Articles tagged with Promoter Regions
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Researchers at the University of Pennsylvania developed novel promoters that drive specific gene expression in rod and cone photoreceptors, outperforming most currently used promoters. These tools address the challenge of treating advanced stages of inherited retinal diseases, potentially restoring vision.
Researchers use CRISPR/Cas9 and CRISPR/Cpf1 genome editing to precisely edit the promoter region of key high-temperature-responsive gene GhCKI, leading to improved anther development and heat tolerance in cotton. The breakthrough provides novel genetic resources for breeding heat-tolerant cotton varieties.
Researchers at U of T have discovered that C2H2 zinc finger proteins, which primarily bind to DNA, also regulate RNA processing through various mechanisms. These proteins modify mRNA, controlling its length and altering it after transcription.
Researchers have discovered several rare types of helper T cells associated with immune disorders such as multiple sclerosis and rheumatoid arthritis. The study found that genetic variants in bidirectional enhancer DNA are linked to specific immune-mediated diseases, including inflammatory bowel disease.
Researchers at Johns Hopkins Medicine have developed a novel approach to target group 3 medulloblastoma tumors in mice, reducing tumor growth by 40-50% and extending survival by up to 84 days. The therapy uses antisense oligonucleotides to block lnc-HLX-2-7 from binding to the HLX promoter region.
Researchers found Mad2 gene expression levels correlate with chromosomal abnormalities in esophageal squamous cell carcinoma, highlighting potential as a clinical biomarker. The study also revealed the deregulation of the Rb-E2F1 circuit and its impact on histone modifications.
Researchers at State University of Campinas discovered genes favoring colossal growth in whales also inhibit cancer development. The study found that certain regulatory regions influence both size and cancer suppression, offering new insights into the evolution of cetacean gigantism.
Researchers have successfully observed the operating principle of promoters in a catalytic reaction in real-time. Using high-tech microscopy methods, they visualized individual La atoms' role in hydrogen oxidation. The study revealed that two surface areas of the catalyst act as pacemakers, controlled by promoter lanthanum.
Researchers have identified a unique bacterial transcription mechanism that enables specific recognition of promoters. This discovery has implications for the design of gene regulation tools and may inform synthetic biology engineering.
Researchers at the University of Pittsburgh School of Medicine have discovered a genetic link between melanoma tumors and telomere maintenance, which could lead to new treatments for the disease. The study found that mutations in the TPP1 gene stimulate telomerase activity, promoting long telomeres that enable cancer cells to divide in...
A research team from China has created a systematic approach to screen a library of promoters and terminators for use in plant synthetic biology. The study successfully engineered the betalain pathway in tobacco and found that quantitatively characterized promoters can be used to ensure optimal gene expression.
Researchers have developed a new method for precisely altering gene expression by supplying and removing electrons, enabling controlled biomedical implants and bioreactors. The improved system allows for accurate control of gene expression in the presence of oxygen, opening up new possibilities for synthetic biology.
A new mathematical framework has been created to study fitness landscapes of regulatory DNA, enabling the prediction of gene expression changes. The framework uses a neural network model trained on millions of experimental measurements to decipher the evolutionary past and future of non-coding sequences.
A new study has identified a transposon promoter that plays a crucial role in the development of mice and may also be essential for human viability. The discovery suggests that ancient viral DNA has been domesticated to regulate key biological processes, such as cell proliferation and embryo implantation.
A team of researchers has cracked the code on dog coat color patterns by identifying five distinct genetic variants that cause different colors. These variants originated in an extinct species and were introduced into modern dogs through hybridization events.
A new process for making RNA has been developed by researchers at the University of Massachusetts Amherst, yielding purer and more abundant RNA at a fraction of the cost. This breakthrough removes the largest stumbling block on the path to next-generation RNA therapeutic drugs.
The study confirms the upregulation of TERT in primary glioblastomas and the gradual expression of all GABP components during malignancy progression. The authors found a positive association between TERT and B1L mRNA expression, highlighting the importance of GABPA/B isoforms in mutated TERT promoter-dependent gliomas.
Researchers at North Carolina State University developed a new technique to alter plant metabolism, reducing harmful chemical compounds, including nicotine and carcinogenic N-nitrosonornicotine (NNN), while promoting beneficial traits like antioxidant-rich anthocyanins. The findings could be used to improve the health benefits of crops.
A study using Finnish data found that the MUC5B promoter variant is a strong predictor of developing interstitial lung disease in people with rheumatoid arthritis, with a lifetime risk of 14.5% by age 80. The risk difference starts to emerge at age 65 and is highest in men with RA who are MUC5B carriers.
Researchers at Cold Spring Harbor Laboratory have successfully applied CRISPR to increase corn kernel numbers by targeting promoter regions that regulate gene activity. This technique holds promise for increasing crop yields per acre and making agriculture more sustainable.
A new CRISPR-based technique allows researchers to profile a cell's entire genome and identify the DNA sequences regulating specific genes. This enables simultaneous testing of thousands of experiments, paving the way for faster discovery of genetic networks and potential therapeutic targets.
Researchers found genetic variation in DDX1 associated with increased expression and poor survival in neuroblastoma. The MAX protein binds to the DDX1 promoter, influencing MYCN-related variants' impact on neuroblastoma risk.
Research finds that tumor suppressor p53 influences insulin receptor gene expression in breast cancer cells, with mutant p53 strongly stimulating INSR promoter activity. This study highlights the complex interplay between p53 and the INSR pathway, with implications for breast cancer treatment.
A gene switch, excessive number of floral organs (eno), plays a crucial role in boosting fruit size during tomato domestication. Analysis reveals that mutations in eno result in larger flowers and fruits, leading to higher yields.
Researchers have designed and synthesized an atomically dispersed co-promoter of Sn and Zn on the CuO surface, demonstrating a greatly enhanced promoting effect in the industrially important Rochow reaction. The synergistic interaction between single-site Sn and Zn co-promoters leads to improved catalytic performance.
Scientists developed a new technique, NET-CAGE, to elucidate the structure of genomic enhancers, which activate specific genes. The method identified 20,000 new human enhancers, revealing differences in their role between promoters and enhancers.
Researchers discovered how the process of cell differentiation is orchestrated during embryogenesis, revealing the DNA sequence code of a key gene called hunchback. By understanding how this 'on/off switch' works, scientists gain new insights into genetic activity and its implications for birth defects and disease.
A new study found that noncoding mutations in promoter regions contribute to autism risk. The researchers analyzed data from 1,902 families and identified de novo mutations in genes involved in neuronal differentiation and developmental delay.
A recent study published online demonstrated that Droplet Digital PCR technology can detect and quantify rare mutations in the TERT promoter region with high sensitivity. The assays detected the mutation in 78% of samples and yielded no false positives, showing its potential as a biomarker for diagnosing and monitoring patients.
Researchers discovered that highly robust regulatory proteins can acquire binding to new promoters in response to mutations, challenging the long-held assumption that robustness and evolvability are mutually exclusive. This finding has significant implications for understanding gene regulation and evolution.
A study by NRG Oncology/RTOG 0424 found that MGMT promoter methylation is associated with improved progression-free and overall survival in high-risk, low-grade glioma patients. The analysis suggests that MGMT promoter methylation should be incorporated into future clinical trial designs to risk-stratify LGG patients.
Scientists at UC Berkeley have developed a way to create hoppy beer without using hops by genetically engineering brewer's yeast. The engineered strains produce two prominent flavor notes found in hops, resulting in beers that are indistinguishable from those made with traditional hopping methods.
Researchers develop a gene promoter library to precisely tune genetic inputs and outputs, allowing for the design of probiotics that can diagnose or fight disease. The toolkit enables the creation of non-leaky promoters that turn on as much as needed, opening new doors for fighting disease.
Researchers at ETH Zurich have developed a method to compress and decompress DNA, enabling the efficient transfer of large amounts of genetic information into cells. This innovation has potential applications in synthetic biology, biotechnology, and cancer research, improving diagnosis accuracy and treatment outcomes.
A team of scientists has successfully analyzed chicken embryo development data, paving the way for similar research in humans. The findings provide insights into the regulation of gene transcription and its role in tissue formation.
Scientists at UC San Diego uncover a previously unknown link between non-coding DNA regions and the formation of immune cells. The discovery reveals a precise mechanism for the pairing of promoter and enhancer elements, which brings them into close proximity to initiate immune cell development.
Scientists at North Carolina State University have found that small variations in the bellwether gene can significantly affect male fruit fly lifespan, but not female lifespans. The study sheds light on sex-specific differences in lifespan and highlights the importance of metabolic genes.
Researchers developed a new method to target select cells in adult brains, using an optogenetic technique. By altering the function of brain circuits and changing behavior, scientists can better understand the roles of specific cell types in the complex brain circuitry.
Researchers discovered mutations in gene promoters that affect cell adhesion and axon guidance pathways in pancreatic cancer, providing new insights into its development and progression. These findings could lead to the identification of novel molecular targets for treatment.
Scientists discovered that genetic material known as introns can play a dramatic role in plant gene activity. Introns act as volume control for some essential genes, making them silent when removed. This finding suggests that many genes may not have a traditional on/off switch.
Researchers have discovered a crucial regulatory mechanism for sex determination in vertebrates, centered on the DMRT1 gene. The study found that the ncEx1 promoter sequence plays a vital role in regulating gene expression, particularly in germ cells and somatic cells.
A group of biologists from the University of Geneva developed a novel technology to identify all transcription factors involved in any process and in response to any signal. The BC-STAR-PROM screening method enables researchers to monitor the activity of thousands of promoters simultaneously, saving time and work.
Enhancers can increase the frequency of gene activity bursts, suggesting these bursts may be critical for genetic regulation. The study found that enhancer location and strength influence bursting frequencies.
Scientists at Hokkaido University developed a new CRISPR/Cas9 technique to unleash silenced genes, changing cell fates. They used DNA repair mechanism MMEJ with CRISPR/Cas9 to replace off-switches with on-switches, enabling efficient gene expression in cultured cells.
Researchers found that head-on collisions between DNA replication and transcription increase mutation rates, particularly in the promoter region. This susceptibility can lead to genetic changes affecting an organism's health, from bacteria to humans.
Researchers have made a major breakthrough in understanding how cells find the right DNA to copy, revealing the role of TFIID and its ability to recognize different sequences for different genes. This finding paves the way for understanding and treating various malignancies.
Researchers discover ApoE4's transcriptional effects, targeting genes associated with sirtuins, aging, insulin resistance, inflammation, and amyloid plaques. This finding offers a unified theory of Alzheimer's disease and potential new screening methods for prevention.
Scientists classify all gene promoters into two distinct types differing in nucleosome stability, with one type found at highly expressed growth-related genes and the other at less frequently expressed genes. The study reveals the role of dynamic nucleosomes in increasing access to promoter DNA for transcription initiation.
Research suggests that retroviral long-terminal-repeat promoters may contribute to the emergence of hepatocellular carcinoma. The study found that these elements are highly activated in liver cancer tumors and non-tumor tissue from patients with different etiologies, including viral hepatitis or alcohol use.
Researchers at EMBL and Stanford University mapped three-dimensional interactions between enhancers and promoters, revealing new insights into gene regulation. The study sheds light on how genetic variants control gene expression and disease predispositions.
A new technique called Promoter Capture Hi-C was used to connect regulatory elements in the mouse and human genomes, providing insight into how genes are regulated. The analysis identified long-range interactions between promoters and enhancers, shedding light on the genetic basis of disease.
Researchers create genomic interactions catalogue to study promoter interactions, identifying genes involved in inflammatory bowel disorders. The catalogue captures over 1 million interactions, revealing new elements for turning genes on or off.
A study found that FOXO1, a protein promoting tissue repair, acts as an inhibitor of wound healing in diabetes patients. High glucose levels slow keratinocyte migration, while insulin speeds up the process. The research suggests inhibiting FOXO1 could speed healing in diabetic patients.
Duke researchers have developed a new method to precisely control gene activity by chemically manipulating proteins that package DNA. This technology allows for the activation of specific gene promoters and enhancers, which could provide a new avenue for gene therapies and guiding stem cell differentiation.
A new study by USC Marshall professor Victor Bennett found that resale markets like Craigslist can add value to tickets sold by concert venues and Ticketmaster. This increase in price benefits both the artist and venue, particularly in high-demand shows.
Researchers at Scripps Research Institute found that a protein with a propensity to form aggregates protects against Alzheimer's disease when produced in the brain. Boosting its production specifically in neurons could help ward off Alzheimer's disease, according to the study published in the Journal of Neuroscience.
The FANTOM project has published an exhaustive map of specificities in gene expression, revealing the first nucleotides of messenger RNA to identify where genes start synthesizing proteins. This study provides insights into how genes are regulated in different tissues, with implications for understanding diseases such as Parkinson's
A study by Byoung-il Bae and colleagues found that a specific gene mutation affects the development of cortical convolutions in the human brain. The researchers discovered that the mutation impacts the production of neuroprogenitor cells around the Sylvian fissure, leading to thinner and more convoluted folds.
A study found that genetic alterations in the PAX gene family may explain head and neck cancer survival disparities between African-American and non-Latino white men. The research identified differential genomic and epigenomic alterations in PAX, NOTCH, and TP53 pathways between the two groups.
Researchers at Joint BioEnergy Institute create dynamic pathway regulation using stress-response promoters to improve chemical product production. This approach enables regulation of artificial metabolic pathways in response to toxic intermediate metabolites.