Articles tagged with Metastasis
Researchers at Duke University Medical Center identified a mechanism where breast cancer cells use cholesterol to develop tolerance to stress, allowing them to resist ferroptosis and proliferate. This finding highlights the importance of lowering cholesterol in preventing cancer progression and offers new approaches for treatment.
A recent study by Chinese Academy of Sciences researchers found that circular RNA circURI1 inhibits the spread of gastric cancer cells. It achieves this by sequestering hnRNPM, modulating alternative splicing in gastric cancer cells. This breakthrough provides a new perspective on the molecular basis of cancer metastasis.
Patients with relapsed metastatic melanoma who received prior anti-PD-1 therapies had a lower response rate to adoptive cell transfer of tumor-infiltrating lymphocytes (ACT-TIL). ACT-TIL was less effective in these patients compared to those who had never received anti-PD-1 therapy. The study found that the objective response rate and ...
Researchers have found that breast cancer stem cells accumulate near a tumor arteriole, which they call the arteriolar niche. This niche promotes cancer cell features and potential development through the LPA/PKD-1 signaling pathway.
Researchers at Massachusetts General Hospital have identified two separate genetic alterations that enable triple-negative breast cancer cells to develop resistance to a highly effective drug. The findings could help improve therapy and prolong survival for patients with this aggressive form of breast cancer.
Researchers discovered that hypoxia induces regional variations in gene-expression patterns in pancreatic cancer, with specific subpopulations of cancer cells surviving under hypoxic conditions. These findings suggest a link between hypoxia and aggressive tumor behavior, highlighting the need for targeted treatments.
Researchers at City of Hope found that advanced colorectal cancer patients with no liver metastases respond to checkpoint inhibitors, achieving a major response in 20% of cases. In contrast, patients with liver metastases showed no positive response to immunotherapy.
Prokineticin-1 is a lymphangiogenic factor involved in human colorectal cancer's lymph node metastasis and lymph vessel formation. High PROK1 expression was found to significantly increase the rate of lymph node metastasis.
Researchers found that microscopic defects in healthy cell alignment can slow down tumor cell invasion. The study used an experimental model to show how topological defects affect the rate of tumor cell invasion, with certain defects causing cancer cells to pass through the barrier more slowly.
Researchers have found a way to harness the power of immunotherapy for advanced prostate cancer by targeting a protein called PIKfyve. Blocking PIKfyve with the inhibitor ESK981 has been shown to increase tumor death and recruit immune T cells, offering new hope for patients with this challenging form of cancer.
Researchers found that cancer cells in lymph nodes avoid immune destruction due to increased physical forces causing impairment of T cell entry. Alleviating solid stress with losartan boosts blood vessels and T cells, suggesting a potential strategy to improve immune responses.
A study found that 50% of metastatic colorectal cancer patients treated with bevacizumab experienced RAS mutation disappearance, suggesting the drug's potential to revert tumors. This discovery may open new therapeutic avenues for primarily RAS mutant patients.
A preclinical study identifies a small molecule inhibitor, KCN1, that dampens tumor drivers and limits disease progression. The study showed KCN1 to be well-tolerated and effective at reducing metastasis, suggesting potential as a treatment for metastatic uveal melanoma.
A new study published in PNAS has identified a protein called AXL as a crucial player in hypoxia, which promotes cancer progression and resistance to treatment. By blocking the action of this protein, researchers observed improved recovery of blood vessels and revitalization of the tumour's immune environment.
Researchers found that reducing PTHrP levels can prevent metastasis and improve survival in mice with pancreatic cancer. The study also showed promising results with anti-PTHrP antibodies targeting human pancreatic cancer cells, offering a new potential treatment approach.
The German National Academy of Sciences Leopoldina hosted a virtual symposium to discuss cancer research, particularly pancreatic cancer, and palliative care. Experts shared insights into the development of rare pancreatic tumors, mechanisms leading to metastasis formation, and resilience in palliative care.
Researchers at University of Arizona Health Sciences found that cancer cells become more aggressive when exposed to tissue stiffening, leading to changes that persist over time. The 'mechanical conditioning' score can quantify these cellular changes and predict patients at high risk for bone metastasis.
Research led by USC investigators reveals that the ABAT enzyme helps medulloblastoma cells feed on GABA in cerebrospinal fluid, allowing them to survive and resist treatment. The study also shows that high levels of ABAT enable medulloblastoma metastases to evade treatment and spread to other parts of the central nervous system.
Researchers identified FTO as a key regulator of cancer metastasis and found that lowering its levels enhances WNT signaling, making tumors more sensitive to WNT inhibitors. This discovery offers encouraging prospects for treating aggressive cancers.
A study published in Journal of Thoracic Oncology found that low-dose computed tomography (LDCT) screening for primary lung cancer is associated with a lower risk of developing brain metastases. Researchers identified 1502 participants diagnosed with lung cancer between 2002 and 2009, where LDCT screening was detected versus other meth...
A new classification of metastatic testicular cancer enables more targeted treatment, improving survival rates. The study reveals significant improvements in prognosis for patients with testicular cancer, with increased 5-year survival rates across all groups.
A team of scientists has developed a new method for tracing the lineage and gene expression patterns of metastatic cancer cells at the single-cell level. The researchers found that a spectrum of aggression exists in cancer cells, with some cells more likely to remain in place and others more likely to spread to other tissues.
Researchers analyzed 36 patients with skin squamous-cell carcinoma, finding that CD8+ T cells infiltrated tumors with lymphatic endothelial cells. Perineural infiltrated sSCC without metastasis showed low lymphatic endothelial cell density, suggesting a link to tumor microenvironment biology.
Researchers analyzed tumor microenvironment of 26 patients with metastatic melanoma to identify patient response in advance of therapy. They found that specific immune cells, such as DC3s, are associated with improved overall survival and active T cell immune response.
Researchers have discovered that natural killer cells and interferon gamma play a crucial role in preventing cancer metastases. Targeted therapies, such as immunotherapy and interferon gamma therapy, show promise in maintaining dormant cancer cells in a state of hibernation.
Researchers have discovered a potential way to prevent Ewing sarcoma tumours from spreading by understanding how they develop a protective shield against the harsh environment of the bloodstream. This breakthrough may lead to the development of a clinical-grade immunotherapeutic treatment for Ewing sarcoma.
Researchers identify immunosuppressive cells as key link between obesity and cancer risk, progression, and metastasis. Altered metabolic factors in obesity activate these cells, leading to poor survival and resistance to immunotherapy in cancer patients.
Researchers discovered a two-stage process leading to aggressive pancreatic cancer, where protein loss allows for tumor transformation and immune evasion. The study suggests reinstating the classical subtype could reduce metastasis.
A new study reveals that small uveal melanomas have molecular genetic alterations, making them highly metastatic tumours. Prompt treatment can significantly increase the chances of cure for these patients.
A multidisciplinary study has found that cells at the centre of kidney tumours have a higher potential to spread to secondary sites around the body. By contrast, cells at the tumour edge had lower rates of metastasis and growth.
Breast cancer researchers followed the progression of cancer in an animal model and found a path that transforms slow-growing ER+/HER2+ cancer into fast-growing ER-/HER2+ cancer. The study suggests different treatments may be needed for each subtype, depending on the path the cells follow.
A new four-drug combination treatment has shown promise in preventing cancer metastasis without triggering drug resistance. The treatment targets multiple pathways to suppress cancer cell spread and may help identify patients who would benefit from such therapy.
A new approach uses T cell engineering to deliver the gene coding for IL-24, which targets cancer cells regardless of their expression of target molecules. This method blocks tumor growth, starves tumors of nutrients, and generates memory T cells that can theoretically kill tumors if they recur.
A recent study suggests that cancer prevalence in medieval Britain may be around 9-14%, significantly higher than the previous estimate of less than 1%. The research used x-rays and CT scans to analyze skeletal remains from six medieval cemeteries, revealing signs of malignancy in five individuals.
Dr. David Lyden, a Weill Cornell Medicine physician-scientist, has been inducted into the Association of American Physicians for his pioneering work on cancer metastasis and spread. His research reveals that tumors produce factors that prime distant organs to become hospitable sites for cancer growth.
Scientists have discovered a potential new therapy target for canine cancer, specifically oral malignant melanoma in dogs. The treatment targets the PD-L1 molecule, which has shown promise in human cancer treatments, and significantly increased survival time for dogs with pulmonary metastatic OMM.
A phase 1 clinical trial found that stereotactic body radiation therapy (SBRT) is safe for treating patients with multiple metastases. The treatment used precisely targeted beams of high doses of radiation to destroy tumors, reducing damage to noncancerous tissue.
The NRG-BR001 trial found SBRT to be safe for patients with multiple metastases, with no dose-limiting toxicities and over 50% of participants alive at 2 years. The study used extensive radiation QA processes and was the first to require 3D image guidance during treatment.
A novel blood-based test has been developed to identify individuals with lymph node metastasis associated with high-risk T1 colorectal cancer, potentially avoiding unnecessary colon surgery. The test demonstrated high accuracy in detecting lymph node metastasis, exceeding expectations.
Researchers developed a system to deliver nucleotide-based drugs more effectively into primary tumor tissue and bone metastases, improving their clinical efficacy. The study found that iRGD-liposomes significantly enhanced the ability of antisense oligonucleotides to inhibit prostate cancer growth and prolong tumor suppression.
Two studies found that the bone microenvironment reduces ER expression in breast cancer cells, leading to resistance to endocrine therapy. The bone microenvironment also triggers reprogramming of cancer cells, promoting their ability to metastasize to other tissues and evade treatment.
A recent study published in Gastroenterology reveals that overexpression of the ZIP4 protein in patients with pancreatic cancer enables tumor cells to transform into a shape-shifting form, evading detection and metastasizing to other organs. Understanding this process is crucial for developing targeted therapies to stop metastasis.
Researchers at HSE University have identified key molecules responsible for breast cancer metastasis by developing an algorithm that recreates the networks of intercellular interactions in cancer cells. The program detects prognostic genes, with transcription factor E2F1 playing a major role in predicting patient outcomes.
Mutant KRAS and p53, the most frequently mutated genes in pancreatic cancer, work together through CREB1 to drive tumor growth and metastasis. Blocking CREB1 reversed these effects and reduced metastases, suggesting a promising new therapeutic target for this deadly cancer.
Breast cancer cells that spread to the brain must boost fatty acid production to survive due to limited access to fats. Inhibiting this process with a fatty acid synthase inhibitor may lead to tumor shrinkage.
Scientists from UNIGE discovered that paxillin helps cells perceive their environment and dock at the right place using cellular crampons. Without functional paxillin, cells can't attach properly and slip continuously.
A study from the University of Notre Dame found that a specific protein called SGK1 promotes survival and increases the likelihood of cancer spreading by blocking cell death. This discovery may have implications for understanding how cancer cells adapt to new environments, such as the brain, where breast cancer can metastasize.
A new CRISPR study has identified the LRRN4CL gene as playing a key role in the spread of certain cancers to the lungs. The research found that over-expression of this gene makes melanoma cells more likely to metastasize to the lungs, and may also be linked to poorer patient outcomes.
Researchers at St. Jude Children's Research Hospital discovered three molecular groups of ATRT with varying clinical outcomes, highlighting the importance of age and metastasis in prognosis and treatment planning. The study sheds light on the biology of this disease and provides valuable insights for developing targeted therapies.
Researchers discovered microRNA-4287 inhibits prostate cancer's progression and metastasis, leading to increased cell cycle arrest. The study found miR-4287 specifically targets SLUG and CD44, suggesting a potential diagnostic and therapeutic tool against advanced prostate cancer.
A retrospective study found that folinic acid with fluorouracil improves progression-free and overall survival in metastatic colorectal cancer patients. The combination also shows a clear clinical benefit regardless of RAS mutational status or tumor side. This suggests folinic acid may be a valuable addition to chemotherapy protocols.
Researchers have made significant progress in understanding how cancer cells communicate to spread, a key step in metastasis. By targeting the VEGF-C protein, they aim to slow down or stop metastatic growth, providing new hope for treating fatal diseases.
Researchers at Princeton University have discovered a new organelle involved in cancer metastasis, which was found through the study of liquid-liquid phase separations. The newly identified organelle plays a key role in regulating the Wnt signaling pathway and is essential for the progression and spread of cancer.
Researchers have identified a novel method using immune cells in cerebrospinal fluid to predict response to immunotherapy for patients with brain metastases. The analysis reveals similarities between immune cells in cerebrospinal fluid and those in brain metastasis, providing valuable insights into tumor microenvironment characterization.
The basement membrane surrounding tumors may control their growth and spread by becoming stiffer as it expands. Researchers used a simple technique to isolate the membrane and measure its elasticity, finding it to be nonlinearly elastic, unlike balloons made of linearly elastic materials.
Researchers have developed a novel stem-cell-based therapy targeting key targets in solid tumors, successfully prolonging the lifespan of mouse models with brain metastatic breast cancer. The engineered molecule EvDRL was delivered via allogeneic stem cells, which crossed the blood-brain barrier to home in on tumors.
Researchers at KIST discovered that red ginseng can significantly suppress lung cancer metastasis, with components Rk1 and Rg5 showing effective inhibition. The study developed a microwave processing method to increase the concentration of these components, leading to potential anti-cancer effects.
A recent study published in Oncotarget identified elevated platelet counts as a prognostic factor for poor outcomes in patients with metastatic clear-cell renal cell carcinoma, particularly those classified as intermediate-risk. These findings highlight the importance of stratification models in guiding treatment decisions and design c...
Researchers at EPFL successfully modeled ILC using a xenograft approach that simulates the tumor with high accuracy. The model reveals unique characteristics of ILC biology, including LOXL1's role in tumor progression.
Researchers identified three m6A modification patterns in HCC, each with distinct metabolic characteristics. These patterns were associated with differences in tumor stage, prognosis, and response to treatment. The study provides novel insights into potential prognostic markers and response to treatment in patients with HCC.