Articles tagged with Cell Pathology
Cancer immunotherapy can cause severe colitis due to hyper-activated immune T cells and deleted regulatory T cells. Researchers at Michigan Medicine have identified a new mouse model that develops colitis after treatment with antibodies used for tumor immunotherapy, revealing the mechanism behind this side effect.
A pioneering study published in The American Journal of Pathology reveals the cytoprotective and proregenerative effects of neuropeptide α-MSH in promoting corneal healing after eye injury. The treatment has shown impressive therapeutic potential in reducing the need for corneal transplants.
Researchers identified key proteins involved in the process, including mTOR and TSC2, which can be targeted to slow or halt disease progression. The study's findings suggest new therapeutic strategies to save dopaminergic neurons and alleviate motor and cognitive symptoms.
A novel study has implicated granulocyte colony-stimulating factor (G-CSF) in both bronchopulmonary dysplasia and retinopathy of prematurity, making it a promising therapeutic candidate. G-CSF deficiency was shown to protect against these diseases, suggesting wide-ranging protection.
A review article links pesticide exposure to an increased risk of developing Parkinson's disease through alterations in the gut microbiota. The authors recommend reducing or replacing agrochemicals and implementing coordinated efforts to develop standardized biomarkers for gut integrity and microbiome changes.
A study published in Nature Communications sheds light on the critical role of P4-ATPases, particularly ATP8B1-CDC50A, in maintaining lipid asymmetry in cell membranes. The research team used cryo-electron microscopy to determine the structure and function of the human flippase complex, revealing its regulation by phosphoinositides.
Researchers have discovered a root cause of Barth syndrome, a deadly metabolic illness, by analyzing faulty cardiolipin molecules and their interaction with cytochrome c. The study used solid-state NMR technology to demonstrate the structural changes that lead to toxic oxidation in mitochondrial membranes.
Researchers found that higher alcohol consumption is associated with biological age acceleration and hypertension in middle-aged and older adults, but not in young adults. The study suggests that alcohol consumption may mediate the association between alcohol intake and quantitative traits like hypertension.
A recent study found that transient inflammatory pain causes persistent mitochondrial and metabolic disturbances in sensory neurons, leading to failure in pain resolution. Targeting the cellular redox balance prevents and treats chronic inflammatory pain in rodents.
Yabing Chen has received two NIH grants totaling over $5 million to investigate vascular diseases and their link to dementia. Her research focuses on Runx2, a master transcription factor involved in both bone formation and calcification of arteries.
Researchers from Universitatsklinikum Bonn have found that a loss of the structural protein ACTL7B blocks spermatogenesis in male mice, leading to infertility. The study suggests that mutations in the Actl7b gene could be a cause of male infertility in humans.
Researchers mapped gene switches and brain cell types associated with various neuropsychiatric disorders, including schizophrenia and bipolar disorder. The study also developed AI tools to predict the influence of individual high-risk gene variants on disease.
Researchers identified abnormal keratin expression patterns in senescent ocular surface cells, which may contribute to severe ocular surface diseases. Gene expression profiles showed substantial differences between senescent and non-senescent cells, highlighting their potential role in pathology.
Five lung stem cell variants dominate CF lungs, causing inflammation, fibrosis, and mucin secretion. CFTR modulators fail to suppress these inflammatory variants, suggesting they as key targets for new drugs.
An international team has decoded the TSPO protein to visualize neuroinflammation, revealing its relationship with microglial cells. The study's findings pave the way for optimizing observation of neuroinflammatory processes and re-reading previous studies.
A new clinical and research partnership has created an AI model that can predict whether cancerous tissue has been fully removed from the body during breast cancer surgery. The model performed as well as humans in identifying positive margins, especially in patients with higher breast density.
A new study led by Dr. Armen Saghatelyan uncovered the migratory mechanisms of neuronal cells in a neurodevelopmental disorder. The team found that modulating autophagy with FDA-approved drug metformin restored the cells' migratory properties.
Researchers highlight microvascular contributions to white matter injury in Alzheimer's disease, sparking calls for exploration of connections between AD, WM injury and cerebral small vessel disease. The study emphasizes the critical need to define mechanisms and diagnostic features of mixed vascular and AD neuropathological change.
Researchers developed a new model of hereditary Alzheimer's disease in marmosets by introducing mutations into the PSEN1 gene, which causes early-onset disease in humans. The study aims to characterize and validate genetic, molecular, functional, and cognitive features of aging and Alzheimer's disease in these animals.
Researchers found that pregnant mice experiencing copy number variation (CNV) showed similarities to aging, with biomarkers and genetic effects appearing during pregnancy and reversing after delivery. This study aims to revolutionize aging treatment by investigating the mechanisms behind post-labor rejuvenation.
Researchers discovered that aging alters the pancreas's circadian rhythm by reorganizing its transcriptome. The study found that fibroblasts play a crucial role in regulating this reorganization, which affects the organ's resilience to aging-related pathologies.
The editorial discusses epigenetic mechanisms leading to oocyte quality loss, a significant factor in age-related fertility decline. Researchers highlight the importance of understanding this process to address the growing issue of advanced maternal age and its impact on reproduction.
Researchers found that a healthy diet from an early age can suppress senescence and loss of fitness in yeast, even late in life. The study proposes an alternative to calorie restriction for improving healthy ageing through dietary change.
A new study found that catheter ablation significantly lowers the incidence of cardiovascular events and death in very old patients with nonvalvular atrial fibrillation. The researchers compared 208 patients who underwent AF ablation with those who received medical therapy only, finding a lower risk of both cardiovascular events and de...
Imperial researchers have imaged Piezo1 channels in human cells and organs, revealing their role in regulating blood pressure, respiration, bladder control, and the immune system. This breakthrough could lead to a better understanding of their role in fundamental physiological processes and potentially new drug targets for diseases.
Researchers have identified a neoplastic fusion transcript RAD51AP1-DYRK4 in luminal B breast cancer, associated with higher ki67 expression and aggressive clinical characteristics. MEK inhibitor trametinib may be effective in blocking the MEK-ERK signaling driven by this fusion.
Researchers studied over 800 clinical assays on renal tumors with MiTF family genes TFE3 and TFEB. The findings show significant age differences between patients with TFEB amplification and those with TFE3 or TFEB translocation, with TFEB amplification being associated with poorer prognosis.
Researchers have created a novel animal model to study the pathogenesis of neurobrucellosis, a severe complication of brucellosis. The model reveals that innate lymphoid cells and interferons play a crucial role in limiting brain damage during Brucella infection.
Researchers propose a novel theory of aging that suggests cell competition is a key factor in the process. The selective destruction theory (SDT) proposes a mechanism of aging that is independent of accumulating damage and consistent with epigenetic rejuvenation.
A large study found that fully vaccinated individuals have lower concentrations of inflammatory markers than unvaccinated participants after symptomatic COVID-19 infection. This suggests that vaccination significantly reduces morbidity and mortality by reducing elevated levels of cytokines and chemokines.
Researchers have identified a novel therapeutic target for pelvic pain in endometriosis by focusing on the IL-1β pathway and its regulation via the JNK signaling pathway. This study suggests that JNK inhibitors may be effective in reducing neuroinflammation and alleviating symptoms of endometriosis-associated pain.
UCSB researchers develop platform to interpret cellular 'stress memory landscape', predicting future reaction to stressors. The study opens window into various cellular stress-related conditions, including aging, cancer and neurodegenerative diseases.
Researchers propose targeting non-canonical HH/GLI signaling to improve response rate and durability of therapeutic effects exerted by SMO inhibition in melanoma. The findings suggest that combined targeting of hedgehog signaling and BRD4 could provide a novel therapeutic option against melanoma.
Researchers developed MemTrax, a continuous recognition test for advanced cognitive impairment screening. The test quickly and accurately quantifies memory processing, storage, and retrieval, providing precise assessments of severity and rate of change over time.
Researchers at Nanyang Technological University discover ponatinib, an existing cancer drug, can block key steps in alternative lengthening of telomeres (ALT) mechanism. This could lead to new treatment options for ALT cancers, which currently lack targeted therapies.
Researchers discovered a novel peptide, T14, that is detectable in human keratinocytes and inversely related to age, with higher levels found in chronically photosensitive individuals. The study suggests that monitoring T14 levels may offer insights into the link between degenerative diseases and epidermal cell profiles.
A new special issue of Calcified Tissue International & Musculoskeletal Research explores how the skeleton functions as both a secretory organ and an endocrine target tissue. Researchers discuss key avenues in this area of research, including deciphering hormone messages encoded in bone cell secretory products.
Patients with GATA2 deficiency have impaired ability to produce immune cells, leading to increased risk of recurrent infections and blood cancers. The study's findings suggest that a zebrafish model may help develop new treatments to slow or reverse the disease.
Researchers found a link between short telomeres in ATII cells and lung fibrosis in post-COVID-19 patients. The study revealed loss of ATII cellularity and shorter telomeres concomitant with increased fibrotic lung parenchyma remodeling.
The MOSAIC project will use cutting-edge spatial omics technologies to map cancer cells and their immune environment in high resolution. By analyzing thousands of patient samples, researchers aim to unlock novel cancer treatments and biomarkers through AI-powered analytics.
Researchers from St. Jude Children's Research Hospital discovered NLRP12 to be the key molecule responsible for inducing inflammatory cell death and pathology in response to heme combined with other cellular damage or infection. This finding provides a new potential drug target to prevent morbidity in certain illnesses.
Researchers found that lymphoid depletion lesions in the spleen of SARS-CoV2-infected mice may trigger novel therapies to restore defective antigen-presenting cell functions in humans. The severity of COVID-19 varies significantly, with dysregulated immune responses linked to poor outcomes.
Researchers found that a combination of amyloid burden and blood markers of abnormal astrocyte activation can predict Alzheimer's disease progression. Testing for these biomarkers may help identify patients at risk, enabling earlier diagnosis and treatment.
Scientists at Temple University have developed a novel gene-editing strategy that disrupts the ability of HIV-1 virus to enter host cells by targeting a rare genetic disorder. This approach may offer another target for developing next-generation CRISPR technology for HIV elimination, while avoiding adverse effects on cell mortality.
A study published in Cell Reports found that saturated fatty acids promote the immune escape of oral cancers in mouse models. Obesity helps establish a type of tumor microenvironment that promotes tumor progression by suppressing STING-type-I interferon pathway and NLRC3.
A team led by Professor Timo Betz has developed a 3D cell culture chamber to grow muscle and other tissue using high-resolution microscopy. The new system will enable scientists to mimic the mechanical situations that confront various living tissues in serious conditions, reducing animal testing and costs.
Researchers review current treatment updates for systemic light chain (AL) amyloidosis, highlighting the need for early diagnosis and effective maintenance therapy. The article discusses the relationship between AL amyloidosis and monoclonal gammopathy of undetermined significance (MGUS), emphasizing the importance of regular monitoring.
Vogel and Benn's study replicates tissue growth in vitro, revealing the importance of ECM interactions. Myofibroblasts play a key role in wound healing and cancer progression, but their transformation into fibroblasts is influenced by ECM composition and structure.
Researchers found that psilocybin facilitates fear extinction in mice by promoting hippocampal neuroplasticity. The study's results improve our understanding of the restorative effects of psilocybin on the brain and may lead to alternative treatments for PTSD.
Researchers found that CUDC-907 selectively induces apoptosis in cells driven to senesce by p53 expression. The compound showed senolytic properties in different models of stress-induced senescence, depending on its inhibitory effects on HDACs and PI3K.
Researchers found that p21 knockout mice experienced reduced senescent cell presence, alleviated chronic lung inflammation, and improved fitness. Resident epithelial and endothelial cells played a significant role in mediating the p21-dependent inflammatory response.
A team of scientists at Max Planck Institute for the Science of Light developed a method to quickly and accurately diagnose cancer using artificial intelligence and real-time deformability cytometry. The method reduces analysis time from hours to under 30 minutes, enabling faster decision-making during surgery.
A team of scientists created a new, fast, and precise method for analyzing cells in tissue samples from cancer patients without the need for a trained pathologist. The method uses artificial intelligence to evaluate data produced by a technique called real-time deformability cytometry.
Impact Journals will participate as an exhibitor at the AACR Annual Meeting 2023, showcasing Aging's growth in impact factor to 5.955. The meeting theme focuses on Advancing the Frontiers of Cancer Science and Medicine.
Astrocytes tune down overactive neurons during acute stress, helping to regulate attention and perception. This discovery provides new hope for treating attention disorders like ADHD.
Researchers discuss cortactin's impact on cancer progression by modulating the Wnt5a/ROR1 signaling pathway. Cortactin expression is found in various cancers, including breast and chronic lymphocytic leukemia, suggesting its potential role in promoting metastasis.
A new fluorescent probe, TiY, has been developed to selectively target and kill cancer stem cells, which are responsible for tumor growth. The probe can be used to simultaneously diagnose and treat cancer, offering a promising approach to improving cancer treatment outcomes.
Research reveals that cold activates cellular cleansing mechanisms that break down protein clumps, preventing age-related diseases like Alzheimer's and Parkinson's. By modulating proteasome activity, scientists have found a potential therapeutic target for aging and related neurodegenerative disorders.
The study found that downregulation of angulin-1/LSR leads to increased claudin-2 expression and altered cell metabolism in human lung adenocarcinoma cells, promoting malignancy. Researchers identified AG1478 and EW-7197 as potential therapeutic agents.
Research by Whitehead et al. reveals that cellular senescence triggers amyloidosis through changes in small extracellular vesicles and extracellular matrix composition. The study provides novel insights into the formation of aortic medial amyloid and offers potential therapeutic targets for mitigating its effects.