Articles tagged with Heart Failure
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Researchers have successfully treated damage caused by heart attacks in non-human primates using gene therapy, restoring both strength and rhythm of the damaged hearts. The treatment improved heart function in pathological conditions with no adverse effects observed.
Researchers developed AI models that can identify signs of heart failure in patients from Appalachia using low-tech electrocardiogram results. The models achieved high accuracy and could potentially provide clinicians with an edge in protecting patients' cardiac health.
Late-breaking clinical trials and science at TCT 2025 will present pivotal data on novel therapies, devices, and techniques aimed at preventing and treating cardiovascular conditions. The symposium delivers high-impact findings that shape clinical practice and enhance outcomes for patients with heart and vascular disease.
A new study found that treatment of heart failure patients with GLP-1 receptor agonists reduces hospitalizations, calorie intake, and greenhouse gas emissions. The study estimates a potential annual CO2-equivalent saving of over 2 billion kilograms, equivalent to 20,000 Boeing 747 flights.
The American Heart Association has extended its Rural Health Care Outcomes Accelerator program until 2028, expanding access to cardiovascular care and quality improvement resources for over 1,000 rural hospitals. This extension aims to address the significant disparities in health outcomes between urban and rural communities.
Researchers have found subtle abnormalities in heart muscle function and blood pumping in young adults with bipolar disorder before the onset of heart failure. The study suggests a link between underlying coronary vascular dysfunction and cardiac impairment.
Researchers found that individuals with a mutation in the TTN gene are 21 times more likely to develop dilated cardiomyopathy than those without. Lifestyle factors such as being overweight or having high alcohol consumption contribute to an earlier diagnosis, and men with the mutation are more likely to develop DCM at a younger age.
A study of 1,081 elderly patients with AFMR found that TEER minimally invasive valve repair significantly lowered mortality and hospitalization rates compared to standard medical therapy alone. The procedure's success was also linked to the degree of residual mitral regurgitation after surgery.
A recent study published in JAMA Network Open found that glipizide, a commonly used type 2 diabetes medication, is associated with a 13% increase in cardiovascular risk compared to dipeptidyl peptidase-4 (DPP-4) inhibitors. The study analyzed data from nearly 50,000 patients and found that glipizide was linked to higher rates of heart ...
A recent study by Florida Atlantic University reveals that up to 40% of hospital transfers from nursing homes can be avoided. The study identified common medical conditions linked to unnecessary hospitalizations, including feeding tube complications and urinary tract infections.
A study from Mount Sinai Hospital found that patients with heart failure and atrial fibrillation who undergo mitral edge-to-edge repair have a doubled risk of death or rehospitalization for heart failure compared to those without AF. The researchers recommend aggressive treatment of AF before the procedure to improve outcomes.
A new Leicester study found that women with type 2 diabetes are nearly twice as likely as men to have hidden heart damage, according to researchers. The study used advanced MRI scans and data from four studies conducted at the NIHR Leicester Biomedical Research Centre.
Scientists are working on a genetic cure for the world's most common inherited heart disease, hypertrophic cardiomyopathy (HCM), with a new gene editing tool. The team aims to correct mutations that cause the disease, which affects 14 million people worldwide.
Researchers aim to replenish the heart's energy reserves by increasing mitochondrial biogenesis, potentially leading to improved recovery rates and longer lives after a heart attack. The project combines synthetic biology tools with animal models and human heart tissue testing.
Research reveals significant drop in heart attack deaths, while increases observed in deaths from heart failure, arrhythmias, and hypertensive heart disease over the past 50 years. Studies suggest advancements in medical treatment, bystander CPR, and public health initiatives have contributed to these findings.
A large global study found that women who experience severe bleeding after childbirth face an increased risk of cardiovascular conditions, including heart failure and ischemic heart disease, for up to 15 years. The study analyzed data from over 9.7 million women across Europe, North America, and Asia.
AIMP3 is essential to avoiding mistakes in protein synthesis, not affecting protein production, according to Brown University researchers. The discovery could lead to new treatments for heart diseases linked to homocysteine buildup and has implications beyond the heart.
A new study involving 121 former elite rowers from Australia found that one in five develops atrial fibrillation, a condition that can lead to stroke and heart failure. The researchers identified genetic and clinical tools that enable early preventive strategies, highlighting the paradox that AFib is more common among fit athletes.
A new multi-cohort study found that exposure to certain metals detected in urine is associated with a higher risk of heart failure. The study analyzed over 10,000 adults across diverse geographic and racial backgrounds and observed consistent associations between elevated urinary metal levels and increased HF risk.
A study published in JACC found that long-term exposure to wildfire smoke may increase the risk of heart failure, particularly among older adults, women, and those living in lower-income areas. The risk was found to be higher with increased levels of PM2.5 air pollution from wildfires compared to other types of air pollution.
This study identifies ageing-related differentially expressed genes (ARDEGs) as potential biomarkers for heart failure with preserved ejection fraction (HFpEF). The ARDEGs were found to be associated with metabolic and immune functions, suggesting a critical role in immune regulation in HFpEF.
A new study led by Boston University School of Public Health reveals that US excess deaths have been increasing for decades, with working-age adults disproportionately affected. The study found that over 1.5 million 'missing Americans' would have been averted if the US had mortality rates similar to other high-income countries.
The American Heart Association's Get With The Guidelines - Heart Failure registry reveals lasting benefits for hospitalized heart failure patients and hospitals. Hospitals engaging with the program consistently outperform peers on process measures and patient outcomes.
A study found that adults hospitalized for RSV had significantly higher odds of cardiac events compared to those with COVID-19 or influenza. The findings suggest that preexisting cardiovascular risk patients should consider vaccination against respiratory viral infections.
A team of researchers from the University of Arizona College of Medicine - Tucson has identified a potential drug candidate for heart failure with preserved ejection fraction (HFpEF). The study, published in Cell Metabolism, found that a key ingredient triggering HFpEF is an enzyme that converts glucose into harmful byproducts, ultimat...
A study of 1,113 patients aged 65+ found that nearly half had two or three overlapping cardiovascular, kidney, and metabolic conditions, leading to poorer physical function and higher mortality rates. The findings support the need for early identification of vulnerable individuals and risk stratification without advanced diagnostics.
A new molecular process discovered by researchers contributes to the failure of donor hearts after transplant, but a therapy using medication for high blood pressure has been found to reduce damage. The treatment significantly improves the function of donor hearts and increases their distance in cold storage.
Two out of five heart failure patients do not see a cardiologist annually, significantly increasing mortality risk. Patients who receive regular cardiology care are 24% less likely to die in the following year, with optimal visits ranging from once to four times per year depending on recent hospitalization and diuretic use.
A landmark Bar-Ilan University study found that individuals with high-normal sodium levels are more likely to develop hypertension and heart failure. The analysis of over 400,000 healthy adults revealed a strong association between higher sodium levels and cardiovascular risk, even among those considered otherwise healthy.
People with critically ill heart disease may benefit from palliative care, which focuses on relieving symptoms and improving quality of life. The new American Heart Association statement suggests integrating palliative care principles into the management of patients with critical cardiovascular illness.
A new analysis of health records from 2016 to 2020 found that takotsubo cardiomyopathy, also known as broken heart syndrome, is associated with a high risk of death and complications. Researchers highlight the importance of careful monitoring and prompt treatment for patients with this condition.
Researchers found that MRI scans can detect heart inflammation, scarring, and impaired function in carriers of a mutated LMNA gene. This information can help clinicians predict which patients are at higher risk and inform decisions about treatments such as defibrillators or transplants.
This observational study of the MIMIC-IV database identifies Charlson Comorbidity Index (CCI), red blood cell count (RBC), and red cell distribution width (RDW) as significant predictors of 90-day readmission in heart failure patients. RBC and RDW show linear correlation, while CCI and age display nonlinear correlation.
A multicenter retrospective study compared perioperative renal function in heart transplantation and LVAD implantation patients with pre-existing renal dysfunction, finding improved outcomes for those receiving the new device. The results suggest that LVAD implantation is a better choice for these patients.
A new Vanderbilt University Medical Center-led study found US veterans with depression had a 14% higher risk of heart failure, even after adjusting for traditional risk factors. The study suggests that screening and treating depression may help prevent future heart failure in patients.
A cohort study of US veterans found that depression is associated with a higher hazard of incident heart failure after controlling for demographic and cardiovascular risk factors. Depression remains consistent as a risk factor even in low-risk cohorts.
Researchers at University of East Anglia developed 4D flow MRI scan to diagnose aortic stenosis more accurately and reliably than current ultrasound techniques. The technology offers more accurate measurements of blood flow through heart valves, leading to better prediction of when patients need surgery.
A study of over a million people found that shingles vaccination lowers the risk of cardiovascular events, including stroke and coronary heart disease, by up to 26%. The vaccine's protective effect lasts for up to eight years, with strongest benefits in younger people and men.
Dr. Kenneth Rosenfield is a distinguished interventional cardiologist recognized for his seminal work in endovascular therapy and pioneering innovative techniques. He has made significant contributions to the field of vascular medicine, including the development of self-expanding stents and drug-coated balloons.
A new analysis shows hospitals participating in the American Heart Association’s IMPLEMENT-HF initiative significantly improved adherence to guideline-directed medical therapy for patients hospitalized with HFrEF. The initiative boosted use of lifesaving medications and integrated health-related social needs assessments into routine care.
A new MRI technique measures a person's 'functional age' of their heart, revealing how unhealthy lifestyles add years to their heart's aging process. This method has the potential to transform heart disease diagnosis and offer a lifeline to millions by catching problems early.
Researchers analyzed medical claims data to identify increased risks of heart failure, atrial fibrillation, and fractures among breast cancer survivors. The study highlights the importance of preventive care for these individuals.
The American Heart Association has awarded $1M to research the link between cardiovascular risk reduction and GLP-1 use. The studies aim to identify predictors of cardiovascular risk reduction among individuals with obesity and cardiovascular disease taking GLP-1 medications, enabling more precise and effective care.
Pediatric hearts fail due to acquired and genetic disorders or congenital heart disease, requiring mechanical circulatory support (MCS) devices. However, adult devices are often used off-label in pediatric patients, deterring innovation and limiting access to life-saving technology.
The first-ever Cardiogenic Shock Academy features a simulation lab, providing hands-on training for treating patients in cardiogenic shock. More than 160 healthcare practitioners from around the world attended the academy, which aimed to address the lack of conclusive research for managing CS.
Scientists developed an injectable therapy that protects the heart from damage after a heart attack by blocking the interaction between two proteins, Keap1 and Nrf2. The study showed decreased inflammation, cell death, and improved cardiac function in animal models.
Researchers developed a new therapy that can be injected intravenously right after a heart attack to promote healing and prevent heart failure. The therapy both prompts the immune system to encourage tissue repair and promotes survival of heart muscle cells after a heart attack, showing effectiveness up to five weeks after injection.
The Mount Sinai Fuster Heart Hospital cardiology faculty practice has received the 2024 Human Experience Pinnacle of Excellence Award from Press Ganey, a leading patient experience organization. The hospital ranks among the top 5% of healthcare providers in delivering patient experience over three years.
A noise-adapted AI model using lead I ECGs estimated heart failure risk with high accuracy, suggesting a potential strategy for early detection. The study's results highlight the promise of wearable and portable ECG devices in identifying at-risk patients.
Researchers discovered a natural mechanism that protects the heart from heart failure with preserved ejection fraction (HFpEF), a serious condition in need of effective treatment. Restoring this mechanism prevents progression of HFpEF and alleviates lipid overload in heart cells, providing molecular evidence for a promising therapeutic...
A new study from Karolinska Institutet found that people with a certain heart valve abnormality are at increased risk of severe heart rhythm disorders even after successful valve surgery. The condition is more common in women and younger patients, and can lead to sudden cardiac arrest.
A new study finds that a remote patient monitoring program reduced hospitalizations by 59% among high-risk patients, even after they mailed back their devices. The program uses digital health devices and clinician support to monitor vital signs and symptoms.
Stephan Windecker, a world-renowned cardiologist, will be honored with the TCT 2025 Career Achievement Award for his extraordinary contributions to interventional cardiology. His extensive research has shaped clinical practice worldwide and influenced the future of cardiovascular medicine.
Researchers developed an injectable hydrogel containing fish swim bladder components to repair damaged heart tissue, showing enhanced cardiac cell adhesion and stretching. The treatment also promoted new blood vessel formation and reduced inflammation in a rat model of ischemic heart failure.
A large long-term study found a significant association between hearing loss and increased risk of developing heart failure. The psychological distress caused by hearing impairment played a key role in this observed association, with socially isolated individuals and those experiencing anxiety and depression facing a heightened risk.
A recent study published in the International Journal of Cardiology analyzed data from multiple clinical trials to assess the therapeutic impact of pulmonary artery denervation (PADN) on pulmonary hypertension patients. PADN showed significant reductions in mean right atrial pressure, mean pulmonary artery pressure, and pulmonary vascu...
A study of nearly 30,000 adults found that heart failure is associated with a significant decrease in cognition at diagnosis and rapid decline over time. Adults with heart failure reach the threshold for meaningful decline in global cognition nearly six years earlier than those without it.
The device uses AI technology to detect potential heart problems and provides real-time health insights. It has multiple points touching the skin near the heart, allowing for more accurate tracking even during movement.
The SUMMIT trial shows tirzepatide reduces the risk of cardiovascular death or worsening heart failure in patients with obesity, chronic kidney disease, and heart failure, while improving kidney function. Researchers found significant improvements in both patient groups with and without chronic kidney disease.
A large randomized controlled trial found no significant difference in health status between patients with restricted and unrestricted fluid intake. Despite this, patients on fluid restriction reported more thirst and had lower overall health scores at baseline compared to those with liberal fluid intake.