Researchers found that lymphoid depletion lesions in the spleen of SARS-CoV2-infected mice may trigger novel therapies to restore defective antigen-presenting cell functions in humans. The severity of COVID-19 varies significantly, with dysregulated immune responses linked to poor outcomes.
SourceElsevier·JournalAmerican Journal Of Pathology·TypeExperimental study·DateJun 1, 2023
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers found that a combination of amyloid burden and blood markers of abnormal astrocyte activation can predict Alzheimer's disease progression. Testing for these biomarkers may help identify patients at risk, enabling earlier diagnosis and treatment.
SourceUniversity of Pittsburgh·JournalNature Medicine·DateMay 29, 2023
Scientists at Temple University have developed a novel gene-editing strategy that disrupts the ability of HIV-1 virus to enter host cells by targeting a rare genetic disorder. This approach may offer another target for developing next-generation CRISPR technology for HIV elimination, while avoiding adverse effects on cell mortality.
SourceTemple University Health System·JournalMolecular Therapy — Nucleic Acids·DateMay 19, 2023
A study published in Cell Reports found that saturated fatty acids promote the immune escape of oral cancers in mouse models. Obesity helps establish a type of tumor microenvironment that promotes tumor progression by suppressing STING-type-I interferon pathway and NLRC3.
SourceMichigan Medicine - University of Michigan·JournalCell Reports·TypeExperimental study·DateMay 16, 2023
A team led by Professor Timo Betz has developed a 3D cell culture chamber to grow muscle and other tissue using high-resolution microscopy. The new system will enable scientists to mimic the mechanical situations that confront various living tissues in serious conditions, reducing animal testing and costs.
Researchers review current treatment updates for systemic light chain (AL) amyloidosis, highlighting the need for early diagnosis and effective maintenance therapy. The article discusses the relationship between AL amyloidosis and monoclonal gammopathy of undetermined significance (MGUS), emphasizing the importance of regular monitoring.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateMay 5, 2023
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Vogel and Benn's study replicates tissue growth in vitro, revealing the importance of ECM interactions. Myofibroblasts play a key role in wound healing and cancer progression, but their transformation into fibroblasts is influenced by ECM composition and structure.
SourceETH Zurich·JournalScience Advances·DateMay 3, 2023
Researchers found that psilocybin facilitates fear extinction in mice by promoting hippocampal neuroplasticity. The study's results improve our understanding of the restorative effects of psilocybin on the brain and may lead to alternative treatments for PTSD.
SourceCactus Communications·JournalChinese Medical Journal·TypeExperimental study·DateMay 2, 2023
Researchers found that CUDC-907 selectively induces apoptosis in cells driven to senesce by p53 expression. The compound showed senolytic properties in different models of stress-induced senescence, depending on its inhibitory effects on HDACs and PI3K.
SourceImpact Journals LLC·JournalAging-US·TypeExperimental study·DateApr 25, 2023
Researchers found that p21 knockout mice experienced reduced senescent cell presence, alleviated chronic lung inflammation, and improved fitness. Resident epithelial and endothelial cells played a significant role in mediating the p21-dependent inflammatory response.
SourceImpact Journals LLC·JournalAging-US·TypeExperimental study·DateApr 17, 2023
A team of scientists at Max Planck Institute for the Science of Light developed a method to quickly and accurately diagnose cancer using artificial intelligence and real-time deformability cytometry. The method reduces analysis time from hours to under 30 minutes, enabling faster decision-making during surgery.
SourceMax Planck Institute for the Science of Light·JournalNature Biomedical Engineering·TypeExperimental study·DateApr 13, 2023
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
A team of scientists created a new, fast, and precise method for analyzing cells in tissue samples from cancer patients without the need for a trained pathologist. The method uses artificial intelligence to evaluate data produced by a technique called real-time deformability cytometry.
SourceMax-Planck-Gesellschaft·JournalNature Biomedical Engineering·TypeExperimental study·DateApr 8, 2023
Impact Journals will participate as an exhibitor at the AACR Annual Meeting 2023, showcasing Aging's growth in impact factor to 5.955. The meeting theme focuses on Advancing the Frontiers of Cancer Science and Medicine.
Astrocytes tune down overactive neurons during acute stress, helping to regulate attention and perception. This discovery provides new hope for treating attention disorders like ADHD.
SourceUniversity of California - San Francisco·JournalNature Neuroscience·DateApr 4, 2023
Researchers discuss cortactin's impact on cancer progression by modulating the Wnt5a/ROR1 signaling pathway. Cortactin expression is found in various cancers, including breast and chronic lymphocytic leukemia, suggesting its potential role in promoting metastasis.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateApr 4, 2023
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
A new fluorescent probe, TiY, has been developed to selectively target and kill cancer stem cells, which are responsible for tumor growth. The probe can be used to simultaneously diagnose and treat cancer, offering a promising approach to improving cancer treatment outcomes.
SourcePohang University of Science & Technology (POSTECH)·JournalTheranostics·DateApr 3, 2023
Research reveals that cold activates cellular cleansing mechanisms that break down protein clumps, preventing age-related diseases like Alzheimer's and Parkinson's. By modulating proteasome activity, scientists have found a potential therapeutic target for aging and related neurodegenerative disorders.
SourceUniversity of Cologne·JournalNature Aging·TypeExperimental study·DateApr 3, 2023
Research by Whitehead et al. reveals that cellular senescence triggers amyloidosis through changes in small extracellular vesicles and extracellular matrix composition. The study provides novel insights into the formation of aortic medial amyloid and offers potential therapeutic targets for mitigating its effects.
SourceImpact Journals LLC·JournalAging-US·TypeCommentary/editorial·DateMar 29, 2023
The study found that downregulation of angulin-1/LSR leads to increased claudin-2 expression and altered cell metabolism in human lung adenocarcinoma cells, promoting malignancy. Researchers identified AG1478 and EW-7197 as potential therapeutic agents.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateMar 29, 2023
Scientists have found that antibodies targeting βII-spectrin on mesangial cells are the trigger for IgA nephropathy. This discovery enables blood-based diagnosis and may lead to improved treatments.
SourceTokyo University of Science·JournalScience Advances·TypeObservational study·DateMar 22, 2023
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Researchers from Kyushu University found that the single mechanosensitive protein VGLL3 induces fibrosis, thickening and scarring tissue. The study suggests targeting this protein could lead to new treatments against fibrosis.
SourceKyushu University·JournalNature Communications·TypeExperimental study·DateMar 22, 2023
A protein called PI3K plays a crucial role in immune cell function, and genetic variations disrupting its signalling have been identified as the root cause of two immunodeficiency disorders. The study reveals how minor disruptions in immune cell signalling can lead to immune deficiency or dysfunction.
SourceGarvan Institute of Medical Research·JournalJournal of Experimental Medicine·TypeExperimental study·DateMar 21, 2023
A Phase II trial led by researchers from the University of Texas MD Anderson Cancer Center demonstrated that adding ipilimumab to a neoadjuvant combination of nivolumab plus platinum-based chemotherapy resulted in a major pathologic response in half of all treated patients with early-stage non-small cell lung cancer. The treatment also...
SourceUniversity of Texas M. D. Anderson Cancer Center·JournalNature Medicine·DateMar 16, 2023
A cross-disciplinary team developed a convolutional neural network to analyze microscopy images of chromosomes with cohesion defects. The algorithm achieved 73.1% accuracy in classifying new images, streamlining experiments with chromosome analysis.
SourceTokyo Metropolitan University·JournalScientific Reports·DateMar 11, 2023
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Researchers at Kyoto University found that neutrophils instruct macrophages to form a bacteria-permissive microenvironment, which could have implications for cancer treatment. The study suggests that A9, an enzyme expressed in neutrophils, may play a key role in this process.
SourceKyoto University·JournaliScience·TypeExperimental study·DateMar 9, 2023
Researchers have identified mitochondrial signaling pathways as critical organelles that promote tumorigenesis and metastasis. In particular, the integrated stress response is found to engage with mitochondria to drive tumor growth, highlighting a new paradigm for understanding aggressive prostate cancer progression.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateMar 8, 2023
Researchers explore CEACAM1, CEACAM5, and CEACAM6's pathological significance in cancer biology and immunology. The review highlights their interactions with pathogens and potential avenues for cancer therapy.
SourceImpact Journals LLC·JournalGenes & Cancer·TypeCommentary/editorial·DateFeb 10, 2023
Researchers investigated the effects of everolimus on the STAT3/HIF-1α/VEGF pathway in TP53 mutant cell lines and xenograft models. Everolimus treatment significantly inhibited cell growth and reduced tumor angiogenesis and lymphangiogenesis.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateFeb 9, 2023
The American Society for Biochemistry and Molecular Biology is hosting its annual meeting, #DiscoverBMB, featuring award lectures by high-profile speakers. The event will take place March 25-28 in Seattle, with topics including quorum sensing and developmental mechanisms in African Trypanosomes and precision oncology.
SourceAmerican Society for Biochemistry and Molecular Biology·DateFeb 7, 2023
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers discovered that bone marrow transplants can halt the development and progression of brain blood vessel disease in adults with sickle cell disease. The study found that receiving stem cell transplants led to positive changes in blood vessels, reducing the risk of stroke among patients with the condition.
According to hyperfunction theory, menopause is also a disease. Aging is a quasi-programmed disease that can be partially treatable by rapamycin. The author suggests that slowing aging may delay the onset of diseases like prostate cancer, obesity, and hypertension.
SourceImpact Journals LLC·JournalAging-US·TypeCommentary/editorial·DateFeb 2, 2023
A new study published in The American Journal of Pathology suggests that promoting autophagy with rapamycin restores intestinal barrier function during sepsis. The study also identifies the PLK1-mTOR axis as a crucial regulator of autophagy and intestinal barrier dysfunction, providing novel insights for treatment of sepsis.
SourceElsevier·JournalAmerican Journal Of Pathology·TypeExperimental study·DateJan 26, 2023
Researchers at Aston University are working with Isterian Biotech to develop small molecule inhibitors targeting transglutaminase 2, a key enzyme in fibrosis. The goal is to stop or reverse pathological crosslinking of proteins that lead to fibrotic diseases such as idiopathic pulmonary fibrosis.
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
In a mouse model of laser-induced CNV, RORα expression was highly increased in the choroidal/RPE complex post-laser, while loss or inhibition of RORα worsened CNV with increased lesion size and vascular leakage. RORα negatively regulates pathological CNV development by modulating angiogenic response and inflammatory environment.
SourceImpact Journals LLC·JournalAging-US·TypeObservational study·DateJan 18, 2023
A new study standardizes the use of optical genome mapping (OGM) for patients with blood cancers, demonstrating its potential as a frontline test for diagnosing hematologic malignancies. OGM outperforms existing tests in detecting cancer-causing gene variants and identifying additional information that can improve patient outcomes.
SourceMedical College of Georgia at Augusta University·JournalJournal of Molecular Diagnostics·DateJan 17, 2023
Researchers at Cedars-Sinai have created a detailed molecular profile of endometriosis, identifying key differences between major subtypes and potential therapeutic targets. The new database will lead to improved care for millions of women suffering from the disease.
SourceCedars-Sinai Medical Center·JournalNature Genetics·DateJan 9, 2023
Researchers identified the molecular mechanism underlying Weiss-Kruszka syndrome, a rare neurodevelopmental disorder characterized by craniofacial anomalies and autistic features. The study reveals that the ZFP462 gene mutation leads to a failure to safeguard neural lineage specification during early embryonic development.
SourceIMBA- Institute of Molecular Biotechnology of the Austrian Academy of Sciences·JournalNature Cell Biology·TypeExperimental study·DateJan 5, 2023
The CNIC study reveals two distinct mechanisms by which cells detect and respond to forces of varying strength, one mediated by caveolae and the other by newly discovered dolines. This finding has significant implications for understanding pathological processes such as atherosclerosis and neurodegenerative diseases.
SourceCentro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)·JournalNature Cell Biology·TypeExperimental study·DateJan 2, 2023
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
A recent study published in Frontiers in Cell and Developmental Biology has found that the unique checkerboard pattern of cells in the organ of Corti is essential for proper hearing. The researchers discovered that when hair cells adhere to each other abnormally, it leads to apoptosis and a decrease in hair cell numbers, resulting in h...
SourceKobe University·JournalFrontiers in Cell and Developmental Biology·TypeExperimental study·DateDec 27, 2022
Langerhans' Cell Histiocytosis (LCH) is a serious disease affecting children that can be fatal in severe cases. Researchers have identified the origin of LCH cells, which are derived from both dendritic and monocyte cells.
SourceKarolinska Institutet·JournalScience Immunology·DateDec 16, 2022
Researchers developed a laser-based approach to perform microbiopsies, enabling fast, painless tissue sampling with minimal damage. The novel technique uses laser ablation to extract tiny tissue volumes, which can be analyzed using virtual H&E imaging and other techniques in minutes, not hours.
SourceSPIE--International Society for Optics and Photonics·JournalJournal of Biomedical Optics·DateDec 14, 2022
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
Researchers found that HOXA5 binds to IκB-α, boosting its cancer-suppressing properties and inhibiting NF-kappa B's transcription of cancer-causing genes. This helps prevent breast cancer formation by 'putting brakes' on an inflammatory pathway.
SourceJohns Hopkins Medicine·JournalCancer Research·DateDec 8, 2022
Researchers explore the interactions between adipose tissues and surrounding blood vessels in connection with lipid metabolism and associated diseases. Targeting angiogenesis may provide a gateway for treating obesity, while its inhibition or promotion depends on the specific disease context.
SourceCactus Communications·JournalChinese Medical Journal·TypeLiterature review·DateNov 22, 2022
A Rutgers-led study found that a gene mutation associated with autism causes an overstimulation of brain cells, disrupting the normal information flow. The researchers used human stem cells and transplanting them into mouse brains to understand how the mutation affects brain development.
SourceRutgers University·JournalMolecular Psychiatry·TypeExperimental study·DateNov 21, 2022
A new study suggests that prelamin A, a precursor of lamin A, accumulates with age and may drive normal aging. Researchers propose this protein as a target for intervention strategies to extend healthspan and lifespan.
SourceImpact Journals LLC·JournalAging-US·TypeCommentary/editorial·DateNov 9, 2022
Researchers have developed a new gene therapy that selectively targets overactive brain cells, reducing excitability and suppressing seizures in mice. The treatment shows promise for treating neurological disorders such as epilepsy, Parkinson's disease, schizophrenia, and pain disorders.
SourceUniversity College London·JournalScience·TypeExperimental study·DateNov 3, 2022
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
Johns Hopkins Medicine researchers have developed a novel genetic engineering approach to deliver gene therapy by utilizing a cell's natural process to
SourceJohns Hopkins Medicine·JournalNature Communications·DateOct 27, 2022
Researchers developed a low-cost, simple imaging system using tumor-targeting fluorescent molecules to determine tumor depth. The portable system provides quantitative information about the depth of tumor cells in the body, helping surgeons remove healthy tissue around tumors for better outcomes.
SourceOptica·JournalBiomedical Optics Express·DateOct 6, 2022
Researchers have designed a smart cell-based delivery system to treat Alzheimer's disease by targeting multiple pathologies, reducing the risk of side effects. The system uses bio-synthesizable drugs and immune cells to deliver combination therapy that addresses all pathologies in a targeted manner.
SourceBuck Institute for Research on Aging·DateOct 4, 2022
Researchers found a specific CAPRIN1 gene mutation linked to impaired protein production, leading to autism spectrum disorders, ADHD, language impairments, and muscle weakness. The study also identified similar symptoms in patients with early-onset ataxia and myasthenia.
SourceUniversity of Cologne·JournalCellular and Molecular Life Sciences·TypeExperimental study·DateSep 22, 2022
The study used a weakly supervised deep learning algorithm to analyze human brain autopsy tissues and predict the presence or absence of cognitive impairment. The model identified a signal associated with decreasing myelin staining, which was linked to cognitive impairment in the white matter.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalActa Neuropathologica Communications·DateSep 20, 2022
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
The University of Ottawa-led team aims to bridge the gap between heart and brain health by developing new diagnostic tools and treatments. They will focus on improving patient outcomes for disorders linked to both organs.
A new study by Kyoto University found that Regnase-1 gene expression is low in patients with pulmonary arterial hypertension (PAH), mirroring the pathology of humans. The protein's mRNA degradation leads to PAH inhibition, offering a potential new treatment for heart failure and premature death.
SourceKyoto University·JournalCirculation·TypeExperimental study·DateSep 6, 2022
A new study published in Frontiers found that excessive blue light exposure can alter cellular functions in fruit flies, potentially leading to accelerated aging. The researchers discovered changes in metabolites essential for cell function and communication between neurons.
SourceFrontiers·JournalFrontiers in Aging·TypeExperimental study·DateAug 31, 2022
Researchers have created a nanobody that can penetrate tough brain cell coatings and disrupt alpha-synuclein clumps, which contribute to neurodegenerative diseases. The nanobody, PFFNB2, shows promise in preventing disease progression in live mouse brains.
SourceJohns Hopkins Medicine·JournalNature Communications·DateJul 28, 2022
A genetic defect in flies leads to motor disorders, similar to those found in humans with Parkinson's disease. The study suggests that Creld, a protein involved in energy production, may play an important role in the development of Parkinson's.
SourceUniversity of Bonn·JournalScience Advances·DateJul 22, 2022
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
A set of genes promoting sweet taste sensation also regulate protein management in flies, according to a new study. The finding suggests a connection between taste-related genes and disorders of protein aggregation.
SourcePLOS·JournalPLOS Biology·TypeExperimental study·DateJul 21, 2022
Researchers identified common cellular mechanisms and dysfunctional processes driving post-COVID lung disease, similar to idiopathic pulmonary fibrosis. The study found shared gene expression patterns and endoplasmic reticulum stress as early triggers of both conditions.
SourceUniversity of California - San Diego·JournalEBioMedicine·DateJul 20, 2022
A new study has identified neurogliaform cells as key regulators of information flow between brain areas. These cells help separate current perception from past experiences, enabling smooth communication between brain regions.
SourceMedical University of Vienna·JournalScience·DateJul 15, 2022
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
Researchers found clots in small venous and arterial blood vessels in normal-looking skin from patients with severe COVID-19, distinguishable from other forms of respiratory illness. Antiviral proteins and interferon-induced inflammatory proteins were also detected, associated with disease severity.
SourceElsevier·JournalAmerican Journal Of Pathology·TypeExperimental study·DateJul 14, 2022