Articles tagged with Lipid Metabolism
Researchers from Tokyo Medical and Dental University discovered a new mechanism that stimulates brain-autonomous neural repair after ischemic stroke by secreting lipids. The mechanism involves PLA2G2E, which increases dihomo-γ-linolenic acid (DGLA) levels, promoting inflammation reduction and neuronal repair.
A molecular switch called Arf1 controls the storage or conversion of lipids into energy in cells. When energy is needed, Arf1 allows lipids to enter mitochondria, where they are converted into ATP.
Researchers found that restricting methionine intake via a low-methionine diet or oral administration of recombinant methioninase-producing E. coli reversed old-age-induced obesity in mice, leading to significant weight loss after just 14 days.
A recent study led by UCLA researchers has identified a potential new strategy for treating glioblastoma by targeting a specific metabolic process in cancer cells. The study found that disrupting this process could make glioblastoma cells more vulnerable to cell death, offering hope for new treatment options.
Researchers found that long-term antibiotic use during adolescence disrupts the healthy gut microbiome, leading to changes in liver metabolism that promotes central fat accumulation. The study suggests that antibiotic treatment may have lasting detrimental effects on liver metabolism and promote adiposity.
A new study from Karolinska Institutet found that exercising in the early active phase increased gene expression involved in fat breakdown and thermogenesis, leading to a higher metabolic rate. This effect was independent of food intake and may prove beneficial for people who are overweight.
Scientists at Sanford Burnham Prebys have discovered a new treatment approach that can kill prostate cancer cells by targeting the PI5P4Kα enzyme. This finding has significant implications for addressing treatment resistance in prostate cancer and may lead to improved treatments for other cancers.
Researchers at Iowa State University have identified a metabolic switch that can be modified to control fat production, which could lead to more effective treatments for childhood obesity and cancer. The discovery involves altering the acetylation levels of fatty acid synthase, an enzyme critical to de novo lipogenesis.
A recent study from the University of Eastern Finland found that genetic background has an effect on the metabolism of essential polyunsaturated fatty acids alpha-linolenic acid and linoleic acid. The study showed that the FADS1 genotype modifies the responses to diets rich in alpha-linolenic acid and linoleic acid.
A study found that leptin stimulates liver fat export and lowers liver fat content in healthy men, suggesting a new approach for treating fatty liver disease. The findings imply that the brain plays a role in liver fat metabolism via the autonomic nervous system, opening up potential new treatment options.
A study reveals that alveolar macrophages, responsible for filtering bacteria and viruses from the lungs, fail to function properly when lacking a crucial transcription factor called C/EBPb. This leads to an accumulation of surfactant in the lungs, causing pulmonary alveolar proteinosis (PAP), a hitherto incurable disease.
Researchers at La Jolla Institute for Immunology discovered how Zika virus forces dendritic cells to churn out lipid molecules, allowing the virus to build copies of itself. This study provides a major step forward in developing antiviral therapies against multiple flavivirus infections.
A recent NIH study found that the loss of 'youth' protein pigment epithelium-derived factor (PEDF) may drive aging in the retina. The study showed that mice lacking PEDF experienced gene changes similar to those seen in age-related macular degeneration, highlighting a potential therapeutic target.
A study found that disruptions in brain sphingolipid metabolism lead to neuronal damage and neurodegeneration in animal models, revealing a new molecular perspective on Gaucher's disease. The research also shows that neuronal activity triggers the production of glucosylceramide, a key factor in the development of this disorder.
Researchers at the University of Exeter have identified a new gene, TMEM63C, that causes a degenerative disease affecting upper motor neuron cells. The study suggests that MNDs are caused by abnormal lipid processing pathways inside brain cells, which could lead to new diagnostic approaches and treatments.
Researchers from NTU Singapore and Waseda University found that fermented soybean waste improves fat metabolism and mitigates the effects of diet-induced obesity. The study, published in Metabolites, showed that mice fed fermented okara gained less body mass and had lower levels of fat and cholesterol.
Researchers identified three NAFLD subtypes with unique lipidomic profiles and varying cardiovascular disease risk. Subtype A shows a lower CVD risk profile, differing from other subtypes, which may explain variation in hepatic versus cardiovascular outcomes.
A study by Osaka University investigated the relationship between autophagy and metabolism during fasting. Autophagy was found to play a key role in promoting fat loss during fasting, particularly through the upregulation of adipogenic genes. The findings may have important implications for understanding metabolism during aging.
Researchers at University of California - Riverside are studying the keto and intermittent fasting diets on a molecular level, finding that women may metabolize fat differently than men. The study aims to understand why keto diet may not be effective for women and how it affects their overall health.
A new clinical study found that grape consumption increased gut bacterial diversity and reduced cholesterol levels, including total cholesterol by 6.1% and LDL cholesterol by 5.9%. This suggests a potential role for grapes in promoting good gut health and supporting heart health.
A recent study published in Scientific Reports found that individuals with inflexible metabolisms exhibit higher carbohydrate oxidation rates at night, indicating a reduced ability to burn fat during sleep. This discovery has the potential for practical use in disease prevention and early intervention.
Researchers have developed poly-ion complex (PIC) nanomicelles loaded with CPT1A inhibitors to deliver drugs into brain cells, reducing fatty acid oxidation and improving treatment for glioblastoma. The delivery system successfully increased cellular concentration of the cargo and biological activity.
Researchers found that curcumin intake increases ApoA-II and HDL-cholesterol concentrations by activating the PPARα signaling pathway, leading to increased AApoAII amyloid deposition. This discovery provides a novel molecular target for understanding amyloidogenesis and treating metabolic disorders.
A recent study by University of Zurich researchers has identified a key mechanism controlling brain development and cognitive function. The study found that a lipid metabolism enzyme, fatty acid synthase (FASN), regulates the lifelong activity of brain stem cells, leading to reduced division and learning deficits.
Inhibiting sphingolipid metabolism in neurons improves neurodegeneration symptoms and increases survival in a mouse model, according to new research. The findings suggest that compromised sphingolipid metabolism in GARP mutations may be a potential cause of neurodegeneration.
Regulating lipid metabolism in neurons has been shown to promote axon regeneration, with triglyceride synthesis impeding and phospholipid synthesis promoting regrowth. This new direction for research may provide translational targets for CNS injury treatment.
A study published in the Journal of Lipid Research found that just a few days of sleep deprivation can affect how the body metabolizes fat from food. The researchers gave participants a high-fat dinner while they were sleep-restricted, and found that their bodies cleared the fat faster than those who had plenty of sleep.
A study by University of Malaga researchers reveals that DNA methylation levels in genes related to lipid metabolism and inflammation are altered in obese patients with a metabolic disease. This dysregulation may contribute to the development of obesity-related diseases such as diabetes, cardiovascular disease, and cancer.
Changes in intestinal bacteria have been linked to metabolic diseases such as diabetes and dyslipidemia. A study found that antibiotic-induced dysbiosis can decrease blood glucose and triglyceride levels, highlighting the potential for targeting intestinal bacteria to prevent or treat these conditions.
Scientists at the University of Bonn have found that ceramide synthase not only produces vital lipids but also regulates gene activity, particularly in response to nutritional status. The enzyme's homeodomain plays a crucial role in adapting gene expression to energy requirements.
Research reveals that exposure to environmental levels of triclocarban can transfer from mother to offspring and interfere with lipid metabolism. This could have serious implications for human health, particularly in early life development.
Researchers summarize vinegar's anti-bacterial, antioxidant, and weight loss capabilities due to organic acids, polyphenols, and acetic acid. The review also highlights potential anticancer activities of certain grain vinegars.
Researchers have identified a key gene in energy metabolism, revealing its crucial role in regulating fat storage. The Sirt7 gene plays a central role in the process, enabling mice to maintain normal weight despite high-fat diets, suggesting new therapeutic approaches for obesity and metabolic disorders.
Researchers found that increased autophagy in germline-less worms led to higher activity of a fat-digesting enzyme, extending their lifespan. The study suggests that recycling fat is beneficial for worms, and may have implications for human diseases such as cancer and Alzheimer's.