Researchers have developed a neural network model called BiteNetPp to detect protein-peptide binding sites, enabling the design of peptide-based drugs. The model consistently outperforms existing methods and can analyze a single protein structure in under a second, making it suitable for large-scale studies.
SourceSkolkovo Institute of Science and Technology (Skoltech)·JournalJournal of Chemical Information and Modeling·TypeData/statistical analysis·DateAug 5, 2021
Scientists at Tokyo University of Science developed a copper-containing polymer that greatly enhances the antibacterial activity of hydrogen peroxide. The use of these tailored polymers resulted in higher catalytic activity and more effective killing of bacteria, opening up new design avenues for antimicrobial drugs.
SourceTokyo University of Science·JournalMacromolecular Rapid Communications·TypeExperimental study·DateJul 27, 2021
Scientists at Tokyo Institute of Technology developed a computational method to predict the cell-membrane permeability of cyclic peptides, exhibiting promising accuracy. The protocol has potential to aid in designing and discovering cyclic peptide drugs with high cell-membrane permeability.
SourceTokyo Institute of Technology·JournalJournal of Chemical Information and Modeling·DateJul 13, 2021
Researchers at ETH Zurich used AI to identify target molecules of natural substances, paving the way for a new class of pharmaceutical agents. The algorithm successfully predicted human receptors and enzymes that interact with natural compounds, leading to the discovery of simpler, cheaper alternatives.
SourceETH Zurich·JournalAdvanced Science·DateJul 7, 2021
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A new approach to molecular drug design has yielded a highly promising bladder cancer treatment candidate that induces rapid shedding of tumour cells and results in significant tumour size reduction. The treatment shows potent effects on patients with non-muscle invasive bladder cancer, demonstrating safety without side effects.
SourceTrinity College Dublin·JournalNature Communications·DateJun 28, 2021
Researchers have visualized the structure of the MFSD2A transporter protein, which allows omega-3s to enter the brain. The study provides insight into how this protein can be used to design drugs that mimic omega-3s and hijack the system for neurological treatment.
SourceColumbia University Irving Medical Center·JournalNature·DateJun 16, 2021
A multidisciplinary team from Brigham and Women's Hospital has designed a stretchable stent based on the principles of kirigami that can support rapid deposition of drug depots. The researchers coated the design with budesonide-loaded polymeric micro-particles to support extended drug delivery, which was tested in the esophagi of pigs.
SourceBrigham and Women's Hospital·JournalNature Materials·DateJun 14, 2021
A mathematical model predicts how bacterial mutations impact antibiotic success. The study suggests measuring mutation levels is crucial for determining treatment failure and informs novel strategies. Multiple mutations limit drug resistance evolution substantially, depending on drug type and administration route.
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
The Protein Data Bank (PDB) is celebrating 50 years of sharing scientific knowledge, with millions of users accessing its data for fundamental biology, energy, and biomedicine. The event highlights the PDB's role in understanding protein folding, including SARS-CoV-2, and structural biology's impact on medicine and drug discovery.
SourceAmerican Society for Biochemistry and Molecular Biology·DateApr 22, 2021
Rice University chemists have developed a novel process for synthesizing fluoroketones, precursors for drug design and manufacture. The new method uses a cerium-based catalyst, which produces functional precursors under mild conditions in about 30 minutes.
The study found the Netherlands recorded the highest usage of NPS, followed by Australia, New Zealand, and the US. Meanwhile, Spain, Italy, and China had the lowest incidence. Countries with higher usage included Australia, New Zealand, and the US, where substances like N-ethylpentylone were detected.
SourceUniversity of South Australia·JournalWater Research·DateFeb 21, 2021
Researchers at Brigham and Women's Hospital have developed a novel zinc-binding prodrug that promotes β-cell proliferation without off-target effects. The Disque Platform, a new screening platform, was used to identify this prodrug, which showed a 2.4-fold increase in β-cell numbers in culture.
SourceBrigham and Women's Hospital·JournalScience Advances·DateDec 16, 2020
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
Princeton University researchers have developed a new method to design and control complex mixtures with multiple phases, mimicking the arrangement of Russian matryoshka dolls. This approach uses graph theory to predict final arrangements of phases in a mixture when surface energies are known.
SourcePrinceton University, Engineering School·JournalPhysical Review Letters·DateNov 30, 2020
Researchers at the University of Bristol have developed a new virtual reality technique to aid in drug design against COVID-19. The innovative tool, called iMD-VR, enables users to 'step inside' a 3D model structure of the SARS-CoV-2 main protease and visualize molecules binding to the enzyme.
SourceUniversity of Bristol·JournalJournal of Chemical Information and Modeling·DateNov 12, 2020
Researchers design theragrippers, tiny star-shaped devices that latch onto intestinal mucosa and release drugs. The devices stay in the intestine for a desired duration, solving a long-sought goal in medicine.
SourceJohns Hopkins Medicine·JournalScience Advances·DateNov 3, 2020
Researchers at Michigan State University have developed a deep learning model to predict the binding sites of known protease inhibitors targeting the SARS-CoV-2 main protease. The model can help drug developers prioritize promising candidates and save time and money in the early stages of drug development.
SourceMichigan State University·JournalChemical Science·DateOct 28, 2020
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Biomedical engineers at Duke University created a combination molecule featuring GLP-1 and FGF21 that controls blood sugar levels and promotes weight loss in mice for up to a week after a single injection. The slow-release ELP linker ensures stable drug release over time.
SourceDuke University·JournalScience Advances·DateAug 26, 2020
Researchers adapted principles of quantum control to calculate alternative interventions for infection and cancer. They developed a mathematical algorithm that can design and speed up specific interventions to prevent or overturn drug resistance, offering a promising approach to defeating drug-resistant diseases.
SourceCleveland Clinic·JournalNature Physics·DateAug 24, 2020
Researchers identified ebselen's binding activity to SARS-CoV-2 main protease, suggesting its potential as a treatment. The distant binding site may provide an alternative target for repurposed drugs.
SourceAmerican Association for the Advancement of Science (AAAS)·JournalScience Advances·DateAug 14, 2020
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
A multidisciplinary team from UTMB has uncovered a new mechanism for designing antiviral drugs for dengue virus. The co-crystal structure of the dengue capsid protein in complex with an inhibitor provides atomic details of how the inhibitor blocks viral infection.
SourceUniversity of Texas Medical Branch at Galveston·JournalProceedings of the National Academy of Sciences·DateJul 13, 2020
Researchers designed millions of protein therapeutics targeting SARS-CoV-2, with over 2,000 showing binding signals. The approach has shown promise in identifying highly promising leads for the spike protein binder.
SourceUniversity of Texas at Austin, Texas Advanced Computing Center·DateJun 30, 2020
Scientists have created a detailed map of the GABAB receptor, revealing its structure and new details of how it moves from inactive to active state. This discovery could help better understand GABA receptors and design better drugs to treat conditions like addiction and psychosis.
SourceDOE/SLAC National Accelerator Laboratory·JournalNature·DateJun 17, 2020
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
A comprehensive study found synthetic cathinones and N-ethylpentylone in Australian wastewater, with users attracted to novel effects and potential risks of paranoia, hallucinations, and panic attacks
SourceUniversity of South Australia·JournalThe Science of The Total Environment·DateJun 15, 2020
Researchers from UTEP have successfully utilized carbon quantum dots to combat neurological disorders, demonstrating their potential in preventing and treating neurodegenerative diseases. The study provides a roadmap for safe use of CQDs in biomedical applications.
SourceUniversity of Texas at El Paso·JournalProcesses·DateJun 5, 2020
Advances in nanoparticles as anticancer drug delivery vectors offer improved targeting efficiency and non-toxicity. The use of external and internal stimulating factors enhances the efficacy of nanopolymer-based platforms, making them ideal for personalized medicine.
SourceBentham Science Publishers·JournalCurrent Pharmaceutical Design·DateJun 4, 2020
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
Researchers at Stanford University School of Engineering used computer simulations to discover how to minimize side effects in a broad class of drugs targeting G protein-coupled receptors. By designing new molecules, they can alter the receptor's shape to deliver beneficial effects while avoiding side effects.
SourceStanford University School of Engineering·JournalScience·DateMay 19, 2020
Researchers created a brain-sparing amphetamine, PEGyAMPH, that avoids cardiovascular side effects and addictive properties. It stimulates lipolysis and thermogenesis to promote fat breakdown and weight loss.
SourceInstituto Gulbenkian de Ciencia·JournalCell Metabolism·DateMay 13, 2020
Researchers at UTA are developing a rapid-response supply chain to deliver COVID-19 medications to underserved populations in Houston. The project aims to free up hospital capacity by providing treatments to critically ill patients first.
A research team at McGill University has gained a deeper understanding of nonribosomal peptide synthetases (NRPSs), tiny natural machines that produce biologically active compounds. This breakthrough could lead to the creation of new potent antibiotics, immunosuppressants and other modern drugs by leveraging bacteria and fungi.
SourceMcGill University·JournalNature Chemical Biology·DateApr 30, 2020
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
László Kürti, a Rice University chemist, has received a prestigious grant to speed up drug design by simplifying the synthesis of essential precursors. The five-year grant will support research into amines and their derivatives, which are present in most drug molecules. This could lead to more environmentally friendly drug development.
Researchers have created a massive computer model of the coronavirus, which will help design new drugs and vaccines. The model, built by Rommie Amaro's team, contains 200 million atoms and simulates the virus's interaction with human cells.
SourceUniversity of Texas at Austin, Texas Advanced Computing Center·JournalACS Central Science·DateMar 24, 2020
Researchers at six universities, including UT Austin, are launching a partnership to turn AI 'black boxes' into human-understandable computer code. This will enable solving hitherto unsolvable problems in fields like drug design and cognitive science.
Researchers at the University of Bristol used virtual reality to predict how common medications work on a molecular level. They successfully 'docked' drug molecules into proteins and were able to accurately predict their binding behavior, including for flu and HIV treatments.
SourceUniversity of Bristol·JournalPLOS ONE·DateMar 11, 2020
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Researchers developed a fluorescence-based technique to monitor single molecules, accelerating structural biology and potentially aiding in structure-guided drug design. The technique uses FRET to visualize biomolecules with unprecedented spatial and temporal resolution.
SourceClemson University·JournalNature Communications·DateMar 9, 2020
A team of Clemson University researchers identified the function of a specific protein in three related parasites that cause African sleeping sickness, Chagas disease, and Leishmaniasis. The discovery provides insights into how these parasites differ from humans, shedding light on potential drug targets.
Scientists have determined the 3D atomic structure of a key enzyme complex in paramyxoviruses, a family of RNA viruses that includes measles, mumps, human parainfluenza and respiratory syncytial virus (RSV). This discovery could lead to the development of new antiviral drugs for these viruses as well as coronavirus.
SourceNorthwestern University·JournalProceedings of the National Academy of Sciences·DateFeb 17, 2020
Researchers have identified four novel genes related to glucose metabolism that appear to explain unexplained low blood sugar in at least four families. The discovery may lead to the development of a novel drug against diabetes. However, more studies are needed to confirm the exact functional significance of these genetic mutations.
SourceUniversity of Southern Denmark Faculty of Health Sciences·JournalScientific Reports·DateFeb 7, 2020
A study on globular glial tauopathy reveals that phosphate groups are not unique to tau protein and can lead to dysfunction in other proteins. Glial cells also play a crucial role in the disease's progression by facilitating the spread of protein inclusions. This research sheds light on potential new drug targets to stop disease progre...
SourceIDIBELL-Bellvitge Biomedical Research Institute·JournalActa Neuropathologica·DateJan 27, 2020
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Researchers at the University of Minnesota are developing a new device to administer a recently developed antidote for cyanide poisoning, which could save lives in mass-casualty settings. The autoinjector, designed by Windgap Medical, would deliver a single dose of sulfanegen, an antidote that takes effect within minutes.
Scientists created artificial organisms by combining contractile and passive tissues, achieving high-performing candidates that matched predicted behaviors. The developed method can be applied to designing living machines for various applications.
SourceProceedings of the National Academy of Sciences·JournalProceedings of the National Academy of Sciences·DateJan 13, 2020
Researchers have identified two distinct types of antibiotics produced by bacteria that target the same cell wall component, offering a promising approach to combatting antimicrobial resistance. The discovery provides chemical blueprints for pharmaceutical chemists to design new, effective drugs.
SourceTrinity College Dublin·JournalNature Communications·DateJan 9, 2020
A risk management program for opioids may not be effective due to design and execution flaws, according to a Johns Hopkins Bloomberg School of Public Health study. The program's educational materials were consistent with FDA guidelines, but assessments of its impact were often inadequate.
SourceJohns Hopkins Bloomberg School of Public Health·JournalJAMA Internal Medicine·DateJan 7, 2020
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
A new study found that VA patients are less likely to skip medications and more likely to afford them compared to non-VA patients. The VA's pharmacy benefit model could be a key to making prescription drugs universally affordable.
SourcePhysicians for a National Health Program·JournalHealth Affairs·DateJan 6, 2020
Researchers aim to understand how biomolecules fold and interact to inform better drug design. The lab combines computer programming with biochemistry to model protein folding, nucleic acid dynamics, and lipid interactions.
A working group of medical organizations analyzed 29 pivotal phase III trials for disease-modifying drugs in MS, finding that patient symptoms and quality of life were often not considered. They suggest improving studies by focusing on patient-reported outcomes and long-term treatment effects.
SourceInstitute for Quality and Efficiency in Health Care·JournalThe EPMA Journal·DateDec 17, 2019
Scientists have determined the structure of the B-Raf protein, which is responsible for about 50% of melanomas. The study reveals an asymmetric organization of the complex, enabling asymmetric activation of the B-Raf dimer, a mechanism that explains the origin of paradoxical activation by small molecule inhibitors.
SourceUniversity of Texas at Austin, Texas Advanced Computing Center·JournalScience·DateDec 17, 2019
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
Researchers have uncovered the near atomic-level structure of a calcium homeostasis modulator, a protein crucial in processing taste stimuli and mitigating brain cell toxicity. This discovery may lead to novel medications for CALHM-related disorders, including Alzheimer's disease and stroke.
SourceVan Andel Research Institute·JournalNature·DateDec 2, 2019
Researchers have developed a deep machine learning algorithm that can predict the quantum states of molecules, enabling faster design of drug molecules and new materials. The algorithm can process complex quantum chemical data in seconds on a laptop or mobile phone, revolutionizing computational chemistry and molecular physics.
SourceUniversity of Warwick·JournalNature Communications·DateNov 19, 2019
Researchers developed a retinal hyperspectral imaging technique to detect early signs of Alzheimer's disease. The test scans the retina for biochemical changes associated with the disease, potentially identifying high-risk individuals and facilitating interventions.
SourceUniversity of Minnesota·JournalACS Chemical Neuroscience·DateNov 11, 2019
Scientists designed a novel approach to create stable and predictable antibody drug conjugates (ADCs) using computational docking molecular simulations. The new therapy, called MAGNET-ADC, can deliver cancer drugs specifically to tumor tissue with reduced toxicity.
SourceBrigham and Women's Hospital·JournalNature Biomedical Engineering·DateNov 8, 2019
A crowdsourcing game called Foldit allows players to design protein structures that are reproduced in labs, showing their accuracy. Researchers also discovered how cooking affects the gut microbiome and found a new material to remove toxic sulfur dioxide gas.
SourceDOE/Lawrence Berkeley National Laboratory·JournalNature Microbiology·DateNov 1, 2019
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Researchers have created a synthetic abscisic acid (ABA) mimic, opabactin, nearly 10 times more effective in manipulating crop water use than natural ABA. The molecule demonstrates high potency in wheat and tomato plants and provides long-lasting protection against underwatering.
SourceAmerican Association for the Advancement of Science (AAAS)·JournalScience·DateOct 24, 2019
The October issue of SLAS Discovery features a two-part special issue on membrane proteins, highlighting the importance of these targets for novel drug design. The issue includes reviews and original research papers on various aspects of membrane protein biology, such as targeting specific transporters and channels.
SourceSLAS (Society for Laboratory Automation and Screening)·JournalSLAS DISCOVERY·DateOct 11, 2019
Researchers developed a customized drug treatment that targets a single child's unique mutation, slowing disease progression and stabilizing symptoms. The 'n of 1' clinical trial was completed in less than a year, offering hope for future personalized treatments.
SourceBoston Children's Hospital·JournalNew England Journal of Medicine·DateOct 10, 2019
Researchers at Cornell University have solved the three-dimensional structure of a protein complex involved in vertebrate vision at atomic resolution, revealing how signals from photons are amplified in the eye. The study provides insights into G-protein-coupled receptors and their role in human vision, with potential implications for ...
SourceCornell University·JournalMolecular Cell·DateSep 30, 2019
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Researchers have developed a new drug delivery strategy targeting K-Ras proteins, responsible for aggressive and untreatable cancers. The approach uses FTase and GGTase I inhibitors to disrupt the lipid modification of mutated K-Ras, blocking its proliferation.
Schistosomiasis, a parasitic disease affecting 200 million people worldwide, can't be cured with current approaches due to poverty's role. Researchers found that mass drug administration programs fail to eradicate the disease, as treated individuals re-expose themselves to contamination.
SourceStanford University·JournalAmerican Journal of Tropical Medicine and Hygiene·DateSep 3, 2019
Researchers at Insilico Medicine have developed a new molecular descriptor, MCE-18, which estimates molecular complexity and defines the evolution of small molecules in medicinal chemistry. The study reveals that modern drug development is becoming more qualitative and smarter, with higher degrees of 3D complexity.
SourceInSilico Medicine·JournalJournal of Medicinal Chemistry·DateJul 11, 2019
A new, more effective influenza vaccine is being tested in the US, aiming to improve seasonal flu shot effectiveness. The vaccine uses adjuvants to enhance protection against infection, with a technology designed by artificial intelligence.
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Researchers have developed effective activators for the bitter taste receptor TAS2R14, which could have significant health effects. The receptors play a role in the human immune system and are found on lung and testicle cells.
SourceLeibniz-Institut für Lebensmittel-Systembiologie an der TU München·JournalCellular and Molecular Life Sciences·DateJul 1, 2019