Articles tagged with Blindness
The USPSTF states that primary open-angle glaucoma affects an estimated 2.7 million people in the US, with Black and Hispanic/Latino individuals being disproportionately affected. The organization concludes that screening for this condition is insufficient due to current evidence.
Researchers revived photoreceptor cells in human macula, responding to bright and dim lights. The study restores communication between retinal cells, transforming brain and vision research.
The new COBRE grant will help WVU recruit researchers and clinician-scientists to develop innovative solutions for preventing and treating incurable vision problems. The project aims to reduce visual disparities in West Virginia by understanding the complex combination of factors that contribute to these problems.
A NIH-funded study found that patients with retinal vein occlusion experience significant visual acuity gains, but require long-term monitoring and treatment. After five years, many participants retained an average of three lines of improvement in their visual acuity.
Research by Sightsavers and others estimates that blind people are nearly four times as likely to experience anxiety and depression as those with no vision impairment. The study highlights the need for governments and organizations to be aware of this issue and design health services to address it.
A new University of Houston study finds racial and ethnic disparities in diabetic eye care, with Whites more likely to receive regular exams than minorities. The study also reveals that Hispanics have the highest prevalence of diabetic eye complications.
Researchers have developed a gene therapy that restores night vision in dogs with congenital stationary night blindness (CSNB), a condition affecting the ON bipolar cells. The treatment enables dogs to navigate mazes in dim light and has a lasting therapeutic effect, paving the way for potential human treatments.
Researchers at OIST Graduate University identified the strip1 gene as essential for keeping retinal ganglion cells alive. The gene suppresses Jun-mediated apoptosis, promoting correct neural circuit formation in the retina. This finding opens promising new avenues for treating diseases like glaucoma.
Researchers at UC Berkeley discover that Antabuse helps improve sight in mice with retinal degeneration by reducing hyperactive retinal cells. The treatment may one day lead to better therapies for humans with inherited diseases like retinitis pigmentosa.
Researchers discovered that fusing Müller glia with adult stem cells can differentiate into ganglion cells, a type of neuron essential for vision. This finding brings hope for recovering the retina's regenerative capacity in humans.
Independence Science has received a $254,767 NSF grant to develop Sci-Dot, a multiline Braille device that collects and analyzes scientific data. The device addresses limitations of current Braille displays and allows blind students to set up and collect experimental data independently.
A new study published in The Lancet Planetary Health found that improved eye health services are associated with moving closer to achieving seven SDGs. Multiple direct connections were discovered between eye health services and increased productivity, household expenditure, income, education, and equality.
Researchers from Trinity College Dublin have pinpointed a key driver gene, SARM1, that contributes to impaired vision and blindness. Deleting this gene shows promise in preserving vision, suggesting targeted therapies may offer long-lasting preservation of sight for various ocular conditions.
Researchers at RIKEN have developed a new retinal transplant technique by engineering human-derived retina sheets to lose bipolar cells, allowing better connections to host retinas and improved responses to light. The technique has shown substantial functional improvement in animal studies and is now poised for human clinical trials.
Researchers found that a third of patients with wet age-related macular degeneration can safely stop eye injection therapy without further vision loss. Patients who stopped treatment showed better visual acuity, gain of vision, and less fluid in their retina compared to those requiring continued injections.
Researchers at WVU are studying the Musashi proteins to understand their role in retinal degeneration and develop a universal therapy. By investigating protein translation and gene suppression, they hope to identify potential pathways to boost protein production and slow vision loss.
Researchers developed a VR-based archery game to understand how blind people move and orient themselves in space. The platform showed that congenital blind individuals rely on body cues rather than environmental sounds for reorientation.
UCI researchers used cryo-electron tomography to study the rod outer segment membrane in the eye, revealing key structural determinants that contribute to blindness. The study's findings could lead to new therapeutic approaches using gene editing technologies.
Researchers developed a dish-based model that replicates the characteristics of dry age-related macular degeneration, allowing them to screen over 1,200 drugs for their ability to slow or halt disease progression. Two drugs, Aminocaproic acid and L745, showed promise in inhibiting key phenotypes associated with AMD.
The Nixon Visions Foundation has given a significant gift to support studies of the PRPH2 gene linked to macular dystrophy and boost stem cell research aimed at developing early diagnosis and a cure for this devastating genetic eye disease. Researchers hope to make a tremendous impact on people with this inherited eye disease.
Scientists found that seven genes associated with bright-light vision are absent in burrowing snakes, demonstrating extensive vision gene loss over millions of years. This challenges the hypothesis that all modern snakes evolved from extreme burrowers, suggesting a different evolutionary path for these subterranean snakes.
Researchers have found that people with genetic risk factors for age-related macular degeneration (AMD) have thinner retinas and photoreceptors, even if they haven't yet lost their sight. This early detection could lead to earlier treatment and lifestyle changes to prevent vision loss.
A NIH study has identified a molecular link between a gene mutation and late-onset retinal degeneration, a rare eye disease. The researchers found that the diabetes drug metformin and gene therapy may be effective treatments for the condition, which can cause abnormal blood vessel growth and deposits of apolipoprotein E.
A recent study published in iScience found that congenitally blind individuals and normal sighted people are equally good at discriminating between sounds. However, those who lost sight later in life had more difficulties with tasks requiring detailed auditory processing, suggesting an adaptation to the new condition.
A recent study published in JAMA Open Network evaluates the performance of the EyeArt AI system, detecting diabetic retinopathy with high sensitivity and specificity. The results demonstrate the ability to accurately detect vision-threatening diabetic retinopathy without physician oversight, facilitating efficient diabetic eye exams.
Researchers from the University of Maryland School of Medicine and NIH found that retinoid therapy improved vision in mice with Usher syndrome, a rare genetic disorder. The study identified key functions of protocadherin-15, which helps recycle molecules essential for eye tissue.
A study to investigate stem cell therapy as a potential treatment for glaucoma, the world's second leading cause of blindness, has received $6.7M in NEI funding. The research team will explore ways to make stem cell-derived neurons survive and integrate into the eye.
A new rapid screening test for glaucoma uses infra-red sensors to monitor eye movement, providing accurate results within seconds. The test could help advance early detection of the disease, a leading cause of irreversible blindness, and make it more accessible for national screening programs.
A team of scientists successfully created a form of artificial vision for a blind woman using a prosthesis hardwired into her brain. The Moran|Cortivis Prosthesis enabled Gómez to identify lines, shapes, and simple letters evoked by different patterns of stimulation.
A new project aims to empower people who are blind to independently review and protect their personal visual content from accidental privacy leaks. Researchers have developed novel computer vision algorithms that can detect sensitive information in images and videos, allowing users to blur or remove private content before sharing.
A case study evaluated the experience of a deafblind adult using three wayfinding support tools on an urban college campus. The tactile map proved to be the most successful tool, while the mobile application yielded the lowest performance and confidence. Simplifying wayfinding tools and tailoring information to individual preferences a...
Researchers at UVA Health System found that fluoxetine, an antidepressant commonly known as Prozac, shows promise against age-related macular degeneration. Patients taking fluoxetine were less likely to develop dry AMD, a condition affecting nearly 200 million people worldwide.
Researchers successfully implanted a microelectrode array in the visual cortex of a blind volunteer, allowing her to identify lines, shapes and simple letters. The implant stimulated neurons to produce phosphenes, creating an image and demonstrating safety and efficacy.
A novel computational platform called scAAVengr uses single-cell RNA sequencing to quickly evaluate viral vectors for delivering gene therapies to the retina with maximum efficiency and precision. This approach saves time and resources by identifying suitable candidates that can deliver therapy to affected parts of the retina accurately.
Researchers developed a new protein treatment that prevents glaucoma from forming in mice and reduces pressure in the eyes. The study provides new targets for therapies and aims to develop an injectable treatment for patients.
A Tanzanian study found that laser treatment (SLT) successfully reduced eye pressure to normal levels in 61% of patients after one year, compared to 31% with daily eye drops. SLT may be an affordable alternative for glaucoma care in Africa.
A new study by MIT researchers has found that blind and sighted readers have sharply different takes on what content is most useful to include in a chart caption. The study created a four-level framework for evaluating charts, which could help develop more effective tools for automatically generating captions and alternative text.
Researchers have discovered toxic DNA buildup in the eyes of patients with geographic atrophy, a devastating form of age-related macular degeneration. Common HIV drugs or safer alternatives, such as Kamuvudines, may block inflammation and protect against retinal cell death, offering new hope for treatment.
A new study provides evidence supporting the involvement of aquaporins in corneal cell proliferation and nerve regeneration, suggesting AQP5 induction as a potential therapy to accelerate corneal defect resurfacing. The study found that AQP5 deficiency can slow down corneal epithelial repair, but its specific mechanism remained unclear.
A new study published in Current Biology reveals that visually impaired babies primarily use touch to respond to stimuli, while sighted babies rely more on auditory cues. The research suggests that both senses will be crucial in designing tools to aid their development.
Researchers at Kyoto University found that monkeys with impaired visual cortex can still identify hidden areas using visual signals, suggesting a possible mechanism for blindsight. The study's findings have implications for understanding human brain functions and artificial intelligence.
A recent study of 1.5 million Israeli teens found that approximately 1% have lazy eye, with a decline in incidence over the past two decades. Socioeconomic factors and ultra-orthodox upbringing are linked to increased risk, while immigrants from certain countries have a higher prevalence
Researchers co-led by Jonathan L. Haines are conducting a comprehensive analysis of genetic data from over 100,000 people worldwide to better understand the condition. The study aims to uncover the genetic architecture of age-related macular degeneration and its impact on diverse populations.
A newly improved robotic cane, funded by NIH/National Eye Institute, uses a color 3D camera, inertial measurement sensor, and onboard computer to guide users to desired locations while avoiding obstacles. The device can provide accurate navigation assistance in large spaces with sensory and auditory cues.
Researchers found that blind and sighted adults share identical understanding of color, including reasoning and explanations, in experiments with natural and man-made objects. This challenges the notion that blind people lack deep knowledge of visual phenomena.
Scientists found that HtrA1 protein levels decrease with age in individuals with chromosome 10 risk variants associated with age-related macular degeneration. The study identified HtrA1 as a protective factor, suggesting it maintains the integrity of the RPE-Bruch's membrane interface.
Researchers design new stimulation protocol for optic nerve stimulation to produce consistent and meaningful visual sensations. They use machine learning approaches to optimize protocols, which have shown promising results in artificial neural networks and psychophysical tests.
Researchers developed a non-contact laser imaging system that can detect telltale signs of major blinding diseases in retinal blood and tissue, allowing for earlier diagnosis and management. The technology, known as photoacoustic remote sensing, improves patient comfort and test accuracy.
A 10-week training program showed that both sighted and blind participants improved on echolocation tasks, with some even performing better than expert echolocators. The study's findings suggest that click-based echolocation can be a valuable tool for people with vision loss or progressive degenerative eye conditions.
A breakthrough study uses oral tactile visualization of complex 3D structures to improve accessibility in STEM education for blind and visually impaired students. Students recognized structures by mouth at 85.59% accuracy, similar to recognition by eyesight using computer animation.
A device created by Dr Matthew Griffith uses absorbed light to fire neurons transmitting signals from the eyes to the brain, acting as an artificial retina for those with lost capacity. The goal is to provide a biomedical solution to vision impairment caused by retinitis pigmentosa and AMD.
Researchers have discovered a new potential mechanism for age-related macular degeneration, suggesting that the structural organization of light-sensing cells may be affected by the disease. This finding offers hope for identifying new molecular targets to treat the condition and potentially reversing its effects.
New fossil discoveries of ancient lamprey growth series overturn conventional wisdom on the origin of vertebrates, including humans. Ancient lamprey larvae were found to have large eyes and toothed suckers like adult phases, contradicting long-held ideas about their evolutionary history.
Researchers at EPFL have developed a retinal implant that uses electrodes to stimulate retinal cells, allowing blind individuals to see simplified images in black-and-white. The system has been tested virtually using virtual reality simulations and has demonstrated promising results, paving the way for potential human trials.
A meta-analysis of 48,000 people found that vision impairment is associated with a higher risk of all-cause mortality compared to normal vision or mild vision impairment. The risk increases significantly among those with severe vision impairment.
Rapidly rising levels of sight loss are largely due to untreated ocular conditions, affecting hundreds of millions globally. A new study highlights the need for standard terminology and robust definitions to measure non-visually impairing eye diseases.
Researchers have developed tactile books with 3D mini-scenarios that allow blind children to explore and identify objects using gestures and body simulations. This innovative approach has been shown to narrow the perception gap between blind and sighted children, enabling them to recognize objects more easily.
New gene editing strategies, including CRISPR technologies, are being investigated for treating inherited retinal diseases. Researchers aim to identify the most viable therapeutic approaches using human retinal tissue and organoids.
New gene editing strategies, including CRISPR technologies, are being investigated for treating inherited retinal diseases. The article highlights the most viable therapeutic approaches and discusses safety concerns and challenges in extending the capabilities of CRISPR-Cas9.
Researchers Gustavo D. Aguirre, Jean Bennett, and Albert M. Maguire receive $1 million prize for developing FDA-approved gene therapy for Leber congenital amaurosis, a genetic disease causing visual impairments. Their work has enabled routine treatment of the condition, restoring vision in children and adults.