Articles tagged with Alzheimer Disease
A study suggests that immune cells, particularly regulatory T cells, play a role in anxiety and depression, with reduced expression of the transcription factor Foxp3 associated with major depressive disorders. Depletion of these cells leads to increased anxiety-like behaviors in mice, highlighting their potential link to these conditions.
The Wang Lab at MPFI will investigate neural circuits underlying Alzheimer's disease with a new $1.038M NIH grant. The research aims to shed light on how the brain forms and maintains memories, particularly in patients with declining cholinergic inputs.
A new study by UC San Diego researchers shows that time-restricted feeding can improve memory and reduce amyloid protein accumulation in mice with Alzheimer's disease. This approach may provide a simple and accessible way to correct circadian disruptions, which are the leading cause of nursing home placement.
Researchers found that C9ORF72 mutations impair neural stem cell renewal, leading to reduced brain regions during embryonic development. This impairment could contribute to disease symptoms later in life. The study used patient-derived nerve cells and laboratory mice to demonstrate the impact of C9ORF72 on neurodevelopment.
Researchers found that natural forgetting can be reversed in certain circumstances, with memories stored in engram cells still intact but inaccessible. Competition between engrams affects recall, and forgotten memory traces can be reactivated by cues or updated with new information.
The FDA approved brexpiprazole, an antipsychotic drug, for treating agitation in elderly patients with dementia, despite trials showing it failed to provide a clinically meaningful benefit and increased the risk of death. The decision may reverse efforts to reduce off-label use of antipsychotics in care homes.
A new study finds that severe behavioral symptoms in older adults are associated with a higher likelihood of divorce, while those with more advanced dementia are less likely to end their marriages. The research analyzed data from 263 married couples and found a positive correlation between neuropsychiatric symptoms and divorce risk.
A new study published in Neurology found that only a small percentage of older adults with early Alzheimer's disease meet the eligibility criteria to receive new monoclonal antibody treatments. The study estimates that around 8% of people with mild cognitive impairment or mild dementia would be eligible for treatment.
Researchers found that vaccines against tetanus, diphtheria, and shingles, as well as pneumococcus, may reduce the risk of developing Alzheimer’s disease by 25-30% in adults over 65. Vaccination is hypothesized to change how the immune system responds to toxic proteins contributing to Alzheimer’s disease.
Researchers found that participants with MCI performed significantly worse on a test of four types of decision-making abilities compared to those without. The study's findings have broad implications for choices about finances, health care, and other daily decisions.
A new study shows that a rule-based natural language processing tool successfully identified patients with unstable access to transportation, food insecurity, social isolation, financial problems, and signs of abuse or exploitation. The tool performed better than deep learning algorithms in identifying these social determinants of health.
Researchers have identified a therapeutic target for Alzheimer's disease by finding that inhibiting an ion pump can slow down cognitive decline and partially restore brain function. The study's findings suggest that maintaining the ion pump could be key to preventing or reversing the disease.
A new imaging technique, tau PET, has been shown to predict cognitive decline in Alzheimer's patients with greater accuracy than current methods. This breakthrough could lead to earlier diagnosis and treatment, improving patient outcomes.
Researchers have discovered a potential fertility benefit associated with the APOE-ε4 allele, which is also known for increasing the risk of Alzheimer's and cardiovascular disease. Tsimane women with one or two copies of the allele had an average increase in live births compared to those without the allele.
Researchers at UC San Diego demonstrate that hematopoietic stem cell transplants can protect against multiple signs and symptoms of Alzheimer's in a mouse model of the disease. The therapy leads to enhanced microglia health, which protects against Alzheimer's pathology, including β-amyloid build-up and neuroinflammation.
Scientists discover unique immune cells in skull's bone marrow, facilitating movement of immune cells between brain and skull, offering new possibilities for diagnosing and treating neurological diseases. Non-invasive skull imaging may enable early detection and monitoring of conditions like Alzheimer's and stroke.
A large long-term study found exposure to high levels of air pollution is associated with increased community mental health services use among people with dementia. Reducing nitrogen dioxide and particulate matter could help free up resources in overstretched psychiatric services.
A team of scientists has developed a technique that uses high-frequency terahertz radiation to slow down amyloid deposition in Alzheimer's disease. The research found that the radiation can modulate protein conformation and delay fibrillation, presenting a promising strategy for treating the disease.
The study reveals a double-layered structure of amyloid-β on GM1-containing membranes that acts as a catalyst for fibrillization. This discovery offers new insights into predicting Alzheimer's disease onset and potentially inhibiting its progression.
Researchers from Boston University propose a data-driven approach to stratify individuals with mild cognitive impairment based on their risk of progressing to Alzheimer's disease. The study uses deep learning and survival analysis to identify key brain regions relevant to AD, enabling early interventions for those at high risk.
Researchers propose disease-oriented dosing of rapamycin to delay age-related diseases and increase lifespan. By decelerating early development of these diseases, rapamycin may help individuals live longer.
A new study from WashU Medicine reveals that patients from underrepresented groups and lower socioeconomic neighborhoods are less likely to receive specialized dementia care. Black patients are also more likely to be diagnosed with advanced-stage dementia, exacerbating healthcare disparities.
A recent study found that Google is more current but biased by advertisers, while ChatGPT is more objective but outdated. The researchers suggest combining both strengths to build a better system.
A new study published in JAMA Ophthalmology found that vision problems are more common in older adults with dementia. The study of nearly 3,000 older adults showed that even mild vision issues were associated with a higher risk of dementia.
A study published in Annals of Neurology suggests that a protein in spinal fluid can predict mild cognitive impairment and dementia years before symptoms appear. The findings may offer new targets for treating or preventing Alzheimer's disease and other dementias.
The study reveals altered magnitudes and coherence between oscillations in brain vasculature and brain waves in older adults. This finding has significant implications for the assessment of Alzheimer's disease and monitoring of neurodegenerative disorders.
Researchers found that Alzheimer's patients exhibit heightened sensitivity to light changes, which can contribute to 'sundowning' and disease progression. Light therapy could help manage these symptoms and potentially slow disease progression.
A new study published in The New England Journal of Medicine found that the MIND diet had a significant improvement in cognition during the first two years, but no significant difference in three-year changes. The study enrolled 604 people with suboptimal diets and family history of Alzheimer's disease.
Researchers from Sahmyook University found that phyllodulcin, a natural sweetener found in hydrangeas, can efficiently inhibit amyloid beta (Aβ) aggregation and dissociate its aggregates in an animal model study. The study suggests that phyllodulcin may be useful in delaying the onset and progression of Alzheimer's disease.
TRIM11 protein levels decreased in Alzheimer's disease models, suggesting replenishment may improve cognitive and motor function. The study reveals that TRIM11 plays a key role in removing tau protein tangles that cause neurodegenerative diseases like AD.
A UCLA Health study found that Kundalini yoga increased activity in a region of the brain impacted by stress and associated with memory decline. The study suggests that this type of yoga, which combines movement and meditation, may be beneficial for older women at risk for Alzheimer's disease.
The American Academy of Neurology has developed an Emerging Issues in Neurology article providing timely guidance on new therapies for early Alzheimer's disease. The guidance explains the eligibility criteria, potential side effects, and limitations of these treatments, which are not a cure for the disease.
Researchers found that people carrying the APOE e4 gene variant, which increases the risk of Alzheimer's disease, may experience reduced smell detection earlier than those without the gene. The study suggests that testing a person's ability to detect odors could be an early indicator of future memory and thinking problems.
A comprehensive review of US-based Alzheimer's disease brain imaging studies found that all racial and ethnic minority groups are underrepresented. The gap is narrowing, but the research highlights the need for more diverse samples to capture details of participants' lived experience.
A new study finds that people with dementia account for nearly 7% of all emergency visits over age 65, with twice the rate of seeking care after accidents or behavioral crises. Better supporting dementia caregivers could prevent future emergency visits and reduce risks associated with antipsychotic medications.
A new study suggests that incorporating olive oil into your diet could help reduce the risk of dying from dementia. Regular olive oil consumption was found to be associated with a 28% lower risk of fatal dementia compared to those who never or rarely consumed olive oil.
Researchers at Case Western Reserve University found that a protein called Slingshot Homolog-1 (SSH1) stops Nrf2 from carrying out its protective biological activity, leading to the decline of brain defense in Alzheimer's disease. Genetically eliminating SSH1 increases Nrf2 activation and slows the development of oxidative damage.
A program integrated community health workers into patient outreach to improve health, doubling annual visits to older adults with type 2 diabetes and dementia. The program resulted in a 17% reduction in hospital admissions and an 11% decline in emergency room visits among homebound patients.
A muscle-building supplement called beta-hydroxy beta-methylbutyrate (HMB) has been shown to reduce plaques and increase factors for neuronal growth in mice with Alzheimer's-like pathology. The study found that HMB stimulates a nuclear hormone receptor to improve memory and learning in mice with Alzheimer's disease.
Researchers from Children's Hospital of Philadelphia have developed an algorithm to help predict Alzheimer's disease risk based on genetic information in patients with various ethnic backgrounds. The tool, called genomic informed risk assessment (GIRA), was tested in different ethnic populations and performed better than existing methods.
A Michigan Medicine study in Texas found that 61.4% of older adults with cognitive impairment are still driving, but one-third of caregivers have concerns about their care recipient's ability to drive safely. Researchers emphasize the need for open discussions between caregivers and healthcare professionals to ensure safety.
A new study published in Aging (Albany NY) suggests that prior training can rescue cognitive decline in aging by improving task performance and strengthening memory processes. The research, conducted on rats, found that prior training enhanced short-term and intermediate memory, while also enabling encoding-boosted long-term memory.
Researchers at the Max Delbrück Center have identified a potential new biomarker for Alzheimer's disease, protein Arl8b. The study found that patients with Alzheimer's have significantly more Arl8b in their cerebrospinal fluid than healthy controls.
Researchers found that compounds in espresso, such as caffeine and trigonelline, can inhibit tau protein aggregation, a process linked to Alzheimer's. The study suggests potential benefits for neurodegenerative diseases.
A new poll of people aged 65-80 found that 80% believe cognitive tests can give early warning signs of memory decline and 60% think healthcare providers should offer them annually. Despite this, only 1 in 5 have had a cognitive screening test in the past year.
A study of 500,000 people in the UK Biobank found small but significant associations between systemic inflammation and later dementia risk. Elevated inflammatory biomarker levels were associated with increased risk of dementia diagnosis and poorer cognitive performance.
Researchers will explore characteristics of misplaced calcifications in eyes and brains, and their roles in AMD and AD. The team aims to examine calcifications at multiple levels, from atomic structures to aggregated morphologies, and their accumulation in cells and animals.
In a phase 3 clinical trial, donanemab significantly slowed clinical progression in patients with low/medium tau and high tau pathology. The treatment cleared brain amyloid plaque, demonstrating its potential to slow Alzheimer disease progression.
The latest Alzheimer's drug, donanemab, has shown encouraging results in slowing cognitive decline by 35% compared to placebo in patients with low-to-intermediate levels of tau. However, its effectiveness is limited for those with more advanced disease, and risks include serious side effects such as amyloid-related imaging abnormalities.
A recent University of Kentucky study found that inhibiting the p38 protein in microglia may alter interactions between brain immune cells and Alzheimer's pathology. The research suggests that early inhibition of p38 may be beneficial without causing noticeable adverse effects.
The COVID-19 pandemic led to increased mortality rates among people with Alzheimer's disease and related dementias. Notably, excess deaths in nursing home/long-term care settings declined in pandemic year 2.
Researchers have captured never-before-seen images of the CALHM1 pore, which assembles into a circular channel with flexible arms resembling octopus tentacles. The discovery reveals how fatty molecules stabilize and regulate the channel, offering potential insights into its role in taste perception and Alzheimer's disease.
Researchers investigated the effects of meditation training and non-native language training on cognition in older adults. Despite initial expectations, these interventions failed to demonstrate salutary cognitive effects, casting doubt on their potential as a preventative measure for aging-related decline.
Researchers developed MemTrax, a continuous recognition test for advanced cognitive impairment screening. The test quickly and accurately quantifies memory processing, storage, and retrieval, providing precise assessments of severity and rate of change over time.
A new biomarker, MTBR-tau243, tracks Alzheimer's disease progression by measuring levels of a specific form of tau in cerebrospinal fluid. The finding has major implications for diagnosing and staging the disease, and could accelerate the development of effective treatments.
A new study published in The Lancet Healthy Longevity journal found that superagers, individuals with razor-sharp memory function, have faster movement speed and better mental health compared to typical older adults. They also tend to have lower rates of anxiety and depression.
The University of Texas Health Science Center at San Antonio has developed an AI algorithm that can accurately count brain lesions on MRI scans in seconds. This tool helps neuroradiologists evaluate patients' brain diseases at earlier stages and identify the most significant lesions associated with stroke and small-vessel disease.
A new study sheds light on the intersection of Alzheimer's caregiving and the LGBT experience, highlighting common themes such as social isolation, financial security, and grief support. The research reveals that LGBT caregivers face unique challenges due to lack of family support and discrimination in care settings.
EPFL researchers have created a novel biosensor, ImmunoSEIRA, to detect misfolded protein biomarkers linked to Parkinson's and Alzheimer's diseases. The sensor employs AI-powered neural networks for disease stage quantification and features gold nanorod arrays with antibodies for specific protein detection.
The 'Fastball' test, a non-invasive EEG assessment, shows promise in detecting Alzheimer's disease earlier with a high success rate and minimal user interaction. With the new £1.5m funding, researchers aim to scale up testing and develop the technology for wider NHS rollout.