Articles tagged with Blindness
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Researchers have successfully restored vision in mice with retinitis pigmentosa using a new CRISPR-based genome editing technique. The PE SpRY system corrected genetic mutations and restored normal electrical responses to light, preserving vision into old age. This breakthrough offers potential for treating inherited blindness.
Researchers used UK Biobank image and genomic data to uncover insights into rare retinal dystrophies, a leading cause of blindness in working-age adults. The study identified new genetic associations with the thickness of photoreceptor cell layers, offering new avenues for research and diagnosis.
UVA scientists have discovered a new contributor to abnormal blood vessel growth in the eye, which could lead to new treatments for macular degeneration and other vision loss conditions. The discovery identifies a key protein that determines VEGF levels, blocking it has reduced VEGF levels significantly without unwanted side effects.
Tactile Engineering's Cadence tablet allows users to access technical diagrams and read equations using a refreshable display of electronic cells. The investment will enable the company to manufacture Cadence in larger quantities, supporting its mission to strengthen Braille literacy and equal-opportunity STEM education.
A new nonhuman primate model of Usher syndrome has been confirmed, providing hope for the development of a treatment for this leading cause of blindness-deafness. The model, created using CRISPR/Cas9 technology, exhibits symptoms similar to those experienced by humans with the condition.
Researchers identified structural changes in the thalamus and strengthened connections with the temporal cortex, enabling visual cortex activation through non-visual stimuli.
Researchers have identified a new genetic risk factor for adult-onset macular degeneration by combining multiple maps. The study reveals that variations in the TRPM1 gene promoter alter LHX2 transcription factor binding, reducing gene activity and increasing disease risk. This finding advances our understanding of AMD's complex pathology.
A new study by Italian neuroscientists found that blind and deaf individuals' brains possess an innate functional architecture for integrating sensory information. This suggests that brain architecture can develop independently from sensory experience, adding weight to the 'nature versus nurture' debate.
A novel treatment involving ACE2-producing probiotic Lactobacillus paracasei may prevent or reverse diabetic retinopathy in Type 1 diabetes patients. The study found that human subjects with retinopathy had a dysregulated systemic RAS and profound gut permeability defects, which were reversed by the probiotic treatment.
Researchers have made a key breakthrough in developing a new treatment for hereditary blindness by using lipid nanoparticles to deliver messenger RNA to the photoreceptor cells. The technology, inspired by COVID-19 vaccines, shows promise in animal models for treating blindness associated with rare genetic conditions.
A new approach to gene therapy for inherited blindness uses lipid nanoparticles to deliver mRNA inside the eye, targeting light-sensitive cells and creating proteins that edit vision-harming gene mutations. The technology has shown promising results in animal studies, including mice and nonhuman primates.
Mount Sinai researchers discovered that age-related macular degeneration (AMD) may be caused by two distinct types of deposits in the retina: drusen and subretinal drusenoid deposits (SDDs). Early intervention with vitamin supplements can slow down drusen formation, while SDDs pose a greater threat to advanced AMD.
Scientists have created eye tissue using patient stem cells and 3D bioprinting, providing a model for studying the genesis of age-related macular degeneration. The printed tissue exhibited patterns of early AMD, including drusen deposits and progression to late dry stage AMD.
Researchers have identified a Vegf-Notch signaling system that enables Muller glial cells to regenerate retinal neurons in zebrafish. This discovery may help understand why the human retina does not regenerate and could inform treatments for blindness.
A new study suggests that human retinal endothelial cells have a protective system against hyperglycemia, which delays the onset of diabetic retinopathy. Prolonged exposure to high glucose actually promotes cell recovery and resistance to damage.
Researchers have developed mini eyes, or organoids, from stem cells donated by patients with Usher syndrome. These mini eyes allow scientists to study light-sensing cells and understand the development of blindness in the disease.
A new study from Mount Sinai Hospital finds a strong association between age-related macular degeneration and severe forms of heart disease, including heart failure, heart attacks, and stroke. The study highlights the importance of increased screening for eye disorders to diagnose undetected heart disease.
A new report explores how to leverage low-cost methods to enable people with visual impairment to move through public, urban indoor and outdoor spaces. Tactile maps were found to be a very useful resource, while an accessible mobile app also showed promise as an orientation and mobility aid.
A large UK Biobank study found that poor quality sleep, including insomnia, short/long sleep duration, snoring, and daytime sleepiness, is associated with a heightened risk of developing glaucoma. The study suggests that targeted screening of high-risk groups and sleep intervention may help prevent the disease.
The University of Missouri has earned an $8 million grant from the National Institutes of Health to expand its National Swine Resource and Research Center. The center will support research using genetically modified pigs to study human diseases, with a focus on therapies that can be translated from pig models to humans.
Researchers at the University of Pennsylvania School of Medicine have developed a gene therapy that rapidly restores night vision in adults with LCA, a common form of congenital blindness. The treatment has been shown to improve rod-based visual functions and correct severe visual deficits in patients.
Researchers have developed a simplified and fast optoretinography approach to measure retinal function, potentially accelerating the development of new treatments for eye diseases. The technique can collect data from three healthy subjects in just ten minutes and has been demonstrated to be reproducible.
Claes H. Dohlman, considered the founder of modern cornea science, is honored with the prestigious Champalimaud Vision Award for his groundbreaking research on corneal physiology and its applications in treating dry eye disease, corneal burns, and keratoprosthesis.
Researchers from Trinity College Dublin have developed a new gene therapy approach targeting mitochondrial function to treat dry AMD, a debilitating eye disease. The therapy has shown benefit in multiple models of the condition, offering hope for a potential treatment that could help millions globally.
Researchers at Brigham and Women's Hospital identified Basal Cell Adhesion Molecule (BCAM) as a key population of proliferative cells involved in corneal regeneration. BCAM plays a crucial role in mediating corneal differentiation, which could lead to future medical therapies for corneal disease.
Researchers at Baylor University have developed a method to create tactile graphics that can be visualized by both blind and sighted individuals, enabling universal access to scientific data. The study used lithophane and 3D printing to convert scientific data into glowing, high-resolution images that can be interpreted through touch.
A bioengineered cornea made from collagen protein can restore vision in people with diseased corneas, offering an alternative to donated human corneas. The implant has been shown to be safe and effective in a pilot study, with patients regaining perfect vision after two years.
A recent study highlights uncomfortable social situations people with blindness face, as well as strategies they use to navigate them. Researchers found techniques for avoiding awkward encounters, recovering from them, and even constructive ways allies can support individuals with visual impairment.
The project seeks to create accessible maker programs for blind and visually impaired learners, developing training materials for librarians and maker professionals. The initiative aims to enhance BVI learners' computational thinking skills and STEM interests, while helping librarians become more confident in working with BVI populations.
Researchers at the University of Tokyo have made a groundbreaking discovery about the development of the visual system in mice. By studying the neural networks in cortical and thalamic regions, they found that parallel pathways from the retinas form earlier than connections within cortical areas, challenging current understanding of co...
A new study successfully introduces healthy photoreceptor cells derived from stem cells into the retinas of dogs, marking significant progress toward a cell-based therapy for blindness. The treatment enables cells to survive and form connections with existing retinal cells, paving the way for a regenerative medicine approach.
A new study found that Black patients are six times more likely to have advanced vision loss after a glaucoma diagnosis, highlighting the need for early eye screening in this population. The research analyzed nearly 210,000 participants and used artificial intelligence to identify visual field loss patterns.
A recent study found that patients vividly remember the way they were told they had their condition, which affects their perception of vision loss and interactions with others. Clinicians should consider empathetic communication when delivering bad news to minimize long-term psychological impact.
Researchers identified Srrm3 as a master regulator gene for photoreceptor cells in the retina, which is critical for visual function. The study found that misregulation of alternative splicing and microexons can lead to devastating health impacts, including vision loss.
The new human cell line, ABC, was developed from retinal pigment epithelial cells and retains their properties, allowing for the study of events relevant to normal repair processes. The research may lead to discoveries in senescence gene programming, neuroprotection, and cellular replacement therapies for blinding eye diseases
A study found that patients with a specific form of age-related macular degeneration are at significant risk for cardiovascular disease and stroke. Researchers discovered a strong association between the disorder's subretinal drusenoid deposits and high-risk vascular diseases.
The study found a positive correlation between poverty levels and the prevalence of vision loss or blindness at the county level. Poverty was associated with a higher risk of visual impairment, highlighting the need for targeted interventions to address this issue.
Researchers found that COVID-19 policies significantly affected the mental health and well-being of people with disabilities. The study identified four groups: heavily impacted, resilient, adapted, and radically changed.
A team from UNIGE has identified a molecular mechanism that causes degeneration of photoreceptors in retinitis pigmentosa, a genetic disease leading to blindness. The discovery could lead to therapeutic treatments targeting this mechanism.
Researchers have created prototypes that provide text descriptions at varying levels of detail, enabling blind and low-vision individuals to drill down from high-level data to more detailed information using just a few keystrokes. The prototypes improved users' ability to identify patterns in the data and navigate through visualization...
The USPSTF states that primary open-angle glaucoma affects an estimated 2.7 million people in the US, with Black and Hispanic/Latino individuals being disproportionately affected. The organization concludes that screening for this condition is insufficient due to current evidence.
Researchers revived photoreceptor cells in human macula, responding to bright and dim lights. The study restores communication between retinal cells, transforming brain and vision research.
The new COBRE grant will help WVU recruit researchers and clinician-scientists to develop innovative solutions for preventing and treating incurable vision problems. The project aims to reduce visual disparities in West Virginia by understanding the complex combination of factors that contribute to these problems.
A NIH-funded study found that patients with retinal vein occlusion experience significant visual acuity gains, but require long-term monitoring and treatment. After five years, many participants retained an average of three lines of improvement in their visual acuity.
Research by Sightsavers and others estimates that blind people are nearly four times as likely to experience anxiety and depression as those with no vision impairment. The study highlights the need for governments and organizations to be aware of this issue and design health services to address it.
A new University of Houston study finds racial and ethnic disparities in diabetic eye care, with Whites more likely to receive regular exams than minorities. The study also reveals that Hispanics have the highest prevalence of diabetic eye complications.
Researchers at OIST Graduate University identified the strip1 gene as essential for keeping retinal ganglion cells alive. The gene suppresses Jun-mediated apoptosis, promoting correct neural circuit formation in the retina. This finding opens promising new avenues for treating diseases like glaucoma.
Researchers have developed a gene therapy that restores night vision in dogs with congenital stationary night blindness (CSNB), a condition affecting the ON bipolar cells. The treatment enables dogs to navigate mazes in dim light and has a lasting therapeutic effect, paving the way for potential human treatments.
Researchers at UC Berkeley discover that Antabuse helps improve sight in mice with retinal degeneration by reducing hyperactive retinal cells. The treatment may one day lead to better therapies for humans with inherited diseases like retinitis pigmentosa.
Researchers discovered that fusing Müller glia with adult stem cells can differentiate into ganglion cells, a type of neuron essential for vision. This finding brings hope for recovering the retina's regenerative capacity in humans.
Independence Science has received a $254,767 NSF grant to develop Sci-Dot, a multiline Braille device that collects and analyzes scientific data. The device addresses limitations of current Braille displays and allows blind students to set up and collect experimental data independently.
A new study published in The Lancet Planetary Health found that improved eye health services are associated with moving closer to achieving seven SDGs. Multiple direct connections were discovered between eye health services and increased productivity, household expenditure, income, education, and equality.
Researchers from Trinity College Dublin have pinpointed a key driver gene, SARM1, that contributes to impaired vision and blindness. Deleting this gene shows promise in preserving vision, suggesting targeted therapies may offer long-lasting preservation of sight for various ocular conditions.
Researchers at RIKEN have developed a new retinal transplant technique by engineering human-derived retina sheets to lose bipolar cells, allowing better connections to host retinas and improved responses to light. The technique has shown substantial functional improvement in animal studies and is now poised for human clinical trials.
Researchers found that a third of patients with wet age-related macular degeneration can safely stop eye injection therapy without further vision loss. Patients who stopped treatment showed better visual acuity, gain of vision, and less fluid in their retina compared to those requiring continued injections.
Researchers at WVU are studying the Musashi proteins to understand their role in retinal degeneration and develop a universal therapy. By investigating protein translation and gene suppression, they hope to identify potential pathways to boost protein production and slow vision loss.
UCI researchers used cryo-electron tomography to study the rod outer segment membrane in the eye, revealing key structural determinants that contribute to blindness. The study's findings could lead to new therapeutic approaches using gene editing technologies.
Researchers developed a VR-based archery game to understand how blind people move and orient themselves in space. The platform showed that congenital blind individuals rely on body cues rather than environmental sounds for reorientation.
Researchers developed a dish-based model that replicates the characteristics of dry age-related macular degeneration, allowing them to screen over 1,200 drugs for their ability to slow or halt disease progression. Two drugs, Aminocaproic acid and L745, showed promise in inhibiting key phenotypes associated with AMD.
The Nixon Visions Foundation has given a significant gift to support studies of the PRPH2 gene linked to macular dystrophy and boost stem cell research aimed at developing early diagnosis and a cure for this devastating genetic eye disease. Researchers hope to make a tremendous impact on people with this inherited eye disease.