Articles tagged with Spinal Cord Injuries
Mercyhurst University researchers have developed new protocols for managing cervical spine injuries in football players, with the goal of achieving the highest level of care. The research, conducted in collaboration with Sports Medicine Concepts and the NFL, aims to standardize emergency management protocols and improve on-field response.
Neural stem cells successfully regenerates axons across the site of complete spinal transaction, leading to functional recovery in rats. The study also showed that adult cells can regenerate into neural stem cells, establishing a new relay circuit that can be measured electrically.
A clinical trial of Ekso-assisted walking in 13 patients with a range of spinal cord injuries found positive results, including improved gait and balance, increased oxygen consumption, and reduced cardiovascular responses. Long-term studies are needed to fully evaluate the effects.
Researchers are testing the upgraded Ekso, a wearable robotic exoskeletal device, to improve mobility in individuals with spinal cord injuries. The new features enable greater user control and collect usage data for monitoring progress.
A new prediction model for long-term functional outcomes after traumatic spinal cord injury is presented, combining acute functional measures with imaging factors. The model has the potential to guide treatment decisions and improve patient care.
The California Institute for Regenerative Medicine has awarded $20 million to UCI and StemCells Inc. to advance joint project treating cervical spinal cord injury using human neural stem cells. The funding will support the collection of data necessary to establish human clinical trials in the US.
Researchers found that mesenchymal stem cell transplantation in animal models of amyotrophic lateral sclerosis (ALS) and spinal cord injury promotes functional recovery. Bone marrow cell transplantation coupled with granulocyte colony-stimulating factor also shows neuroprotective and angiogenic effects in ALS animal models.
Researchers at EPFL successfully rehabilitated rats with spinal cord injuries using a combination of robotic harnesses and electrical-chemical stimulation. The study, published in Science, reveals that the dormant spinal column can be awakened to restore voluntary movement, suggesting new methods for treating paralysis.
A 71-year-old man regained partial thumb and finger movement after undergoing nerve transfer surgery to bypass a cervical spinal cord injury. The procedure, described as reducing the severity of the injury by placing healthy motor nerves close to damaged ones, took less time than traditional repair methods.
A new surgical technique has restored some hand function to a quadriplegic patient with a spinal cord injury, allowing for basic independence. The procedure involves rerouting working nerves in the upper arms and can potentially benefit patients with C6 and C7 spinal cord injuries.
Kessler Foundation researchers Mark Nash et al won the 2012 Apple Award for their article on extended-release niacin monotherapy for treating dyslipidemia risks in persons with chronic tetraplegia. The study, conducted across multiple SCI research centers, demonstrates the efficacy and safety of this treatment approach.
A combination of treatments including a polymer scaffold, neurotrophin-3, and chondroitinase enhanced the benefits of neural stem cell transplantation in rat models. This approach promoted nerve growth, improved cell survival and migration, and restored neuroplasticity.
Researchers have discovered that administering FTY720, an oral drug shown promise for multiple sclerosis, significantly improves motor function recovery in mice with spinal cord injuries. The study suggests targeting sphingosine 1-phosphate receptors may be a new avenue to counteract the degeneration of the spinal cord in human SCI.
A study published in PLoS One found that surgery less than 24 hours after a traumatic cervical spine injury leads to reduced neural tissue destruction and improved clinical outcomes. The research, known as the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS), involved 313 patients with spinal cord injuries.
Kessler Foundation partners with Ekso Bionics to test the wearable, robotic battery-powered exoskeleton's potential in rehabilitation research. Scientists will study its impact on circulation, bone density, and overall health.
A new therapeutic strategy using a single injection of fibronectin has shown potential to improve patient outcomes in treating chronic neuropathic pain following spinal cord injury. This approach inhibits the development of mechanical allodynia, a common type of chronic pain experienced by spinal cord injury patients.
Ryan Gilbert, assistant professor at Rensselaer Polytechnic Institute, receives a $500,000 NSF CAREER Award to create novel biomaterials that can reduce astrocyte reactivity and aid nerve regeneration after spinal cord injuries. The project aims to deliver therapies directly to the injury site to promote axon growth.
Researchers at UCSF have found that neutrophils use mechanical force to transmit tension across their membrane, restricting activity to the leading edge and enabling them to attack invaders. This discovery could lead to new therapies for conditions such as spinal cord injury and cancer.
The 2011 revision of the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) was published to guide consistent classification of spinal cord injuries. The new guidelines improve data reliability for clinical care and research studies.
Six patients with traumatic spinal cord injuries tested Ekso exoskeletal device, showing promising results that will guide protocol development for a planned clinical study. The research aims to measure gains in overall health among users of individuals using Ekso in rehabilitation settings.
Researchers found changes in motor cortex of the brain in patients with spinal cord compression, which may impact surgical procedures and patient outcomes. The study also identified a 15% decrease in N-acetylaspartate levels, suggesting potential implications for reversibility and treatment.
Researchers found that dental pulp stem cells can inhibit nerve cell death, promote nerve regeneration, and replace lost support cells in rats with severe spinal cord injuries. The study aims to translate this approach into an effective treatment for severe spinal cord injury.
A one-time injection of fibronectin immediately after spinal cord injury can limit pain for an extended period, according to Cleveland Clinic research. The treatment suppresses inflammatory response and maintains blood-spinal cord barrier integrity.
The Kessler Foundation has received grants totaling $296,261 to study the impact of cultural factors on health-related quality of life for people with spinal cord injuries. Dr. Denise Fyffe will use the Patient-Reported Outcomes Measurement Information System (PROMIS) to examine the cultural sensitivity of PROMIS quality of life instru...
Researchers have found evidence that meninges, a membrane surrounding the central nervous system, contains self-renewing stem cells. This discovery may lead to new treatments for spinal cord injuries and degenerative brain disorders, as these stem cells can proliferate and form glial scars after injury.
The New England Regional Spinal Cord Injury Center at Boston Medical Center has been awarded a five-year grant to continue as the leading center in New England for spinal cord injury care, education, and research. This designation underscores the center's commitment to staying on the cutting edge of spinal cord research and treatment.
New research reveals that spinal cord injuries are associated with a higher risk of developing heart disease, particularly in individuals with autonomic dysfunction. The study suggests that screening the autonomic system may be beneficial in evaluating cardiovascular health in spinal cord patients.
The University of Louisville and Frazier Rehab Institute have been awarded a $2.2 million grant to establish a Spinal Cord Injury Model System, which aims to provide comprehensive rehabilitative care and advance research into treating spinal cord injuries. The program will serve the states of Kentucky, Indiana, Ohio, and Tennessee.
Researchers believe that timing has finally come to support the conduct of human clinical trials for stem cell therapy in spinal cord injuries. Currently, research is largely stuck at the animal model stage. Studies evaluate 11 different cell types/sources and provide evidence justifying their use.
A new technology, FLAMES (floating light activated micro-electrical stimulators), has been developed to help individuals with spinal cord injuries. The device is wirelessly controlled and can activate nerves in the spinal cord, allowing patients to regain motor functions.
Researchers at Case Western Reserve University have restored breathing function in an adult rodent model of spinal cord injury by biologically regenerating lost nerve connections to the diaphragm. The enzyme-based technique showed promising results, with 80-100% breathing function restored and maintained for six months.
A study by Wayne State University researchers found that self-rated physical ability tops injury severity as a determining factor of health ratings in adults with spinal cord injuries. The study suggests that people with disabilities can still rate their health as excellent or good despite being confined to a wheelchair or paralyzed.
A study published in Cell Transplantation investigated the optimal routes for transplanting neural stem/progenitor cells in animal models of spinal cord injury. Intralesional injection was found to be the best method, with high cell survival rates and no complications. This method holds promise for treating other disorders
A team of scientists has achieved a significant breakthrough in treating paralysis, allowing a paralyzed man to stand and take steps with assistance. The study uses epidural electrical stimulation to mimic brain signals, enabling the spinal cord's neural network to initiate movement.
Researchers at the University of Louisville have achieved significant breakthroughs in treating paraplegia through epidural spinal cord stimulation and extensive locomotor training. The study's results, published in The Lancet, show that a paralyzed man can stand, step, and move his legs voluntarily with assistance.
Scientists have created a chemically synthesized siRNA molecule that decreases RhoA protein production, promoting tissue healing and reducing pain after spinal cord injuries. The minimally-invasive treatment shows promise for treating over 250,000 people living with spinal cord injuries in the US.
Researchers mapped spinal cord function using MRI to improve injury diagnosis and treatment. Attention levels impact spinal cord processing, affecting pain management for those with spinal cord injuries.
A new clinical prediction rule has been developed to predict a patient's chances of walking independently after a spinal cord injury, with accuracy exceeding 95%. The model uses a combination of age and four neurological test results, providing a simple yet effective tool for physicians to counsel patients and their families.
Researchers have discovered that specific human astrocytes derived from stem cells can repair damaged nervous systems and promote locomotor function in spinal cord injured rats. The study reveals the importance of creating beneficial cell types through tissue culture before transplantation, providing a potential new avenue for treating...
Two projects will test BCI technology in patients with spinal cord injuries, allowing them to control computer cursors and prosthetic limbs using their thoughts. The projects aim to gain a better understanding of how to train and motivate patients who will benefit from BCI technology.
Researchers found that functional electrical stimulation (FES) therapy worked better than conventional occupational therapy alone to increase patients' ability to pick up and hold objects. FES therapy also improved daily activities such as dressing and eating, with significant implications for quality of life and independence.
Patients with strokes and spinal cord injuries are prone to life-threatening blood clots. Despite the high risk, many do not receive preventive therapy. Studies show that starting heparin medication within 24-48 hours can be both safe and effective in preventing recurrent VTE.
Scientists identify specific receptors, TLR-2 and dectin-1, that can be targeted to stop damage while promoting nerve cell growth after a spinal cord injury. An experimental compound was found to activate the TLR-2 receptor alone, enhancing axon growth without causing cell death.
Researchers at the University of Florida discover that some children with spinal cord injuries may not regain movement after traditional assessments. However, through locomotor training, these children were able to improve their walking ability and trunk control, highlighting a potential new approach for rehabilitation.
Researchers discovered that connections in the spinal cord regrew spontaneously and extensively after a mild spinal cord injury in primates, restoring 60% of original connections. This finding holds significant promise for developing new treatments for patients with spinal cord injuries.
Researchers found a significant decrease in macrophage activity at spinal cord injury sites in mice without spleens, indicating the spleen's role in promoting inflammation. Understanding how these cells function and manipulating their release could improve treatment options for spinal cord injuries.
The Northwestern University-led trial assesses the safety and tolerability of human embryonic stem cell-derived oligodendrocyte progenitor cells in paralyzed subjects with spinal cord injuries. The goal is to evaluate if these stem cells improve neuromuscular control or sensation in the trunk or lower extremities.
Neuralstem's spinal cord stem cells survive and differentiate into neurons in rat brains affected by stroke, leading to improved motor skill and strength measurements. The study shows significant promise for treating post-stroke symptoms and paralysis.
A UC Irvine study shows that human neural stem cells can reverse long-term hind-limb paralysis in mice with chronic spinal cord injuries. The therapy demonstrates potential for treating a broader population of patients with spinal cord injuries.
Neural stem cells can repair damaged spinal cords by promoting nerve cell generation, restoring hind limb function in mice. Vitamin D may help prevent allergic bronchopulmonary aspergillosis in cystic fibrosis patients.
A team of researchers has developed an approach to repairing spinal cord injuries using manipulated neural stem cells. In a mouse model, the cells were combined with valproic acid and resulted in impressive restoration of hind limb function. Further work is needed to determine if this approach can be used in human patients.
Researchers at UCI, UCSD, and Harvard have induced robust regeneration of nerve connections that control voluntary movement after spinal cord injury. By deleting a cell growth inhibitor called PTEN, they achieved this breakthrough by turning back the developmental clock in a molecular pathway critical for the growth of corticospinal tr...
The US Department of Defense has awarded over $1 million to a team of researchers at the University of Western Ontario to develop an antibody treatment for spinal cord injuries. The therapy targets inflammation caused by CD11d protein, which can limit damage and improve recovery rates.
A team of researchers at Johns Hopkins University School of Medicine has shown that treating injured rat spinal cords with the enzyme sialidase improves nerve regrowth, motor recovery, and nervous system function. The treatment also showed improvements in blood pressure control and increased number of sprouted nerve ends.
Spinal cord injuries affect approximately 12,000 people annually and 259,000 Americans currently live with long-lasting SCI. A new study suggests that a multidisciplinary approach is most likely to achieve results in treating spinal cord injuries, leveraging expertise from several fields.
A study published by the German Cancer Research Center found that CD95L promotes tissue-damaging inflammatory reactions in injured spinal cord tissue. Blocking this molecule may offer a new approach to treating severe inflammatory diseases.
Researchers have discovered a compound that prevents short circuits caused by damaged nerves, restoring function and transmitting signals more efficiently. The experimental drug, 4-aminopyridine-3-methyl hydroxide, may also be used to treat multiple sclerosis.
A UCI embryonic stem cell treatment has shown promise in restoring limb function in rats with neck spinal cord injuries. The therapy may also benefit individuals with cervical damage, which currently lacks effective treatments.
Purdue researchers have discovered a new approach for repairing damaged nerve fibers in spinal cord injuries using copolymer micelles, which not only deliver drugs but also directly repair axons. The treatment boosts axon recovery from 18% to 60%, showing promising results for treating spinal cord injuries.
Weill Cornell Medical College researchers aim to boost NAD+ levels after spinal cord injury, potentially preventing permanent nerve death. The study involves synthesizing a molecule that increases NAD+ production in cells, which may activate sirtuins and prevent cell death.