Articles tagged with Phenotypes
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
WheatNet achieves superior performance in detecting wheat spikes with an average precision of 89.7% across filling and maturity stages, outperforming traditional methods. The method integrates a Transform Network to minimize color feature discrepancies and demonstrates excellent counting accuracy.
Researchers identified Benidipine as a compound promoting the death of cigarette smoke-induced senescent lung cells, improving lung emphysema. The dihydropyridine family of calcium channel blockers constitutes a new class of senolytics that could improve lung diseases.
Researchers developed a background-resistant model to predict wheat Leaf Area Index (LAI) across diverse soil backgrounds, showing substantial improvement in prediction accuracy. The model demonstrated good estimation accuracy for different soil backgrounds and reliably captured seasonal LAI dynamics under various treatments.
Researchers discuss a new approach integrating genomic, epigenomic, transcriptomic, and machine learning methods to identify functional genetic variants and characterize their mode of action in regulating target genes. This method aims to improve understanding of disease etiology and prioritize causative inherited genetic variants.
A recent study by Harvard researchers provides an engineering approach to understanding the failure of macrophages in cancer therapies. The team found that different phenotypes exhibit different penetration into tumors, with M0 macrophages showing improved transport efficiency.
The German Research Foundation has renewed funding for the Research Training Group 'Gene Regulation in Evolution' at Mainz University, focusing on the role of gene regulation in adaptation and evolution. The program will recruit 13 new doctoral students and continue to support interdisciplinary research and personal development.
Researchers created an immunodeficient mouse model of physiological ovarian aging, mirroring female fertility decline with age. The study found decreased oocyte quality, impaired follicle activation and growth, and increased mitochondrial dysfunctions in Old mice.
A new study finds that higher cardiovascular health is associated with decelerated biological aging, as measured by phenotypic age. Greater adherence to all Life's Essential 8 metrics can slow down the body's aging process and have numerous benefits.
Researchers discovered BMAL1 is significantly upregulated in senescent cells and modulates the senescence program through AP-1. The study highlights a previously unappreciated role of BMAL1 in regulating cellular senescence and circadian clock components.
A recent study found that temperature variations during asexual propagation induce significant hereditary epigenetic and phenotypic modifications in Fragaria vesca ecotypes. DNA methylation patterns play a crucial role in this process, with noticeable differences between 18℃ and 28℃ conditions.
Post-Acute Sequelae of COVID-19 research aims to track long-term health symptoms in survivors. A $3.7 million grant will support the development of self-supervised deep learning technologies to recognize post-COVID lung progression phenotypes.
Researchers identified abnormal keratin expression patterns in senescent ocular surface cells, which may contribute to severe ocular surface diseases. Gene expression profiles showed substantial differences between senescent and non-senescent cells, highlighting their potential role in pathology.
A groundbreaking study by Florida Atlantic University reveals that agency emerges from the coupled relation between humans and their environment. Infants are found to discover their causal powers and transition from spontaneous to intentional behavior at a critical level of coordination, marking an abrupt increase in movement rate.
Researchers found that pregnant mice experiencing copy number variation (CNV) showed similarities to aging, with biomarkers and genetic effects appearing during pregnancy and reversing after delivery. This study aims to revolutionize aging treatment by investigating the mechanisms behind post-labor rejuvenation.
The editorial discusses epigenetic mechanisms leading to oocyte quality loss, a significant factor in age-related fertility decline. Researchers highlight the importance of understanding this process to address the growing issue of advanced maternal age and its impact on reproduction.
Researchers found that inhibiting NLRP3 signaling reduces podocyte senescence, improves lifespan, and slows down healthy podocyte aging in mice. This discovery holds promise for treating age-related kidney diseases.
Researchers have identified KIAA0930 as a key factor causing muscle atrophy in cancer cells, which could lead to the development of new anti-cachexia therapies. The study found that KIAA0930 knockdown cells showed increased muscle mass and weight compared to control cells.
Researchers developed a tailored approach to weight loss and cardiometabolic risk factors, showing significant improvement in targeted areas like abnormal fullness and emotional eating. The study suggests the need for an actionable, phenotype-based classification of patients in obesity treatment, moving beyond reliance on scales or bod...
Researchers investigated hepatic hydrogen sulfide production in a mouse model of Hutchinson-Gilford Progeria Syndrome (HGPS) and found reduced H2S levels in RC-fed mice, with partial rescue on high-fat diet. This study suggests that accelerated aging in HGPS may be partially explained by reduced hepatic H2S levels.
Researchers investigated premature senescence in biliary atresia and assessed senotherapies. They found that human allogenic liver-derived progenitor cells reduced early markers of senescence and improved liver disease in a preclinical model, providing encouraging results for pediatric biliary cirrhosis treatment.
A new review paper suggests ACSL4 status as a biomarker for breast cancer subtype classification and predictor of response to hormone-based therapies. The enzyme may also serve as a target for developing new treatment modalities in quadruple negative breast cancer.
Researchers developed Eye2Gene, an AI system that accurately identifies genetic causes of inherited retinal diseases from retinal scans. The system achieved higher accuracy than human experts in identifying causative genes, with a ranking score above 70% in over 70% of cases.
A recent study by the INSPIRE group identified four clinically distinct symptom presentations in patients with long COVID, suggesting that each patient experiences post-COVID symptoms in a unique way. The study's findings may lead to more targeted treatments for persistent symptoms.
Researchers tested zoledronic acid's effects on cellular senescence using multiple approaches. The study found that zoledronic acid killed senescent cells with minimal effects on non-senescent cells and reduced circulating SASP factors, including CCL7, IL-1β, TNFRSF1A, and TGFβ1.
Researchers discover that senescence-associated secretory phenotype (SASP) can induce neuroendocrine transdifferentiation (NED) in breast cancer epithelial cells, promoting tumor progression and aging-related features. SASP's dual role in cancer involves both antitumoral and tumorigenic effects.
Researchers have identified distinct senescence subpopulations and dynamic changes in the transcriptome of human cells undergoing senescence. The study provides new understanding of the heterogeneous nature of senescence and its impact on aging diseases.
Researchers have highlighted the importance of stromal vitamin A pathway in regulating IL-6 expression in colorectal cancer-associated fibroblasts. The study found that disrupting retinol-mediated IL-6 expression could be a potential approach to target CAFs during CRC treatment.
A new study presents a chronic wound murine model that characterizes the role of persistent senescent cell accumulation in delayed wound closure. The molecular profiles of senescent cells demonstrate the adverse influence of SASP factors, highlighting a potential root-cause-driven therapeutic strategy.
Researchers developed an AI-based method to predict Fv/Fm ratios from chlorophyll a fluorescence without dark adaptation, improving plant phenotyping speed and accuracy. The LSSVM model showed excellent performance with high correlation coefficients and low root mean square errors.
A Cornell University-led project has reconstructed Balto's phenotype using ancient DNA extraction and analysis. The research reveals that Balto had a genetically healthier and less inbred lineage than modern breeds, with characteristics adapted to the extreme environment of 1920s Alaska.
Researchers develop imaging-based computer algorithms to boost crop-breeding data using self-supervised contrastive learning methods, outperforming conventional supervised approaches. The study uses wheat as a model crop and finds that these new methods can improve plant phenotyping accuracy and scalability.
Researchers found that CUDC-907 selectively induces apoptosis in cells driven to senesce by p53 expression. The compound showed senolytic properties in different models of stress-induced senescence, depending on its inhibitory effects on HDACs and PI3K.
The Hastings Center's new report provides direction for research and communications in social and behavioral genomics, highlighting both potential benefits and significant risks. The report recommends engaging with stakeholders, justifying population definitions and phenotype measurement, and conducting studies with adequate power.
A new phenotyping approach analyzes crop traits at the 3D level using a rail-based field phenotyping platform with LiDAR and an RGB camera. The method provides accurate quantification of crop traits such as plant height, leaf shape, and leaf color.
A new study from the University of Eastern Finland identified 12 cell types involved in CAD pathogenesis. The genetic risk factors for CAD take effect via smooth vascular muscle cells, which change their phenotype as the disease progresses.
Researchers have built a new model to examine Usher Syndrome, a leading cause of combined deafness and blindness. The model replicates the visual problems not addressed by previous models, offering insight into strategies for designing therapeutic interventions.
A new study analyzing European job applications found that having a non-white phenotype reduces the likelihood of employment by approximately 20%, while dark-skinned Caucasians face a 10% decrease compared to white applicants. The combined effect of ethnicity and phenotype leads to significant discrimination levels across Europe.
A team approach to identifying patient cohorts using EHR data improves matching rates for certain e-phenotypes, such as infection and cancer. However, results vary across specialties and phenotypes, highlighting the need for expert collaboration in building accurate search queries.
Researchers analyzed 1.5 million patients with 53 million electronic notes to identify 9,477 distinct phenotypes and demonstrated a high degree of agreement with expert judgment in various clinical fields.
Researchers found that metformin + leucine (MET+LEU) treatment prevents myotube atrophy by reversing cellular senescence and improving proteostasis. The study used C2C12 myoblasts, aged mouse single myofibers, and human primary myotubes to demonstrate MET+LEU's skeletal muscle cell-autonomous properties.
Richard McIndoe is leading a national research initiative to advance understanding of diabetes and obesity through the National Centers for Metabolic Phenotyping in Live Models of Obesity and Diabetes (MPMOD). The MPMOD initiative provides access to advanced testing services, including bariatric surgery on mice, to enable new insights ...
Researchers found that senescence-associated exosomes (SA-EXOs) from MSCs induce fibrosis and activate invasive characteristics in neighboring cells via the TGF-β pathway. SA-EXOs play a large role in cancer-related fibrosis, and their unique miRNA content influences myofibroblast phenotypes.
Researchers have developed a new method for downregulating gene translation in plants using upstream open reading frames (uORFs). The study, published in Nature Biotechnology, demonstrates the potential for precise and incremental regulation of gene expression.
Researchers explore cellular senescence's complex relationship with growth stimulation and cell cycle arrest, revealing potential anti-aging drug targets. Understanding these mechanisms is crucial for developing new treatments for age-related diseases.
Researchers discovered that telomere shortening is associated with early subjective depressive symptoms and cognitive complaints among healthy elderly individuals. The study also found a link between telomere shortening and increased interleukin-6 levels.
A new study published in Genes, Brain and Behavior found that genetic variants in LINGO2, OAS1, and HECTD1 are associated with different mathematical abilities in Chinese children. The study refined genome-wide association studies of math skills and added population diversity to the literature.
Researchers have identified three novel pathogenic variants of the ATR gene as predisposing to male breast cancer. These variants were found in a cohort of individuals with early onset and familial breast cancers, using a combination of exome sequencing and functional investigations. The study suggests that extended genetic analysis ca...
Researchers used unconventional methods to study fruit fly phenotypes, finding that loss of epigenetic mark led to changes in behavior, gene expression, metabolism, and offspring production. This knowledge can aid in predicting ecological patterns of change in wild animal populations.
Researchers from Purdue University have received funding from the Trask Innovation Fund to develop and test their innovations. The awards will support projects in various fields, including plant phenotyping, genome editing, and radiative cooling paints, aiming to enhance commercial value and industry applications.
A new study found that women with pre-pregnancy migraine had greater risks of preterm delivery, gestational hypertension, and preeclampsia. Migraine with aura was associated with a higher risk of preeclampsia than without aura.
Researchers found that clearance of p16Ink4a-positive cells did not impact β-cell mass, but improved β-cell function and proliferative capacity in a subset of HFD mice. The targeted subpopulation of β-cells is non-proliferative and non-SASP producing.
Autism research focuses on understanding heterogeneity between individuals, with Prof Michael Lombardo's project testing stratification by functional skills. The goal is to isolate specific biological markers and treatment responses.
Concordia researchers analyzed muscle and fat mass data from a large US sample population to find that high levels of fat mass are linked to poorer overall health. While BMI was surprisingly effective in predicting some cardiometabolic outcomes, the study suggests new body-composition phenotypes may be a better predictor.
Researchers identified 17 clusters of single cells in peripheral blood, showing upregulation of antigen processing and presentation pathways and downregulation of genes involved in ribosome pathways with age. The study also found senescent T cells resistant to apoptosis, potentially targeted for treatment.
Researchers at Kyoto University found that a poor, low-yeast diet causes fruit flies' larvae to grow dendrites in an unexpected way. The hyperarborization phenotype is triggered by a simultaneous deficiency in vitamins, metal ions, and cholesterol, which increases the production of Wingless signaling molecules from body wall muscle.
Researchers discovered host proteins APOBEC3 can aid HIV's latency, a major hurdle to cure research. The finding raises questions about the role of these proteins and potential ways to block their activity to inhibit viral persistence.
Researchers identified key metabolic pathways in tumor-associated macrophages that contribute to cancer development and progression. Targeting these pathways may provide a new perspective for immunotherapy-based cancer treatments.
Scientists have developed a novel metric to analyze the rate of convergent evolution in protein-coding DNA sequences. This approach can reveal which genetic changes are associated with phenotypic traits, shedding light on how species diversify over time.
Researchers developed AI-powered software to measure and classify pacu fish, enabling breeders to select animals with higher fillet yield and faster weight gain. The system uses deep learning and can recognize different parts of the fish even in challenging environments.
A systematic review and meta-analysis of 53 studies found that obesity is not a universal phenotype in children with type 2 diabetes. Further studies are needed to understand the mechanisms driving this condition in children with type 2 diabetes.