Articles tagged with Inflammation
A Bar-Ilan University study reveals that directing attention toward bodily sensations reduces inflammation and accelerates recovery in healthy volunteers. The study found that nearly 90% of participants showed smaller inflammatory responses when focusing on the affected area, with faster return to baseline.
Pregnant women with a history of child abuse experienced increased inflammation when exposed to mild stress, associated with greater pregnancy complications, including premature birth. Mindfulness exercises may help pregnant women improve their health and reduce harm from childhood trauma.
A coral-inspired 3D-printed scaffold reprograms immune cells to promote angiogenesis and bone regeneration, shifting macrophages from inflammatory M1 state to reparative M2 state. The scaffold also enhances angiogenesis, new bone formation, and reconstruction of bone defects.
A new study from Florida Atlantic University finds that men who consume high amounts of ultra-processed foods have increased risks of prostate cancer. Men with the highest UPF intake had a possible 34% higher risk, although the finding did not reach statistical significance.
Researchers have discovered that proteins released from mitochondria can activate the immune system in a similar way to invading bacteria. Elevated levels of mitochondrial proteins were found circulating in the bloodstream even when no live bacteria were present, leading to excessive inflammation.
Researchers found that exercise-induced molecular changes contribute to neuronal health, improving movement and quality of life in PD patients. Exercise types such as aerobic exercises, resistance training, balance training, and multimodal exercise were found to be helpful in reducing falls, disabilities, and improving brain function.
Researchers have uncovered a key mechanism explaining how allergic inflammation in the skin can progress to a body-wide allergic response. IL-13 acts on dendritic cells, enhancing their ability to present allergens and promoting immune responses that produce antibodies.
Researchers found the nucleocapsid protein amplifies inflammatory pathways in macrophages, fueling tissue-damaging immune responses. The study suggests a possible mechanism for cardiac injury seen in severe COVID-19 cases and points to targeted treatments
Researchers developed a new approach to eliminate pathogenic bacteria like Porphyromonas gingivalis in periodontitis without harming healthy tissue. This therapy preserves beneficial oral microbes, reducing bone loss and improving oral microbiota in mouse models.
A team of scientists has identified a multi-step process where neutrophils are guided to specific tissue sites to confront infecting microbes or viruses. The study found that a signaling complex formed by TRPV2 and CB2R directs migration selectively toward sites of infection.
Researchers found that a single dose of rapamycin rapidly improved symptoms in adult mice with autism-like changes, reversing abnormal brain signaling and behavior within two hours. The study suggests the adult brain's functional circuitry, not just its physical structure, as a target for future treatment approaches.
Researchers discover a previously unknown mechanism of action for a synthetic peptide that mitigates excessive inflammatory responses in allergic asthma. The peptide inhibits a key inflammatory switch in the immune system, opening up new avenues for treating chronic inflammatory diseases.
A study by Kumamoto University researchers reveals a hidden communication network between the skin and bone marrow that drives psoriatic inflammation. This pathway highlights a crucial role for neutrophils in fueling psoriatic flare-ups, suggesting a promising new target for future therapies.
A study published in Cancer Research identified an immune pathway that promotes the progression of oral precancerous lesions into head and neck squamous cell carcinoma. The researchers found that targeting a key inflammation signal known as interleukin-1 alpha (IL-1α) could help restore immune surveillance and prevent high-risk lesions...
A clinical trial showed semaglutide improved liver scarring in patients with advanced fatty liver disease and early-stage cirrhosis. Non-invasive blood tests reflected treatment-related improvements more clearly than liver biopsies, which could reduce reliance on invasive procedures.
Researchers have identified a protein called vitronectin that triggers the scarring in lungs leading to idiopathic pulmonary fibrosis. This discovery opens up a new potential treatment pathway using the vitronectin-macrophage pathway to inhibit scar tissue growth.
Researchers at Texas A&M University have found a way to intervene early in traumatic brain injuries using a natural, gut-derived chemical that prevents post-traumatic epilepsy from taking root. The treatment reduced brain inflammation, improved memory and mood, protected brain cells, made seizures both rarer and harder to trigger.
Researchers have found that stimulating a nerve in the external ear may help to ease inflammation in the lungs of mice. The study suggests a novel device could be developed to target inflammatory pathways and treat diseases like asthma, pulmonary fibrosis, and rheumatoid arthritis.
A new study reveals that macrophages, a key immune cell type, age differently across tissues and between sexes. The researchers found that aging macrophages become more focused on responding to stress and cellular damage, but lose some molecular programs involved in maintaining healthy tissue structure.
The study found associations between mitochondrial heteroplasmy and cardiometabolic parameters in patients with metabolic syndrome. Intermediate heteroplasmic mutations were associated with the degree of vascular stenosis and lipid metabolism parameters.
A pilot clinical trial assessed ibuprofen's safety and efficacy as an adjunct to standard TB treatment in patients with pre-XDR-TB and XDR-TB. Participants showed a reduced inflammatory response, indicating potential benefits for host-directed therapies.
The NF-κB signaling pathway plays a central role in pathogenesis and therapeutic targeting of immunological diseases. Dysregulation underpins many conditions, making it a crucial target for treatment. Emerging concepts like ubiquitin code editing and spatial immunology hold promise but require experimental validation.
Macrophages are critical drivers of chronic allograft failure, with emerging strategies targeting key macrophage signaling pathways providing an important conceptual shift. Targeted therapies, such as inhibiting the purinergic pathway and mTOR/NF-κB pathway, show promise in preventing chronic rejection.
A new study found that specific gut bacteria from children with stunted growth can be passed to their offspring, causing inflammation and damage to the intestinal lining. The researchers identified Campylobacter concisus as a key contributor to this process, which may hold promise for future treatment and prevention strategies.
Glial cells play critical roles in determining brain recovery after TBI, and researchers have identified ways to selectively modulate their functions. The study highlights the importance of coordinated cellular behavior and suggests that targeting glial responses could lead to effective therapies.
Researchers have found that oyster meat extract can effectively reduce TNF-α-induced intestinal inflammation by interrupting NF-kB signalling pathways and decreasing COX-2 enzyme expression. This natural supplement has potential as a sustainable solution for managing chronic inflammatory diseases.
A USC interdisciplinary team has identified a promising pathway to turn off brain inflammation before it does its damage, increasing the risk of late-onset Alzheimer's. The Norman and Mary Pattiz Foundation funding will support research on novel drug discovery, early detection, and prevention of Alzheimer's disease.
A study by IBEC researchers found that dynamic protein usage, measured by endocytic turnover rate (ETOR), plays a critical role in blood–brain barrier function and is disrupted under inflammatory conditions. This discovery may lead to novel therapeutic strategies for restoring neurovascular health.
Researchers identified a previously unrecognized immune system pathway that connects cigarette smoking to cardiovascular disease. Cigarette smoke activates immune cells, triggering widespread inflammation throughout the body and accelerating plaque buildup in arteries.
Researchers discovered biomarkers indicating overactivity and dysfunction in the immune system, which can lead to chronic critical illness. Identifying these markers could allow doctors to intervene earlier, leading to shorter ICU stays and improved patient outcomes.
Researchers at UT MD Anderson Cancer Center have achieved high response rates in patients with hard-to-treat acute myeloid leukemia (AML) using an all-oral combination therapy. The study also provides insights into the origins of cancer, revealing that tumors evolve rapidly through bursts of genetic changes.
Researchers at the University of Zurich have developed epigenetic drugs that can reprogram perivascular fat cells to reduce inflammation and improve blood vessel health. By targeting specific gene-expression regulators, these drugs aim to prevent vascular damage in people with obesity and metabolic disease.
A study from the University of Oklahoma reveals that microplastic exposure can exacerbate fatty liver disease, especially in high-fat dietary conditions. Researchers used advanced mapping technology to pinpoint specific regions of liver damage caused by polyethylene exposure.
A new study has identified a two-protein complex involved in exporting R-loops, which triggers an immune response causing harmful inflammation. The study tested an approved drug called KPT-330 and found significant improvements in inflammation, liver damage, fat gain, muscle loss, and lifespan in preclinical models.
Researchers at UC Riverside link immune signaling to disrupted brain function and cognition after concussion, finding a crucial link between TLR4 and MMP-9. Blocking these pathways may limit changes in brain circuits and improve long-term neurological outcomes.
Researchers from Kyushu University discovered that the circadian clock protein BMAL1 drives macrophages towards a pro-inflammatory M1 state by activating inflammatory signaling pathways. This mechanism links the body clock to intracellular metabolism and immune function, offering new insights into treating inflammatory diseases.
Researchers at IGTP identify N-glycosylation as essential for preserving immunomodulatory function of extracellular vesicles. The study found that intact N-glycosylation can reduce monocyte recruitment to inflamed endothelium, contributing to a better understanding of these vesicles' therapeutic potential.
Researchers from Florida Atlantic University have identified a key immune pathway that appears to drive damaging inflammation in Huntington disease. Blocking this pathway reduced brain inflammation, protected neurons, and improved movement in a humanized mouse model of the disease.
A study led by Northwestern University identified a new biological culprit behind cognitive decline in people with HIV: the degradation of protective sugar molecules. Flu drugs preserved these sugar molecules and protected the brain in lab and mouse studies.
Research in flies shows that tumor cells with chromosomal instability can become senescent and release signals altering neighboring tissue behavior. This process promotes tumor growth by inducing the death of nearby healthy cells.
A 14-protein signature in the blood can predict lung cancer risk more than five years before diagnosis, according to researchers at the Francis Crick Institute. The team used machine learning on plasma data from over 48,000 people to identify the signature, which reflects an altered inflammatory lung environment.
This study found that Justicia carnea ethanol extracts effectively reduced oxidative stress markers, inflammation, and lipid peroxidation in a mouse model of chronic pancreatitis. The extracts also preserved islet glucagon expression, indicating potential therapeutic benefits for pancreatic damage.
A new study found that chronic oral inflammation can impair female fertility by triggering a systemic immune response that affects the ovaries. This leads to oxidative damage, reduced egg quality, disrupted follicle development, and reduced live birth rates.
A study identified alterations in the endocannabinoid system associated with severe acute pancreatitis, including decreased circulating levels of 2-AG. Restoring 2-AG levels reduced inflammation and lung damage, highlighting the system's role in the disease's pathophysiology.
A new study found that drinking tomato-soy juice lowered pro-inflammatory proteins in healthy adults with obesity after four weeks. The findings hint at the juice's promise as a functional food that may help curb chronic inflammation and improve health outcomes for patients with pancreatitis.
Researchers developed a senolytic therapy using dasatinib and quercetin, which preserved disc structure and reduced inflammation, highlighting JUN signaling as a key pathway. This preclinical study provides evidence for a potential therapeutic strategy to slow disease progression in individuals with genetic susceptibility.
Steatotic donor livers are susceptible to post-transplant dysfunction due to galectin-3 (LGALS3)-mediated pyroptosis. LGALS3 modulates NLRP3 inflammasome activity by regulating its ubiquitination, exacerbating graft injury.
Researchers at UT MD Anderson Cancer Center have uncovered genetic and cell-state adaptive mechanisms that drive resistance to KRAS inhibitors in patients with KRAS-mutant colorectal cancer. Targeting early inflammatory responses by adding TBK1 blockade may be a promising combination strategy to overcome treatment resistance.
A new study replicated patient- and sex-specific hallmarks of Inflammatory Bowel Disease (IBD) in a human organ chip, identifying stromal fibroblasts as key drivers of inflammation, fibrosis, and enhanced cancer risk. The model also recapitulated the impact of pregnancy hormones on IBD severity in female patients.
Interleukin 6 is investigated as a treatment target for depression in this randomized clinical trial. The study highlights the therapeutic potential of IL-6 or IL-6 receptor inhibition and proposes suitable patient selection methods.
IEC-HS is a rare but potentially fatal complication of CAR-T therapy, characterized by sustained inflammatory response and distinct biochemical differences from CRS. Targeted therapies, such as interleukin-1 blockade, are gaining attention for its management.
A new study reveals that ALS unfolds through a domino-like sequence of events starting with an early breakdown in motor neurons, followed by a damaging inflammatory response. The findings suggest that targeting these immune signatures could slow down disease progression.
Researchers found that Rhein reduces pancreatic and intestinal damage, restores intestinal barrier integrity, and promotes repair macrophage responses. PPARγ is identified as the central mediator of Rhein's effects.
Research finds association between high air pollution and increased risk of post-surgical complications, including sepsis, pneumonia, and surgical wound infection. Higher levels of PM2.5 air pollution above EPA daily limits increase risk by 8%.
A study finds microplastics in the human brain associated with increased risk of stroke and dementia. Apheresis, a medical treatment, is proposed as a potential removal method for microplastics from the body.
Researchers discovered brown adipose tissue protects against atherosclerosis and inflammation in humans with obesity, showing lower arterial inflammation and healthier blood profiles. Higher brown fat activity correlates with reduced vascular inflammation and improved cardiovascular health.
Researchers discovered that stress hormones trigger neutrophils to detach from blood vessel walls and travel to the heart, causing inflammation. Blocking these stress signals with beta blockers may prevent excessive inflammation and improve heart healing.
Researchers at Vanderbilt University Medical Center discovered that enterotoxigenic Bacteroides fragilis reshapes intestinal cell metabolism to support its growth, causing diseases like diarrhea and colorectal cancer. The study provides new possibilities for intervention by targeting metabolic interactions between host and microbes.
A study published in Nutrition, Metabolism and Cardiovascular Diseases found that plant-based dietary patterns were associated with significantly lower C-reactive protein levels compared to omnivorous diets. This reduction may indicate less background inflammation and lower cardiovascular risk.
The study reveals that hair follicles contain specialized sentinel cells that monitor environmental exposure and microbial presence, potentially linking immune detection to sensory signaling. The discovery may have implications for understanding skin infections, immune disorders, and topical therapeutics.