Articles tagged with Thyroid Diseases
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A new study found that maternal thyroid hormones are crucial for fetal neurodevelopment, and gestational thyroid imbalance increases the risk of autism spectrum disorder. Women with persistent thyroid dysfunction across pregnancy were at a higher risk of having children with autism.
The European Society of Endocrinology (ESE) has announced the winners of the 2026 ESE Awards, which recognize outstanding contributions to improving knowledge and expertise in endocrinology. This year's winners include Martin Reincke for his work on neuroendocrinology and Maria-Christina Zennaro for her research on hypertension.
A new study found that age-, sex-, and race-specific standards could reclassify many thyroid disease diagnoses, with nearly half of subclinical hypothyroid cases being over-diagnosed. The study suggests using these standards to establish more accurate reference intervals for thyroid disease.
The IOF Advanced Course on Osteoporosis is a comprehensive, 18-hour online training programme designed to equip healthcare professionals with the latest knowledge in osteoporosis prevention, diagnosis, and management. The course aims to promote timely diagnosis and treatment, reduce patient burden, and improve global outcomes.
AIC100 demonstrated encouraging responses and an acceptable safety profile in patients with two types of advanced thyroid cancer, including anaplastic thyroid cancer (ATC) and relapsed/refractory poorly differentiated thyroid cancer (PTDC). The therapy showed significant tumor shrinkage and disease control in 56% of patients.
A new study finds that radioiodine therapy significantly increases relative survival rates in differentiated thyroid cancer patients, with benefits observed across low-, intermediate-, and high-risk subgroups. The treatment reduces recurrence rates and improves long-term survival in high-risk groups, while also showing promise for low-...
A study led by IGTP identifies an epigenetic signature of 156 altered CpG sites in primary tumours that can help stratify patients according to their risk of developing distant metastases. The findings contribute to a better understanding of the disease and open new avenues for patient stratification and personalised treatment strategies.
The European Society of Endocrinology and the European Hormone and Metabolism Foundation launch a global campaign to raise awareness about hormone balance and its impact on chronic diseases. Small steps can make a big difference in improving hormone health.
Researchers have identified promising drug targets for managing metabolic dysfunction-associated fatty liver disease, including FXR agonists and PPARα/γ agonists. These therapies aim to modulate lipid metabolism, inflammation, and fibrosis in the liver.
A study found that 10% of South Asian immigrants aged 45 and older in Canada had hypothyroidism. Higher dietary intake of fat, lower consumption of fruits and vegetables, and increasing age were associated with a higher risk of the condition. Early recognition and treatment are crucial to minimize preventable health impacts.
A new review reveals how sleep disturbances exacerbate dementia symptoms, impacting overall health and caregiver well-being. The study emphasizes the need for holistic approaches to address coexisting conditions like cardiovascular disease and diabetes.
Boston Medical Center and Boston University researchers have made a breakthrough in developing cell-based therapy for hypothyroidism. They derived transplantable thyroid follicular epithelial cells from human induced pluripotent stem cells, which can be transplanted into thyroid-deficient animal models.
Researchers have unveiled a complex interplay between liver X and thyroid hormone receptors that regulates critical brain functions and protects against neurodegeneration. LXRs play a crucial role in regulating thyroid hormone function in the brain, while both receptors are essential for normal brain development and maintenance.
A Carnegie Mellon-led team has secured a $42 million grant to develop implantable, cell-based bioelectronic devices for real-time therapy and disease monitoring in patients with thyroid disorders. The devices will offer adjustable, low-cost treatment and continuous biomarker measurement.
A large study found that women with premature ovarian insufficiency are 2.6 times more likely to have an autoimmune disorder, with some conditions increasing the risk by 26 times. The study suggests a strong link between POI and severe autoimmune diseases, highlighting the need for medical professionals to be aware of this increased risk.
High levels of lipoprotein (a) found in 20-34% of Polish patients with heart disease or at risk. Lp(a) measurements may be crucial in preventing cardiovascular diseases and atherosclerosis progression.
A new study found that subclinical hypothyroidism before 21 weeks of pregnancy is associated with a more than quadrupled risk of overt hypothyroidism or thyroid replacement therapy within 5 years of delivery. Individuals with higher levels of antibodies against a thyroid enzyme were also at increased risk.
A new study found that subclinical hypothyroidism diagnosed before 21 weeks of pregnancy is associated with higher rates of overt hypothyroidism or thyroid replacement therapy within 5 years after delivery. Women with high TSH values and elevated TPO antibodies were at increased risk.
A start codon variant in the LAG3 gene is associated with decreased expression of the protein and increased risk of autoimmune thyroid disease. The variant, found in Iceland and Finland, has a founder effect and demonstrates the power of bottlenecked populations to identify rare disease-associated variants.
A new study has found that women with a family history of endocrine diseases, including type 2 diabetes and polycystic ovary syndrome, are at a higher risk of experiencing pregnancy loss. The study, which examined over 366,000 women in Denmark, found a significant association between endocrine disease and pregnancy loss.
A study analyzing pooled clinical trial data found that teprotumumab maintained improvements in signs and symptoms of thyroid eye disease in most patients after 51 weeks. Nearly two years after the final infusion, 82% of patients did not require further treatment.
A new study found that pregnant women with lower socioeconomic status are exposed to higher levels of thyroid-disrupting chemicals, particularly polyaromatic hydrocarbons. This increased exposure has the potential to worsen health disparities among low-income populations.
A study found that patients with thyroid eye disease who received teprotumumab infusions maintained efficacy 51 weeks after treatment. Nearly two years later, 82% of patients did not require additional treatment for their condition.
A 8-year retrospective review found that atypia of undetermined significance (AUS) in thyroid fine needle aspiration cytology diagnoses have a risk of malignancy after repeat sampling. Nuclear atypia is associated with upgrading and surgery, while architectural patterns are less predictive of malignancy.
Researchers found a correlation between genetic variations in three telomere-related genes and an increased risk of developing papillary thyroid cancer. The study suggests that individuals with these variants may benefit from closer monitoring for secondary cancers, and highlights the role of long telomeres in cancer development.
A new study published in Thyroid found that individuals with low-risk differentiated thyroid cancer (DTC) in the US experience lower mortality rates compared to the general population. The most common causes of death were malignancies and cardiovascular disease.
A new study from Johns Hopkins Medicine finds that excess thyroid hormone levels are associated with a higher risk of cognitive disorders in older adults. The research suggests that clinicians should avoid overtreatment when prescribing thyroid hormone therapy to prevent potential negative consequences.
Researchers found that immunomodulatory drugs used to treat rheumatoid arthritis can reduce the risk of autoimmune thyroid diseases. Patients treated with these drugs had a 46% lower risk of developing an autoimmune thyroid disease compared to those without rheumatoid arthritis.
The American Thyroid Association has appointed Dr. Trevor E. Angell as the new Editor-in-Chief of Clinical Thyroidology. Dr. Angell succeeds Angela M. Leung and aims to continue the journal's upward trajectory. He brings expertise in thyroid diagnosis and treatment, having published research on thyroid nodules and molecular testing.
Thyroid cancer incidence is significantly higher in more affluent areas of São Paulo State, Brazil, compared to less developed regions like Barretos. The study suggests overdiagnosis may be responsible for this trend, with mortality rates remaining similar across socioeconomic groups.
Researchers from Boston University Chobanian & Avedisian School of Medicine summarize current evidence on hyperthyroidism management, focusing on Graves' disease and toxic nodular disease. The review highlights the importance of recognizing clinical signs and treating underlying causes to minimize health impacts.
A new study published in Exp. Mol. Med. has identified Thrap3 as a key player in exacerbating non-alcoholic fatty liver disease (NAFLD) by inhibiting AMPK, a crucial regulator of fat metabolism. Inhibiting Thrap3 expression presents a promising avenue for treating NAFLD.
A new nanogel-based carrier delivers a synthetic thyroid hormone mimick to liver cells, resulting in weight loss and improved cholesterol levels. The treatment also resolves liver inflammation with minimal side effects, offering potential for other liver-based diseases.
Inflammatory breast cancer is a rare and aggressive form of breast cancer with poor outcomes. Research highlights the role of ERβ as a mediator of estrogen signaling, demonstrating its tumor suppressive effects in preclinical models. ERβ's antimetastatic activity may hold promise for improving treatment options for IBC.
A study by Brigham and Women's Hospital found associations between phenol biomarkers and altered thyroid hormone levels in women attending a fertility clinic. The presence of certain environmental chemicals, such as bisphenol A and triclosan, was linked to changes in thyroid function, potentially affecting female fertility.
A new approach uses pretherapy imaging and dosimetry to personalize radioactive iodine treatment for refractory differentiated thyroid cancer patients. The method allows researchers to calculate personalized dosage of treatment, resulting in improved outcomes.
Researchers found that radioactive iodine and thyroidectomy significantly increased survival rates for patients with hyperthyroidism. The treatments were associated with a decreased risk of death compared to antithyroid drugs, and had varying effects on weight gain.
A new study at Boston University School of Medicine found that specific subpopulations of hypothalamic neurons play a major role in regulating thyroid hormone levels. The researchers also discovered that these neurons respond to fasting and weight loss, shedding light on the central control of metabolism.
Scientists discovered a novel method to activate G protein-coupled receptors from inside cells, which can help develop drugs with fewer or no side effects. This new process uses a non-peptide message molecule called PCO371 that binds to the intracellular region of the receptor and interacts directly with G protein subunits.
A Keck School of Medicine study found exposure to PFAS, known as 'forever chemicals,' disrupts key biological processes in children and young adults, increasing risk of diseases such as developmental disorders, cardiovascular disease, and cancer. The study highlights the importance of regulating PFAS as a class of chemicals.
Researchers used materials science to analyze microcalcifications in breast tissue, revealing groups that reflect tissue type and malignancy. The study also found variations in mineral composition and trace metals in malignant calcifications.
A study of 1,300 patients found most thyroid cancers are discovered in asymptomatic individuals, supporting the hypothesis of ongoing subclinical disease detection. The findings contradict the notion of a rising incidence of thyroid cancer.
A study published in the Endocrine Society's Journal of Clinical Endocrinology and Metabolism found that undertreatment with thyroid hormone replacement can lead to longer hospital stays and higher readmission rates. Patients with high TSH levels before hospitalization had a 49% higher risk of 30-day readmission.
Researchers at Children's Hospital of Philadelphia define a 3-tiered molecular classification system for pediatric differentiated thyroid cancer, where fusion oncogenes are associated with more invasive disease and lower remission rates. The study contrasts findings from adults, who have a two-tiered system based on BRAF mutations.
Researchers found that vitamin D and/or omega-3 fatty acid supplements significantly lowered the rate of autoimmune diseases like rheumatoid arthritis, polymyalgia rheumatica, and psoriasis. The largest benefit was seen after two years of supplementation with daily doses of vitamin D (2000 IU) and marine omega-3 fatty acids (1000 mg).
Researchers found high levels of per- and polyfluorinated alkyl substances (PFAS) in anti-fogging sprays and cloths sold on Amazon. The products contained fluorotelomer alcohols and fluorotelomer ethoxylates, which are associated with impaired immune function, cancer, and other health disorders. The study highlights the need for more r...
A study by University of New South Wales has found that one in five future thyroid cancers in Australia is attributable to current levels of overweight and obesity. The prevalence of obesity has doubled in the last two decades, with 75% of Australian men and 60% of women being overweight or obese.
Researchers used Mendelian randomization to analyze the genetic association between thyroid function and serum lipid profiles, finding a distinct causal relationship. The study highlights the importance of pituitary-thyroid-cardiac axis in diseases related to dyslipidemia.
Dr. Catherine F. Sinclair has been selected as the next Editor-in-Chief of VideoEndocrinology, a pioneering videojournal covering thyroid, parathyroid, and endocrine-related procedures. She brings extensive experience in surgical management of neck endocrine diseases and is an internationally recognized expert.
Researchers investigating COVID-19's impact on the thyroid gland found atypical inflammation in 1/3 of patients after 3 months, raising concerns about potential long-term damage. The study aims to determine if this inflammation triggers permanent thyroid dysfunction.
A new FDA-approved medication has been shown to effectively treat thyroid eye disease in patients of all ages and genders, regardless of their smoking status. According to a study, teprotumumab reduces inflammation and tissue buildup behind the eye, leading to improved symptoms and quality of life.
A study of 30,180 patients with papillary thyroid microcarcinoma found that nearly 20% had pathological signs of aggressive disease, increasing the risk of distant metastasis. The research emphasizes the need for new preoperative tests to identify high-risk tumors and thorough patient counseling on all treatment options.
The American Association of Endocrine Surgeons has published comprehensive clinical guidelines for surgical treatment of thyroid disease in adults. The guidelines emphasize personalized, evidence-based care and focus on optimizing patient outcomes.
A new minimally invasive treatment has shown significant improvement in symptoms and quality of life for patients with thyroid eye disease. The drug, teprotumumab, blocks inflammatory autoimmune pathophysiology and has the potential to alter the course of the disease.
Radioactive iodine is now the recommended frontline treatment for patients with thyroid gland overactivity, including Graves' disease. The new guidelines, developed by University of Birmingham researchers, show that radioactive iodine improves cardiovascular outcomes and cures 90% of cases.
Researchers developed a novel noninvasive imaging technique using multispectral optoacoustic tomography (MSOT) and ultrasound to diagnose thyroid disorders. MSOT/ultrasound images revealed significant biomarker changes in Graves' disease and malignant thyroid nodules, showing promise for improved diagnostics.
A University of Cincinnati study found that abnormal thyroid function is present in just over 6% of psychiatrically hospitalized youth. The research suggests that targeted screening should focus on patients with a family history of thyroid disease, recent weight gain, or treatment with specific medications.
The guidelines present key areas for research, including biomarkers of thyroid action in cardiovascular tissues and clinical trials involving thyroid medications. The connection between thyroid and cardiac function has been identified as a crucial area for further investigation.
A new study published in the Journal of Pediatric Surgery found that post-operative success rates for pediatric thyroid patients correlate with institution patient volume. The study showed extremely low complication rates, underscoring the importance of high-volume centers with specialized pediatric surgeons.
Researchers found that autoimmune diseases like Addison's and vitiligo often cluster together due to genetic links. In contrast, celiac disease tends to be less associated with other autoimmune conditions.