Researchers at Kumamoto University and collaborators developed a method to produce human trophoblast stem cells from late-gestation placentas, opening a new avenue for studying pregnancy complications. The resulting patient-derived models reproduce key features associated with preeclampsia, enabling the uncovering of molecular mechanis...
A new clinical trial will investigate whether adding the oral medication vorasidenib to standard chemotherapy improves progression-free survival for people with newly-diagnosed, grade 3 IDH-mutant astrocytoma. The study aims to recruit 400 individuals with this type of brain cancer and evaluate the safety and side-effect profile of the...
A recent study found that women have a 21% lower risk of death compared to men, but a 12% higher risk of severe side effects from cancer treatment. The research, conducted in partnership with international collaborators, analyzed data from over 20,000 cancer patients and identified sex-based differences in survival and treatment toxicity.
Researchers discovered that a small subpopulation of AIB1-expressing cells in breast cancer enables invasion and metastasis. The study suggests that these subpopulations play a crucial role in tumor growth and spreading to distant sites.
Scientists have identified specific long noncoding RNAs that regulate gene expression and life cycle progression of the deadly Plasmodium falciparum malaria parasite. The discovery could lead to new therapeutic strategies against malaria.
A new study from Duke University identifies 1,500 genes essential for invasive cell behavior in C. elegans worms. The researchers created a 'parts list' of these genes and proteins, which may help identify effective ways to stop cancer's spread.
Researchers discovered a type of triple-negative breast cancer cell that can trigger dormancy, evading therapies and allowing for efficient survival in distant organs. This finding highlights the need for more selective therapeutic strategies targeting both dividing and invasive dormant cells.
Researchers have identified fascin as a key player in promoting cancer development, with the protein controlling cell movement and invasion. Forcing fascin into the nucleus of cancer cells could prevent their growth and movement.
Researchers at TIBI developed a minimally invasive method for targeted delivery of immunotherapeutic treatments, resulting in slower tumor growth and higher activation of T-cells. The injectable gelatin biomaterial containing silicate nanoplatelets showed sustained drug release and controlled ICI delivery.
A study by Michigan Medicine researchers has identified oncostreams, highly active cells connected to brain tumor growth and invasion. The team found that eliminating Collagen 1 production from tumor cells reduces tumor aggressive behavior. This discovery could lead to novel therapeutic targets for treating lethal brain tumors.
Researchers led by Atsuo Sasaki aim to identify mechanisms behind cell movement and energy allocation in cancer cells, with potential applications beyond cancer treatment. They will use scanning ion-conductance microscopy and machine learning technology to study the role of GTP in cellular migration.
Researchers found that COPD leads to premature senescence of the immune system, reducing CD4+ and CD8+ T cells. This disruption impairs the immune system, making COPD patients more susceptible to infections.
Researchers at Mount Sinai have discovered a previously unknown mechanism by which not-yet-malignant breast cancer cells can travel to other organs and 'turn on' to become metastatic. The study identified potential diagnostic biomarkers, including the transcription factor NR2F1, that could help predict relapse.
Researchers discovered that sialylation of the epidermal growth factor receptor modulates cell mechanics and enhances cancer cell invasion. ST6Gal-I, an enzyme that adds sialic acid to EGFR, plays a key role in tumor progression and metastasis.
Researchers have found that treating prostate cancer cells with novel CDK8 and CDK19 inhibitors reduces their potential to migrate into surrounding structures. This suggests a promising approach to overcome resistance against anti-androgenic therapy, offering new therapeutic options for patients with advanced disease.
Research reveals extracellular vesicles facilitate coordinated responses among pathogenic fungal cells, enabling them to overcome host defenses. The discovery could lead to the development of more effective therapies to combat fungal infections.
Researchers develop innovative non-contact agitation technology to assess motility and invasive capacity of cancer cells in tissue sections. The study reveals significant increases in Rac/Cdc42 activity in tumor areas, with stronger correlations found in advanced cancer stages.
Researchers have identified two glucose transporters that disrupt the energy supply to invading worm cells and stop them in their tracks. By deactivating these genes, glucose and ATP levels dropped, and worm cells stalled their spread. This discovery could lead to new ways to cut off cancer cells' fuel lines and prevent metastasis.
A new study reveals that the curved shape of a predatory bacterium enables it to efficiently invade and consume harmful bugs like E.coli and Salmonella. The bacterium, called Bdellovibrio bacteriovorus, uses a specialized protein to sculpt its own shape, allowing it to fit into prey cells and grow inside them.
A new phenomenon was discovered where increased pressure leads to a sudden burst of rapid and coordinated cellular motion, spraying outwards from the tumour. This fluid-like pushing mechanism can kill cancer cells but also enables them to survive and multiply in new environments.
Researchers identify two genes, GLI1 and Notch1, responsible for aggressive growth and spread of triple negative breast cancers in African American women. A combination approach using inhibitors and chemotherapy agents significantly inhibits tumor growth and metastasis.
Researchers at San Diego State University have discovered a novel way bacteria infect cells by producing long threads, which grows up to 100 times the size of a bacterium in 30 hours. This mechanism allows the bacteria to rapidly infect multiple cells and access more nutrients for growth.
Research from the University of Virginia Health System found that long-term use of ACE inhibitors and angiotensin receptor blockers can lead to hardened kidney vessels. The drugs, commonly prescribed for high blood pressure and heart failure, were associated with damage in both lab mice and humans.
Researchers identified antibodies targeting conserved sites on the spike protein, showing promise against future variants. Antibodies from vaccinated individuals retained some activity, while those with prior infection had reduced effectiveness.
A new study reveals the sophisticated mechanism by which adenoviruses infect human cells and transfer foreign DNA into their nucleus. Protein V plays a crucial role in increasing the virus particle's stability and preventing premature DNA release, which triggers an anti-viral alarm system.
Researchers at Massachusetts General Hospital have uncovered important details about Shigella's translocon, a pore that injects bacterial proteins into infected cells. The findings may help develop an effective strategy to block this critical component of infection and prevent diseases like dysentery.
A UBC-led research team discovered that SARS-CoV-2 attaches to and deactivates galectin-8, a sensor protein that protects cells against infection. By disabling this defense system, the virus can hijack host cells to produce more viruses.
Researchers from the University of Seville discovered that a single amino acid mutation in Salmonella enzymes enables them to modify more proteins in infected cells, leading to increased virulence. This finding has significant implications for developing inhibitors as alternative antibacterial treatments.
Researchers found a correlation between high levels of Gas6 and zika-induced neurological complications. Gas6 helps the virus invade human cells, facilitating viral replication and aggravating infection. The discovery paves the way for future research on developing drugs to combat the virus.
Research at CNRS reveals that compressed cell nuclei can lead to DNA damage and accelerated aging in healthy cells. In breast tumors, this damage enables tumor cells to invade neighboring tissues with increased risk of metastasis.
Researchers at the University of São Paulo found that a hypertonic saline solution can inhibit SARS-CoV-2 replication by up to 88% in human epithelial lung cells. The study suggests that the use of such a solution could contribute to the development of novel prophylactic interventions or treatments for COVID-19.
The Luxembourg Institute of Health (LIH) research team discovered a key regulator, ZFAND3, that drives glioblastoma invasion by activating specific genes. Deactivating or overexpressing ZFAND3 in GBM cells impaired or enhanced their invasive capabilities, respectively.
Michigan Technological University and University of Massachusetts researchers develop a way to mimic the body's environment in vaccines, keeping viruses stable through crowding. This method has potential to improve access to vaccinations against various viruses, bypassing the cold chain.
Scientists have developed an optical elastography technique that can detect biomechanical alterations in cells and tissues non-invasively. The new technique uses Brillouin microscopy to highlight microscopic processes driving mechanical modification in biological tissues.
A new test developed by Johns Hopkins University can accurately pinpoint and capture the deadliest cells in glioblastoma, a type of fatal brain cancer. The method's accuracy in predicting patient outcomes varies from 86% to 100%, suggesting its potential for developing targeted therapeutics.
Tiny finger-like projections called filopodia play a crucial role in invasive behavior of rare lung cancer cells. The cells have longer filopodia than their counterparts, which is linked to the gene MYO10, stabilizing these structures. This discovery could help develop treatments that prevent cancer from spreading.
Researchers at Baylor College of Medicine and Indiana University have found that rotavirus induces hundreds of discrete and highly dynamic calcium spikes during peak infection. These spikes can be attenuated by genetically knocking down the virus's NSP4 protein, which disturbs calcium balance within cells.
Researchers found that cancer cells switch to brute force and build a protrusion when MMP enzymes aren't available. This allows them to penetrate the basement membrane and invade other organs. The study identified a mitochondrial gene target that could be used to develop new treatments.
A study using Drosophila has demonstrated that chromosomal instability promotes invasive behavior in epithelial cells, activating key signaling pathways. The researchers identified the oncogene Fos and tumour suppressor Capicua as crucial players in this process, paving the way for future treatments.
A study describes a microfluidic system to concentrate and encapsulate circulating tumor cells, which are cancer cells that can travel through the bloodstream. Experiments with prostate cancer cells revealed high matrix metalloprotease enzyme activity.
Researchers have found that the cell layer surrounding breast milk ducts acts as an active defense mechanism to prevent cancer cells from spreading, grabbing stray cells and pulling them back in up to 92% of the time. This discovery challenges previous assumptions about the myoepithelial layer's role in cancer invasion.
Researchers found that impairing Paneth cells allows gut bacteria to invade the small intestine, causing major inflammation. Normal autophagy in Paneth cells is required to regulate bacteria, keeping it at bay and preventing disease.
Researchers identify a fleeting, yet key structure that allows cells to break through tissues and spread to other parts of the body. A single protrusion bulges out from the cell surface, wedges a hole through the protective layer, and swells until the breach is wide enough for the entire cell to squeeze through.
Researchers at Lomonosov Moscow State University discovered a new method of destroying cancer cells through a process called entosis, where one cell invades and digests another. The study reveals the five stages of entosis, which involves changes in structural and functional characteristics of both cells.
Researchers at the Francis Crick Institute have worked out how major players in border formation between tissues keep cells in the right places. They found that ephrins and their Eph receptors trigger signalling inside both cells, stopping them from mixing, and that N-cadherin suppresses repulsion between like cells.
A study published in Oncogene has shed new light on the molecular mechanisms of ovarian cancer spread. Researchers found that N-cadherin plays a key role in metastasis by enabling cancer cells to anchor to new sites in the body, and that disrupting this process may provide a therapeutic strategy.
Lung cancer cells in an invasive pack have specialized roles as leaders and followers, which depend on each other for mobility and survival. The leader-follower symbiosis could be a key target for future treatments aimed at impairing or preventing cancer metastasis.
A QUT-led project has identified the mechanism by which melanoma cells switch from proliferative to invasive behavior, opening up new pathways for cancer treatment. The discovery reveals a specific regulatory pathway involving the NFIB-EZH2 axis, which could potentially be targeted with existing drugs.
Researchers discovered that Immunoglobulin D (IgD) keeps 'traitor cells' in lockdown, preventing auto-antibodies from damaging body tissues. IgD promotes the formation of germinal centres, allowing these cells to target invaders when needed.
Researchers observed microsporidia fuse animal cells together to multiply and spread within hosts' uninfected cells. The process allows for rapid replication and invasion of the entire intestinal organ.
A new group of cells has been discovered in the human colon that can wash away invading bacteria, potentially preventing inflammatory bowel disease. These sentinel cells detect bacteria and trigger a rapid chain reaction of mucus production to push out the invaders.
New research identifies genetic variants associated with autoimmune diseases, providing potential therapeutic targets for treatments. The study mapped DNA regions regulating immune cells and found links to various autoimmune diseases.
Gram-negative bacteria use vesicles to communicate with and influence neighboring cells, triggering a deadly response in the body. The vesicles can lead to inflammation, fever, and low blood pressure, making sepsis difficult to cure.
Researchers have successfully observed raft domains in live cells using new fluorescent probes, revealing dynamic interactions between gangliosides and cholesterol. The findings open up new avenues for investigating how toxins, bacteria, and viruses invade cells through these membrane structures.
A newly discovered human protein called intelectin has the ability to selectively identify and distinguish between human cells and those of disease-causing microbes. This discovery could lead to the development of new antibiotics and strategies to combat infectious diseases.
Researchers found that oral thrush activates a mechanism in T-reg cells to transform inflammation-fighting cells into cells that allow the disease to flourish. The study may lead to new ways to fight diseases by identifying chronic inflammation and blocking inflammatory proteins.
Researchers discovered that cells with low levels of profilin 1 protein in breast tumors have increased capacity to metastasize and invade other tissues. The protein regulates the formation of invasive structures called invadopodia, which play a critical role in tumor invasion and metastasis.
Researchers at EMBL found that IGF-1 enhances T-reg cell production, suppressing auto-immune diseases like type-1 diabetes and multiple sclerosis. The molecule is already approved for use in patients, paving the way for clinical trials.
Researchers at Rice University created patches infused with conductive single-walled carbon nanotubes to overcome limitations in current patches, which hinder the transfer of electrical signals between cardiomyocytes. The patches can serve as full-thickness repairs without inducing abnormal cardiac rhythms.
Researchers have developed a minimally invasive gene therapy procedure that transforms ordinary heart muscle cells into specialized 'biological pacemaker' cells. This breakthrough could lead to a long-lasting treatment for patients with heart rhythm disorders, potentially eliminating the need for electronic pacemakers.