Researchers at Chalmers University of Technology have shown that graphene oxide nanoflakes can reduce the accumulation of misfolded amyloid peptides in yeast cells, which are similar to human neurons affected by Alzheimer's disease. This suggests that graphene oxide may hold great potential for treating neurodegenerative diseases.
SourceChalmers University of Technology·JournalAdvanced Functional Materials·TypeExperimental study·DateOct 4, 2023
New research from Cold Spring Harbor Laboratory explores how adult brains adapt through critical periods of learning, such as caring for young. MECP2 dysfunction causes neurodevelopmental disorder Rett syndrome, but the study finds that brain circuits can be rapidly rewired in adults.
SourceCold Spring Harbor Laboratory·JournalJNeurosci·DateOct 4, 2023
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A team of researchers from Mass General Brigham has developed a monoclonal antibody that reduces abnormal tau proteins associated with Alzheimer's disease in a preclinical model. The therapy, inspired by a genetic variant that provides resistance against the disease, offers an alternative approach to existing treatments.
SourceMass General Brigham·JournalAlzheimer s & Dementia·TypeExperimental study·DateOct 4, 2023
A study published in Alzheimer's Research & Therapy suggests a possible association between chronic stress and an increased risk of developing mild cognitive impairment or Alzheimer's disease. The research, conducted on 44,447 individuals between 18-65 years old, found that those with chronic stress or depression had a higher risk of d...
SourceKarolinska Institutet·JournalAlzheimer s Research & Therapy·TypeObservational study·DateOct 1, 2023
A new tau PET radiotracer, 18F-SNFT-1, demonstrates high sensitivity and specificity in identifying Alzheimer's disease. This improved tracer enables earlier diagnosis and potential therapeutic interventions.
SourceSociety of Nuclear Medicine and Molecular Imaging·JournalJournal of Nuclear Medicine·DateSep 29, 2023
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Researchers analyzed over 2 million cells from 400 postmortem brain samples to identify cellular pathways that could become new drug targets for Alzheimer's treatments. They found impairments in mitochondrial function, synaptic signaling, and protein complexes, as well as disrupted lipid metabolism.
SourceMassachusetts Institute of Technology·JournalCell·DateSep 28, 2023
Researchers at Weill Cornell Medicine have discovered that a tiny chemical modification on mRNAs, known as m6A, is key to the formation of stress granules during cell stress. Longer mRNAs dominate stress granules because they have high levels of m6A, which triggers their sequestration.
SourceWeill Cornell Medicine·JournalNature Structural & Molecular Biology·DateSep 28, 2023
Researchers identified key proteins regulating cholesterol distribution within cells, including OSBP1, ORP92, and GRAMD1s. This discovery sheds light on the critical mechanisms underlying cellular cholesterol distribution, offering insights into various health conditions.
SourceNanyang Technological University·JournalNature Communications·TypeRandomized controlled/clinical trial·DateSep 28, 2023
A special supplement presents insights on neurodegenerative diseases, including Alzheimer's and Parkinson's, affecting 55 million people worldwide. Researchers explore novel molecular pathways and therapeutic approaches, such as acupuncture therapy, to alleviate the burden of brain disorders.
SourceIOS Press·JournalJournal of Alzheimer’s Disease·TypeSystematic review·DateSep 28, 2023
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
A new study suggests that hot flashes experienced during sleep may be an early indicator of women at higher risk of Alzheimer's disease. The study, which involved nearly 250 midlife women, found a greater number of sleep hot flashes to be associated with an increased likelihood of Alzheimer's.
An international team has decoded the TSPO protein to visualize neuroinflammation, revealing its relationship with microglial cells. The study's findings pave the way for optimizing observation of neuroinflammatory processes and re-reading previous studies.
SourceUniversité de Genève·JournalNature Communications·TypeNews article·DateSep 25, 2023
Researchers identified potential therapeutic targets for Alzheimer's disease and other conditions using a new approach combining AI-driven target identification with protein phase separation analysis. The study provides insights into the role of protein phase separation in human disease and its potential as a therapeutic target.
SourceInSilico Medicine·JournalProceedings of the National Academy of Sciences·DateSep 25, 2023
Scientists have identified thousands of non-coding genetic variants linked to Alzheimer's disease, focusing on their impact on microglial gene expression and function. The study found that turning off specific regions can affect multiple genes, highlighting the complex mechanisms underlying AD.
SourceUniversity of North Carolina Health Care·JournalNature Genetics·DateSep 22, 2023
Scientists have identified a long non-coding RNA called SNHG8 that plays a crucial role in the development of toxic protein tangles in brain diseases like Alzheimer's. Replacing this RNA can prevent stress granule formation, which contributes to tau aggregation and brain damage.
SourceWashU Medicine·JournalMolecular Psychiatry·TypeExperimental study·DateSep 21, 2023
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers propose that cerebrospinal fluid leaks could contribute to the link between traumatic brain injury and dementia. The hypothesis suggests that treating these leaks could mitigate dementia symptoms in some patients with a history of TBI. Further research is needed to confirm this potential association.
SourceUniversity of Toronto·JournalAlzheimer s & Dementia Translational Research & Clinical Interventions·DateSep 21, 2023
Researchers developed a non-invasive blood test using nanotechnology and AI to detect early neurodegeneration signs of Alzheimer's disease. The test could be done by GPs, providing near real-time results for patients, potentially improving health outcomes.
SourceAustralian National University·JournalSmall Methods·TypeExperimental study·DateSep 20, 2023
A new three-year grant will provide specialized dementia services and supports to underserved communities in Broward County. The project aims to improve quality of life for individuals living with or at risk of Alzheimer's disease, as well as their family caregivers.
Researchers identified a link between SARS-CoV-2 infection and Alzheimer's disease-like cognitive symptoms, triggered by Tau protein hyperphosphorylation. The study found increased Tau levels in infected cells, indicating pathological alterations to the protein.
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
A UCSF telecare program improves outcomes for patients with dementia and lightens the load on caregivers. The average monthly Medicare cost per patient was $526 lower for those in the Care Ecosystem compared to usual care.
SourceUniversity of California - San Francisco·JournalJAMA Internal Medicine·DateSep 18, 2023
Repeated traumatic brain injury contributes to Alzheimer's disease by promoting de novo tau pathogenesis and facilitating pathological tau transmission in mouse models. Axonal microtubule disruption is a key molecular mechanism underlying rTBI-induced protein pathogenesis.
SourceChinese Academy of Sciences Headquarters·JournalScience Translational Medicine·TypeExperimental study·DateSep 14, 2023
Researchers developed a new imaging technique using Bessel beam two-photon microscopy to detect stalling in brain capillaries, which can indicate acute neurological issues. The approach generates clear images of all capillaries every two seconds, providing better temporal resolution and enabling the detection of short stalling events.
SourceSPIE--International Society for Optics and Photonics·JournalNeurophotonics·DateSep 13, 2023
Researchers at Drexel University found that the brains of Alzheimer's patients showed profoundly different bacterial profiles compared to healthy controls. The study identified five brain microbiomes, four of which are hypothesized to be present at different times in the evolution of the disease.
SourceDrexel University·JournalFrontiers in Cellular and Infection Microbiology·TypeData/statistical analysis·DateSep 13, 2023
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Brigham researchers discovered a nasal immunotherapy approach that reduces inflammation and improves cognitive function in Alzheimer's mouse models. The treatment also expands regulatory T cells and changes gene expression patterns in the brain.
SourceBrigham and Women's Hospital·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateSep 13, 2023
Scientists have detected over 300 proteins associated with lipoproteins in the central nervous system, far more than previously thought. The most common protein, apolipoprotein E (APOE), plays a key role in delivering nutrient-rich lipids and protein tools to perform tasks such as wound healing and neuron creation.
SourceDOE/Pacific Northwest National Laboratory·JournalScience Advances·TypeImaging analysis·DateSep 12, 2023
Researchers highlight microvascular contributions to white matter injury in Alzheimer's disease, sparking calls for exploration of connections between AD, WM injury and cerebral small vessel disease. The study emphasizes the critical need to define mechanisms and diagnostic features of mixed vascular and AD neuropathological change.
SourceImpact Journals LLC·JournalAging-US·TypeCommentary/editorial·DateSep 12, 2023
The collaboration has garnered $5.68 million of grant support, with a five-year $2.13 million National Institutes of Health R01 grant and a five-year $2.89 million NIH R01 grant. Researchers are using computational biology to model a key Alzheimer's protein called TREM2 and its interactions with small chemical molecules.
A large-scale study of the UK Biobank data found that shorter white blood cell telomeres are associated with a higher risk of dementia, including Alzheimer's disease and vascular dementia. Telomere length was also linked to smaller total brain volume and reduced brain structure.
SourceBMJ Group·JournalGeneral Psychiatry·TypeObservational study·DateSep 11, 2023
Sky & Telescope Pocket Sky Atlas, 2nd Edition
Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
Researchers at Columbia University are using focused ultrasound to non-invasively open the blood-brain barrier, enabling delivery of gene-editing vectors to treat Alzheimer's and Parkinson's. The technology has shown promising results in reducing beta amyloid and tau loads, as well as improving memory deficits.
SourceColumbia University School of Engineering and Applied Science·JournalProceedings of the National Academy of Sciences·DateSep 11, 2023
Researchers have discovered that irisin-based therapies might help combat Alzheimer's disease by reducing amyloid beta deposits and enhancing neprilysin levels. Exercise-induced irisin treatment led to a remarkable reduction of amyloid beta pathology in a 3D human cell culture model of AD.
SourceMassachusetts General Hospital·JournalNeuron·DateSep 8, 2023
Researchers at St. Jude Children's Research Hospital discovered a subset of immune cells that slows Alzheimer's disease progression by interacting with microglia. The cells, called CD8+ T cells, use a molecular handshake to signal to the microglia to stop causing uncontrolled inflammation, which in turn slows plaque growth and symptoms.
SourceSt. Jude Children's Research Hospital·JournalNature Immunology·DateSep 7, 2023
A Phase I clinical trial has shown that a treatment designed to clear senescent cells in the brain is safe and effective in reducing inflammation. The treatment, which combines dasatinib and quercetin, was found to clear amyloid from the brain and lower inflammation in the blood.
SourceAtrium Health Wake Forest Baptist·JournalNature Medicine·DateSep 7, 2023
The Stevens INI is expanding its health disparities research with a new award to examine vascular causes of dementia in Asian Americans. The project aims to use innovative imaging techniques and clinical translations to better understand cerebral small vessel disease (CSVD) and its impact on cognitive impairment and dementia.
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Research finds antipsychotics used inappropriately among home-bound patients with Alzheimer's disease, leading to poorer patient outcomes. Commonly used antipsychotic quetiapine is often prescribed based on behavioral symptoms and limited daily activities.
SourceWiley·JournalJournal of the American Geriatrics Society·DateSep 6, 2023
Researchers at Pitt Public Health analyzed thousands of human genomes to find new gene variations influencing Alzheimer's disease risk. They identified 15 additional variations in the APOE gene and other genome areas that may influence disease risk, although more research is needed for definitive conclusions.
SourceUniversity of Pittsburgh·JournalMolecular Psychiatry·DateSep 6, 2023
Researchers at IU School of Medicine have discovered a critical gene mutation in the PLCG2 gene that heightens the risk of Alzheimer's disease. The study found specific rare variants that elevated or reduced the susceptibility to the disease, shedding light on the genetic underpinnings.
SourceIndiana University School of Medicine·JournalImmunity·DateSep 6, 2023
Researchers developed a new model of hereditary Alzheimer's disease in marmosets by introducing mutations into the PSEN1 gene, which causes early-onset disease in humans. The study aims to characterize and validate genetic, molecular, functional, and cognitive features of aging and Alzheimer's disease in these animals.
SourceUniversity of Pittsburgh·JournalAlzheimer s & Dementia Translational Research & Clinical Interventions·DateSep 6, 2023
Researchers found that ferroptosis, a form of cell death caused by iron buildup, destroys microglia cells in the brain's immune response, contributing to cognitive decline. The study's findings may lead to the development of compounds targeting microglial degeneration, offering new hope for Alzheimer's and vascular dementia treatments.
SourceOregon Health & Science University·JournalAnnals of Neurology·TypeImaging analysis·DateSep 5, 2023
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Researchers aim to prevent Alzheimer's development by encouraging regular light-intensity physical activity, using wearable devices and personalized goal-setting. The study will explore the effectiveness of short-term goal prompts in promoting long-term adherence to physical activity.
A team of researchers at Dartmouth's Geisel School of Medicine has been awarded a $16.2 million grant to study inequities in healthcare for adults with Alzheimer’s disease and related dementias, with a focus on racialized and marginalized populations. The five-year renewal grant will explore how intersecting identities affect treatment...
SourceThe Geisel School of Medicine at Dartmouth·DateAug 31, 2023
A new article published in RadioGraphics warns of a potential side effect of novel Alzheimer's treatments: amyloid-related imaging abnormalities (ARIA). ARIA can cause swelling or bleeding in the brain and may be asymptomatic. Radiologists must monitor for ARIA to plan image monitoring per established guidelines.
SourceRadiological Society of North America·JournalRadiographics·DateAug 31, 2023
A review article confirms neurofilament light (NfL) blood levels can predict the severity and rate of neurodegeneration in Alzheimer's disease. High NfL levels are correlated with brain damage, cognitive decline, and increased risk of developing the disease.
SourceWayne State University - Office of the Vice President for Research·JournalBrain·TypeLiterature review·DateAug 31, 2023
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
A new blood-based test called p-tau217 has shown great promise in identifying Alzheimer's disease by stratifying patients into low, intermediate, and high-risk groups. The two-step workflow reduces the need for confirmatory testing in uncertain cases.
SourceUniversity of Gothenburg·JournalNature Aging·DateAug 31, 2023
Scientists at CU Anschutz Medical Campus discover that long-term potentiation requires structural functions of CaMKII, not enzymatic actions. This breakthrough opens the door to therapeutic use of inhibitors targeting only CaMKII activity.
SourceUniversity of Colorado Anschutz Medical Campus·JournalNature·TypeExperimental study·DateAug 30, 2023
Researchers found that individuals with a genetic mutation linked to early-onset Alzheimer's disease had slower cognitive decline if they had higher education levels. The study also revealed that the APOE e4 mutation, which significantly increases risk for sporadic Alzheimer's disease, was less detrimental to cognitive function in thos...
SourceMass General Brigham·JournalNature Communications·TypeObservational study·DateAug 30, 2023
A study of medical and genetic data reveals that carrying a particular gene version reduces the risk of Alzheimer's and Parkinson's by over 10% on average. The protective allele, DR4, also correlates with a later onset of symptoms in both diseases.
SourceStanford Medicine·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateAug 30, 2023
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
A new molecule called A11 has been found to reduce inflammation and improve memory in models of Alzheimer's disease. By targeting the genetic transcription factor PU.1, A11 suppresses inflammatory gene expression in microglia immune cells, leading to reduced neurodegeneration and improved cognition.
SourcePicower Institute at MIT·JournalJournal of Experimental Medicine·TypeExperimental study·DateAug 29, 2023
Researchers at Purdue University have developed a 'mini-brain' that tracks the effects of concussive force on brain cells, revealing a link between head trauma and Alzheimer's disease. The study found that even hours after a hit, acrolein production leads to misfolded amyloid beta protein aggregation.
SourcePurdue University·JournalLab on a Chip·TypeExperimental study·DateAug 29, 2023
A new study will examine the role of lifestyle physical activity in cognition among insufficiently active older adults with higher risks for Alzheimer’s or related dementias. The research aims to identify achievable lifestyle health behaviors that can reduce the risk of these conditions.
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
Researchers at Massachusetts General Hospital have developed a novel 3D human cellular model that mimics the intricate interactions between brain cells and immune invaders, providing insights into how immune cells contribute to Alzheimer's disease progression. The study identified specific types of immune cells called CT8+ T Cells surg...
SourceMassachusetts General Hospital·JournalNature Neuroscience·TypeExperimental study·DateAug 25, 2023
Research suggests that certain gut problems, such as gastroparesis, dysphagia, and irritable bowel syndrome (IBS), may precede the development of Parkinson's disease. A nationwide medical record network study found a significant association between these conditions and an increased risk of Parkinson's diagnosis.
SourceBMJ Group·JournalGut·TypeData/statistical analysis·DateAug 24, 2023
Researchers from FAU will examine the effects of smoke-related air pollution on social isolation, cognitive function and risk of Alzheimer's disease in rural residents along Lake Okeechobee. The five-year study aims to promote early awareness of the disease and earlier modification of associated risk factors.
Researchers developed a digital biomarker that detects early signs of Alzheimer's disease using EEG headbands, identifying abnormal levels of proteins in sleep patterns. The study found measurable problems with memory reactivation in 205 aging adults, paving the way for affordable devices to monitor brain health.
SourceUniversity of Colorado Anschutz Medical Campus·JournalAlzheimers Disease & Dementia·DateAug 23, 2023
Researchers at the University of Sydney have developed a nanoscale optical technique to monitor protein aggregates forming in cells, which can lead to neurodegenerative diseases such as Alzheimer's and ALS. The study provides a new window into the transition of proteins from liquid to solid phase.
SourceUniversity of Sydney·JournalProceedings of the National Academy of Sciences·TypeObservational study·DateAug 23, 2023
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
Researchers at Mass General Brigham used stem cells from patients with Alzheimer's disease to study the impact of SORL1 gene damage. They found that loss of normal SORL1 function leads to a reduction in key AD proteins APOE and CLU, highlighting a potential new strategy for treatment.
SourceMass General Brigham·JournalCell Reports·TypeObservational study·DateAug 22, 2023
A study suggests that immune cells, particularly regulatory T cells, play a role in anxiety and depression, with reduced expression of the transcription factor Foxp3 associated with major depressive disorders. Depletion of these cells leads to increased anxiety-like behaviors in mice, highlighting their potential link to these conditions.
SourcePNAS Nexus·JournalPNAS Nexus·TypeExperimental study·DateAug 22, 2023
The Wang Lab at MPFI will investigate neural circuits underlying Alzheimer's disease with a new $1.038M NIH grant. The research aims to shed light on how the brain forms and maintains memories, particularly in patients with declining cholinergic inputs.
SourceMax Planck Florida Institute for Neuroscience·DateAug 22, 2023
A new study by UC San Diego researchers shows that time-restricted feeding can improve memory and reduce amyloid protein accumulation in mice with Alzheimer's disease. This approach may provide a simple and accessible way to correct circadian disruptions, which are the leading cause of nursing home placement.
SourceUniversity of California - San Diego·JournalCell Metabolism·DateAug 21, 2023
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
Researchers found that C9ORF72 mutations impair neural stem cell renewal, leading to reduced brain regions during embryonic development. This impairment could contribute to disease symptoms later in life. The study used patient-derived nerve cells and laboratory mice to demonstrate the impact of C9ORF72 on neurodevelopment.
SourceKeck School of Medicine of USC·JournalCell Reports·TypeExperimental study·DateAug 18, 2023
Researchers found that natural forgetting can be reversed in certain circumstances, with memories stored in engram cells still intact but inaccessible. Competition between engrams affects recall, and forgotten memory traces can be reactivated by cues or updated with new information.
SourceTrinity College Dublin·JournalCell Reports·DateAug 17, 2023
The FDA approved brexpiprazole, an antipsychotic drug, for treating agitation in elderly patients with dementia, despite trials showing it failed to provide a clinically meaningful benefit and increased the risk of death. The decision may reverse efforts to reduce off-label use of antipsychotics in care homes.
SourceBMJ Group·JournalThe BMJ·TypeCommentary/editorial·DateAug 17, 2023
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.