Articles tagged with Pathology
Researchers developed a new DNA analysis technique to study old genetic samples, shedding light on disease evolution and changes in biology over time. The approach has potential for unlocking the root causes underlying shifting landscapes of modern diseases.
Acute lung injury is characterized by diffuse inflammation and intractable hypoxemia, with N6-methyladenosine methylation playing a crucial role in its pathogenesis. The review synthesizes findings from multiple studies, highlighting the dynamic nature of m6A methylation and its associated proteins.
The study highlights the frequent use of aerosol therapy in critically ill patients with acute respiratory distress syndrome (ARDS), with bronchodilators being the most commonly prescribed drugs. However, the lack of sound scientific evidence and randomized controlled trials suggests that standardized protocols are needed to align clin...
The Association for Molecular Pathology recognized Dr. Laposata's contributions to clinical laboratory practice and his role in challenging the FDA's rule on laboratory-developed test regulation. The award preserves diagnostic innovation, ensures patient access, and avoids escalating healthcare costs.
A new study projects that US funding cuts will result in a catastrophic effect on pediatric TB, with children in Sub-Saharan Africa and Southeast Asia experiencing a significant spike in preventable cases and deaths over the next decade. The loss of US bilateral health aid is projected to result in an additional 2.5 million pediatric T...
A new multi-omics tool, GoT-Multi, has enabled researchers to gain insights into how cancers evolve towards greater aggressiveness and therapy resistance. The tool can analyze diverse types of pathology samples and quickly process large numbers of cells, revealing new details about cancer progression.
The Association for Molecular Pathology has created a standardized biomarker report template to simplify complex molecular profiling data presentation to oncologists and healthcare providers. The template includes guidelines for clear formatting, therapeutic guidance, and references to clinical practice guidelines.
Paul N. Staats, MD, has been appointed Chair of the University of Maryland School of Medicine's Department of Pathology, overseeing clinical services to multiple hospitals and laboratories. He will drive partnerships and expand outpatient laboratory services.
Researchers found tiny air pollution particles sticking to red blood cells after exposure to roadside pollution, which can travel to organs like brain and heart. Wearing an FFP2 face mask reduces the amount of particles stuck to red blood cells.
A University of Georgia-led study surveyed over 18,000 people across 68 nations, finding that those in countries with historically higher disease risks believe the human species is headed in a good direction. This positive outlook may be an evolutionary adaptation that enhances resilience against disease and stress.
A Cornell University study detected disease-causing microbes like Salmonella, Cronobacter, and E. coli in raw cat foods sold frozen, refrigerated, and freeze-dried. These pathogens can transfer from pets to humans, especially young children, the elderly, pregnant individuals, and those with weakened immune systems.
Research links oral bacteria to Parkinson's disease via the gut-brain axis, finding Streptococcus mutans produces metabolite imidazole propionate that contributes to disease progression. Targeting the oral-gut microbiome may offer a new therapeutic approach for Parkinson's treatment.
Researchers have created a statistical model using 20 years' worth of sentinel chicken data to predict elevated West Nile virus activity up to six months in advance. This breakthrough could lead to proactive preventative measures and improve disease outbreak response.
A new reporting checklist introduces key methodological details to improve reproducibility and transparency in AI-based automated image analysis. The guidelines will support clear communication of methods and reduce cognitive bias, promoting the translation of AI tools into routine pathology workflows.
Researchers at Uppsala University have developed an AI system that can detect subtle tissue changes indicative of prostate cancer, missing it from human pathologists. The study found the AI detected cancers in over 80% of cases where pathologists missed them.
Researchers envision AI-powered systems that identify patients at risk of mental health struggles, provide continuous psychological monitoring and tailor interventions. AI can also overcome barriers to mental health care by delivering support exactly where and when it's needed, including rural areas.
Researchers identified a distinctive CT imaging pattern called PRACE that predicts severe postpartum hemorrhage cases requiring emergency procedures. The finding was strongly associated with the need for uterine artery embolization and improved maternal outcomes.
Elaine R. Mardis, Alexis B. Carter, and Dara L. Aisner receive AMP's top honors for groundbreaking work in cancer genomics and molecular diagnostics. Drs. Mardis and Carter will deliver keynote lectures at the AMP Annual Meeting & Expo.
A new study from Emory University reveals that maintaining optimal cardiovascular health can significantly improve overall physical and psychological well-being. The review confirms that heart-healthy behaviors positively impact brain function, vision, hearing, muscle strength, and reduce the risk of chronic diseases.
Researchers have developed a groundbreaking method called PathoPlex that can analyze over 100 different proteins in the same small piece of tissue, revealing complex disease processes. This technology combines advanced image processing with machine learning to map human disease in detail.
A recent study published in JAMA Otolaryngology–Head & Neck Surgery found an association between cannabis use disorder and benign salivary gland tumors. The researchers call for further prospective research to confirm this association and understand the relationship between cannabis use and these tumors.
The WHO Reporting System for Soft Tissue Cytopathology provides a standardized classification system to improve diagnostic accuracy and guide clinical decision-making. The system aligns with the WHO Classification of Soft Tissue and Bone Tumours and incorporates cytomorphologic features, ancillary studies, and clinical correlation.
A recent Northwestern University study analyzed brain tissue from 174 donated brains, including some from former amateur football players. The researchers found no elevated levels of phosphorylated tau (p-tau) protein in the CA2 region of the hippocampus, which is often associated with CTE and normal aging.
Researchers found that smartphone sensors can detect major forms of psychopathology. The study's results may lead to the development of symptom monitoring tools to fill gaps in current practice.
A new study found that amylin administration exacerbates tauopathy by impairing lysosomal mechanisms in a hybrid diabetes model. The research highlights the intricate relationship between diabetes and Alzheimer's disease, suggesting that amylin plays a key role in the pancreas-brain axis.
Researchers developed a new protocol to detect even low levels of T. cruzi parasites in patients, allowing for accurate monitoring of treatment outcomes and potentially leading to more effective drug treatments. The test was tested on human, macaque, and canine subjects, with promising results.
The Association for Molecular Pathology (AMP) has announced the election results for 2026-2027 leadership positions, including President-Elect Yassmine M.N. Akkari and Secretary-Treasurer Jonathan A. Nowak. The newly elected leaders will drive AMP's mission to advance molecular diagnostics.
Researchers at St. Jude Children's Research Hospital have identified a novel combination therapy approach to treat pediatric acute myeloid leukemia (AML) fueled by NUP98 fusions. Targeting the complex alone or in combination with another anticancer drug significantly increased survival in AML model systems.
The addition of perioperative toripalimab to platinum-based chemotherapy has demonstrated significant improvements in disease-related outcomes, including event-free survival and major pathologic response rates. However, this is associated with a small increase in grade 3–5 toxicities and immune-related adverse events.
Researchers have identified a key player in the development of Fusarium head blight, a devastating disease that severely damages wheat and barley crops worldwide. The discovery of FgTPP1 could lead to the development of genetically engineered disease-resistant grains.
A new study from the University of Georgia found that socioeconomic factors like poverty, international travel, and poor access to healthcare contribute to animal-borne disease outbreaks. Environmental factors such as climate change and close contact with livestock also play a role in spreading diseases.
Charles G. Mullighan, a leading leukemia researcher at St. Jude Children's Research Hospital, has been elected Fellow of the Royal Society. His work on genomic research has advanced the understanding and treatment of acute leukemia in children.
FLT3 mutations significantly impact AML prognosis and treatment response; next-gen sequencing enhances mutation detection and MRD monitoring. FLT3 inhibitors offer promising avenues for durable remission.
A new film series, 'The Deadly Five,' is launched to raise awareness of five critical animal infectious diseases affecting animal and public health. The series explores disease surveillance, prevention, and control through scientific insights and global collaborations.
Researchers have made significant discoveries about the role of GP38 in viral infections and pathogenesis, highlighting its potential as a target for vaccines and medical countermeasures. Non-neutralizing GP38-specific antibodies have shown protective efficacy against lethal challenge, reducing circulating GP38 and vascular leak.
The Association for Molecular Pathology (AMP) has won a court ruling that vacates the FDA's rule on laboratory-developed test procedure regulation. This decision will avoid adding billions of dollars in healthcare costs and protect access to high-quality care for hundreds of millions of Americans.
The national healthcare initiative has been extended for five years to provide world-class healthcare services to every Guyanese citizen. The partnership will establish a national cancer center, modernize national health facilities, and implement an advanced digital health system.
Researchers have created a new imaging technique that uses the nanostructures found on butterfly wings to analyze cancerous tissues, providing a simpler and more accessible tool for cancer diagnosis. The method has shown comparable results to conventional staining methods and advanced imaging techniques, offering a stain-free alternative.
A new study at U-M Health shows that hospitals can focus the use of preoperative tests on high-risk patients, while safely reducing unnecessary testing in others. The result is less wasted money and resources, as well as less time wasted for patients and clinical staff.
Mayo Clinic's Digital Pathology platform is transforming pathology by leveraging large datasets and AI models for faster, more accurate diagnoses. The partnership with NVIDIA and Aignostics aims to improve patient care and accelerate medical breakthroughs.
Cerebral vascular malformations (CVMs) are redefined as genetic and molecular-driven conditions, with innovative diagnostic approaches like next-generation sequencing and non-invasive imaging genomics. Targeted therapies, including MEK inhibitors and mTOR inhibitors, offer effective alternatives to traditional surgical methods.
A study found that standard medical reports are often difficult for patients to understand, leading to increased worry. In contrast, patient-centered pathology reports provide clear and concise information, improving patient comprehension and reducing anxiety.
Most study participants struggled to understand standard prostate cancer pathology reports, but found patient-centered reports easier to comprehend. PCPRs reduced perceived worry in low-risk conditions compared to traditional reports, suggesting their inclusion could enhance patient care.
Researchers discovered a link between HSV-1 and Alzheimer's disease, suggesting that viral infections play a role in the disease. The study also found that tau protein initially protects the brain from the virus but contributes to brain damage later.
Adding camrelizumab to neoadjuvant chemotherapy significantly improved pathological complete response in patients with early or locally advanced triple-negative breast cancer. The treatment showed substantial benefits, leading researchers to explore its potential as a neoadjuvant strategy.
Dartmouth researchers propose a new way of thinking about masking and social distancing rules using game theory, considering them as two distinct actions. The study finds that people respond differently to these measures based on their perception of the disease's severity, trending towards masking or no protective action over time.
The Association for Molecular Pathology has published a joint consensus report on SARS-CoV-2 genomic surveillance, outlining key considerations for next-generation sequencing methods. The report provides guidance on pre-analytical, analytical, and post-analytical aspects of NGS-based surveillance programs.
A UCD researcher has received an ERC Synergy Grant to develop innovative x-ray technology for tissue biopsies, enabling detailed visualization of cellular changes in whole tissues. The project aims to advance understanding of diseases and provide new ways to diagnose and treat various conditions.
Researchers developed an AI-based method to analyze kidney lesions in female patients with Alport syndrome, predicting renal prognosis and guiding treatment interventions. The approach uses a modified stain and deep learning to detect basement membrane lesions, showing a positive correlation with proteinuria concentration.
A new AI model generates detailed images of cancer tissue that imitate what its staining would look like, reducing the need for resource-intensive lab analyses. The VirtualMultiplexer uses contrastive unpaired translation to create accurate virtual pictures of diagnostic tissue colorations.
A new AI-based digital platform has been developed to analyze tissue sections from lung cancer patients, making diagnosis faster and more accurate. The platform uses algorithms that enable fully automated analysis of digitized tissue samples, allowing for personalized therapy based on molecularly specific genetic changes.
A commercial AI tool was effective in excluding pathology and had lower rates of critical misses on chest X-rays compared to radiologists. The study found that the AI tool could autonomously report more than half of all normal chest X-rays without decreasing standard of care.
Researchers have identified a metal deficiency in SOD1 protein associated with motor neurone disease using native ambient mass spectrometry imaging. This breakthrough could lead to new insights and treatments for the disease, which affects around 5,000 people in the UK.
α-Synuclein pathology in asymptomatic stages is linked to NBM atrophy, leading to attention/executive impairment. MRI signatures can detect this pathology in memory clinic populations.
Researchers found that combining plasma p-tau217 and Aβ42/40 levels could predict early brain Aβ accumulation in people with subthreshold Aβ accumulation. These biomarkers may help screen participants for primary prevention trials.
Researchers discuss HER2 in breast cancer, highlighting the prognostic and predictive factors. They found an independent positive prognostic effect of HER2-low compared to HER2-zero in early breast cancer, challenging the long-held view that HER2-negative tumors do not benefit from trastuzumab-based therapy.
A cross-sectional study of CTE patients found that years of contact sports participation are linked to substantia nigra pathology, leading to parkinsonism. The study suggests that repetitive head impacts may trigger neuropathologic processes in individuals with CTE.
Scientists developed customized AI tools, including ChatGPT, to provide accurate responses on digital pathology. The tools help pathologists without extensive coding experience analyze tissue samples, bridging the gap between pathology and digital pathology skills.
Longitudinal study finds that higher baseline body mass index is associated with more depressive symptoms over time. Children's cognitive performance also declines as they enter adolescence, highlighting the importance of monitoring children with overweight or obesity for depression problems.
A team of researchers from Tokyo Medical and Dental University developed a novel kind of optical coherence tomography (OCT) to investigate the detailed structure of the sclera in living patients. They found that the sclera is divided into inner and outer layers with different structural arrangements, which can provide important insight...