Articles tagged with Toxicity
New research reveals that stricter vehicle standards are changing the composition of exhaust, with more toxic oxygenated compounds released. This shift highlights the importance of considering individual VOC species in future emissions regulations.
Pyrogallol's toxicity in aquatic organisms has been linked to oxidative stress and damage across multiple biological systems. The analysis identifies the need for broader environmental surveillance, long-term ecological studies, and improved exposure assessment to determine its effects on human health.
Biochar's ability to retain carbon in soil is strengthened by cadmium contamination, with mechanisms including cation bridging and microbial inhibition. This unexpected interaction has implications for using biochar in contaminated agricultural soils.
Lip cosmetics products are routinely ingested and absorbed through lip tissue, but existing frameworks were never designed to assess this dual-pathway exposure route. Researchers found significant gaps in testing and regulation, including inadequate absorption data and outdated ingestion assumptions.
New research suggests that tire microplastics can create environmental hotspots that facilitate the persistence, transfer, and spread of antibiotic resistance genes through cities. The microplastics can develop dense microbial biofilms, release chemicals that select for resistant bacteria, and contribute to oxidative stress.
Researchers developed an AI framework that extracts and organizes large amounts of information about plastic chemicals from text and images. The system achieved high accuracy and completeness in extracted data, identifying 2,144 chemicals with persistence, bioaccumulation, and toxicity characteristics.
A new study uses machine learning to predict chemical toxicity in rare and endangered species, reducing the need for direct biological testing. The model achieved strong performance predicting acute and chronic toxicity, with life stage being a key factor.
Researchers at Stanford University have identified a new type of immune cell called ruptoblasts in flatworms, which can kill surrounding cells through an explosive process called ruptosis. This discovery could hold important insights for modern medicine and may lead to targeted treatments for bacterial infections or tumors.
A University of Cincinnati research team will examine how microplastics and nanoplastics accumulate in the body and affect cardiovascular health, with a focus on potential toxicity and worsening outcomes after a heart attack. The five-year study aims to advance understanding of microplastic impact on heart diseases.
Researchers found that repeated vaping can create harmful byproducts in high-puff electronic cigarettes, including methylglyoxal and glyoxal, which are associated with significant cell damage. The study suggests that users of heavily used devices may inhale higher levels of these compounds than those using fresh devices.
In patients with symptomatic rheumatic heart disease, digoxin significantly reduced the risk of a composite of all-cause death or new-onset or worsening heart failure. The treatment had little risk of toxicity, making it a promising therapeutic option for these patients.
Scientists at the University of Virginia Health System have developed a suite of AI-powered tools, called YuelDesign, YuelPocket and YuelBond, to transform how new drugs are created. These tools can design drug molecules tailored to fit their protein targets exactly, even accounting for protein flexibility.
Scientists create fluorescent nanoplastics that resemble real-world plastics in morphology, enabling real-time tracking and studying chronic exposure effects. The study reveals that smaller particles retain longer in the body, highlighting the need for further research on health risks due to microplastic ingestion.
A new study found that MET signaling plays a critical protective role in acetaminophen-induced acute liver failure by reducing liver damage and accelerating regeneration. The findings suggest targeting MET signaling could become a game-changer for treating drug-induced ALF, potentially reducing the need for emergency liver transplants.
The review synthesizes over a decade of research on ammonia inhibition in anaerobic digestion, highlighting emerging tools to stabilize biogas production from nitrogen-rich wastes. Biological and material-based solutions, digital technologies, and synthetic biology are discussed as potential mitigations.
A comprehensive review outlines how ammonia disrupts biogas production and identifies practical strategies to prevent system failure. Emerging solutions include the integration of artificial intelligence and machine learning into digester monitoring.
Researchers at the University of Geneva have created a laboratory platform to rapidly evaluate the toxicity of new cancer treatments using human tissue-derived cell clusters. This approach allows for safer evaluation and could lead to personalized treatment options.
A Stanford University-led study found that gas stoves emit significant amounts of nitrogen dioxide, a pollutant linked to health issues such as asthma and lung cancer. Replacing gas stoves with electric ones reduces nitrogen dioxide exposure by over a quarter on average across the US.
A large-scale laboratory screening identified 168 chemicals toxic to human-made gut bacteria. Washing fruit and veggies before consumption may help avoid exposure to these pollutants. Researchers developed a machine learning model to predict chemical harm, emphasizing the need for safer industrial practices.
Researchers analyzed 70 plastic children's products sold in Brazil and found high levels of toxic substances, with barium levels up to 15 times higher than permitted. The study highlights the need for stricter enforcement measures to protect children's health.
Scientists at St. Jude Children's Research Hospital developed a new approach to safely reduce therapy in children with medulloblastoma, a pediatric brain tumor. The analysis of almost 900 patients identified four actionable treatment recommendation groups from low to high intensity.
A recent study at the University of Gothenburg discovered that two medications, cholestyramine and colesevelam, can rapidly eliminate perfluoroalkyl substances (PFAS) from the body. The findings suggest a potential therapeutic application for these medicines in reducing PFAS levels.
Researchers at the Federal University of São Carlos developed a sensor that can identify sodium nitrite in beverages. The device uses cork, laser-induced graphene, and electrochemical oxidation to detect the substance, which has potential carcinogenic effects. The sensor performed excellently with high sensitivity and good stability.
Pediatric marijuana ingestions have increased by over 1,000% in the past seven years, primarily due to increased access to cannabis products during the COVID-19 pandemic. Children under 5 years old are most affected, with Black children and those from publicly insured households being disproportionately exposed.
A new study by Environmental Working Group found that consuming certain fruits and vegetables can increase pesticide levels in people's bodies. The study suggests that everyday food choices can drive significant pesticide exposure and highlights the need for safer food systems.
A federally funded study found children with leukemia who were exposed to pesticides during their mother's pregnancy had a higher risk of death. The study, published in Cancers, examined over 800 children and showed pesticide exposure increased child mortality by up to 60%.
A new review warns that strobilurin fungicides, widely used in farming, are contaminating staple foods, water, and human bodies. Small amounts can cause harm, interfering with cell energy production and potentially disrupting hormones.
A new storage method significantly reduces the acute toxicity of Artemisia argyi essential oil by 40%, while enhancing its antioxidant and analgesic activities. The study uses gas chromatography-mass spectrometry and zebrafish models to assess changes in chemical composition, toxicity, and bioactivity during storage.
Research at University of Arizona Health Sciences found PFAS exposure affects gene activity, tied to cancers, neurological disorders, and autoimmune conditions. Changes in miRNA activity indicate potential health risks, suggesting a link between environmental exposures and disease.
A study by University of Notre Dame researchers found that almost a third of reusable menstrual products contain PFAS, despite being marketed as eco-friendly. The presence of these toxic fluorinated compounds poses risks to both users and the environment when disposed of.
Protonation of carbon nitride increases its affinity with phospholipid membranes, leading to enhanced phospholipid membrane-rupturing capabilities. Surface characterization revealed reduced net negative charge, allowing for tight binding with phospholipid headgroups.
A new multi-cohort study found that exposure to certain metals detected in urine is associated with a higher risk of heart failure. The study analyzed over 10,000 adults across diverse geographic and racial backgrounds and observed consistent associations between elevated urinary metal levels and increased HF risk.
Cessation of public water fluoridation would lead to higher rates of tooth decay and increased healthcare costs in the US. The model suggests that current safe levels of fluoride have substantial ongoing benefits.
Researchers developed a cell-based reporter assay that can quantify epigenetic changes induced by chemicals and potential carcinogens. The epi-TK assay detects gene silencing and activation, reflecting epigenetic changes associated with both gene expression and DNA methylation.
A group of long-lasting compounds called PFAS are ubiquitous in everyday products and the environment. Researchers hope to learn which ones are more toxic, and for whom, by using tiny worms to test their health effects.
A UCLA study validates the predictive power of PROSTOX, a genetic test that uses microRNAs to identify patients at higher risk of developing long-lasting urinary side effects from radiation therapy. The test helps doctors and patients choose safer treatment options, reducing the burden of long-term complications.
Researchers developed a biosensor using an Amydetes vivianii firefly enzyme that detects pH changes in mammalian cells, which could be used to study diseases and assess drug toxicity. The technique is non-toxic and stable, providing a stronger glow than previous luciferases.
Researchers propose GLDH as a more liver-specific biomarker for detecting liver injury, offering greater specificity than current ALT and AST tests. The test performed similarly to ALT for detecting liver injury but was not impacted by associated muscle injury.
A new study confirms that a shorter, higher-dose-per-day radiation course is as effective as conventional radiotherapy for treating early-stage prostate cancer without increasing side effects. The study found similar cancer control rates and fewer gastrointestinal issues with the new approach.
Recent studies have identified over 1,000 new chemicals in food contact materials, including per- and polyfluoroalkyl substances (PFAS) and phthalates. The updated FCCmigex database now includes 5,294 chemicals from 1,500 scientific studies.
Researchers confirm presence of potentially toxic Ostreopsis ovata algae in La Concha Bay, highlighting importance of substrate type and need for further study. Continued monitoring is advised to determine level of concentration and control situation.
Researchers at USC Stem Cell discovered a gene called KCTD20 that suppresses glutamate toxicity, leading to enhanced tau protein clearance. This approach offers a promising therapeutic strategy for patients with tau-related neurodegenerative diseases, including Alzheimer's disease.
Researchers found that polymers used as flame retardants can break down into dozens of smaller molecules, causing mitochondrial dysfunction and developmental harm. The study also detected these pollutants in soil, air, and dust near electronic waste recycling facilities.
Low-dose microplastic exposure leads to abnormal reproduction in females, characterized by oocyte meiotic maturation defect and H4K16 hyperacetylation. HDAC3 insufficiency is proposed as a key mechanism underlying this toxicity.
A new biodegradable polymer-based delivery system efficiently transports mRNA, outperforming existing lipid nanoparticles in delivery efficiency and expression duration. The study also shows improved immune response results without liver accumulation or toxicity.
Nanomaterials are being studied for their potential in combating marine oil spills, with promising results showing improved removal efficiency and reduced toxicity. The researchers emphasize the need for eco-friendly and sustainable approaches to minimize environmental risks.
A recent study published in Lancet Oncology reveals a significant link between early side effects from radiation therapy for prostate cancer and long-term complications. Men who experience moderate acute urinary or bowel side effects during treatment are nearly twice as likely to develop late urinary or bowel issues, respectively. This...
A phase 2 clinical trial found that a combination of two HER2 inhibitors was more effective and better tolerated than standard EGFR inhibitor-based therapy for patients with HER2-positive metastatic colorectal cancer. The study showed that the level of HER2 amplification in tumors played a key role in determining treatment outcomes.
A cross-sectional study found that children exposed to secondhand cannabis smoke at home have significantly higher urinary cannabinoid biomarker levels, indicating increased exposure to toxic and carcinogenic chemicals. Reducing in-home cannabis smoking can substantially reduce child exposure to these harmful substances.
Researchers at Chalmers University of Technology found that biochar significantly reduces DDT uptake by earthworms in contaminated soil, halving the toxin's presence. This method could enable farming on land deemed unusable due to environmental risks.
Scientists have discovered a way to remove toxic compounds from potatoes, making them safer to eat and easier to store. By engineering plants to control when and where these compounds are produced, researchers envision crops that can be stored without risk of toxicity.
A new study reveals DNAN, a chemical compound replacing TNT in explosives, harms plants by accumulating throughout the plant and lingering for longer. This poses a risk of animals consuming infected plants, introducing toxin into the food chain.
A new study found that residential garden produce grown near the Fayetteville Works fluorochemical plant can contain high levels of GenX and other PFAS, posing an exposure risk to consumers. Water-rich produce like berries and figs exhibited the highest PFAS levels, with daily intake estimates suggesting a significant health concern.
Patients receiving MRI-guided SBRT experienced significantly fewer urinary and bowel side effects compared to CT-guided treatment. MRI guidance also correlated with improved scores on specific quality-of-life measures, including bowel function and sexual health.
Researchers identified two microbe strains capable of degrading petroleum hydrocarbons, holding promise for treating contaminated marine oil spills. These microorganisms also exhibit potential to reduce the toxicity of oily wastewater, offering a sustainable solution for environmental remediation.
A new study by Brown University researchers found that using personal care products during pregnancy is associated with higher concentrations of PFAS in blood plasma and breast milk. The study suggests that people concerned about their exposure may benefit from cutting back on these products.
Researchers at Baylor College of Medicine discovered that TYK2 transforms tau into a toxic protein contributing to Alzheimer's disease. Partially restraining TYK2 could be a strategy to reduce tau levels and toxicity.
Researchers at WVU are developing a hybrid of silver and carbon nanotubes to reduce antibiotic-resistant infections in open bone fractures. The study aims to create a safe and effective antimicrobial material that can be used on various medical products.
A recent study published in the Journal of the American Veterinary Medical Association has revealed new insights into treating cats exposed to toxic lilies. The study found no significant difference in acute kidney injury prevalence between inpatient and outpatient groups, suggesting that outpatient management may be a viable option fo...
The study evaluated large language models for healthcare applications, highlighting dimensions such as fairness, bias, and toxicity. It emphasizes the need for standardized applications and metrics to ensure real patient care data is considered.