Articles tagged with Cardiovascular Disorders
Research finds no significant increase in cardiovascular events among men with low testosterone undergoing testosterone treatment. Testosterone was found to reduce serum total cholesterol and triglycerides, but no significant differences were seen in other parameters.
Patients with primary glomerular diseases have a significantly higher risk of cardiovascular events, including coronary artery disease and stroke. The study found that inclusion of kidney-specific risk factors improved the prediction of cardiovascular events.
Researchers at Keck School of Medicine of USC are testing the efficacy of 3K3A-APC as a cerebroprotectant to reduce brain bleeds in acute ischemic stroke patients. The experimental drug has shown promising results in Phase 2 clinical trials, reducing incidence of brain hemorrhage by nearly 20%.
Patients with a history of unprovoked venous thromboembolism who stop treatment after negative D-dimer tests experience an eight-fold increased risk of recurrence compared to those on low-dose apixaban. Low-dose apixaban was found safe and effective for these patients
A new study published in Open Heart found that patients with asymptomatic severe aortic stenosis benefit from early valve replacement surgery to prevent irreversible heart muscle damage. The research showed that timing of surgery is crucial in reducing mortality and hospitalization rates.
A team of researchers has successfully treated damaged pig hearts with cardiac progenitor cells, demonstrating the formation of new cardiac tissue and improved cardiac function. The treatment could potentially be used to treat patients with serious heart failure, particularly older patients with coexisting conditions.
Researchers studied cavefish genome-wide map of liver tissue to understand metabolism evolution and its potential applications for humans. The study found striking similarities in metabolic adaptations among cavefish populations, raising questions about universal adaptation mechanisms that could be triggered in other species like humans.
A study by Kobe University researchers has illuminated the characteristics of Myeloid immune cells in coronary plaque, a major contributor to acute coronary syndrome. The findings suggest that macrophages and monocytes accumulate in the plaques of patients with acute coronary syndrome, leading to increased inflammation.
Researchers discovered a connection between atherosclerotic plaques and the central nervous system, involving immune cells, nerves, and cardiovascular tissues. This 'ABC' circuit can be modulated or disconnected, potentially leading to innovative therapies for treating atherosclerosis.
Researchers found that AI-enhanced diagnosis helps doctors accurately detect fetal congenital heart disease, with fellows making the most accurate diagnoses. The new system uses graphical charts to represent the AI's analysis of ultrasound videos, improving accuracy and trust among medical professionals.
A Cleveland Clinic-led trial found that an experimental 'gene silencing' therapy significantly reduced blood levels of lipoprotein(a), a key driver of heart disease risk, by up to 96%-98%. The therapy targets the gene responsible for Lp(a) production and has shown strong efficacy with no major safety concerns reported.
Researchers found smokers have significantly lower A1AT levels, which may reduce cardiac tissue protection during a heart attack. No difference was detected in hypertensive and non-hypertensive individuals.
The trial evaluated the use of mavacamten as an alternative to heart surgery or alcohol septal ablation for treating hypertrophic cardiomyopathy. Findings showed significant reduction in left ventricular outflow tract pressure gradient and improvements in quality-of-life measures.
The Experimental Biology (EB) 2022 meeting features live presentations and a moderated Q&A session on groundbreaking studies. The virtual press conference reveals potential treatments for Parkinson's disease, COVID-19 vaccine-associated side effects, and alleviating food allergies.
This year's Experimental Biology 2022 meeting features groundbreaking studies on COVID-19 vaccine-associated symptoms in non-menstruating people, a plant compound showing promise for alleviating food allergies, and the potential of omega-3s to boost immunotherapy's cancer-fighting power. Researchers also explore the safety of using CBD...
A study published by The Endocrine Society found that eating potatoes in the morning, whole grains in the afternoon, and less processed meat in the evening may improve long-term survival in people with diabetes. This eating pattern is associated with better heart health outcomes.
Researchers found that impaired kidney function is preferentially associated with cardioembolic stroke in a large cohort of patients. Low filtration rates and high urine protein levels predicted increased risk of cardioembolic stroke, disability, and mortality.
Researchers at the University of Copenhagen have made a groundbreaking discovery that could phase out medications derived from pig intestines. The team has successfully created a synthetic alternative to heparin in a laboratory setting, using cell factories, similar to insulin production.
Researchers found that daily life movement, including housework and self-care activities, significantly benefits cardiovascular health. Women with at least four hours of daily life movement had a 43% lower risk of cardiovascular disease, 62% lower risk of cardiovascular disease death.
Researchers at the University of Cincinnati have discovered a unique class of medications that act as blood thinners by inhibiting an enzyme in tick saliva genes. These new anticoagulant medications show great promise in treating patients with various coronary issues, including heart attacks and strokes.
A new study has identified the critical genes most likely to cause coronary heart disease and trigger heart attacks. The research provides a prioritized list of 162 genes, which will enable more accurate genetic testing and targeted therapies for patients at risk of coronary heart disease.
A new study reveals that social isolation and loneliness can increase cardiovascular disease risk by 8% and 5% respectively. Women who experience high levels of both social isolation and loneliness have a 13-27% increased risk of heart disease, compared to those with low levels.
A multidisciplinary research team from the University of Pittsburgh seeks to improve vascular graft integration by developing fully biodegradable tissue-engineered vascular grafts. The goal is to keep compliance-matched as it degrades and remodels, reducing long-term graft failure rates.
A study led by Ohio State University Wexner Medical Center finds that Black patients with dilated cardiomyopathy have a higher risk of family members being affected. The research analyzed data from 1,220 patients and their relatives, revealing that 39% of Black patients had at least one first-degree family member with the condition.
A new study found that curtailed sleep increases the release of troponin after exercise, a biomarker linked to cardiovascular disease. While regular exercise counters adverse effects of sleep loss on metabolism, curtailed sleep may increase the risk of heart injury during strenuous exercise.
Researchers developed AI tools to precisely measure the synergistic effects of existing medical conditions on the heart and blood vessels. The study found that comorbidities significantly influenced transplant risks, with some adults facing 405 times higher risks than those without cardiomyopathy.
A molecule of RNA called CARMN has been found to play a crucial role in maintaining healthy smooth muscle cells in the blood vessel wall, which can help prevent atherosclerosis and angioplasty-induced restenosis. Restoring healthy CARMN levels may lead to new approaches for treating heart disease.
Researchers at Boston Medical Center created a new resource to manage long-term heart disease risk after specific pregnancy complications. The review synthesizes recommendations for primary care clinicians to assess and manage risk, focusing on preeclampsia, gestational diabetes, and preterm delivery.
A Cleveland Clinic study found that prior weight loss achieved with bariatric surgery was associated with a 60% lower risk of developing severe COVID-19. Patients who underwent weight-loss surgery had better clinical outcomes, including reduced hospitalization and need for supplemental oxygen.
Cleveland Clinic researchers have identified the gut microbial gene cluster responsible for converting carnitine into TMAO, which promotes heart disease and stroke. The study found that dietary modifications may help reduce diet- and TMAO-associated cardiovascular disease risk by targeting the gbu gene cluster.
An extensive study of over 400,000 individuals found no association between total alcohol consumption and ventricular arrhythmias, contradicting the traditional Holiday Heart Syndrome. Higher spirit intake was linked to an increased risk of ventricular arrhythmias, but not SCDs.
Scientists have found that the gene PBK is overexpressed in pulmonary hypertension, causing excessive cell proliferation and thickening of pulmonary artery walls. They are now exploring PBK inhibitors to reduce cell proliferation and improve heart and lung function.
Researchers found that up to one in five patients experience increased troponin levels after major surgery, indicating potential heart damage. These patients were also more likely to be anaemic before the operation.
Katherine Tucker, a renowned nutritionist, has been awarded the top honor at UMass Lowell for her exceptional teaching, research, and service to the university. She will deliver the annual Distinguished University Professor Lecture and continue to lead her research team in establishing long-term interventions for diverse populations.
A large US sample of 17,000 adults found that usual seafood consumption was not associated with increased risk of cardiovascular-related deaths or any cause. The study suggested that mercury exposure from seafood does not significantly impact mortality rates.
Researchers developed a predictive model that maps electric activity of mouse, rabbit, and human cardiac cells, allowing translation of findings across species. The model is expected to accelerate drug development and improve understanding of disease mechanisms.
The OPT-PEACE trial found that dual antiplatelet therapy (DAPT) followed by single anti-platelet therapy (SAPT) results in less gastrointestinal mucosal findings than continued DAPT. SAPT also reduces clinical GI bleeding and new ulcers compared to DAPT.
A study found that consuming high amounts of herbs and spices daily can lead to significant reductions in systolic and diastolic blood pressure. The researchers discovered that adding just 1.3 teaspoons of herbs and spices a day to an average American diet resulted in lower blood pressure after four weeks.
A randomized trial comparing plug-based and suture-based vascular closure techniques after TAVR found that the plug-based technique had a shorter time to hemostasis but higher access-site complications. The study, CHOICE-CLOSURE, reported similar mortality rates between both groups.
A new study published in PLOS Medicine found that people who abstain from alcohol do not necessarily have a shorter survival time than those who consume low to moderate amounts. The study, which analyzed data from over 4,000 German adults, suggests that factors such as previous substance abuse or poor health are more significant predic...
Researchers are developing a standardized training program to address physician bias and improve equity in advanced heart failure treatments. The program, called SOCIAL HF, aims to reduce barriers to equitable treatment through evidence-based bias training and objective criteria.
Researchers at University of Pittsburgh and Prairie View A&M University developed an algorithm to repurpose cancer drugs for pulmonary hypertension, a devastating lung disease. Two compounds improved human cells and rodent markers, supporting broader drug-repurposing platform use.
Researchers discovered a mechanism that could prove useful in treating heart failure with preserved ejection fraction (HFpEF), a common and hard-to-treat condition. The new approach reduces exposure to increased cardiac stiffness, which is associated with lower-filling pressures inside the heart chambers.
A new research center, C2DREAM, will study the impact of structural and interpersonal racism on health inequities for BIPOC communities. The program aims to develop novel cardiovascular health interventions for rural and urban BIPOC communities.
A new study found that women whose menstrual cycle length increased two years before menopause had better vascular health than those with stable cycles. Changes in cycle length may predict cardiovascular disease risk, allowing clinicians to recommend preventive strategies.
Research by Christine M. Albert and team found that the risk of developing atrial fibrillation is dependent on the dose of omega-3 fatty acids, contradicting previous studies. High doses may increase risk, while lower doses appear to be safe for most patients.
The Rutgers-NYU Center for Asian Health Promotion and Equity aims to address significant disparities in the Asian community's relationship with heart health and mental health. The center will focus on cardiometabolic disease and mental health research to inform practice and policy at local, regional, and national levels.
A new study published in Neurology suggests that people with diabetes who have had a stroke may benefit from maintaining blood sugar levels between 6.8% and 7.0% to lower the risk of future vascular events. The study found that those admitted to the hospital with A1C levels above 7.0% were at increased risk for heart attacks and strokes.
A recent study published by George Washington University researchers found that inclusionary zoning policies associated with lower rates of heart disease. The study also found that communities with such policies had fewer residents with high blood pressure and higher cholesterol.
Researchers found that frequent cannabis users were 2 times more likely to have had a heart attack compared to non-users. The study also found an association between recent cannabis use and myocardial infarction across different forms of consumption.
New study finds that rescue breathing cardiopulmonary resuscitation (CPR) is preferable to compression-only CPR for infants, children, and adolescents in case of cardiac arrest. Rescue breathing CPR was associated with higher odds of favorable neurological outcomes and overall survival compared to compression-only CPR.
A team of researchers is developing a smartphone-based device that can predict the size of aortic aneurysms and detect fluid overload in postpartum women. The device uses arterial waveforms, which can be easily recorded with a smartphone camera or smart scale, to provide a non-imaging solution for AA screening.
A study by the American Academy of Neurology found that immigrants to Canada have a significantly lower rate of stroke compared to long-term residents. The researchers analyzed medical records of over 8 million people and found that immigrants had a 33% lower risk of stroke, with the greatest reduction seen among older immigrants.
Research found that longer and more frequent night shifts increase the risk of atrial fibrillation and coronary heart disease. Genetic predisposition did not affect the link between night shifts and AF risk.
A study by Texas A&M University researchers has developed a simulation-based approach to accurately predict the effects of altered gravity on an individual-by-individual basis. The approach identifies key factors influencing cardiovascular responses and increases accuracy and saving time compared to traditional methods.
Researchers developed a new imaging technique that uses light and sound to detect plaques in arteries, potentially preventing strokes and heart attacks. The technique uses nanoparticles that absorb light and emit sound waves, allowing doctors to visualize the plaques in a non-invasive way.
Researchers found that people who eat more vitamin K-rich foods have a lower risk of heart disease and peripheral artery disease. Vitamin K2 intake was also associated with reduced hospitalization rates for cardiovascular disease.
A multi-disciplinary team of researchers has identified a molecular switch called Them1 that prevents fat burning in cells by blocking access to fuel sources. This discovery may contribute to the development of a new type of obesity treatment.
The American College of Cardiology has issued clinical guidance on reducing ASCVD risk in patients with persistent hypertriglyceridemia, recommending lifestyle intervention and non-statin therapies. The guidance emphasizes the importance of individualized nutrition guidance for these patients.