Researchers create detailed 3D reconstructions of human liver tissue, comparing healthy and cirrhotic livers, showing dysregulation of metabolite transport, reduced specialized cells, and disruption of vascular networks. The study highlights the importance of understanding organ structure for bioprinting artificial organs.
A study by RIKEN researchers identifies a MYCN-driven biomarker that predicts the risk of liver cancer. The biomarker, known as the MYCN niche score, uses machine learning to analyze gene expression patterns and indicates whether a tumor-free liver is at high risk for developing tumors.
Research reveals that podocytes in aged rats adapt by increasing volume and forming atypical junctions to compensate for loss, while exporting unnecessary cellular components into the extracellular space. The study employed array tomography to elucidate age-related structural changes, shedding light on the mechanisms of aging glomeruli.
The review outlines how vascular-immune crosstalk affects various diseases, revealing novel therapeutic opportunities. It highlights the shared embryonic origin of blood vessel cells and immune cells, as well as coordinated immune cell trafficking mechanisms.
Advanced 3D imaging reveals that vascular amyloid deposition follows a specific pattern, starting from surface vessels and spreading inward along connected pathways. The study provides new insights into the spatial organization of amyloid pathology in cerebral amyloid angiopathy.
A cohort study found combined GLP-1RA and progestin therapy reduces endometrial cancer risk in women with benign uterine pathology or endometrial hyperplasia. The study suggests potential benefits of this treatment approach for nonmalignant uterine diseases.
This study analyzed clinical and pathological characteristics of bone marrow metastasis from non-hematolymphoid malignancies. Prostate and breast carcinomas were the most common malignancies associated with BMM, and anti-neoplastic treatments improved overall survival.
Research at the University of Colorado Anschutz Linda Crnic Institute found significant alterations in liver metabolism among individuals with Down syndrome, including elevated bile acids and biomarkers of liver dysfunction. The study suggests that dietary interventions may help improve health outcomes.
Researchers found that TL1A, a key immune signaling protein, stimulates the growth of new white blood cells in the bone marrow, which then promote tumor formation in the gut. The study suggests that blocking TL1A activity could be an effective strategy to treat IBD and prevent associated colorectal tumors.
A machine learning model has identified the most important drivers of cancer survival in nearly all countries, highlighting factors such as national wealth, access to radiotherapy and universal health coverage. The model provides data-driven roadmaps for policymakers to prioritize resources and close survival gaps.
A new foot-and-mouth disease vaccine developed by Diamond Light Source is projected to deliver over $1.3 billion in annual benefits, transforming global livestock resilience. The vaccine's unique features, including heat stability and scalability, make it a game-changer for farmers worldwide.
A new nanodrug called Nano-273 could offer improved survival for patients with pancreatic and lung cancers by activating the immune system and blocking tumor growth. The drug, developed by University of Houston researcher Wei Gao, has shown promising results in early studies.
A recent study published in Gut journal revealed that Streptococcus anginosus produces methionine metabolites, which significantly contribute to the development of gastric cancer. The research opens new paths for microbiota-targeted prevention strategies.
A new rapid test for hepatitis C could identify more patients who can be cured if insurers increase reimbursement to cover the test's high cost. The test's point-of-care feature makes it ideal for early screening and treatment in clinics and emergency rooms.
The study reveals that MCL1 directly influences the mTORC1 complex, controlling bioenergetics and tumorigenesis in cancer cells. Genetic analyses also show that MCL1 inhibitors inhibit mTOR signaling, addressing a previously unresolved problem in cancer therapy.
The International Association for Dental, Oral and Craniofacial Research (IADR) celebrates the robust inclusion of oral health in the adopted declaration. This recognizes that ~3.7 billion people live with oral diseases, imposing a significant health burden. IADR urges Member States to translate commitments into concrete national actio...
A new study led by Harvard Medical School researchers found that AI models analyzing pathology samples can infer demographic information, leading to biased diagnoses. The team developed a framework called FAIR-Path to reduce bias in these models, which showed improved performance across demographics.
NEJM Clinician curates highly relevant clinical insights from over 150 peer-reviewed journals to give physicians clear guidance without the noise. The weekly publication delivers summaries and commentary in a concise, 30-minute read, helping healthcare providers stay informed and confident in their decisions.
A new, slow-growing tumor has been identified with a distinctive bone-covered shell, previously misdiagnosed as cancerous. Researchers describe the ossifying spindled and epithelioid tumor (OSET) for the first time, highlighting its unique characteristics and potential consequences of incorrect diagnosis.
Researchers argue that widely used proxies for aging may conflate genuine modifications with simpler effects on physiology. Targeting specific pathologies can extend lifespan without slowing aging process. Historically, increased human lifespan was primarily driven by reduced infectious disease mortality, not a fundamental slowing of a...
Researchers are presenting groundbreaking findings at the Association for Molecular Pathology's annual meeting, including a novel technique to study ancient DNA and rapid detection of serious fungal pathogens. The Association for Molecular Pathology is providing press materials and resources for media coverage.
Scientists have developed a targeted genetic test to improve diagnosis for X-linked dystonia-parkinsonism, a rare and disabling movement disorder that affects primarily men of Filipino ancestry. The test correctly identified cases that routine sequencing methods have missed, leading to proper diagnoses and end diagnostic odysseys.
Researchers have developed a molecular test capable of detecting three major pathogenic fungi at once, with a much quicker turnaround than traditional methods. The test bypasses the slow culture process by detecting genetic material directly, eliminating errors and reducing laboratory risk.
Artificial intelligence is being used to improve diagnostic accuracy in molecular pathology, with studies showing 93% accuracy for cancer diagnosis. Researchers are also using AI to analyze chromosomal changes in blood cancer patients and provide personalized treatment plans.
Researchers have discovered that optical genome mapping can reveal hidden causes of pregnancy loss, including chromosomal changes in genes known to be linked to recurrent pregnancy loss. The study found structural changes in the genome that were missed by traditional genetic sequencing methods.
Researchers have developed a new molecular test to identify Lyme disease earlier and more accurately than traditional methods. The test can detect as few as five bacterial cells and has an estimated sensitivity of 90.9%, making it a potential new avenue for testing Lyme disease.
Researchers have made significant advancements in diagnosing acute myeloid leukemia (AML), a common and aggressive form of blood cancer. Genetic testing can now predict relapse after stem cell transplant and detect hidden gene fusions that were previously undetectable.
Researchers developed a new DNA analysis technique to study old genetic samples, shedding light on disease evolution and changes in biology over time. The approach has potential for unlocking the root causes underlying shifting landscapes of modern diseases.
Acute lung injury is characterized by diffuse inflammation and intractable hypoxemia, with N6-methyladenosine methylation playing a crucial role in its pathogenesis. The review synthesizes findings from multiple studies, highlighting the dynamic nature of m6A methylation and its associated proteins.
The study highlights the frequent use of aerosol therapy in critically ill patients with acute respiratory distress syndrome (ARDS), with bronchodilators being the most commonly prescribed drugs. However, the lack of sound scientific evidence and randomized controlled trials suggests that standardized protocols are needed to align clin...
The Association for Molecular Pathology recognized Dr. Laposata's contributions to clinical laboratory practice and his role in challenging the FDA's rule on laboratory-developed test regulation. The award preserves diagnostic innovation, ensures patient access, and avoids escalating healthcare costs.
A new study projects that US funding cuts will result in a catastrophic effect on pediatric TB, with children in Sub-Saharan Africa and Southeast Asia experiencing a significant spike in preventable cases and deaths over the next decade. The loss of US bilateral health aid is projected to result in an additional 2.5 million pediatric T...
A new multi-omics tool, GoT-Multi, has enabled researchers to gain insights into how cancers evolve towards greater aggressiveness and therapy resistance. The tool can analyze diverse types of pathology samples and quickly process large numbers of cells, revealing new details about cancer progression.
The Association for Molecular Pathology has created a standardized biomarker report template to simplify complex molecular profiling data presentation to oncologists and healthcare providers. The template includes guidelines for clear formatting, therapeutic guidance, and references to clinical practice guidelines.
Paul N. Staats, MD, has been appointed Chair of the University of Maryland School of Medicine's Department of Pathology, overseeing clinical services to multiple hospitals and laboratories. He will drive partnerships and expand outpatient laboratory services.
Researchers found tiny air pollution particles sticking to red blood cells after exposure to roadside pollution, which can travel to organs like brain and heart. Wearing an FFP2 face mask reduces the amount of particles stuck to red blood cells.
A University of Georgia-led study surveyed over 18,000 people across 68 nations, finding that those in countries with historically higher disease risks believe the human species is headed in a good direction. This positive outlook may be an evolutionary adaptation that enhances resilience against disease and stress.
A Cornell University study detected disease-causing microbes like Salmonella, Cronobacter, and E. coli in raw cat foods sold frozen, refrigerated, and freeze-dried. These pathogens can transfer from pets to humans, especially young children, the elderly, pregnant individuals, and those with weakened immune systems.
Research links oral bacteria to Parkinson's disease via the gut-brain axis, finding Streptococcus mutans produces metabolite imidazole propionate that contributes to disease progression. Targeting the oral-gut microbiome may offer a new therapeutic approach for Parkinson's treatment.
Researchers have created a statistical model using 20 years' worth of sentinel chicken data to predict elevated West Nile virus activity up to six months in advance. This breakthrough could lead to proactive preventative measures and improve disease outbreak response.
Researchers at Uppsala University have developed an AI system that can detect subtle tissue changes indicative of prostate cancer, missing it from human pathologists. The study found the AI detected cancers in over 80% of cases where pathologists missed them.
A new reporting checklist introduces key methodological details to improve reproducibility and transparency in AI-based automated image analysis. The guidelines will support clear communication of methods and reduce cognitive bias, promoting the translation of AI tools into routine pathology workflows.
SourceSAGE·JournalVeterinary Pathology·TypeCommentary/editorial·DateAug 22, 2025
Researchers envision AI-powered systems that identify patients at risk of mental health struggles, provide continuous psychological monitoring and tailor interventions. AI can also overcome barriers to mental health care by delivering support exactly where and when it's needed, including rural areas.
Researchers identified a distinctive CT imaging pattern called PRACE that predicts severe postpartum hemorrhage cases requiring emergency procedures. The finding was strongly associated with the need for uterine artery embolization and improved maternal outcomes.
Elaine R. Mardis, Alexis B. Carter, and Dara L. Aisner receive AMP's top honors for groundbreaking work in cancer genomics and molecular diagnostics. Drs. Mardis and Carter will deliver keynote lectures at the AMP Annual Meeting & Expo.
Researchers have developed a groundbreaking method called PathoPlex that can analyze over 100 different proteins in the same small piece of tissue, revealing complex disease processes. This technology combines advanced image processing with machine learning to map human disease in detail.
A new study from Emory University reveals that maintaining optimal cardiovascular health can significantly improve overall physical and psychological well-being. The review confirms that heart-healthy behaviors positively impact brain function, vision, hearing, muscle strength, and reduce the risk of chronic diseases.
A recent study published in JAMA Otolaryngology–Head & Neck Surgery found an association between cannabis use disorder and benign salivary gland tumors. The researchers call for further prospective research to confirm this association and understand the relationship between cannabis use and these tumors.
The WHO Reporting System for Soft Tissue Cytopathology provides a standardized classification system to improve diagnostic accuracy and guide clinical decision-making. The system aligns with the WHO Classification of Soft Tissue and Bone Tumours and incorporates cytomorphologic features, ancillary studies, and clinical correlation.
A recent Northwestern University study analyzed brain tissue from 174 donated brains, including some from former amateur football players. The researchers found no elevated levels of phosphorylated tau (p-tau) protein in the CA2 region of the hippocampus, which is often associated with CTE and normal aging.
Researchers found that smartphone sensors can detect major forms of psychopathology. The study's results may lead to the development of symptom monitoring tools to fill gaps in current practice.
A new study found that amylin administration exacerbates tauopathy by impairing lysosomal mechanisms in a hybrid diabetes model. The research highlights the intricate relationship between diabetes and Alzheimer's disease, suggesting that amylin plays a key role in the pancreas-brain axis.
Researchers developed a new protocol to detect even low levels of T. cruzi parasites in patients, allowing for accurate monitoring of treatment outcomes and potentially leading to more effective drug treatments. The test was tested on human, macaque, and canine subjects, with promising results.
The Association for Molecular Pathology (AMP) has announced the election results for 2026-2027 leadership positions, including President-Elect Yassmine M.N. Akkari and Secretary-Treasurer Jonathan A. Nowak. The newly elected leaders will drive AMP's mission to advance molecular diagnostics.
Researchers at St. Jude Children's Research Hospital have identified a novel combination therapy approach to treat pediatric acute myeloid leukemia (AML) fueled by NUP98 fusions. Targeting the complex alone or in combination with another anticancer drug significantly increased survival in AML model systems.
The addition of perioperative toripalimab to platinum-based chemotherapy has demonstrated significant improvements in disease-related outcomes, including event-free survival and major pathologic response rates. However, this is associated with a small increase in grade 3–5 toxicities and immune-related adverse events.
Researchers have identified a key player in the development of Fusarium head blight, a devastating disease that severely damages wheat and barley crops worldwide. The discovery of FgTPP1 could lead to the development of genetically engineered disease-resistant grains.
A new study from the University of Georgia found that socioeconomic factors like poverty, international travel, and poor access to healthcare contribute to animal-borne disease outbreaks. Environmental factors such as climate change and close contact with livestock also play a role in spreading diseases.
Charles G. Mullighan, a leading leukemia researcher at St. Jude Children's Research Hospital, has been elected Fellow of the Royal Society. His work on genomic research has advanced the understanding and treatment of acute leukemia in children.
FLT3 mutations significantly impact AML prognosis and treatment response; next-gen sequencing enhances mutation detection and MRD monitoring. FLT3 inhibitors offer promising avenues for durable remission.