Articles tagged with Inflammation
A Japanese research team has developed a biohybrid approach that works inside the body, transforming engineered skin into a visible indicator of internal biological states. The system leverages the body's natural skin regeneration to support long-term biomarker monitoring, providing a visual readout without blood sampling.
A recent study from Michigan State University found that blocking postoperative inflammation may actually delay recovery and prolong pain. The researchers used a mouse model to investigate the role of TNF-α signaling in postoperative pain resolution.
The meeting report highlights the emerging importance of infection-driven senescence in understanding chronic diseases, including respiratory viruses like influenza and SARS-CoV-2. Researchers found that senescent cells contribute to persistent inflammation and reduced healing, particularly in older adults during chronic infections.
A comprehensive review reveals the therapeutic effects of Borago officinalis, a plant with diverse compounds targeting inflammation and metabolic pathways. The study highlights its potential in treating cardiovascular disease, diabetes, and neurodegenerative disorders.
A University of Toronto-led study has discovered a potential biomarker linked to multiple sclerosis disease progression that could help identify patients most likely to benefit from new drugs. The findings were validated in both mouse models and humans, suggesting a possible surrogate marker for leptomeningeal inflammation.
Researchers at the University of Minnesota Medical School identified a key protein called GDF3 that drives inflammatory responses in older adults. The study showed that GDF3 signals through SMAD2/3, inducing permanent changes in the genome and increasing inflammatory cytokines.
A subset of depressed individuals with chronic, low-grade inflammation may benefit from anti-inflammatory treatment, according to a systematic review and meta-analysis. The study found that anti-inflammatory medications significantly reduced depressive symptom severity and anhedonia in these patients.
Researchers discovered that brain enzyme OTULIN regulates tau protein accumulation and has implications for treating neurodegenerative diseases. The study revealed OTULIN's role in controlling gene expression and RNA metabolism, suggesting a potential therapeutic target.
University of Minnesota researchers found that reducing chronic inflammation can significantly protect against age-related macular degeneration (AMD)-like pathology in preclinical models. The strategy aims to intervene before severe damage occurs, potentially delaying or preventing vision loss for those with early signs of AMD.
Researchers at MD Anderson have discovered bacterial genetic and cellular elements within brain tumor cells, potentially influencing tumor behavior. Inflammation may also drive the earliest stages of lung cancer, with targeting proinflammatory pathways emerging as a potential early intervention approach
Researchers identified 251 genetic variants that significantly affect circulating protein levels in Greenlanders, showing stronger genetic control over certain proteins in the Inuit population. The study uncovered 70 previously unreported associations and found links between Arctic-adapted genes and disease development.
The inflammatory response plays a dual role in ischemic stroke, exacerbating damage while facilitating tissue repair. Key biomarkers like IL-6, CRP, and MMP-9 aid early diagnosis, prognostic evaluation, and guiding thrombectomy, offering promising therapeutic targets for precision medicine.
A new type of DNA damage, glutathionylated DNA adducts, accumulates at high levels in mitochondrial DNA, affecting energy production and stress response. The discovery sheds light on how cells sense and respond to stress, with potential implications for diseases like cancer and diabetes.
A mouse study by University of California, Riverside scientists suggests microplastic exposure may accelerate the development of atherosclerosis in males. The study found microplastics dramatically worsened plaque buildup in male mice, but not females.
A new study found that individuals with a history of major depression showed higher MRI markers associated with neuroinflammation in the VTA, suggesting increased extracellular inflammatory processes. Current depressive symptom severity was associated with distinct microstructural changes indicating different underlying pathophysiologi...
Research on leptin reveals its multifaceted roles in MAFLD, including regulation of energy balance and metabolism. Leptin therapy shows promise in rare cases of leptin deficiency but is largely ineffective in obesity-associated hyperleptinemia.
A new study identifies fatty acid elongase ELOVL5 as a key promoter of inflammation resolution in the lungs. The research reveals that ELOVL5 works through a dual mechanism to dampen inflammatory pathways and generate pro-resolving lipid signals.
A Cochrane review found that low-dose colchicine reduced heart attacks and strokes in people with a history of heart disease or stroke. The study involved nearly 23,000 participants and showed that taking colchicine could prevent about two of each heart attack and stroke among those with cardiovascular disease.
Researchers at UT Health San Antonio School of Dentistry are studying novel targets and approaches to treat oral squamous cell carcinoma, the most common type of oral cancer. The studies aim to reduce pain management and mucositis in patients undergoing radiotherapy.
Arctigenin, a monomer of Fructus Arctii, exhibits anti-inflammatory activity and prevents MASH progression through modulating the NLRP3/GSDMD-N axis in macrophages. ATG administration also reduces hepatic macrophage infiltration, serum enzyme levels, and lipid peroxidation while enhancing antioxidant enzyme activity.
A team of researchers from Rice University and the Houston Methodist Research Institute will study how the brain responds to neural implants. They aim to develop more stable and longer-lasting brain-computer interfaces and neuroprosthetics, which could treat neurological disorders such as Parkinson’s disease, epilepsy, and stroke.
Researchers at University of Texas M. D. Anderson Cancer Center discover that inflammation is responsible for driving the earliest stages of lung cancer, identifying potential targets for early intervention and suggesting a promising approach to intercepting lung cancer development.
Researchers created a multidimensional molecular map of brain development after birth and its response to inflammation, finding that some developmental programmes can be reactivated during neuroinflammation. This study provides new clues for understanding how myelin is broken down in diseases like MS.
A new study analyzing linked electronic health records found that COVID-19 infections led to a higher and longer-lasting risk of rare heart complications, including myocarditis and thrombocytopenia, compared to vaccination. The research team estimated an additional 2.24 cases of myocarditis per 100,000 children after COVID-19 infection.
Researchers develop a compound that reduces cell death, inflammation, and organ damage in diabetes. The drug candidate, RAGE406R, prevents the interaction between two proteins that enable heart and kidney injury, and accelerates wound closure.
Researchers at UC San Diego School of Medicine developed an AI-powered approach to decode macrophage gene expression patterns. They identified a 53-gene signature that separates reactive from tissue-healing macrophages, resolving a longstanding debate in Crohn's disease.
Researchers identified a significant association between perfluoroheptanoic acid (PFHpA) exposure and metabolic dysfunction-associated steatotic liver disease (MASLD) in adolescents. The study used advanced models to reveal PFHpA's role in disrupting biological pathways, leading to liver damage and inflammation.
Researchers at St. Jude Children's Research Hospital found that metabolism guides the activation states of regulatory T cells, which dampen inflammation. The study reveals a link between mitochondrial function and lysosome activity in controlling these immune cells.
Researchers identified C-C chemokine ligand 5 (CCL5) as a key player in kidney injury and repair, with the molecule behaving both protectively and harmfully. The study suggests future drugs could target only its damaging effects, paving the way for more precise treatments for chronic kidney disease.
Researchers identified a genetic inflammatory signature that defines specific depression subtypes and influences antidepressant outcomes. Higher CRP polygenic scores were associated with reduced weight and appetite loss, earlier age of onset, and lower employment status after treatment.
Post-traumatic vasospasm (PTV) is a sudden narrowing of brain arteries that can lead to stroke and long-term neurological damage. Early diagnosis using tools like transcranial Doppler ultrasound and S100 protein blood tests is crucial to prevent secondary brain injury.
Researchers at UCLA Health have identified a sex-chromosome linked gene that drives inflammation in the female brain, making women more susceptible to conditions like Alzheimer's disease and multiple sclerosis. Deactivating this gene and using diabetes medication metformin showed promising results in reducing symptoms in female mice.
A new human lung alveolus chip model enables investigation of viral replication, inflammatory responses, and genetic off-target effects of a novel pan-influenza CRISPR therapy. The study achieved significant reductions in virus load and host inflammatory response after a single administration.
Denis Evseenko and Toby Maher are developing a regenerative drug to block cells that promote fibrosis in the lungs, aiming to slow or reverse IPF damage. The team plans to test the safety and therapeutic potential of their drug-like molecules in animals and human cells.
Research reveals that ovarian aging is not just about egg quality, but also the surrounding cells and tissues. The study found that eggs cluster in pockets surrounded by egg-free zones, which decline in density with age, influencing egg lifespan and maturation.
Researchers found that Reelin-based therapeutics could help restore the integrity of the gut barrier, reducing inflammation and symptoms of depression. The study suggests a promising new treatment targeting both brain and gut processes.
Researchers explored the therapeutic potential of cannabidiol for Alzheimer's disease by assessing its effects on immune responses and neuroinflammation. CBD treatment reduced expression of key regulators for neuroinflammation in Alzheimer's mice, associated with less proinflammatory molecules.
Research found that inflammatory markers are linked to different aspects of cancer-related fatigue, with some effects persisting after treatment. The study suggests targeting inflammation for developing treatments to alleviate this debilitating symptom.
The review highlights the critical roles of phospholipids in regulating immune cell migration, differentiation, and survival, as well as their regulatory effects on inflammation. Dysregulated phospholipid metabolism is linked to various diseases, including autoimmune disorders, cardiovascular disease, and cancer.
Double negative T cells (DNT cells) play an indispensable role in suppressing intestinal inflammation, acting as antigen-presenting cells. Their impaired function may contribute to the pathogenesis of Crohn’s disease, suggesting they could be a potential therapeutic target.
The American College of Cardiology has released a scientific statement on inflammation and its connection to various cardiovascular diseases, including coronary artery disease and heart failure. The statement confirms years of research confirming the importance of inflammation as an underlying contributor to CVDs.
The NF-κB signaling pathway plays a key role in regulating immune responses, inflammation, cell development, and proliferation. Research into its functions and mechanisms continues to uncover new breakthroughs in immunology and life sciences.
The loss of Trp53 leads to more aggressive tumor growth and weaker immune responses in ovarian cancer. Researchers developed a mouse model that mimics human HGSC, showing how the disease progresses and evades the immune system.
The USC team is developing a new drug aimed at a previously unexplored biological target in Alzheimer’s disease, focusing on a trigger of brain inflammation. They have identified an enzyme that predisposes the brain to inflammation and are now working to find a drug that can block it without harmful side effects.
The new journal aims to publish high-quality research on immunity and inflammation, covering all areas of immunology and focusing on the role of inflammation. It seeks to foster a deeper understanding of inflammation's role in immunity and promote innovative approaches to prevent and treat inflammation-related diseases.
A new study from the University of Oklahoma has identified CD82 as a contributing factor to blood vessel leakage, which can initiate inflammation. The researchers found that lowering cholesterol levels with statins can strengthen vessel walls and reduce leakage.
Researchers have designed smart nanomedicines that scavenge ROS, re-programme immunity and restore tissue homeostasis to treat chronic inflammation. The work outlines design rules, AI-assisted screening and scalable synthesis for next-generation anti-inflammatory therapeutics.
A USC Stem Cell-led team has successfully generated lab-grown kidney structures, or organoids, that exhibit kidney-like functions such as blood filtration and urine production. The 'assembloids' achieved maturity levels comparable to newborn mouse kidneys, paving the way for developing new therapies for patients awaiting transplant.
A new study found that cocoa extract supplements rich in flavanols decreased hsCRP levels, an inflammatory marker associated with cardiovascular disease. The results suggest cocoa extract's anti-inflammatory potential may help explain its heart-protective effects.
Stem cell transplantation has been shown to reverse stroke damage in mice by regenerating neurons and restoring motor functions. The treatment also improved blood-brain barrier integrity, reduced inflammation, and promoted new blood vessel formation.
Researchers from the Stowers Institute for Medical Research have identified a common process that powers the creation of protein formations that assemble like a 3D puzzle, triggering inflammation and cell death. This 'Catch-22' mechanism may be one of the fundamental reasons why we age.
Researchers found that an astrocytic 'brake' mechanism, fueled by the neurotransmitter GABA, blocks spinal cord repair after injury. Inhibiting this pathway with the MAOB inhibitor KDS2010 enables recovery of spinal cord function in animal models.
A consortium led by the University of Southampton aims to advance cutting-edge treatments for lung cancer, blood cancers, and chronic inflammation. The ON-TRACT project will train researchers in academic, industrial, and clinical settings to develop safer and more effective treatments.
Researchers found that improving diet quality reduced chronic musculoskeletal pain from 50% to 24%, while also decreasing pain-related quality of life. The study suggests that adopting a healthier diet may lead to meaningful reductions in pain and improve overall wellbeing.
A study led by Dr. Eliza McElwee finds that inflammation triggered by infection can lead to fetal brain inflammation and preterm birth. By administering a complement inhibitor, pregnant mice showed reduced inflammation and increased viability of offspring, suggesting a potential new therapeutic approach.
Researchers at Institute of Science Tokyo found that basophils suppress lung inflammation during ARDS recovery, suggesting potential treatment strategies. Basophils release interleukin-4, which helps immune cells coordinate responses and alleviate lung inflammation.
Researchers found that methotrexate significantly lowers systolic blood pressure in people with rheumatoid arthritis. The study suggests that this could be a new benefit of the drug beyond its usual role in treating inflammation, and may also provide protection against heart disease.
Scientists at Trinity College Dublin discovered that electrically stimulating macrophages can shift them into an anti-inflammatory state, promoting faster tissue repair. This breakthrough offers a potentially powerful new therapeutic option for treating inflammation-driven diseases and injuries.
This review synthesizes evidence from clinical trials on the efficacy of transcutaneous vagal nerve stimulation (tVNS) in managing abdominal pain, improving gastrointestinal symptoms, and enhancing motility in disorders such as functional dyspepsia, gastroparesis, irritable bowel syndrome, and inflammatory bowel disease. tVNS demonstra...
A new investigational drug, ION224, shows promise in treating metabolic dysfunction-associated steatohepatitis (MASH), a serious form of fatty liver disease. By targeting the DGAT2 enzyme, the drug helps reduce fat buildup and inflammation, two major drivers of liver damage.