Articles tagged with Inflammation
Researchers found that olpasiran significantly lowers lipoprotein(a) levels by over 95% and reduces oxidized phospholipids, which promote atherosclerosis. The study also showed no significant effects on inflammatory markers.
Macrophages may help prevent peripheral neuropathy by slowing its onset and reducing damage. Researchers discovered that these immune cells produce chemokines to recruit other macrophages, which protect against sensory axon loss.
Researchers at Virginia Tech have developed a way to convert gut bacteria into miniature protein factories that produce and release targeted proteins inside the lower intestine. This breakthrough could potentially treat chronic diseases.
A study investigates the efficacy of EFC as a potential treatment for RA, showing anti-inflammatory effects on fibroblast-like synoviocytes and alleviating disease severity in animal models. The findings highlight the therapeutic potential of PDIs in RA management.
Researchers identified a link between Alzheimer's disease, cell function, and cholesterol in the brain. Lowering oxysterol levels freed trapped ABCA1, restoring its healthy state, and showed potential as a new treatment approach.
Researchers at TUM found that cystic fibrosis causes changes in the immune system as early as birth, leading to frequent inflammation and infections. These changes are not affected by CFTR modulator therapies.
A Northwestern University study found that a fiber-free juice diet can trigger shifts in gut and oral bacteria linked to inflammation and cognitive decline. The study suggests that juicing without fiber may disrupt the microbiome, potentially leading to long-term health consequences.
Researchers discovered that a topical ABT-263 treatment effectively reduces aged skin senescence markers, priming the skin for improved subsequent wound healing. The treatment also triggered inflammation, which surprisingly helped the healing process by 'waking up' the skin's repair systems.
Researchers at Lancaster University have developed a new method to detect Alzheimer's disease by analyzing changes in brain oxygenation dynamics and neuronal function. The study found that individuals with Alzheimer's disease exhibit altered respiratory frequency, which may be an early indicator of the condition.
A recent study suggests that prolonged exposure to low-dose traffic-derived PM2.5 particles can cause fatty liver disorder in mice. The study found changes in liver function, inflammation, and scar tissue formation, highlighting the potential health risks of air pollution on the liver.
A systematic review and meta-analysis found that cold-water immersion can reduce stress levels within 12 hours, improve sleep quality, and boost quality of life. However, these benefits may fade after three months. Cold showers also showed promise in reducing sickness absence and improving mood.
Researchers explore structural and functional characteristics of Russula vinosa Lindblad polysaccharides, finding potential applications in pharmaceuticals and functional foods. The study reveals that structural differences between polysaccharides influence immunomodulatory activities.
A new study from the University of Southern Denmark reveals that the brain's self-healing abilities are hindered by inflammation after a stroke. The researchers mapped specific cells that play a central role in rebuilding myelin, but found gender differences in how men and women respond to injuries.
Researchers discovered that cells caught up in sepsis send out messages to other cells, causing them to die and fueling the spiraling inflammation. By understanding this process, scientists may be able to develop a treatment for inflammatory diseases like sepsis.
New research reveals that lipid-associated macrophages (LAMs) are crucial for liver repair, while Kupffer cells also adapt to take on a LAM-like phenotype. The Trem2 gene is essential for clearance of dying liver cells and promoting tissue repair.
Researchers discovered that removing arginase-II gene can slow down muscle aging in mice, leading to improved muscle health and reduced inflammation. This finding suggests targeting the Arg-II gene could help maintain muscle strength and mobility in older adults.
Researchers developed mucoadhesive films combining xyloglucan and green tea extract to treat oral mucositis, a painful inflammation caused by cancer treatment. The films demonstrated high strength and adhesion forces comparable to commercial products, showing promise as a novel treatment for oral mucositis.
Research identifies IL-1R1-expressing neurons in key brain regions, including the somatosensory cortex and hippocampus, which regulate sensory processing, mood regulation, and memory. The study provides new insights into how inflammation contributes to sensory, mood, and memory disorders.
A preclinical study by Weill Cornell Medicine investigators found that an immune protein called the inflammasome helps prevent blood stem cells from becoming malignant by removing certain receptors and blocking cancer gene activity. The study suggests that targeting the earliest stages of cancer may lead to new therapies.
Regular aerobic exercise has been shown to significantly reduce disease markers associated with Alzheimer's, protecting healthy brain cells and restoring balance in the aging brain. The study highlights the potential for aerobic exercise to serve as a cornerstone in preventive strategies for Alzheimer's.
IL-8+ neutrophils are central drivers of inflammation in alcohol-associated hepatitis, and targeting them may lead to selective reduction of inflammation. Several strategies for targeting IL-8 signaling have been proposed, including therapeutic antibodies and inhibitors.
Researchers at Karolinska Institutet used AI to analyze brain images from 70-year-olds and found that factors like inflammation and high glucose levels are associated with an older-looking brain. A healthy lifestyle, on the other hand, was linked to brains with a younger appearance.
Researchers found that neuroinflammation in the hippocampus significantly alters motivation and behaviour in mice, particularly in females. This study suggests that treatments targeting hippocampal neuroinflammation could help reduce cognitive and behavioural symptoms in diseases such as Alzheimer's and Depression.
The study, published in Aging, introduces a new therapy for osteoarthritis that uses extracellular vesicles derived from fat tissue to repair damage caused by aging cells. The treatment showed strong therapeutic effects in both cellular and mouse preclinical studies, reducing inflammation and DNA damage markers in human joint cells.
Research from Radboud University Medical Center shows that lockdowns during the COVID-19 pandemic strengthened the immune system's response to microorganisms. The study found that after lockdowns, inflammation levels in the body were low but the immune system reacted more intensely to viruses and bacteria.
A new Northwestern Medicine study reveals how metformin lowers glucose levels by targeting mitochondrial complex I in cells. The drug also improves COVID outcomes and reduces inflammation, suggesting that mitochondrial complex I inhibition may be a unifying mechanism behind its diverse effects.
Researchers at Brigham and Women's Hospital and Wyss Institute receive grant to expand diagnostic biomarker search, shedding light on asthma's unexplained causes. The team aims to develop a test distinguishing different forms of asthma, improving treatment courses.
Researchers discovered a novel combination of plasma-based biomarkers that can predict liver fibrosis in Latino adolescents with obesity. The study found that dihydroxyacetone phosphate (DHAP) and alanine transaminase (ALT) were significantly associated with fibrosis, suggesting a potential low-cost, noninvasive screening tool.
Researchers at Indian Institute of Science discover that viruses like SARS-CoV-2 mimic host proteins to trigger excessive cell death and tissue damage in humans. In contrast, bats show mild symptoms despite harbouring similar viruses, highlighting species-specific responses to viral infections.
Researchers have developed implantable sensors that track protein levels in real time, enabling continuous monitoring of inflammation at the cellular level. The technology has been successfully tested in diabetic rats, detecting changes in cytokine proteins associated with inflammation.
A new study reveals that glyphosate exposure in mice can cause lasting brain inflammation and accelerate Alzheimer's disease-like pathology, even after a significant pause from exposure. The herbicide's byproducts have been found to accumulate in brain tissue, raising serious concerns about its safety for human populations.
Women with infertility are at higher risk of developing SARD, including lupus and Sjögren's syndrome, even after accounting for pre-eclampsia and other pregnancy complications. Infertility treatments do not appear to increase this risk, suggesting that women may be undiagnosed or untreated.
A scoping review found associations between myositis disease activity and gluten exposure in patients with inflammatory myopathies and celiac disease. The study suggests that gluten may act as an exogenous antigen driving myositis in genetically predisposed patients.
A new study finds that fine particulate air pollution (PM2.5) exposure is associated with altered immune responses and increased inflammation in pregnant women, leading to adverse birth outcomes. The study highlights the importance of minimizing air pollution exposure in pregnant women to protect maternal and fetal health.
Research highlights Nup93's critical role in endothelial cell function and vascular health, with promising findings for new treatments to slow down aging. Low Nup93 levels are associated with inflammation and cellular aging, while restoring its levels can reverse harmful effects.
A new UC Davis Health study has uncovered the mechanisms by which Salmonella bacteria evade the body's natural defenses in the gut. The research found that Salmonella alters the gut's nutrient environment to fuel its replication in the large intestine, creating an imbalance that helps the pathogen survive. This new understanding could ...
Scientists at UMC Utrecht developed a new technology to isolate and study gut bacteria recognized by IgA antibodies, which are associated with various diseases. The next-generation IgA-SEQ method allows for high-throughput identification and analysis of these immunostimulatory bacteria, shedding light on their role in health and disease.
Dr. Philip Gold's landmark paper reveals depression's full-body impact, documenting structural brain changes and disruptions in hormone systems. His analysis highlights interconnected mechanisms underlying the disease, opening new therapeutic possibilities for innovative treatments targeting neuroendocrine dysfunction.
A new scientific statement highlights improvements in diagnosis, initial treatment, and long-term management of patients with Kawasaki Disease, emphasizing the need for tailored management strategies. Advances in cardiac imaging techniques and risk categorization have led to better patient outcomes.
A clinical study found that an FasL inhibitor, asunercept, led to a faster recovery of COVID-19 patients in eight days compared to 13 days in the control group. The treatment also reduced mortality by about 20%. The study suggests a new therapeutic concept for severe COVID-19.
Developed by University of Copenhagen researchers, a new nanofiber patch reduces psoriasis treatment frequency to once a day, improving comfort for patients. The patch releases two active ingredients at different rates, addressing the need for multiple products in psoriasis treatment.
Research highlights correlation between preeclampsia and COVID-19 in pregnant women, identifying biomarkers for differential diagnosis. The review article emphasizes the pathophysiological similarities between the two conditions, including shared pathways involving the renin-angiotensin system and ACE2.
Researchers developed a new diagnostic tool called FlowBEAT to measure antibodies in nasal cavities, finding that more than 70% of people with mild or moderate COVID-19 develop protective autoantibodies in the nose. These autoantibodies may play a role in regulating the immune system and preventing excessive inflammation.
A new study suggests that a keto diet rich in ketone bodies may help alleviate symptoms of multiple sclerosis and other autoimmune disorders. The diet promotes the production of indole lactic acid, which blocks the activation of immune cells responsible for these conditions.
Researchers at Gladstone Institutes created a new mouse model to study Alzheimer's disease, transplanting human neurons into mouse brains. The study found that immune cells called microglia cause harmful inflammation and clumps of misfolded proteins when interacting with the APOE4 protein.
Researchers from Texas A&M University synthesized research findings to improve medical devices and therapy success rates. The review emphasizes the need to understand macrophage cell behavior to develop targeted immunotherapy treatments.
Dr. Andero Galí's groundbreaking research connects mouse and human fear responses, using techniques like in vivo calcium imaging in mice and human fear response studies. His approach aims to create a more comprehensive understanding of the human brain by breaking down traditional barriers between animal and human studies.
Professor Vicki Clifton's team has identified a sex-specific variant of the glucocorticoid receptor isoform that enhances inflammation in the placenta during maternal stress. This finding could transform how clinicians approach pregnancy complications and neonatal care, leading to targeted interventions based on placental function.
This study explores the radioprotective effects of Licochalcone B on radiation-induced cell damage and mortality in mice. Lico B significantly improves antioxidant levels, reduces DNA damage, and lowers inflammatory factors.
A new intervention will be developed by University of South Australia researchers to help young people with chronic childhood arthritis overcome barriers to physical activity and mental wellbeing. The VITAL Project aims to validate, understand, and empower activity in people with Juvenile Idiopathic Arthritis, reducing pain invalidatio...
Researchers found that physically fitter patients with metastatic lung cancer live longer and respond better to chemotherapy. The study identified biomarkers in blood plasma that can indicate which patients are most likely to respond to treatment.
A new study suggests that a healthy diet may help keep low-grade prostate cancer from progressing to more aggressive states in men undergoing active surveillance. The research team led by Johns Hopkins Medicine found that a reduced risk of prostate cancer progression is associated with a healthy diet.
Researchers detected microplastic particles in the breath of wild bottlenose dolphins, suggesting inhalation may be a key route of exposure. The study supports the idea that dolphins could be exposed to potentially harmful microplastics through this pathway.
Researchers found that fermented black garlic extract reduced tumor aggressiveness parameters, including cell proliferation, without affecting normal prostate cells. The extract altered key signaling pathways related to inflammation, suggesting its potential as a dietary supplement to prevent or slow down prostate cancer progression.
A new study suggests that a hydrogen sulfide-generating molecule targeting mitochondria can significantly slow weight gain and reduce liver fat accumulation in mice. The treatment, AP39, inhibits key metabolic pathways associated with obesity and inflammation, offering a promising new option for treating metabolic diseases.
A new five-year NIH-funded study will investigate the impact of stress, illness, and inflammation on bias in healthcare workers, particularly towards patients from racial minority groups. The research aims to identify situations that increase bias and develop effective anti-bias strategies.
A new nanotherapy infusion was tested in pig models to prove its effectiveness and lack of side effects. The infusion targets specific immune cells that eat away at plaque cores, reducing blood vessel inflammation.
Researchers found that patients who consumed caffeine had better vascular health, as measured through endothelial cells. The study suggests that caffeine may play a role in controlling disease progression and improving cardiovascular health.
Researchers found inhibiting ACMSD increases NAD+ levels, reducing inflammation and fibrosis in mouse models of MASLD/MASH. Boosting NAD+ production could protect against severe liver damage and cirrhosis.
A new study found that common breast cancer treatments, including chemotherapy, radiation, and surgery, can increase expression of aging markers in breast cancer survivors. The study suggests that these treatments can have a more extensive impact on the body than previously thought, leading to accelerated biological aging.