Articles tagged with Insulin Secretion
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CHOP researchers have developed a targeted treatment that controls blood sugar in patients with hyperinsulinism, a genetic disease. The study found exendin-(9-39) reduces likelihood of fasting hypoglycemia by 76% and protein-induced hypoglycemia by 82%
Researchers at Lund University have found a link between microRNA levels and insulin secretion in type 2 diabetes. By reducing the levels of miR-200c, they were able to increase insulin secretion in human cells.
Researchers identified peripheral tissues as source of blood amyloid beta, which regulates blood glucose levels and suppresses insulin secretion. The study suggests a possible mechanism linking type 2 diabetes to Alzheimer's disease development.
Researchers at Boston Children's Hospital have developed an organoid platform that identifies drugs that enhance enteroendocrine cell action, potentially reversing diabetes, obesity and gastrointestinal conditions. The system identified three chemicals that drive the formation of EE cells and hormone production.
Regular physical activity significantly changes metabolite profiles, associated with a lower risk of type 2 diabetes. The study found improved insulin secretion and reduced fasting glucose levels in physically active men.
A randomized controlled trial found that late eating, associated with high melatonin levels, impairs blood sugar control through a defect in insulin secretion. Participants with the genetic variant in the MTNR1B gene had higher blood sugar levels, highlighting the importance of considering genetics in food timing recommendations.
Individuals with high-risk prediabetes significantly improved their blood glucose levels through more exercise and healthy eating behavior, while those at low risk showed limited benefits from conventional lifestyle intervention. The study's findings support personalized interventions tailored to each patient's risk profile for effecti...
A multicenter clinical trial demonstrates insulin secretion from engrafted stem cells in patients with type 1 diabetes. The study shows 20% reduced insulin requirements and 13% more time spent in target blood glucose range over a one-year follow-up period.
Microtubule structures play a crucial role in regulating insulin release from pancreatic beta cells, with dynamic turnover leading to increased insulin secretion. The findings have important implications for understanding diabetes and could lead to new treatments.
A transgenic pig model has been developed allowing for the first time the in vivo fluorescent labeling of age-distinct insulin secretory granule pools. This model enables researchers to study insulin turnover in normoglycemic conditions, closing the translational gap between humans and rodents.
Researchers developed an experimental device to improve blood sugar control in HI patients. The bihormonal bionic pancreas (BHBP) helps maintain stable glucose levels without human error in calculating doses.
Researchers found that certain peptides associated with migraine pain can regulate insulin production in mice, potentially preventing type 2 diabetes. The study suggests that these peptides could be developed into therapeutic strategies to control blood sugar levels, while minimizing the risk of migraines.
A study revealed that incretin-based drugs act on the Gq signaling pathway to promote insulin secretion and improve blood glucose levels in diabetic patients. The researchers found that a switch from Gs to Gq signaling occurs in pancreatic β-cells due to continuous cell excitation.
Researchers discovered a previously unknown way that pancreatic cells decide how much insulin to secrete, pointing to an overlooked enzyme known as pyruvate kinase. Stimulating pyruvate kinase not only increases the secretion of insulin but also has other metabolically protective effects in the liver, muscle and red blood cells.
A study in Journal of Biological Chemistry describes a new way to determine the age of insulin-storage parcels and sheds light on how their age affects their release into the bloodstream. This finding could help experts better understand diabetes and fine-tune therapies for it.
Disturbances in the internal clocks of pancreatic cells are linked to type-2 diabetes. Researchers successfully restored clock function using a natural compound, improving insulin secretion and providing new hope for diabetes care. The study shows that synchronizing the internal clocks can help regulate blood sugar levels.
A new study confirms breastfeeding is crucial for preventing diabetes, as early weaning increases insulin secretion and susceptibility to Type 2 diabetes. The research suggests that not breastfed rat pups are more likely to develop insulin resistance and the adult form of the disease.
A recent study has identified the gene function that protects against type 2 diabetes, revealing a zinc transporter's role in insulin secretion. The research found that individuals with a specific mutation in the SLC30A8 gene have enhanced glucose-stimulated insulin secretion and reduced blood sugar levels.
Researchers at Uppsala University have identified a previously unknown protein, Sac2, that regulates insulin secretion from β-cells. Lowering Sac2 levels leads to reduced insulin secretion, highlighting the importance of fat composition on secretory granule function.
Researchers at Ohio University are investigating the pulsatility of pancreatic islets in an effort to prevent or reverse type 2 diabetes. By forcing exhausted beta cells to pulse, they aim to restore their healthy functioning and improve health prospects for patients with pre-diabetes and diabetes.
A new study from Lund University found that Indian women are younger and leaner when developing gestational diabetes compared to Swedish women. The researchers identified a gene linked to increased risk in Swedish women but protective effects in Indian women.
Researchers found that silencing microRNA-132 improved insulin secretion and reduced blood glucose in mice and human islet cells. The study suggests antagomir-132 as a potential treatment approach for type 2 diabetes.
Researchers found that low-carb diets resulted in significantly greater energy expenditure compared to high-carb diets. Participants on the low-carb diet burned an average of 209-278 kilocalories per day more than those on the high-carb diet, leading to improved weight loss maintenance.
Scientists have discovered a way to restore normal insulin cell function in type 2 diabetes by blocking a protein called VDAC1. The study showed that the substance can prevent the development of the disease and improve glucose control. Further studies are needed, but the findings offer new hope for treatment options.
A novel process produces cell-sized lipid vesicles that can be functionalized to interact with cells, inducing specific cellular responses. The technology has high therapeutic potential for treating Type 2 diabetes.
A randomized clinical trial of 609 overweight adults found no significant difference in weight loss between low-fat and low-carbohydrate diets. The study also failed to find associations between genetic makeup, insulin secretion levels, and weight loss outcomes.
A study by Uppsala University researchers reveals that a vesicle attachment defect is the root cause of insulin secretion problems in type-2 diabetes. The defect leads to slowed arrival of new insulin-containing vesicles at the cell membrane, resulting in insufficient insulin release.
A new type of diabetes has been identified caused by a mutation in the RFX6 gene, leading to reduced insulin secretion and increased risk before age 20. GIP analogs may provide a novel treatment option for patients with this condition.
A study published in The FASEB Journal discovered that a commonly known protein complex can stimulate insulin secretion in pancreatic cells. This finding provides insights into new treatments for conditions where the body produces insufficient insulin, such as diabetes.
Researchers found Epac2A controls insulin release amount and timing at cell membrane sites. Patients with type 2 diabetes have lower Epac2A levels, suggesting a link to reduced insulin secretion.
A mislocalized calcium channel contributes to failed insulin secretion in type-2 diabetes, disrupting the cellular signal for release. Researchers found that the channel proteins are located too far away from insulin vesicles, causing secretion to fail.
Researchers discovered a dual peptide called PGLP-1 that promotes insulin secretion and inhibits gluconeogenesis, potentially improving glycemic control in type 1 diabetes. It also shows promise in reducing insulin resistance in patients with type 2 diabetes.
Researchers found that a SNAP23 inhibitor increases insulin secretion in mice, suggesting a novel therapy for diabetes. The study also showed that SNAP23 promotes vesicle fusion in nonneuronal cells, including pancreatic cells.
Studies reveal genes respond differently to high insulin levels and sustained low levels, with some expressing quickly and others repressing themselves. Researchers developed a method to control gene expression using temporal patterns and doses of insulin.
Researchers found that just 1-10% of beta cells control islet responses to glucose, serving as pacemakers for insulin secretion. This discovery could pave the way for therapies targeting these 'hubs' to treat type 2 diabetes.
A new experimental and clinical study from Lund University shows that the sleep hormone melatonin impairs insulin secretion in people with a specific gene variant. The researchers found that carriers of this gene have a higher risk of developing type 2 diabetes, with impaired insulin secretion and increased glucose levels in their blood.
Researchers found that IL-1β increases insulin levels in healthy human islets. In contrast, islets from obese individuals with type 2 diabetes were not responsive to IL-1β stimulation. The study suggests that IL-1R signaling plays a crucial role in glucose homeostasis.
Researchers found that a cell aging program increases insulin secretion in human and mouse pancreatic beta cells, improving their function. This discovery suggests that cellular aging can bring unexpected benefits to the production of insulin, potentially leading to new insights and treatments for diabetes.
Researchers found that microtubules limit glucose-stimulated insulin secretion, but also allow for increased release when destabilized. Targeting microtubule regulation may offer new ways to treat type 2 diabetes.
Researchers at Duke University Medical Center and the University of Alberta have discovered a new biochemical pathway that controls insulin secretion from islet beta cells in the pancreas. The study found that impairing this pathway, known as S-AMP production, disrupts normal glucose-stimulated insulin secretion.
A study by University of Alberta researchers discovered a new molecular pathway that manages insulin production, offering hope for restoring the 'dimmer switch' in Type 2 diabetes. The findings suggest that this pathway can be revived to control insulin secretion from islet cells.
Researchers have created a smart insulin patch that can detect increases in blood sugar levels and secrete doses of insulin, potentially replacing painful injections for diabetes. The patch uses microneedles to administer insulin, which is released when blood glucose levels get too high.
Researchers have identified a gene that may help reactivate insulin-producing beta cells in diabetics. The team, led by Professor Tessem and including four students with Type 1 diabetes, has made significant breakthroughs in understanding the molecular pathways involved.
Researchers at the University of Helsinki have uncovered a new regulatory system that senses nutrient deprivation and inhibits growth in fruit flies. This system, which involves protein kinase ERK7, prevents secretion of insulin-like peptides during starvation.
Researchers at Lund University have developed a personalized treatment for type 2 diabetes that targets the disease mechanism itself, rather than just its symptoms. The treatment, which uses a drug called Yohimbin, has shown promising results in improving insulin secretion in patients with the genetic risk variant.
Researchers found that pyruvate oxidation directly influences β-cell growth and maturity, highlighting the importance of glucose metabolism for β-cell mass maintenance. The study demonstrates a critical role for pyruvate dehydrogenase complex in regulating β-cell development and plasticity.
Researchers at the University of Montreal have identified a novel enzyme, ABHD6, that breaks down a fat-like signal involved in insulin release. Inhibiting this enzyme may increase insulin levels in blood and improve sensitivity to insulin, providing a potential new target for type 2 diabetes treatment.
A newly discovered human peptide called humanin may become a new treatment for diabetes by increasing insulin secretion and improving glucose metabolism in beta cells. Humanin levels naturally decline with age, suggesting potential benefits for patients with other conditions like stroke, heart disease, and Alzheimer's.
Scientists at Scripps Research Institute have created a comprehensive roadmap of the protein interactions that enable cells in the pancreas to produce, store and secrete insulin. The finding makes possible a deeper scientific understanding of the insulin secretion process and how it fails in insulin disorders such as type 2 diabetes.
Researchers at UC San Diego identified fractalkine as a new therapeutic target for treating type 2 diabetes. Administering the protein stimulated insulin secretion and improved glucose tolerance in mouse models and human islets.
Researchers develop a human liver-chimeric mouse model to study malaria parasites and understand human host/parasite interactions. Additionally, studies reveal the link between serum ferritin levels and insulin sensitivity, as well as the role of granulocyte-colony stimulating factor in protecting against influenza infection.
A study published in PLOS Genetics identified a gene and protein involved in regulating insulin secretion in obese mice. The researchers found that a single amino acid difference in the tomosyn-2 protein destabilizes it, leading to an insufficient insulin response and diabetes susceptibility.
A study has identified a gene, Tomosyn-2, that confers diabetes susceptibility in obese mice by regulating insulin secretion. The protein acts as a brake on insulin release from the pancreas, and its destabilization allows for sufficient insulin production to prevent diabetes.
Researchers at York University have identified a protein called nesfatin-1 that stimulates insulin secretion and regulates appetite, leading to potential weight loss and improved blood sugar control. The study found that rats administered with nesfatin-1 ate less, used more stored fat and became more active.
Barbara E. Corkey, PhD, is being honored by the American Diabetes Association for her 35-year contributions to understanding diabetes and its treatment. Her work has shown that oscillations in beta cell Ca2+ fluxes influence insulin secretion and that elevated glucose and lipids cause tissue malfunction in diabetes.
A Mayo Clinic research team has demonstrated a promising alternative strategy for treating type 2 diabetes by blocking the breakdown of insulin. In mouse studies, these mice showed increased insulin levels, weight loss, and improved blood sugar control.
A research team led by Makoto Tominaga found that TRPM2, a body temperature sensor, plays a crucial role in regulating insulin secretion. In TRPM2-deficient mice, impaired insulin secretion and elevated blood glucose levels were observed.
A study found that the protein tPA protects nerve cells in the brain from death caused by reduced blood flow, leading to two proposed models for its protective effect. Another study identified IL-15 as a potential new target for treating type II refractory celiac disease.
A specific gene in the pancreas affects insulin secretion, leading to improved blood glucose regulation and potential new treatments for diabetes. The discovery opens a new understanding of diabetes pathophysiology.
Researchers develop cheap and efficient method to identify small molecules for diabetes treatment, finding NAADP plays a crucial role in insulin secretion. This discovery could lead to a new class of drugs to treat type 2 diabetes.