Articles tagged with Dopamine
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The American Academy of Neurology has issued a guideline recommending treatment options for early Parkinson's disease, including levodopa as the best first treatment. The guideline also highlights potential side effects and risks associated with medications, such as dyskinesia and impulse-control disorders.
A study published in Translational Psychiatry found that patients with high expectations of SSRI treatment showed a four times higher improvement rate compared to those with low expectations. The effect was attributed to the influence of dopamine on the brain's reward pathways.
Researchers have identified significant neurological effects of social isolation on the brain, including altered neural circuits and increased risk for disease. Social isolation can cause permanent changes in behavior and lead to health issues like anxiety and depression.
A new study in rodents suggests that repeated stress during infancy can lead to lasting behavioral issues due to increased dopamine levels in the brain. The research team found that stressful conditions caused pups to spend less time near their mothers and peers.
A new study reveals that pain activates a specific region of the brain, which reduces dopamine activity and leads to decreased motivation. Artificially restoring dopamine neurons reverses this effect, suggesting potential treatments for pain-related emotional changes.
Researchers have identified a new pathway for opioid-induced reward in the brain, paving the way for creating safer opioids. By altering the opioid peptide receptor MOPR, pharmaceutical companies can potentially create drugs that bypass the brain's reward system.
Researchers found that a balance between dopamine D2 receptors and RGS is crucial for normal long-term memory formation. An imbalance in these molecules is thought to contribute to the development of schizophrenia and dystonia.
Researchers at The Graduate Center, CUNY, found that increased signaling of the sonic hedgehog protein can inhibit LID in animal models of Parkinson's disease. This could lead to a potential therapeutic solution for most Parkinson's patients.
Research reveals that dopamine levels increase with stressful stimuli, rewriting the 'pleasure molecule' narrative, and suggesting new treatment approaches for psychiatric diseases and addiction. The discovery has significant implications for understanding dopamine's role in behavior and developing evidence-based treatments.
Researchers have discovered a new pathway in the brain that plays a key role in rewards and reinforcement. GABA neurons from the ventral tegmental area project to the nucleus accumbens shell, promoting reward processing. This finding offers new avenues for understanding psychiatric diseases such as depression and addiction.
A study found that transcranial stimulation can increase the benefits of aerobic exercise and improve gait in Parkinson's patients. The treatment uses a weak current delivered by electrodes placed over specific brain regions, activating the pre-frontal cortex.
A study on red junglefowl chicks found that early experiences can affect impulsivity, contradicting initial expectations. The researchers also discovered a link between gene expression and impulsivity, suggesting that genetic factors contribute to individual differences in impulsive behavior.
Researchers at UC San Diego found that mice can manipulate unpredictable dopamine pulses, which occur approximately once per minute, and learn to anticipate and act upon them. This new understanding opens a dimension in the study of dopamine and brain dynamics.
A new study suggests that gene therapy delivered into the brain may be safe and effective in treating AADC deficiency. The therapy resulted in clinical improvement of symptoms, including reduced oculogyric crises, improved movement and motor function, and better sleep patterns.
A case report highlights the importance of recognizing remdesivir-induced hemodynamically unstable sinus bradycardia in COVID-19 patients. The patient experienced significant bradycardia after starting treatment with remdesivir, but resolved after stabilization with dopamine infusion.
A new study by Norwegian University of Science and Technology researchers found that dopamine levels are linked to passion and goal achievement in men, which may explain the higher prevalence of autism diagnoses in males. The study also found no significant gender difference in passion or grit among women.
Scientists create synthetic melanin-like nanoparticles to overcome limitations of current dopamine delivery methods, achieving efficient and controlled release in the brain. The proposed method demonstrates promising results in reversing Parkinson's symptoms with high biocompatibility and non-toxicity.
Researchers have developed a novel nitrogen-doped dual-emission carbon dot as an effective fluorescent probe for ratiometric detection of dopamine. The new probe simplifies the detection process, reducing the need for complex nanomaterial combinations.
A rare mutation causes Parkinson's disease-like symptoms by disrupting dopamine transport, suggesting treatments targeting the transporters could alleviate symptoms. A malaria drug helps alleviate movement problems in genetically modified fruit flies with the mutation.
A NYITCOM researcher has secured a $1.6 million NIH grant to study the role of brain cells called astrocytes in regulating dopamine signaling. The study aims to identify new therapeutic treatments for clinical depression, which affects over 260 million people worldwide.
Researchers discovered that a protein called VGLUT plays a key role in regulating sex differences in brain vulnerability to age-related dopamine neuron loss. Higher levels of VGLUT were found in female neurons, correlating with greater resilience to neurodegeneration and mobility deficiencies.
Researchers from Osaka University discovered that subconscious viewing of one's own face can activate the dopamine reward pathway in the brain. This finding provides new insights into how the brain processes self-facial recognition and suggests that the dopamine reward pathway plays a key role in this process.
Research suggests that tolerance, cooperation, and reduced aggression in domesticated birds are linked to increased language complexity in humans. The study analyzed genomic, neurobiological differences between domesticated Bengalese finch and its wild relative, finding altered stress hormone balance and brain connectivity patterns.
Researchers at NYU Grossman School of Medicine discovered that individual nerve cells control the release of dopamine, a key player in motivation and movement. The finding challenges traditional views on dopamine regulation and provides new insights into Parkinson's disease.
A new study found that increased dopamine in the brain's striatum triggers auditory hallucination-like experiences in mice, shedding light on a possible causal role for dopamine-dependent neurological circuits in psychosis. This breakthrough could inform novel targeted treatments for schizophrenia and other psychotic disorders.
A new study in mice and people offers a promising entry point to developing new therapies for schizophrenia. Researchers found that hallucination-like events were more common among individuals who experienced spontaneous hallucinations, suggesting a link between brain circuits underlying both human and mouse minds.
A new study published in Frontiers in Synaptic Neuroscience reveals that neurons in a brain area associated with depression connect to an anti-reward system during cocaine withdrawal. This reorganization of brain circuits may drive negative behavior and depressive symptoms.
A new study published in Neuron shows that dopamine neurons play a key role in regulating pain responses in male and female mice, with females responding by focusing attention elsewhere when in pain. The research provides insights into the neural pathways involved in sex differences in pain sensitivity.
A study published in Neuron reveals that the brain learns from subconscious visual stimuli through the activation of dopamine-producing cells. The discovery has significant implications for developing targeted therapies for conditions like Parkinson's disease and improving brain plasticity in situations such as trauma or ageing.
Researchers at Osaka City University discover sesaminol protects against neuronal damage and increases dopamine levels in Parkinson's disease models. The study suggests sesaminol may be the first-ever medicine for Parkinson's disease, potentially derived from industrial waste.
Researchers at Ohio State University used graph theory to model homeostasis in the human body, predicting changes in dopamine levels and identifying properties of graphs that can help prevent system breakdowns. This approach could lead to targeted medical care for people who need it.
Grafting neurons from monkeys' own cells into their brains relieved debilitating movement and depression symptoms associated with Parkinson's disease. The autologous transplants showed significant improvements within six months, with dopamine levels doubling and tripled within a year.
A team at NYU Tandon School of Engineering developed planar micro-sensors using nano-graphitic carbon, increasing sensitivity and spatial resolution for brain studies. The sensors' performance can be adjusted by engineering material structure, offering new prospects for future brain studies.
Researchers at McMaster University have discovered a dopamine receptor pathway that becomes abnormally activated in acute myeloid leukemia (AML) cancer stem cells. This led to the clinical investigation of thioridazine as a new therapy for adult AML patients, revealing encouraging results.
Dopamine plays a key role in regulating blood glucose levels, and its blockade by antipsychotic medications can lead to uncontrolled glucose production and obesity. The study reveals that pancreatic alpha cells produce dopamine, which acts on both insulin-producing beta cells and other receptors.
A study by Scripps Research has discovered a memory gating system employing dopamine to direct transient forgetting, a temporary lapse of memory that spontaneously returns. The mechanism was found to be separate from long-term memory recall.
A study conducted at the University of Turku found that patients with schizophrenia have an increased risk of developing Parkinson's disease. The research suggests that alterations in the brain's dopamine system may be a key factor contributing to this increased risk.
Researchers at Uppsala University have discovered a link between faulty L-Dopa metabolism and severe side effects in Parkinson's patients. Abnormally elevated levels of L-Dopa and its metabolite were detected in brain regions outside the striatum, suggesting alternative mechanisms underlying motor disorders.
A study by neuroscientists from Florida Atlantic University demonstrates that the act of coming home produces a signal of comfort in mice, triggering a rapid increase in dopamine release. This finding suggests that 'home is where the brain is' and has implications for understanding addiction and mood disorders.
St Petersburg University researchers found that lack of TAAR5 leads to higher dopamine neurons and increased adult neurogenesis, potentially treating neurodegenerative disorders like Parkinson's disease. TAAR5 is present in neurogenic areas and regulates adult neurogenesis.
Researchers used EEG to study how music affects the brain's reward system, finding increased activity in regions involved in emotional processing, movement control, and auditory processing. Chills induced by favorite songs release dopamine, triggering a physiological response that indicates greater cortical connectivity.
Research finds that older, frail adults with a high-dopamine genotype are more likely to maintain a faster gait and may be more resilient to mobility disablement as they age. The study suggests that dopamine levels could influence mobility in elderly populations, with potential implications for pharmacologic supplements.
Researchers recorded real-time changes in dopamine and serotonin levels in patients' brains during tasks, revealing that serotonin levels increased with uncertainty and decreased with confidence. The study provides insight into how dopamine and serotonin regulate perception, decision-making, and cognition, potentially leading to improv...
Researchers have found that dopamine and serotonin, traditionally linked to reward processing, also integrate perceptions with actions, influencing how people perceive the world. This discovery could provide new insights into psychiatric and neurological disorders.
A new treatment method for Restless Legs Syndrome (RLS) has been patented by East Carolina University associate professor Stefan Clemens. The method targets the increased D1 receptor levels in RLS patients suffering from augmentation, leading to reduced activation and improved long-term efficacy.
Researchers found that the combination of alcohol and nicotine alters gene regulatory pathways in developing fetuses, leading to major deficiencies in brain development. This can cause synaptic rearrangements and lead to neurological disorders.
A study found that a ferry protein in the pancreas plays a crucial role in regulating insulin levels and protecting against the negative effects of a high-fat diet. The researchers discovered that this protein, VMAT2, helps to shield beta cells from oxidative stress, which can lead to diabetes.
Researchers have developed two new spectral variants of dLight1 sensor, allowing for the simultaneous assessment of dopamine and other neurochemical release. These sensors provide high resolution, real-time imaging of the spatial and temporal release of dopamine in live animals.
Researchers create temporary synthetic coating that can be adapted to deliver drugs, aid in digestion, or prevent nutrient absorption. The coating, made from dopamine molecules, can improve lactose digestion efficiency up to 20-fold and potentially treat conditions like diabetes and obesity.
A supersensitive dopamine detector developed using 2D materials can help diagnose disorders such as Parkinson's disease and schizophrenia. The detector is low-cost, flexible, and can detect dopamine in real-time, making it a promising tool for non-invasive monitoring.
Research on Drosophila melanogaster reveals that dopaminergic neurons respond to both internal behavioral states and external signals, enabling flexible and individualized decision-making. The study provides insights into how dopamine contributes to neural circuit functionality and behavior.
Researchers at the University of Tsukuba found that dopamine neurons represent different parts of the decision-making process, including both evaluation and choice. The study suggests that these neurons send decision signals to other brain areas, ultimately influencing muscle action and informing choices in everyday life.
A single treatment inhibiting PTB converts astrocytes into dopamine-producing neurons, restoring dopamine levels and eliminating Parkinson's disease symptoms in mice. The study provides a proof of concept for a new therapeutic approach.
Researchers from the University of Cambridge and King's College London discovered that problems in how the brain recognizes and processes novel information lie at the root of psychosis. The study found that defective brain signals in patients with psychosis could be altered with medication, leading to new treatment development pathways.
Researchers from EPFL have solved the high-resolution structure of an activated form of a dopamine receptor in a native lipid membrane environment. By combining computational allosteric and de novo protein design approaches, they created a highly stable but activated receptor whose structure could be studied and solved.
Researchers embed dopamine receptors in phospholipid membrane to study their structure and behavior. The findings could lead to the development of more precise drugs for treating conditions like Parkinson's disease and addiction.
Researchers at MIT's Picower Institute discovered that dopamine signaling plays a crucial role in coordinating distinct behavioral outputs in C. elegans, enabling the animals to disperse eggs efficiently across a nutrient-rich environment. By analyzing high-frame-rate videos of nematodes using a custom microscopy platform, the team ide...
Researchers at McLean Hospital identified two molecules naturally produced by the body that stimulate dopamine production, which may help reverse Parkinson's disease progression. Prostaglandin A1 and E1 protect dopamine-producing neurons from dying and increase dopamine levels without side effects.
A joint research team has identified dopamine D2 receptors in cholinergic interneurons as a key factor in susceptibility to cocaine addiction. The study found that DRD2 overexpression and reduced cell activation in ChINs contribute to the development of cocaine addiction.
A study by NTU Singapore-Harvard University has identified a promising molecular pair, Prostaglandin E1 and Prostaglandin A1, that can boost dopamine levels and slow Parkinson's disease. The researchers found that these hormone-like substances can activate Nurr1, leading to increased dopamine production and neuroprotection.