Articles tagged with Pathology
Researchers found that combining plasma p-tau217 and Aβ42/40 levels could predict early brain Aβ accumulation in people with subthreshold Aβ accumulation. These biomarkers may help screen participants for primary prevention trials.
Researchers discuss HER2 in breast cancer, highlighting the prognostic and predictive factors. They found an independent positive prognostic effect of HER2-low compared to HER2-zero in early breast cancer, challenging the long-held view that HER2-negative tumors do not benefit from trastuzumab-based therapy.
A cross-sectional study of CTE patients found that years of contact sports participation are linked to substantia nigra pathology, leading to parkinsonism. The study suggests that repetitive head impacts may trigger neuropathologic processes in individuals with CTE.
Scientists developed customized AI tools, including ChatGPT, to provide accurate responses on digital pathology. The tools help pathologists without extensive coding experience analyze tissue samples, bridging the gap between pathology and digital pathology skills.
Longitudinal study finds that higher baseline body mass index is associated with more depressive symptoms over time. Children's cognitive performance also declines as they enter adolescence, highlighting the importance of monitoring children with overweight or obesity for depression problems.
A team of researchers from Tokyo Medical and Dental University developed a novel kind of optical coherence tomography (OCT) to investigate the detailed structure of the sclera in living patients. They found that the sclera is divided into inner and outer layers with different structural arrangements, which can provide important insight...
Research suggests that four proposed AI search engines for automating search and retrieval of digital histopathology slides have inadequate performance for routine clinical care. The algorithms showed less than 50% accuracy in some cases, highlighting the need for rigorous external validations and standardization before clinical adoption.
A new study by Mass General Brigham researchers found that larger 'foundation models' can help mitigate disparities between different demographic groups and enhance model accuracy. The findings emphasize the need for more diverse training datasets and demographic-stratified evaluations of AI systems.
Two new Review articles explore AI's application in early cancer detection, highlighting its potential to enhance diagnostic accuracy and improve treatment selection. The articles emphasize the need for a robust, multi-disciplinary approach to integrate AI into medicine.
The study reveals that smartphone-based cognitive assessments can provide reliable and valid results for diagnosing frontotemporal lobar degeneration. These findings suggest a scalable solution for remote evaluations, which may enhance early detection.
Researchers discovered compounds with untapped therapeutic potential for treating BPH, melanogenesis, and nerve damage. Metformin restored sex hormone homeostasis, epimedin B stimulated pigmentation function, and hydralazine suppressed ferroptosis to aid in axon regeneration.
Researchers at Mass General Brigham have developed two AI foundation models, UNI and CONCH, to advance computational pathology. These models excel in diagnostic accuracy, prognostic insights, and predicting therapeutic responses, with universal applications in anatomic pathology.
Researchers demonstrate efficacy of airborne ultrasound technology to detect low-amplitude movements produced by vocalizations at the chest surface. The technology allows for contactless mapping of surface vibrations, offering a better window on respiratory health and enabling better diagnoses of respiratory diseases.
A new rapid test has been developed to identify hantavirus in South Korea, paving the way for early outbreak control. The Flongle sequencing-based diagnostic is cost-efficient and can detect HTNV genomes within 3 hours.
A new roadmap has been published by IEEE EMBS, outlining five primary medical challenges that need to be addressed through advanced biomedical engineering approaches. The paper, written by 50 renowned researchers from 34 prestigious universities, aims to guide future research and funding for groundbreaking innovations.
Researchers from Pusan National University discovered a link between diabetes and periodontitis, showing pro-inflammatory cytokines rise in classical monocytes. The study highlights the systemic impact of these conditions on immune regulation and suggests a potential therapeutic target to reduce diabetes risk.
A team of researchers from Texas Heart Institute and Baylor College of Medicine have made a significant discovery about the underlying molecular cell states within transplanted pediatric hearts. They found that donor-derived tissue-resident macrophages are crucial for graft acceptance, but their loss leads to allograft failure.
Researchers at the BU CTE Center found a clear dose-response relationship between CTE pathology and cognitive and functional symptoms, including memory and executive function issues. This study provides valuable insights into diagnosing CTE in living patients, potentially leading to new treatments.
Persistent withdrawn and somatic symptoms in adolescence increase the risk of suicidal thoughts in mid-adolescence. The study found that these symptoms persist or increase over time to be particularly concerning for suicidal risk.
A new study by Northwestern University found that lab-trained AI models are easily misled by tissue contaminants, resulting in errors in diagnoses and vessel damage detection. The researchers suggest improving the problem of quantifying and addressing biological impurities in AI models to enhance accuracy.
A study published in PLOS ONE reveals that Vikings in Sweden had a high prevalence of tooth decay, with many exhibiting severe caries and other dental pathologies. The findings provide insights into the lives of these ancient Scandinavians and their attempts to treat dental issues.
A study of 4,819 women with benign breast disease found an increased risk of breast cancer compared to the general population. The study's findings suggest that pathologic classifications could improve breast cancer risk stratification.
A new study finds that analyzing surgical lymphatic fluid for HPV DNA can predict cancer recurrence and guide treatment decisions. The test was found to be more sensitive than traditional methods, detecting high-risk patients who may be missed by standard tools.
A study of 103,000 early-stage breast cancer patients reveals a significant racial disparity in chemosensitivity and survival rates. Black patients are more likely to experience residual disease after neoadjuvant chemotherapy, leading to a higher mortality risk.
A study published in The Lancet Neurology found that monitoring brain injury biomarkers and glucose variation over the first week of hospitalization can provide a more accurate picture of the pathological process. This allows for division into different groups with distinct disease trajectories and prognoses, enabling personalized trea...
Researchers analyzed a World Mosquito Program trial and found that excluding transmission dynamics likely underestimates the impact of Wolbachia-infected mosquitoes. The study suggests that true efficacy may be higher than initially reported, with potential reductions in dengue fever cases ranging from 77% to 94-97%.
Researchers found that Wolbachia pientis infection restores fruit fly fertility, enabling them to produce more offspring than uninfected flies. This discovery has significant implications for controlling insect populations and range, potentially increasing mosquito populations that do not carry human diseases.
The Association for Molecular Pathology published guidelines for validating and reporting clinical circulating tumor DNA assays. The recommendations aim to promote standardization and quality improvement in liquid biopsy assays, which have emerged as a key technology in molecular diagnostics.
The American Phytopathological Society has created a new series of distinguished reviews in honor of Harold H. Flor, who developed the gene-for-gene concept in plant pathology. The series presents authoritative reviews on molecular plant-microbe interactions, providing a historical perspective and future directions for research.
A new generative AI model enhances clinical accuracy and textual quality of chest radiograph reports, surpassing traditional methods like teleradiology. Its implementation could enable timely alerts for life-threatening conditions, aiding imaging interpretation and documentation.
A UCLA-led team has discovered the nerve supply that activates brown adipose tissue, a potential key to treating obesity. The study found nerve branches in all eight cadavers dissected, which may lead to using nerves to stimulate BAT activity for weight loss.
A new study found three genes strongly linked to vegetarianism, including those involved in lipid metabolism and brain function. The study suggests that genetics play a role in determining whether someone can stick to a strict vegetarian diet.
Researchers unveil a groundbreaking MRI technology that non-invasively assesses brain iron homeostasis, shedding light on its role in normal brain function, aging, and disease. The technology offers sensitivity to changes in iron mobilization capacity and can differentiate between tumor tissue and healthy tissue.
A new blood-based test called p-tau217 has shown great promise in identifying Alzheimer's disease by stratifying patients into low, intermediate, and high-risk groups. The two-step workflow reduces the need for confirmatory testing in uncertain cases.
A study of 1.3 million people found that those with hospital-treated depression have a high risk of developing conditions like bipolar disorder, schizophrenia, and anxiety disorders. Genetic analysis also revealed a link between depression and reduced cognitive abilities, such as abstract thinking and mental flexibility.
A case series reveals that young brain donors with a history of repetitive head impacts exhibit severe symptoms, which may be caused by multiple factors. Further research is needed to clarify the association between exposure to head impacts and clinical symptoms in young athletes.
Researchers found a high incidence of systemic amyloidosis in Japanese squirrels, characterized by severe glomerular amyloid deposition. The study suggests that fibrinogen Aα-chain is a precursor protein and the amino acid sequence plays a crucial role in maintaining protein stability.
A new study highlights the difficulty in diagnosing blood disorders like myelodysplastic syndromes/neoplasms (MDS), which can lead to treatment mistakes. The researchers found that expert pathologists disagreed with local pathologists' diagnoses in about 20% of cases, leading to wrong initial treatments for patients.
In a phase 3 clinical trial, donanemab significantly slowed clinical progression in patients with low/medium tau and high tau pathology. The treatment cleared brain amyloid plaque, demonstrating its potential to slow Alzheimer disease progression.
Researchers at University of California San Diego find that impaired mitochondria, not inflammation, drive Gulf War illness symptoms, potentially leading to new treatment strategies. The study's findings have implications for other health conditions marked by increased inflammation.
Professor Coppedè's appointment aims to enhance the journal's focus on cutting-edge genomics research, covering topics like genome sequencing and functional genomics. He will lead Current Genomics to greater success by staying at the forefront of genomics discoveries and advancements.
The Association for Molecular Pathology has published clinical CYP3A4 and CYP3A5 genotyping assay recommendations to standardize testing across laboratories. The guidelines aim to improve patient care by providing guidance on allele selection, assay validation, and therapeutic recommendations.
A multicenter study found that deep learning-based computer-aided diagnosis significantly improved radiologists' diagnostic performance for breast lesion classification on ultrasound. The use of CAD resulted in a 6.0% upgrade of BI-RADS category 3 assessments to category 4A, with 16.7% being malignant.
A new paper by Robert K. Naviaux outlines the array of processes that drive healing and whose dysfunction underlies chronic illnesses like diabetes and autism. The cell danger response is triggered by exposure to threats, but persists even after the threat is gone, causing inflammation and cell dysfunction.
A study presented at the ARRS Annual Meeting reveals institutional variability in projection order and image acquisition timing for CEM protocol. Earlier-obtained recombined imaging is significantly preferred for cancer lesion characterization, with a trend towards prioritizing imaging the side of pathology.
Researchers develop a new technique to measure blood attenuation using a fluorophore-coated guidewire, improving the accuracy of near-infrared fluorescence in cardiovascular imaging. The method provides accurate information on vessel walls and outperforms existing correction methods.
Researchers identified a technique to detect abnormal protein deposits linked to Parkinson's disease, confirming its accuracy for early detection and characterisation. The α-synuclein seed amplification assay (αSyn-SAA) can identify people with Parkinson's disease and at-risk individuals prior to diagnosis.
This study of 690 patients with early-stage breast cancer found racial disparities in pathological complete response to neoadjuvant chemotherapy, affecting survival outcomes. Racial disparities varied across different breast cancer subtypes and highlight the importance of understanding tumor biology.
The new test helps detect new HIV infection and follows current guidelines for testing patients on HIV prevention medication. The study identified successful efforts and opportunities for process improvement during the first three months of implementation.
A new machine learning model combines fusion gene profiling, serum PSA level, and Gleason score to predict prostate cancer recurrence with improved accuracy. The model outperformed clinical data alone and provided valuable insights into the mechanism of disease progression.
Ultrafast MRI provides beneficial information for predicting DCIS upgrade to invasive cancer, including time to enhancement and lesion size. A study found that UF-MRI can accurately predict lesions diagnosed as DCIS at percutaneous biopsy that will be upgraded to invasive cancer at surgery.
Researchers evaluate an integrated NGS system, delivering accurate diagnoses in under 24 hours and expanding targeted treatments available to patients with myeloid neoplasms. The assay identified 80-92% of genetic variants, demonstrating promising results for accelerating precision therapies.
A study found that unintentional weight loss in people with Down syndrome coincides with brain changes associated with Alzheimer's disease, indicating it could be an early predictor. The researchers suggest that weight loss may be a useful tool for making an earlier diagnosis.
Researchers found that measles virus mutations in its fusion protein allow it to infect nerve cells, leading to subacute sclerosing panencephalitis. The team's discovery sheds light on the evolutionary mechanisms of viruses like coronaviruses and herpesviruses.
Researchers at Tokyo University of Agriculture and Technology discovered a novel amyloid protein, α-S1 casein, which can cause disease in humans. The study found that overexpression and N-terminal truncation of α-S1-casein led to its formation as an amyloid protein.
Researchers developed a multimodal imaging-based tool, the active biopsy guidance system (ABGS), to improve oral cancer diagnosis. The ABGS provides clinically actionable direct visible guidance for biopsies, enhancing precision and potentially saving lives.
A recent study published in PLOS ONE reveals the discovery of 92 fossilized egg nests belonging to titanosaurs, some of India's largest dinosaurs. The finds provide insights into the reproductive habits and nesting behaviors of these prehistoric creatures, shedding light on their lives shortly before they went extinct.
Research from Brigham and Women's Hospital found that genetic analysis can identify up to 65% more A2 donors, increasing potential kidney transplants for recipient candidates with blood type B. This could improve availability and equity in kidney transplantation.
A new classification system, MPATH-Dx Version 2.0, has been developed to simplify diagnoses of melanocytic skin lesions. The system categorizes lesions into four classes, providing guidance on treatment and surveillance for patients.
A new AI tool developed by Brigham and Women's Hospital improves the accuracy of time-critical pathology diagnostics during surgery. The tool, which leverages deep-learning technology, translates frozen tissue samples into high-quality images, increasing diagnostic accuracy and reducing the need for lengthy laboratory tests.