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How do mushrooms become magic?

Scientists are conducting a first-of-its-kind study to investigate the origin of psychedelic compounds in fungi, including psilocybin found in 'magic mushrooms'. The research aims to understand the evolution of these compounds and their potential applications in medicine and conservation.

A new understanding of the neurobiology of impulsivity

A new genetically based score developed by McGill University researchers can identify children at high risk for impulsive behavior with a high degree of accuracy. The score was created by analyzing the co-expression of genes in key brain regions, providing a novel understanding of the neurobiology of impulsivity.

SourceMcGill University·JournalMolecular Psychiatry·DateSep 22, 2022

Rare human gene variant in ADHD, autism exposes fundamental sex differences

A new study reveals key differences in dopamine disposal machinery between male and female mice with a rare human genetic variant found in boys with ADHD or ASD. Females exhibit unique behavioral changes, such as increased anxiety and novelty recognition issues, while males display reduced social behavior and perseverative traits.

SourceFlorida Atlantic University·JournalMolecular Psychiatry·TypeExperimental study·DateSep 21, 2022

Molecular changes in the brain in the aftermath of a traumatic event may help explain long-term susceptibility or resilience

Researchers found that stressed mice exhibited decreased neuron excitability in the dorsal hippocampus, which may drive social avoidance, while resilient mice showed increased excitability. This difference was linked to changes in stress hormone receptors and HCN1 protein expression.

SourceMedical College of Georgia at Augusta University·JournalMolecular Psychiatry·DateSep 20, 2022

Wireless activation of targeted brain circuits in less than one second

Researchers from Rice University, Duke University, Brown University and Baylor College of Medicine developed a magnetic technology to wirelessly control neural circuits in fruit flies. They used genetic engineering to express heat-sensitive ion channels in neurons that control the behavior, and iron nanoparticles to activate the channels.

SourceRice University·JournalNature Materials·TypeExperimental study·DateJul 14, 2022

Scientists discover key genes behind insect migrations

Researchers have identified over 1,500 genetic differences between migratory and non-migratory hoverflies, shedding light on the genetic pathways involved in migration. The study reveals suites of genes being activated in concert, including insulin signalling for longevity and pathways for immunity.

SourceUniversity of Exeter·JournalMolecular Ecology·TypeData/statistical analysis·DateJul 8, 2022

Natural selection may be making society more unequal

A new study published in Behavior Genetics found that natural selection favors characteristics associated with lower earnings and poorer education, such as having more children. The research, led by UEA, analyzed data from over 300,000 people in the UK and suggests that this may be contributing to increasing income inequality.

SourceUniversity of East Anglia·JournalBehavior Genetics·TypeData/statistical analysis·DateJul 7, 2022

The secret lives of mites in the skin of our faces

Researchers analyzed DNA of Demodex folliculorum mites living in human hair follicles, finding unusual body features and behaviors due to their isolated existence. The study suggests these mites may transition from external parasites to internal symbionts as they shed unnecessary genes and cells.

SourceUniversity of Reading·JournalMolecular Biology and Evolution·TypeObservational study·DateJun 21, 2022

Why hungry worms take risks

Researchers used worms to study how hunger signals in the gut communicate with the brain, leading to riskier behavior. The findings suggest that proteins in intestinal cells move dynamically to transmit signals about hunger, driving worms to cross toxic barriers.

SourceSalk Institute·JournalPLOS Genetics·TypeExperimental study·DateMay 5, 2022

Alcohol use linked to lower connectivity in brain areas that process emotions

Researchers found lower functional connectivity between brain areas involved in social and emotional processing in individuals at risk of developing alcohol use disorder. This impairment may affect their ability to interpret facial expressions and respond to their environment, increasing the likelihood of disordered drinking.

SourceUniversity of California - San Diego·JournalAlcoholism Clinical and Experimental Research·DateFeb 8, 2022

New research on magnetite in salmon noses illuminates understanding of sensory mechanisms enabling magnetic perception across life

A new theory outlines how magnetite crystals in specialized receptor cells of salmon and other animals may have roots in ancient genetic systems developed by bacteria, suggesting a common evolutionary history between magnetite-producing bacteria and fish. The findings have the potential for widespread application, from improving salmon...

SourceOregon State University·JournalProceedings of the National Academy of Sciences·DateJan 10, 2022

The link between electrical voltage and brain flexibility a new study by Tel Aviv university found, for the first time; a direct and significant link between changes in G-protein-coupled receptors and the brain’s ability to adapt to external changes

A Tel Aviv University study found a significant link between changes in G-protein-coupled receptors and brain adaptability. Disabling the voltage sensor of these proteins caused uncontrolled brain flexibility, leading to excessive habituation to odors.

SourceTel-Aviv University·JournalNature Communications·DateJan 4, 2022

Reduce frailty to lower dementia, study finds

A large-scale new study found that frailty was a strong risk factor for dementia, even among people at high genetic risk, and that it can be modified through a healthy lifestyle. Over 10 years, dementia was detected in 1,762 participants, with those who were frail before diagnosis having a much higher risk.

SourceUniversity of Exeter·JournalJournal of Neurology Neurosurgery & Psychiatry·TypeObservational study·DateDec 21, 2021

Medicinal cannabis oil found effective for treating autism

Researchers at Tel Aviv University successfully treated autism in animal models with medical cannabis oil, improving behavioral and biochemical parameters. The treatment showed significant improvement in compulsive and anxious behaviors, and a decrease in the concentration of the arousing neurotransmitter glutamate.

SourceTel-Aviv University·JournalTranslational Psychiatry·DateDec 19, 2021

Swirling bacteria mimic Van Gogh’s ‘The Starry Night’

Researchers from Rice University and the University of Wyoming discovered self-organization into circular aggregates in Myxococcus xanthus, a model system for social cooperation. The circular behavior is linked to TraAB protein overexpression, which creates a sticky bond between cells, preventing reversals.

SourceRice University·JournalmSystems·TypeExperimental study·DateDec 13, 2021

Largest genetic study of suicide attempts confirms genetic underpinnings that are not driven by underlying psychiatric disorders

A large-scale genome-wide association study has identified a region on chromosome 7 containing DNA variations that increase the risk of attempting suicide. The study found overlap between the genetic basis of suicide attempts and related psychiatric disorders, as well as non-psychiatric risk factors such as smoking and sleep disturbances.

SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalBiological Psychiatry·TypeObservational study·DateNov 30, 2021

In a cross-adoption experiment researchers at Tel Aviv University found that adopted baby fruit bats behave like their adoptive mothers

Researchers at Tel Aviv University conducted a cross-adoption experiment with fruit bat pups to determine whether boldness is genetic or learned. The findings indicate that the pups behave like their adoptive mothers, not biological mothers, suggesting that boldness is an acquired trait passed on through mother's milk.

SourceTel-Aviv University·JournalBMC Biology·DateNov 16, 2021

Behaviour resembling human ADHD seen in dogs

Researchers identified environmental factors and breed-specific traits contributing to canine ADHD-like behaviour. Dogs who spent more time alone at home were more hyperactive, impulsive and inattentive, while breeds bred for work displayed increased hyperactivity and impulsivity.

SourceUniversity of Helsinki·JournalTranslational Psychiatry·DateOct 15, 2021

Can parental care influence sperm-mediated effects in threespine sticklebacks?

A new study found that parental care does not seem to affect sperm-mediated effects in threespine sticklebacks, contrary to previous expectations. The researchers tested the behavior and stress responses of offspring from predator-exposed fathers with or without parental care.

Chronic stress may impact treatment completion and survival outcomes in patients with breast cancer

A study found that chronic stress, measured by allostatic load, was associated with a lower likelihood of completing chemotherapy and lower overall survival rate in patients with lymph node-positive or high-risk lymph node-negative HER2-negative breast cancer. Allostatic load may be a better predictor than genetic ancestry for chemothe...

Differences in brain structure between siblings make some more susceptible to developing severe antisocial behaviour

Researchers discovered structural differences in brain regions responsible for decision-making and empathy in adolescents with conduct disorder compared to their unaffected siblings. These findings suggest that small changes in brain function may contribute to the development of antisocial behavior in some siblings.

SourceUniversity of Bath·JournalPsychological Medicine·TypeRandomized controlled/clinical trial·DateOct 4, 2021

True behavior of the ‘pleasure molecule’ will reshape how we treat psychiatric diseases and addiction

Research reveals that dopamine levels increase with stressful stimuli, rewriting the 'pleasure molecule' narrative, and suggesting new treatment approaches for psychiatric diseases and addiction. The discovery has significant implications for understanding dopamine's role in behavior and developing evidence-based treatments.

SourceVanderbilt University·JournalCurrent Biology·DateSep 16, 2021