystem inflammatory syndrome in children found no serious COVID-19 vaccine reactions. The vaccine's safety profile appears comparable to that of the general population, at least 90 days after MIS-C diagnosis.
A study in California prisons found that recent vaccination and boosters significantly reduced infectiousness of COVID-19, with a 11% decrease per additional dose. Prior infection also provided protection, with a 23% risk of transmission compared to 33% for those who had never been infected.
A US study of 15,000 nursing homes found that pre-Omicron vaccination boosts reduced COVID-19 cases and deaths among residents and staff. Newer variants rendered original vaccine less effective.
Patients with cancer are at a higher risk of SARS-CoV-2 infection and worse outcomes than those without cancer. Triple vaccination is associated with a lower risk of poor outcomes in these patients.
The study found that COVID-19 vaccination in patients with blood cancer activates a strong T cell response, providing protection against serious illness. Patients who form antibodies tend to produce high-quality antibodies capable of neutralizing different SARS-CoV-2 variants.
A new study from the University of Virginia Health System found that mRNA booster shots increase the durability of antibodies to COVID-19. The boosters led to longer-lasting antibodies, even in those who had previously recovered from a COVID-19 infection.
A study published in The BMJ found that people who believe in conspiracies and reject the covid-19 vaccine are more likely to endorse mythical causes of cancer than non-conspiracists. However, awareness of actual causes of cancer is generally higher among these groups.
A study in Serrana, Brazil showed that mass vaccination reduced severe cases and death rates even while gamma and delta variants were circulating. Vaccination coverage reached 80% of the target population.
A new study reveals that Chinese Communist Party zero-covid volunteers have suffered from stress and anxiety due to the pressure of enforcing policies. The researchers found an increasingly pressurized grassroots infrastructure, with volunteers facing high workloads and hierarchical chains of command.
A multi-state study found that bivalent booster vaccines significantly reduce COVID-19-related emergency department or urgent care visits and hospitalization rates. The study showed a 57% reduction in COVID-19 related emergency department or urgent care visits compared to unvaccinated adults.
New research reveals that COVID-19 nasal antibodies provide first-line defence but decline nine months after infection, while blood antibodies last at least a year. Vaccination boosts blood antibodies to prevent severe disease, but has limited effect on nasal IgA levels.
A new respiratory vaccine has been shown to provide complete protection against lethal SARS-CoV-2 challenge in mice. The vaccine uses a DNA encoding a viral protein and is delivered through the mucous membranes, targeting immune cells in the nose and lungs.
A large real-world study has confirmed that COVID-19 vaccination is more effective than natural immunity in preventing death, hospitalizations, and emergency department visits for any cause. Vaccinated individuals had a 37% lower risk of all-cause death and hospital admission rates compared to those with natural immunity.
A large Finnish study of 5.5 million residents found no evidence of an increased risk of sudden sensorineural hearing loss following COVID-19 vaccination. The study controlled for previous disease and other potential confounding factors, providing reassurance about the safety of COVID-19 vaccines.
Researchers developed a method to produce SARS-CoV-2 RBD antigen using bio-engineered plants, offering a scalable solution for diagnostic assays and subunit vaccines. This breakthrough could facilitate large-scale production of antigens, supporting global vaccination efforts.
The Pfizer-BioNTech COVID-19 vaccine provided modest short-term protection against Omicron infection among children ages 5 to 11, with higher effectiveness for those with prior infection; a booster dose restored and maintained protection for at least three months.
A recent study published in the American Journal of Obstetrics & Gynecology MFM found that pregnant individuals have a similar long-term immune response to SARS-CoV-2 mRNA vaccination as non-pregnant individuals. The study also showed that vaccination during pregnancy provides protection to unborn babies, which is essential for their C...
Researchers found that adult hospitalisations from Omicron-related SARS-CoV-2 infections were less severe than those from Delta infections. The Pfizer-BioNTech vaccine was effective in preventing hospitalisations and severe outcomes, even with increasing Omicron variant transmissibility.
A new study in The American Journal of Medicine found that adults who neglect COVID-19 vaccination may also neglect basic road safety guidelines. Unvaccinated individuals were more likely to be involved in traffic crashes, with a 72% increased relative risk compared to those vaccinated.
A randomized controlled trial found that a low-carbohydrate, high-fat diet helped patients with type 2 diabetes achieve better weight loss and glucose control over a 6-month intervention compared to a high-carb, low-fat diet. However, changes were not sustained 3 months after the intervention.
Researchers at La Jolla Institute for Immunology have confirmed that the smallpox vaccine MVA-BN (JYNNEOS) can teach T cells to recognize and fight the mpox virus. The study suggests that the JYNNEOS vaccine may provide protection against severe disease and could be effective in immunocompromised individuals.
A recent study published in Nature Cardiovascular Research found a link between COVID-19 and postural orthostatic tachycardia syndrome (POTS), with patients infected five times more likely to develop the condition. Vaccination was also linked, but at a lower risk, emphasizing the importance of vaccination in reducing POTS.
A new study published in BMJ Open found that COVID vaccines are more effective in areas with higher infection rates, highlighting the need for targeted vaccine distribution. The researchers calculated absolute risk reduction and number needed to be vaccinated, revealing significant differences in effectiveness across geographical regions.
A survey study found adolescents who received routine childhood vaccines were more likely to receive a COVID-19 vaccine dose. This may indicate that addressing hesitancy about routine vaccinations can reduce concerns about COVID-19 vaccines.
Researchers found that Covid vaccines effectively protect HIV-positive individuals, particularly after a third booster shot. The study also revealed a surprisingly strong cellular immune response in HIV-positive people, similar to those in healthy individuals.
A global study published in Nature finds that the unvaccinated face significant prejudice in most countries, with many vaccinated people harboring discriminatory attitudes towards them. The study suggests that this prejudice could lead to severe consequences for society, including hindered vaccination uptake and increased mistrust.
A national study confirms that vaccination significantly reduces disease severity and hospitalization risk for COVID-19, even among individuals who develop breakthrough cases. Hospital stays are shorter, ICU admissions are less common, and hospital deaths are lower among vaccinated adults compared to unvaccinated individuals.
A recent study published in Frontiers in Medicine found that COVID-19 vaccines significantly reduce the likelihood of reinfection and severe symptoms. Vaccinated individuals who have recovered from the virus have a 50% to 60% lower risk of reinfection compared to those who are not vaccinated.
Administration of vaccine boosters to nursing home residents significantly reduces SARS-CoV-2 infections and hospitalizations. The study suggests that booster vaccination may play a crucial role in preventing COVID-19-related morbidity and mortality among vulnerable populations.
The Cochrane review analyzed data from 41 randomized controlled trials of 12 different COVID-19 vaccines, involving 433,838 people worldwide. The review found that most vaccines reduced the risk of COVID-19 infection and severe disease, with few reported side effects.
Research finds that individuals who received monoclonal antibodies before COVID vaccination exhibit a diverse antibody response, increasing the coverage provided by vaccines. This phenomenon, known as antibody feedback inhibition, is beneficial for diversifying immune responses to viruses.
A new study from Ohio State University found that individuals with greater certainty in their views on vaccines are more likely to become vaccine advocates. This discovery could aid in identifying target audiences for interventions aimed at increasing pro-vaccine certainty.
A systematic review of 23 studies found COVID-19 mRNA vaccine-associated myopericarditis is rare in adolescents and young adults with a low incidence rate. The condition generally has favorable early outcomes, but continued follow-up is recommended.
A new study found that earlier vaccine hesitancy predicts subsequent nocebo side-effects following the booster vaccination. Only 16% of one’s vaccine side effects were explained by earlier vaccine hesitancy, highlighting the importance of tailored public health messaging.
A large study found that most Canadian children and adults younger than 60 had been exposed to SARS-CoV-2 through a combination of vaccination and infection. The study, conducted in British Columbia, shows a dramatic change in the proportion of the population with antibodies over the first 2.5 years of the pandemic.
Researchers have found that experimental vaccines, including a protein-based vaccine candidate with an adjuvant, provide superior protection against lung disease and higher levels of neutralizing antibodies compared to mRNA vaccines. The results inform the optimization and development of COVID-19 vaccines for young infant populations.
Research found that while broad T-cell response against SARS-CoV-2 spike protein is currently protective, recognition of seven out of ten T-cell targets mutated in COVID-19 variants is impaired. The study suggests ongoing mutation could lead to decreased overall immune system protection.
A follow-up study found that the 2-dose vaccines still provided protection against lung disease one year after vaccination as infants. The adjuvanted protein vaccine candidate maintained higher levels of neutralizing antibodies and provided superior protection compared to the mRNA vaccine.
A study published in PLOS Medicine suggests that primary vaccination provides moderate protection against Omicron infection regardless of prior infection history. However, the additional benefit of an original booster dose is unclear in people who have previously experienced COVID-19 infection.
A global Phase 2/3 clinical trial found that vaccination with SCB-2019 reduced the risk of transmitting SARS-CoV-2 infection to household members. The study showed a significant reduction in symptomatic cases among vaccinated household contacts and indicated that vaccines can play an important role in controlling future outbreaks.
A large study from Argentina found that COVID-19 vaccines remain effective in preventing death in children and adolescents, regardless of the predominant circulating variant. The study's results show that vaccinated children had a 67% reduced risk of death related to COVID-19 infection during the omicron period.
Researchers found that antibodies against one of the two main domains of the SARS-CoV-2 viral entry machinery elicit a broad antibody response against many variants. This suggests strategies for clinical development of variant-resistant vaccines.
Researchers at Texas A&M University engineered DARPins to block the interaction between the COVID-19 virus and host cells, significantly reducing disease progression. The nasal sprays showed effectiveness against various variants, including omicron, and could provide a lower-cost therapeutic option for those at high risk.
Healthcare workers in Massachusetts prefer strategies supporting education, trust in community-based communication, and accessibility of vaccination sites to increase COVID-19 vaccine and booster rates. These approaches were seen as more effective than mandates or incentives in improving vaccination uptake.
A Brazilian team developed an electrochemical immunosensor to detect SARS-CoV-2 antibodies, achieving 88.7% sensitivity and 100% specificity in just five minutes. The device can be adapted for other diseases and has potential for monitoring seroconversion and seroprevalence.
A Rutgers study found that COVID-19 patients, especially those treated with antibiotics, experience significant disruptions in their gut microbiome balance. This imbalance may lead to the development of targeted probiotic supplements to improve treatment outcomes.
A recent study found that the proportion of COVID-19 deaths among young people increased in 2021 compared to 2020, resulting in a 7.4% rise in Years of Life Lost due to the virus. The median age of COVID-19 deaths decreased from 78 years in 2020 to 69 years in 2021.
A community pharmacy-led vaccination scheme in South East London successfully supported over 6,000 patients to overcome initial hesitancy around Covid-19 jabs. The programme, which ran for six months, found that a lack of understanding about the vaccine was the biggest reason for patients' hesitation.
A new study published in PLOS Medicine found that COVID-19 vaccination provides significant protection against reinfection, with varying levels of effectiveness (60-94%) across different variants. The study analyzed data from over 200,000 people in Denmark and showed that vaccination offered up to 71% protection during the Alpha period...
A team from UNIGE has revealed the existence of a hidden 'pocket' on the surface of the non-structural protein Nsp1, which could be used to develop new treatments against Covid-19. This discovery paves the way for innovative therapies targeting the Nsp1 protein and its potential application against other coronaviruses.
A systematic review of 36 studies found that influenza vaccination reduced the risk of SARS-CoV-2 infection by 20% and poor outcomes like ICU admission and death by 17-31%. The findings suggest that routine influenza vaccination could offer non-specific immunity against COVID-19 symptoms.