Researchers at USC Stem Cell lab discovered nearly 40 genes associated with immune cell production, including those related to diseases like myelodysplastic syndrome. The study found that gene activity was linked to specific levels of immune cell production, offering insights for improving bone marrow transplantation strategies.
SourceKeck School of Medicine of USC·JournalScience Advances·TypeExperimental study·DateJan 26, 2024
A microbial sensor, Nod1, plays a crucial role in the development of blood stem cells. The discovery could lead to the creation of patient-derived blood stem cells, eliminating the need for bone marrow transplants and improving lives of leukemia, lymphoma, and anemia patients. Researchers are continuing to study the complex interaction...
SourceIowa State University·JournalNature Communications·TypeExperimental study·DateDec 19, 2023
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Researchers at Kobe University developed a new model of mice with humanized immune systems to test anti-cancer drugs targeting the immune system. The study showed that a therapy blindfolding immune cells to self-recognition can activate them to attack tumor cells, promoting an effective cancer response.
SourceKobe University·JournalFrontiers in Immunology·TypeExperimental study·DateDec 14, 2023
Researchers discovered a link between gene therapy and the accumulation of stem cells with genetic mutations, which can lead to accelerated growth and increased blood cancer risk. The study suggests that younger patients may be safer candidates for gene therapy due to fewer genetic mutations.
SourceUniversity of York·JournalNature Medicine·TypeExperimental study·DateNov 16, 2023
Researchers discovered Leishmania parasites in blood-related stem cells of chronically infected mice, challenging the textbook understanding of the disease. The finding may lead to new treatment options and improve our understanding of why some people develop visceral leishmaniasis despite having immune disorders.
SourceOhio State University·JournalCell Reports·DateSep 29, 2023
A small molecule drug improved the fitness of hematopoietic stem cells used in cell transplants, potentially enhancing the success of procedures like ex vivo gene therapy. The study found that targeting extracellular vesicles relieved stress on cells outside the body, improving their performance when transplanted back in.
SourceChildren's Hospital of Philadelphia·JournalBlood·DateSep 27, 2023
Dr. Hung Nguyen is studying how medium chain fatty acid foods like coconut oil and avocados affect GVHD severity and mortality in transplant patients. His goal is to develop a dietary approach that reduces inflammation and corticosteroid use, improving patient outcomes for blood cancers.
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A team of researchers at Tokyo Medical and Dental University has identified a gene called Rasip1 as crucial for blood cell development. SOX17, a transcription factor, is found to activate Rasip1, leading to the formation of hematopoietic stem cells and associated hematopoietic activity.
SourceTokyo Medical and Dental University·JournalInflammation and Regeneration·DateSep 13, 2023
Researchers discover compound Urolithin A restores mitochondrial function in hematopoietic stem cells, rejuvenating blood reconstitution capability and improving immune system function. The study shows promising results in aging mice, paving the way for potential interventions targeting age-related health conditions.
SourceUniversity of Lausanne·JournalNature Aging·DateSep 6, 2023
Researchers found that mutations in blood stem cells can promote the development of colitis-associated colon cancer (CAC) by increasing blood vessel formation. Blocking certain drugs, such as axitinib, inhibited CAC tumor growth in mice with clonal hematopoiesis, suggesting potential therapeutic strategies.
SourceRockefeller University Press·JournalJournal of Experimental Medicine·TypeExperimental study·DateAug 24, 2023
A new study by Weill Cornell Medicine researchers found that severe COVID-19 infection can alter the immune system's response, causing long-lasting changes to gene expression in immune system stem cells. This can lead to symptoms of prolonged inflammation and 'long COVID' in affected individuals.
CHOP and Penn Medicine researchers have developed a proof-of-concept model for delivering gene editing tools directly into diseased blood cells within the body. This approach aims to reduce costs and increase access to gene therapies for blood disorders, which currently require chemotherapy and stem cell transplants.
SourceChildren's Hospital of Philadelphia·JournalScience·DateJul 27, 2023
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Hematopoietic stem cell culture technology improves genome editing in HSCs by increasing successful correction rates to 100%, eliminating genetic mutations, and enhancing cell transplantation outcomes. This breakthrough enhances the efficiency and safety of gene editing in treating genetic diseases.
SourceUniversity of Tsukuba·JournalCell Stem Cell·DateJul 10, 2023
A new database linking RNA editing to blood cell differentiation has been established, providing a platform to accelerate research on leukemia and other pathologies. The REDH database includes detailed information on RNA editing sites in healthy and malignant hematopoietic cells.
SourceCactus Communications·JournalChinese Medical Journal·TypeObservational study·DateJul 10, 2023
Researchers use base editing technology to restart fetal hemoglobin expression in SCD patient cells, achieving higher and more stable levels than other genome editing technologies. The approach has potential as a 'one-size-fits-all' treatment for all mutations that cause SCD and beta-thalassemia.
SourceSt. Jude Children's Research Hospital·JournalNature Genetics·DateJul 3, 2023
Researchers have developed a new standard for preventing graft-versus-host disease (GVHD) after stem cell transplant, showing improved efficacy and reduced side effects compared to the current gold standard. The new regimen achieved higher rates of patient survival without GVHD complications, making it a more effective option for patie...
SourceJohns Hopkins Medicine·JournalNew England Journal of Medicine·DateJun 22, 2023
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A team led by Professor Satoshi Yamazaki has established a novel culture system that supports long-term ex vivo expansion of human hematopoietic stem cells (HSCs), overcoming previous limitations. The new system, which uses chemically-defined cell culture media, significantly improves HSC growth and proliferation.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
SourceXi'an Jiaotong-Liverpool University·JournalNano Letters·TypeExperimental study·DateMay 8, 2023
A study by Linköping University researchers found that blood stem cells from leukemia patients remain in the bone marrow, but become defective over time, leading to long-term effects on blood formation. This discovery may explain why many leukemia survivors experience blood cell function disorders later in life.
SourceLinköping University·JournalHaematologica·TypeExperimental study·DateApr 5, 2023
A study published in the Journal of Infection found that mNGS was significantly more effective at detecting bloodstream infections than conventional microbiological tests (CMTs), identifying 187 infection cases compared to CMTs' 81. Viral infections were the most common type, with CMV being the leading cause.
SourceBGI Genomics·JournalJournal of Infection·DateMar 23, 2023
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Researchers at Lund University discovered a novel mechanism linking RNA splicing to the development of leukemia in myelodysplastic syndrome patients. The study highlights the critical role of core spliceosome component SF3B1 and its regulation by N6-methyladenosine (m6A) modification, which provides a
SourceLund University·JournalMolecular Cell·DateMar 21, 2023
Researchers found that severe herpesvirus infections can strongly activate host cellular immunity, leading to a therapeutic effect on refractory adult T-cell leukemia/lymphoma. This activation may play an important role in the survival of patients with this intractable disease.
SourceImpact Journals LLC·JournalGenes & Cancer·TypeCommentary/editorial·DateFeb 24, 2023
Researchers have successfully converted pluripotent stem cells into hematopoietic stem and progenitor cells using optimized transcription factors. The resulting PSC-derived cells generated all types of white blood cells in mice without giving rise to tumors or leukemias, suggesting a promising future for PSC-based transplant therapies.
SourceInternational Society for Stem Cell Research·JournalStem Cell Reports·DateFeb 16, 2023
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Researchers at Columbia University Irving Medical Center have found that an anti-inflammatory drug can turn back time in mice and reverse some of the effects of age on the hematopoietic system. By targeting the aging niche, the study suggests a new strategy for maintaining healthier blood production in older adults.
SourceColumbia University Irving Medical Center·JournalNature Cell Biology·TypeExperimental study·DateFeb 6, 2023
A new Pitt study reframes understanding of graft-versus-host disease, suggesting that GVHD is locally maintained by donor T cells in target tissues. The research, published in Immunity, offers an alternative model that could guide development of novel therapies and improve outcomes for stem cell recipients.
SourceUniversity of Pittsburgh·JournalImmunity·TypeExperimental study·DateJan 30, 2023
Researchers at Children's Hospital of Philadelphia have developed a custom-built application to automate the determination of engraftment after hematopoietic stem cell transplant. The tool has been shown to improve accuracy of reported engraftments, reducing errors in neutrophil and platelet engraftment reporting.
SourceChildren's Hospital of Philadelphia·JournalTransplantation and Cellular Therapy·DateJan 23, 2023
In an emergency situation like infections or blood loss, the body needs to quickly compensate for the loss of blood cells. Scientists have found that progenitor cells in mice are responsible for regenerating mature blood cells, not hematopoietic stem cells.
SourceGerman Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)·JournalCell Stem Cell·DateJan 17, 2023
Researchers identified 17 clusters of single cells in peripheral blood, showing upregulation of antigen processing and presentation pathways and downregulation of genes involved in ribosome pathways with age. The study also found senescent T cells resistant to apoptosis, potentially targeted for treatment.
SourceImpact Journals LLC·JournalAging-US·TypeObservational study·DateJan 17, 2023
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A retrospective study found that hematopoietic stem cell transplants delayed disability progression and improved symptoms in people with active secondary progressive multiple sclerosis. The study suggests that these transplants may be more effective than some MS medications, but further research is needed to confirm the findings.
SourceAmerican Academy of Neurology·JournalNeurology·DateDec 21, 2022
The study shows that RXR ensures hematopoietic stem cells remain youthful and fit, reducing the risk of developing myeloproliferative syndromes. The regulatory action of RXR on these cells is essential for maintaining a balanced production of blood cell types throughout life.
SourceCentro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)·JournalBlood·TypeExperimental study·DateDec 15, 2022
Researchers from Kumamoto University reveal how hematopoietic stem and progenitor cells orchestrate intestinal tissue repair through microbial signals. The study found that acute gut inflammation triggers the activation and expansion of immune progenitor cells, which migrate to lymph nodes to promote tissue repair.
SourceKumamoto University·JournalThe EMBO Journal·TypeExperimental study·DateDec 8, 2022
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Researchers have characterized the functional significance of DDX41 in molecular processes underlying cancer. The study reveals that DDX41 serves crucial functions in transcriptional processes, RNA splicing, and genomic integrity maintenance, which may hold significance in treating hematopoietic malignancies.
SourceKumamoto University·JournalLeukemia·TypeExperimental study·DateNov 17, 2022
A new statistical method called CLIMB provides a more efficient way to analyze genomic data across multiple conditions. The method combines principles from two traditional techniques, reducing computational intensity and producing biologically interpretable results.
SourcePenn State·JournalNature Communications·TypeData/statistical analysis·DateNov 14, 2022
Researchers identified a specific gut bacterium responsible for antibiotic-induced GVHD after stem cell transplants. A sugar supplement was found to improve gut health by distracting the bacteria from attacking mucin in the intestinal lining, reducing complications such as GVHD.
SourceUniversity of Texas M. D. Anderson Cancer Center·JournalCell·DateSep 29, 2022
Researchers discovered that macrophages eliminate stressed stem cells with high levels of reactive oxygen species, while healthy cells are amplified. The study found that a specific marker, calreticulin, acts as an 'eat me' signal for stressed cells.
SourceBoston Children's Hospital·JournalScience·DateSep 27, 2022
Researchers found that getting enough sleep influences the environment where monocytes form, develop, and get primed to support immune function. This process, hematopoiesis, occurs in the bone marrow and can accelerate clonal hematopoiesis, an age-related condition linked to cardiovascular disease.
SourceNIH/National Heart, Lung and Blood Institute·JournalJournal of Experimental Medicine·DateSep 21, 2022
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Research at Kumamoto University reveals that fetal liver blood cells are stem cell-independent, contrary to the long-held view that HSCs are essential for their production. The study provides new insights into the origin of HSCs and suggests a reconsideration of their role in embryo formation.
SourceKumamoto University·JournalNature·TypeExperimental study·DateSep 20, 2022
A recent study published in Frontiers in Pediatrics suggests that modern immunotherapies, such as CAR-T cell therapy, could replace traditional stem cell transplantation for high-risk ALL patients. The review also discusses the importance of reducing long-term side effects, including organ damage and secondary cancers.
SourceSt. Anna Children's Cancer Research Institute·JournalFrontiers in Pediatrics·DateSep 7, 2022
A KAUST-led research team identified two drug treatments that boost the activity of molecules involved in cell adhesion, enhancing the ability of blood-forming stem cells to enter the bloodstream and produce new blood. This breakthrough could lead to improved bone marrow transplant success for leukemia patients.
SourceKing Abdullah University of Science & Technology (KAUST)·JournalBlood Advances·DateAug 25, 2022
A recent study published by the German Cancer Research Center found that inflammation in early life leads to a permanent decline in functional blood stem cells, suppressing their ability to regenerate. Mice exposed to inflammatory challenges developed clinically relevant features of aging, including anemia and decreased number of cells...
SourceGerman Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)·JournalCell Stem Cell·DateAug 4, 2022
A Purdue University chemical engineer has improved upon traditional methods to produce off-the-shelf human immune cells that show strong antitumor activity. The new method, developed by Xiaoping Bao, mass-produces CAR-neutrophils from human pluripotent stem cells with superior and specific antitumor activities against glioblastoma.
SourcePurdue University·JournalCell Reports·DateAug 3, 2022
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Researchers studied the immunogenic potential of the 4CMenB vaccine in hematopoietic stem cell transplant recipients, finding 90% of patients developed protective antibody levels after two doses. The trial supports including meningococcal B vaccination alongside A, C, W, and Y vaccines from 6 months post-transplant to improve protection.
SourceInstitut Pasteur·JournalClinical Microbiology and Infection·DateJul 29, 2022
Researchers create CDyB, a fluorescent probe that targets SLC35C2 transporter in B cells, allowing for live-cell distinction from T cells. The study enriches the molecular probe toolbox and opens possibilities for multi-dimensional cell analysis.
SourceInstitute for Basic Science·JournalAngewandte Chemie·TypeExperimental study·DateJul 21, 2022
A groundbreaking study using cellular barcoding in mice reveals that blood cells originate from two independent sources: hematopoietic stem cells and embryonic multipotent progenitor cells. These findings have significant implications for understanding blood cancers, bone marrow transplant, and the aging immune system.
SourceBoston Children's Hospital·JournalNature·DateJun 15, 2022
Researchers aim to understand how HIV affects cardiovascular health and the impact of substance use on this relationship. They plan to develop a human bone marrow chip model to study HIV pathogenesis and explore potential strategies for caring people with HIV who face cardiovascular disease.
The study found that mice lacking both Runx1 and Runx2 in CAR cells showed a significant reduction of HSPCs and immune cells, along with an increase in fibrosis. The researchers suggest that Runx1 and Runx2 may be potential targets for the diagnosis and treatment of myelofibrosis.
SourceOsaka University·JournalNature Communications·TypeExperimental study·DateJun 9, 2022
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Researchers used heterochronic parabiosis to connect old and young mice, revealing key mediators of systemic rejuvenation. Aged stem cells in bone marrow were revitalized by exposure to young blood, regaining lymphoid differentiation potential.
SourceChinese Academy of Sciences Headquarters·JournalCell Stem Cell·TypeExperimental study·DateMay 26, 2022
A study led by Kobe University researchers found that idiopathic autism is caused by epigenetic abnormalities in hematopoietic cells, leading to immune dysregulation and brain-gut axis disorders. The study used BTBR mice as a model and identified histone deacetylase HDAC1 as a common mechanism underlying these pathologies.
SourceKobe University·JournalMolecular Psychiatry·TypeExperimental study·DateMay 1, 2022
A UCLA-led team has created a roadmap tracing each step in human blood stem cell development, providing a blueprint for producing fully functional blood stem cells. The map could help expand treatment options for blood cancers and inherited disorders.
SourceUniversity of California - Los Angeles·JournalNature·TypeObservational study·DateApr 13, 2022
Researchers identified a signature of nonresponse to CAR T therapy in leukemia cells, characterized by DNA methylation and stem cell-like phenotypes. Decreased expression of genes involved in antigen presentation also hindered the immune response.
SourceAmerican Association for Cancer Research·DateApr 12, 2022
Researchers developed a new treatment option for relapsed or refractory CD30+ lymphoma using natural killer cells complexed with a CD30/CD16A bispecific antibody. The treatment showed an overall response rate of 89% in patients with advanced lymphoma.
SourceAmerican Association for Cancer Research·DateApr 10, 2022
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Researchers discovered that a genetic mutation causing odd-shaped nuclei may lead to earlier diagnosis and treatment of certain leukemias. The study found that the loss of nuclear Lamin B1 induces defects in nuclear morphology and genome instability, setting the stage for cancer.
SourceUniversity of Washington School of Medicine/UW Medicine·JournalCell Stem Cell·TypeExperimental study·DateApr 4, 2022
Dr. John E. Dick will receive the inaugural AACR Award for Outstanding Achievement in Blood Cancer Research for his groundbreaking discoveries on leukemic stem cells and their mechanisms. His research has provided crucial insights into leukemia progression, survival rates, and treatment response.
SourceAmerican Association for Cancer Research·DateMar 25, 2022
A study published in Nature Medicine defines distinct subgroups of stem cells that expand during MDS treatment and drive resistance. Researchers found that targeting these specific stem cell classes with therapies like venetoclax may improve outcomes for patients with disease progression.
SourceUniversity of Texas M. D. Anderson Cancer Center·JournalNature Medicine·DateMar 2, 2022
Scientists have discovered the signature of genes expressed by hematopoietic stem cells that can produce healthy blood cells after being transplanted. This finding could enable scientists to expand these cells outside the body or convert other types of stem cells into functional blood cells.
SourceMassachusetts General Hospital·JournalNature Communications·TypeExperimental study·DateMar 1, 2022
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Researchers found that infusing bone-marrow stem cells into mice with sepsis increased their survival by 50-60% and decreased inflammation. This treatment could offer an alternative to current granulocyte transfusions, which have limited benefits.
SourceeLife·JournaleLife·TypeExperimental study·DateFeb 15, 2022
A new study reveals that histone H3.3 plays a crucial role in maintaining the balance between self-renewal and differentiation of blood stem cells, leading to abnormalities when deleted. The protein anchors key epigenetic marks at developmental genes and endogenous retroviruses, contributing to an inflammatory response and skewed produ...
SourceWeill Cornell Medicine·JournalNature Cell Biology·DateJan 28, 2022
Researchers discovered a protein, syndecan-2, that helps identify and deploy blood stem cells for treatments. Transplanting only cells expressing syndecan-2 could make blood stem cell transplants more efficient and less toxic.
SourceCedars-Sinai Medical Center·JournalBlood·DateJan 25, 2022
Survival rates for adult patients with relapsed acute lymphoblastic leukemia (ALL) after hematopoietic cell transplantation have increased significantly over the past two decades. The two-year overall survival rate rose from 27.8% in 2000-2004 to 54.8% in 2015-2019, despite a significant increase in patient age at relapse.
SourceAmerican Association for Cancer Research·JournalClinical Cancer Research·DateJan 12, 2022
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Researchers at UC Davis Health developed a new treatment that simultaneously blocks IL-6 and TNF cytokines, providing superior protection against acute graft-versus-host-disease severity and mortality. The dual-cytokine blockade approach did not impair beneficial graft-versus-tumor effects.
SourceUniversity of California - Davis Health·JournalBlood·DateDec 16, 2021