Articles tagged with Immune System
Researchers found that activating programmed cell death (necroptosis) in white blood cells leads to inflammation and auto-antibody attachment, contributing to disease progression. Inhibiting necroptosis may offer a new treatment approach for ANCA vasculitis.
Researchers at UMD School of Medicine are studying a new approach to tackle antibiotic resistance by targeting the immune system's response to harmful bacteria. They aim to prevent inflammation and white blood cell activation using special molecules or peptides, which could pave the way for treating a wide range of infections.
A study by Fred Hutchinson Cancer Center has identified a specific subset of adult blood stem cells responsible for regenerating the entire blood and immune system. The 5% subset, marked as CD34+CD45RA-CD90+, was found to rebuild all different cells of the blood and immune system within 10 days after being infused in nonhuman primates.
Research reveals that APC protein mutations harm the immune system, preventing it from controlling gut inflammation, which supports cancer development. This dysfunction affects regulatory T cells, leading to a deregulation of the immune system.
Scientists have discovered that T cell activation leads to a depletion of amino acids in the blood, which in turn affects neurotransmitters serotonin and dopamine, causing anxiety and fear responses. In mice without PD-1 receptor, they found behavioral changes dominated by anxiety and exacerbated fear responses.
A new study reveals that cancer cells can use the body's own immune system to wake themselves up and fuel their growth after treatment, leading to relapse. Researchers found that immunotherapies targeting this response could delay or prevent cancer return in mice, suggesting a promising approach for patients at risk of relapse.
Researchers found noroviruses hide in extremely rare gut cells that fail to communicate with T cells, allowing the virus to evade the immune system. The study informs vaccine development and may explain limited effectiveness of current vaccines.
A new study aims to find the lowest dose of chemotherapy needed for babies with severe combined immunodeficiency (SCID) undergoing bone marrow transplant. The goal is to restore the immune system safely and effectively with less toxicity than current regimens.
Researchers have developed a new software tool that reveals molecular connections between breast cancer tumor cells and immune system cells in the bloodstream. The study found that these connections vary depending on the type of breast cancer, potentially leading to new treatment and monitoring strategies.
Researchers identified a new mechanism for how spinal cord injury weakens the immune system, leading to increased susceptibility to pneumonia. Disrupting nerve fibers to the adrenal glands may be a promising treatment strategy to prevent or reduce infections.
Researchers at Salk Institute discover two microRNAs that help cancer cells survive and subvert the immune response by lowering cGAS levels. Inhibiting these microRNAs in tumor cells slowed tumor growth, but their effect was diminished in immune-deficient mice.
Researchers at the University of Adelaide have found a significant reduction in alcohol drinking behavior by mice that had been given a drug blocking a specific response from the immune system in the brain, highlighting the importance of the brain's immune system in driving desire to drink alcohol.
A new study from Weill Cornell Medicine reveals that nerve cells in the gut play a crucial role in triggering an immune response to infection. The researchers found that these nerve cells communicate with immune system cells through a protein called neuromedin U, enabling them to rapidly respond to threats.
Scientists have identified an early predictor of Inflammatory Bowel Disease (IBD) through a groundbreaking collaboration. By analyzing the microbiome, researchers found parallel changes in gut bacteria that may indicate disease onset.
Scientists at Stanford University School of Medicine characterized the immune system changes during pregnancy and found a precise timing pattern. The study used mass cytometry to analyze blood samples from 18 women with full-term pregnancies and validated the findings in an additional group of 10 women.
Researchers have discovered a new immunotherapy combination that effectively kills cancer cells, with promising results for treating aggressive breast and rare pediatric muscle cancer. The combination uses existing cancer drugs in a whole new way to stimulate the immune system.
A USC study found that the Zika virus targets specific white blood cells in pregnant women, handicapping their immune system and increasing the chances an unborn baby will be harmed. The virus exploits this weakness to infect and replicate, particularly during the first and second trimesters.
A new treatment combines gold nanostars and immunotherapy to treat cancer. The treatment successfully cured two mice and vaccinated one mouse against the disease. By destroying tumors and triggering the immune system, the treatment activates immunity against remaining cancerous cells.
Researchers will investigate regulatory mechanisms and biomarkers of healthy aging, aiming to understand why the immune system weakens with age. The study may lead to new treatments for age-related health issues, such as increased vulnerability to infections and cancers.
Researchers studied viruses from different eras to understand how they evade the host's immune response. Viruses collected in the 1990s are more effective at suppressing immune systems than those from the 1950s, leading to severe symptoms and high mortality rates.
A rare genetic mutation in the POL III sensor can turn chickenpox into a life-threatening infection, leading to brain inflammation and pneumonia. Individuals with this mutation have an increased risk of developing severe illness.
Researchers discovered that a single protein from Group A Streptococcus bacteria can wipe out macrophages but not other immune cells, triggering an early warning system. This finding has implications for vaccine design and treatment of toxic shock syndrome.
Researchers found that T cells from people with PD responded to alpha-synuclein to a greater degree than those gathered from healthy controls. Four genetic variations were associated with T cell reactivity, and over half of people with PD carried at least one variant.
Researchers have discovered a key new mechanism regulating T-cell response to foreign antigens and cancer. LFA-1 on T-cells mediates adhesion to cancer cells, enabling immune-cell rejection of cancer.
A new study published in PLOS Medicine reveals that changes to the immune system occur rapidly after a traumatic injury, with levels of immune cells and molecules altered within minutes. The research aims to improve outcomes for patients who have suffered trauma by identifying those at risk of developing life-threatening complications.
A protein called Blimp-1 regulates the immune system in patients with lupus, leading to an overactive immune response that attacks healthy tissue. The study's findings suggest a link between low Blimp-1 levels and increased risk of lupus in females.
Scientists have found that human immune cells contain particles with neurotransmitters like dopamine, which play a crucial role in immune responses. This discovery opens the door to using available drugs to improve therapies for lymphoma, autoimmunity, and immunodeficiency disorders.
Researchers found differences in immune system factors between men and women with bipolar disorder, particularly in zinc levels associated with depression severity in women. This study suggests that biological changes in the body could be used to diagnose the disease and tailor treatments differently for men and women.
Researchers at the University of Colorado Anschutz Medical Campus discovered a process protecting against autoimmune disease also prevents the body from creating antibodies that can neutralize HIV-1. By temporarily relaxing immunological tolerance, scientists believe they may be able to elicit protective antibodies with vaccination.
Three case reports published in NEJM demonstrate the efficacy of cancer immunotherapy in gray zone lymphoma, a rare subtype of Hodgkin and Non-Hodgkin forms of the disease. Nivolumab and pembrolizomab showed promising results in treating patients with PD-L1 over-expression.
A recent study suggests that the human herpesvirus 6 (HHV-6) may impede the brain's ability to repair itself in diseases like multiple sclerosis. The virus produces a protein called U94 that can impair the normal function of cells in the brain, potentially accelerating disease progression.
Aging individuals with implants face unique challenges due to immunosenescence and delayed immune responses. The study investigates the impact of aging on macrophage activity and white blood cell function, seeking ways to optimize implant success and minimize negative effects.
Researchers at Linkoping University discovered that lutein can suppress long-term inflammation in patients with coronary artery disease. The study found that higher levels of lutein were associated with lower levels of inflammatory markers and reduced inflammatory activity in immune cells.
Researchers found that autoimmunity plays a role in Parkinson's disease, where the immune system attacks the body's own tissues. The study identified alpha-synuclein protein as a trigger for immune response, raising hope for new diagnostic tests and therapies to prevent neuronal death.
Scientists discovered fetal immune system establishment as early as 2nd trimester, allowing independent responses and immune tolerance. Dendritic cells expressing Arginase-2 regulate TNFα production, preventing unwanted inflammatory responses.
Researchers at UMD's Jewell Laboratory have developed a precision system using quantum dots to control the display of self-antigens, promoting tolerance and elimination of paralysis in pre-clinical mouse models. This breakthrough could pave the way for more selective and effective therapies for MS and other autoimmune diseases.
Macrophages, known as the Pac-Man of the immune system, promote healing by regrowing severed nerves in rats, offering a promising alternative to current treatments like autografts. The approach uses biological signals to recruit younger, undifferentiated cells destined to become pro-healing macrophages.
Researchers at Michigan State University are studying how DHA prevents the onset of lupus when triggered by inhaling toxic minerals. The study aims to understand the cellular mechanisms behind this phenomenon and explore potential nutritional interventions to prevent disease flaring and progression.
Okinawa Institute of Science and Technology researchers identified JunB as a key target to selectively disable toxic T Helper 17 cells, reducing the risk of auto-immune diseases. By inhibiting JunB, these cells can still accumulate in the gut and respond to infections without turning rogue.
Researchers at the University of Birmingham discovered a breakthrough in how genetic makeup affects the immune system and cancer treatment. The study focused on the ULBP6 protein, which plays a crucial role in removing damaged cells and signals to white blood cells to kill them.
Researchers have created artificial viruses that can specifically target and destroy cancer cells by stimulating the immune system. The unique combination of alarm signals and cancer cell proteins enables the creation of a powerful army of killer cells to identify and destroy cancer cells.
Researchers at the University of Delaware have developed a new method to label and visualize the sugar backbone of bacterial cell walls, also known as the 'cell jacket'. This breakthrough allows scientists to better understand how the immune system misidentifies beneficial bacteria, leading to chronic inflammatory diseases. By using th...
Researchers at the Center for Cell-Based Therapy found that patients with more autoreactive lymphocytes before treatment have a shorter therapeutic effect. In contrast, those with fewer autoreactive lymphocytes experience a longer-lasting response to stem cell therapy.
A new combination immunotherapy has shown promise in treating advanced kidney cancer, with the potential to identify biomarkers for many cancers. The study's principal investigator, Dr. Timothy Kuzel, hopes that this treatment will help more patients benefit from immunotherapy.
In a breakthrough study, Johns Hopkins researchers identified a new way that the brain communicates with the immune system, using vesicles and small fat-like molecules to send signals. This discovery may lead to the development of new treatments for brain injuries by targeting the inflammatory response.
Scientists have created a vaccine that boosts specific parts of the immune system attacking HIV viral genes, prolonging resistance and allowing for more efficient defense. This approach may lead to an effective HIV vaccine by targeting weak immunostimulatory parts of viruses.
Researchers developed a novel mathematical model to explore interactions between prostate tumors and common immunotherapies, predicting their effects on patient-specific immune systems. The study highlights a potential therapeutic strategy for managing tumor growth more effectively.
A research lab at the University of Kansas is analyzing human immune responses to develop an effective vaccine or drug therapy against Epstein-Barr Virus. By studying B cells, researchers aim to understand why some people are protected from EBV-associated diseases while others suffer from health issues.
Researchers at the University of Rochester Medical Center have developed a practical way to use light to guide T cells towards tumors, overcoming the challenges of immunotherapy. The innovative method could lead to safer and more effective treatment options for cancer patients.
A comprehensive catalog of diseases associated with human leukocyte antigen (HLA) gene variations has been generated by researchers at Vanderbilt University Medical Center. The catalog identifies individuals at risk for certain autoimmune diseases and potential new associations with multiple sclerosis and cervical cancer.
A study funded by Morris Animal Foundation has shed light on how the deadly facial tumor disease in Tasmanian devils evades the immune system. The research found that DFT cells produce a molecular shield to hide from attacks, offering potential strategies for protection.
Researchers found that wild dolphins have chronically activated immune systems due to exposure to pathogens, parasites, and pollutants. This could lead to immunologic dysregulation and increased vulnerability to disease in both humans and animals. In contrast, dolphins in managed care environments have less activated immune systems.
Wild mice have highly-activated immune systems due to exposure to infections, with more activated myeloid cells compared to laboratory mice. The study's findings emphasize the importance of considering natural variability when interpreting research results.
A study found that malaria parasites in one African village had distinct gene combinations that allowed them to evade the human immune system. This discovery highlights the importance of considering diverse strains of the parasite in malaria-control efforts.
Research reveals that strong feelings about immigrants are controlled by the immune system, particularly in people with a hypersensitive behavioral immune system. This leads to misconceptions about infection risks and a reluctance to interact with immigrants, blocking integration paths.
A comprehensive review examines the role of type I interferon in controlling herpes simplex virus type 1 infection. The study reveals that newborns are more susceptible to HSV-1 infection, which can lead to serious and potentially life-threatening diseases like herpes simplex encephalitis.
Researchers found that strokes damage immune cells, making patients more susceptible to life-threatening infections like pneumonia. Therapies targeting damaged immune cells or bypassing their dysfunction could help recover from stroke, the study suggests.
Cytomegalovirus has evolved to hide from the immune system by presenting decoy markers, tricking NK cells into thinking infected cells are healthy. The immune system responds by evolving new mechanisms to detect and kill the virus, including a molecule called NK1.1.
A new study links common reovirus infection with the development of celiac disease, an autoimmune disorder caused by an improper immune response to gluten. Reovirus-induced immune responses can lead to the loss of oral tolerance to gluten, setting the stage for celiac disease.
Case Western Reserve University researchers aim to combat chronic inflammation by targeting oral complications in HIV patients, which can lead to malnourishment and further weaken the immune system. The team will investigate regulatory T-cells and study tissues from HIV-positive patients taking common antiretroviral drugs.