Articles tagged with Neurology
Researchers from Children's Hospital of Philadelphia found that dysfunction in a key brain cell subtype contributes to chronic symptoms in Dravet syndrome. The study suggests that increasing expression of Nav1.1 in parvalbumin interneuron axon may be a viable therapeutic target for patients.
A new American Heart Association scientific statement finds that timely treatment can help avoid additional disability and health impacts in people with pre-existing disabilities or dementia. The statement also highlights the need for increased awareness of potential biases and improved patient-centered care.
A new study by University of Cincinnati researchers analyzed outcome data from a large cohort of patients and found correlations between different risk factors, including age, hemorrhage size, location, and cognitive impairment, which were associated with poor outcomes. The results also showed that Black and Hispanic populations were m...
Researchers at UVA Health System discovered a cluster of cells in the brainstem that controls the body's response to severe blood loss. The study found that re-activating these neurons can restore blood pressure and heart rate in lab rats, offering new hope for treating traumatic injuries.
Scientists have created electrodes from recycled coffee grounds that can detect trace levels of biomolecules in vitro, offering a more sensitive surface for neurochemistry detection. The researchers hope to boost their neurochemical detection abilities by fabricating entire electrodes with carbon from coffee grounds.
A new study found that excessive daytime napping among seniors is associated with an increased risk of developing dementia and Alzheimer's disease. After a diagnosis of mild cognitive impairment or Alzheimer's, daytime napping duration triples, suggesting that the brain's wake-promoting neurons may be affected by dementia pathology.
Brainwide association studies need thousands of individuals to yield higher reproducibility, as smaller samples often uncover strong but spurious associations. Larger sample sizes lead to more likely reproductions of correlations, with effect sizes decreasing as the number of participants increases.
Researchers at UC San Francisco have identified five genes that enable efficient sleep, contrasting with current thinking that lack of sleep accelerates neurodegeneration. These genes may confer protections against neurological disease and improve sleep quality, paving the way for new treatments.
Researchers found that low blood oxygen levels correlate with longer time to regain consciousness in patients with severe COVID-19. The study involved 795 patients and found that 72% recovered consciousness before hospital discharge, but 25% took 10 or more days to recover.
Researchers assessed risk factors associated with mortality and neurologic disability three months after intracerebral hemorrhage, finding a link between certain comorbidities and poor outcomes. The study used a racially and ethnically diverse cohort to identify key risk factors for death and disability.
Researchers found that the Klotho gene can suppress glioblastoma cell viability and induce apoptosis, leading to a significant decrease in tumor growth. The study contributes to the development of new diagnostic and treatment approaches for malignant brain tumors.
A new study led by UC San Francisco reveals that 87% of seniors with dementia would stop at least one medication if their doctor said it was possible. Polypharmacy contributes to challenges with adherence and adverse interactions, but most patients are willing to reduce their medications.
A new genetic-labeling method developed by Osaka City University researchers uses a single gene to reveal neuronal circuits from multiple upstream regions. The 'intersectional, anterograde transsynaptic targeting system' demonstrates enhanced synaptic specificity in two different mouse brain circuits.
Researchers at the Medical College of Wisconsin uncovered that conceptual knowledge is tied to perceptual and experiential information. They used fMRI to measure neural activity while participants read hundreds of words, finding that experiential information was key to understanding word meaning.
Researchers investigated the association between acute respiratory failure in early childhood and long-term neurocognitive outcomes. The study found that children who experienced severe respiratory distress were more likely to have impaired cognitive function and behavioral problems later in life.
A new study published in Neurology: Neuroimmunology & Neuroinflammation suggests that some patients with long-COVID experience long-lasting nerve damage due to infection-triggered immune dysfunction. The study found peripheral neuropathy in 59% of patients, with symptoms including weakness, sensory changes, and pain.
Researchers found that viewing nostalgic images from childhood reduced pain perception in adults, with the strongest effect on low-intensity pain. Nostalgic images decreased activity in brain regions involved in pain perception, including the left lingual gyrus and parahippocampal gyrus.
Researchers discover a genetic mechanism linking ALS and dementia to UNC13A protein corruption, providing hope for new treatments by blocking corrupted instructions. The study found that genetic variants increase the risk of UNC13A mRNA corruption in patients with ALS and FTD.
Researchers at UCL have created a technique called magnetomechanical stimulation that uses microscopic magnetic particles to control touch-sensitive brain glial cells. This allows for precise and remote activation of astrocytes, providing a new tool for understanding their function and potential treatment of neurological disorders.
Researchers developed behavioral task for rats to press lever within 3.2 seconds, earning rewards based on accuracy. Rats chose correct feeder based on temporal error, showing 'error monitoring' ability.
A new study at McGill University found that an AI tutoring system improved surgical skills and learning outcomes among medical students compared to human instructors. The AI-powered Virtual Operative Assistant taught safe techniques and provided personalized feedback, leading to a 36% better performance rate.
Researchers studied how diverse neural network training datasets impact generalization. They found that data diversity is key to overcoming bias, but also degrade performance when neural networks are trained for multiple tasks simultaneously. The study highlights the importance of designing diverse and controlled datasets in machine le...
A new UCLA study has found that hippocampal neurons in rats accurately map the position of a moving object even when stationary, challenging prevailing hypotheses about brain function. The findings open up new research avenues into memory disorders such as Alzheimer's disease.
A recent study by researchers from Ritsumeikan University found that athletes with a history of sprained ankle showed reduced gut bacteria diversity compared to those without such a history. This suggests that musculoskeletal injury may have a negative impact on the gut microbiota, potentially leading to long-term health consequences.
Markita del Carpio Landry, a young immigrant scientist, receives the Vilcek Prize for Creative Promise for her groundbreaking research on neurochemical communication and gene-editing technologies. Her work aims to address medicine's most compelling problems, including aberrations in neurotransmitter signaling.
Researchers found that starting DOACs within 1-4 days after stroke onset reduces stroke recurrence without increasing major bleeding risks. The '1-2-3-4-day' rule is proposed as a feasible real-world clinical setting guideline.
Studies using magnetic resonance imaging found a correlation between decreased blood flow in specific brain areas and tinnitus severity. Researchers at the University of Illinois Urbana-Champaign explored these links to better understand the causes of tinnitus.
Researchers at University of California San Francisco have catalogued over 40 previously unknown cell types in the human brain's blood vessels. These findings connect hemorrhagic stroke with novel immune cells, offering new targets for therapies.
Researchers found elevated protein levels and unexpected antibodies in cerebrospinal fluid of patients with post-COVID cognitive symptoms, suggesting inflammation and a systemic response. The study suggests an activated immune system may be the cause of brain fog, a common after-effect of COVID-19.
A pre-clinical study showed that the use of extracellular matrix supports improved nerve fibre regeneration across large nerve defects. The team's novel ECM-loaded medical device increased pro-repair inflammation, blood vessel density, and regenerating nerves, offering a promising alternative to current therapies.
UCSF researchers discovered a small cluster of neurons in the brain stem that regulates tempo and coordinates breathing with vocalization. This finding has implications for understanding speech pathologies, as altered wiring in this system may cause difficulties with speaking.
A recent study published in Alzheimer's & Dementia found that regular exercise enhances the connections between neurons in older adults, maintaining healthy cognition. The research, led by Kaitlin Casaletto and William Honer, suggests that physical activity may help boost synaptic functioning and safeguard against dementia.
A UMass Chan clinical trial demonstrates the safety and efficacy of an antisense oligonucleotide in suppressing mutant C9ORF72, a common cause of familial ALS. The treatment led to reduced levels of neurotoxins and stable or improved ALS functional scores.
Cleveland Clinic researchers have identified the gut microbial gene cluster responsible for converting carnitine into TMAO, which promotes heart disease and stroke. The study found that dietary modifications may help reduce diet- and TMAO-associated cardiovascular disease risk by targeting the gbu gene cluster.
A new study from Children's Hospital of Philadelphia found that family members of children with life-threatening conditions are 50-70% more likely to experience mental and physical health issues. The study examined four types of life-threatening conditions and found mothers, fathers, sisters, and brothers to be at higher risk.
Research found the female genital field's location varies among women and is thicker with more frequent sex. The somatosensory cortex devotes space to detecting touch, and the region's structure alters in relation to use.
The worldwide incidence and mortality rates for stroke decreased slightly over the three decades, but the overall numbers are still high. Ischemic stroke is highly preventable, and more resources should be devoted to prevention, especially in low- and middle-income countries.
Researchers from Tel Aviv University have identified the biological mechanism causing nerve destruction in ALS, a fatal neurodegenerative disease. They found that TDP-43 protein accumulation in neuromuscular junctions inhibits local protein synthesis and mitochondrial activity, leading to degeneration and death of motor neurons.
A new study suggests that sun exposure may reduce the risk of multiple sclerosis in children and young adults by up to 52%. Vitamin D levels are also found to be higher in individuals with increased sun exposure, which may play a role in protecting against autoimmune diseases.
Scientists have created a new imaging method that can detect microscopic soft tissue damage in animal spines, which may lead to improved treatments for lower back pain. The technique uses fluorescent molecules to target denatured collagen and produce precise 3D maps of spinal damage.
A new web-based application can predict which epilepsy patients will not benefit from stereo-electroencephalography (SEEG), a costly and invasive procedure. The '5-SENSE' score reliably identifies patients who will not have a focal seizure onset zone, allowing clinicians to avoid unnecessary procedures.
The human brain contains trillions of contact points, requiring massive computational resources. Researchers outline the need for exascale computing power to tackle brain complexity.
A new study by Ritsumeikan University reveals that whole-body dynamic balance training increases brain connectivity and improves motor learning. The research found significant changes in brain activity associated with offline learning, opening up new avenues for studying neural networks during natural tasks.
Researchers at Children's National Hospital have successfully developed a personalized T cell immunotherapy that targets and kills unique proteins in individual tumor cells. This approach, combining genetic sequencing and protein identification, offers a promising treatment option for children with hard-to-treat brain tumors.
The insular cortex processes both positive and negative emotions and receives information from the body, including heart rate and breathing. In mice, the brain uses bodily signals to regulate fear, keeping it within a healthy range.
Researchers found that candesartan reduces accumulation of extracellular matrix proteins and normalizes blood flow in mice with hereditary cerebral small vessel disease. The study suggests a potential new treatment avenue for age-related cerebral arteriopathy.
Researchers at UCSF discovered a narrower blood pressure range during surgery that significantly improves neuromotor recovery in patients with spinal cord injuries. Patients whose mean arterial blood pressure was between 76 mmHg and 104-117 mmHg had maximal recovery, indicating a potential new treatment guideline.
Researchers at Universidad Complutense de Madrid have discovered alterations caused by ALS in the retina, which can be used as biomarkers for diagnosis and treatment monitoring. The study found changes in microglial cells and ganglion cell loss, with modifications evolving over the course of the disease.
A peer-reviewed study published in Life journal proves Reflex identifies biomarkers for concussions, enabling accurate clinical diagnosis and decision-making. The study, conducted by Purdue University, uses pupillary light reflex to measure concussion patients' recovery and prevent compounding injuries.
A major Finnish–Norwegian study found that obesity does not lower the risk of subarachnoid haemorrhage, as smoking habits are a significant factor in the condition. The study analyzed over 200,000 individuals and comprehensively considered confounding factors.
Researchers at University of California San Diego School of Medicine identified the anterior insula's role in predicting and emotionally processing pain in HIV-DSP patients. The study suggests that reduced anterior insula activity or increased cingulate activity may improve pain outcomes for these patients.
Researchers found that future goals are represented by a pattern of neural activity resembling previous visits, and this activity can re-emerge upon decision to target a location. The orbitofrontal cortex plays a key role in representing future goals during navigation.
Researchers have made significant progress in generating neurons in the lab, a potential therapeutic option for replacing lost neurons in neurodegenerative conditions like Parkinson's disease. A $9 million grant will support further research and development of this novel treatment approach.
A new rapid screening test for glaucoma uses infra-red sensors to monitor eye movement, providing accurate results within seconds. The test could help advance early detection of the disease, a leading cause of irreversible blindness, and make it more accessible for national screening programs.
A first-in-human study at Cleveland Clinic found that targeting the dentate nucleus with deep brain stimulation was safe and feasible for promoting post-stroke rehabilitation, enabling significant functional improvement in upper extremity hemiparesis. The study's adaptive design allowed for extended treatment duration if patients conti...
A new study found that translocator protein 18 kDa (TSPO) correlates with worse survival outcomes in male glioblastoma patients compared to females. The variation in the protein's structure is associated with shorter overall and progression-free survival times, suggesting its potential as a prognostic biomarker.
Researchers identify key neurons and signaling pathway regulating female activity before ovulation. Discoveries could lead to new treatments for menopause that sidestep estrogen and reactivates the circuit with CRISPRa technology.
A recent study published by the American Academy of Neurology found that women are underrepresented in stroke clinical trials, with a participation-to-prevalence ratio of 0.84. This disparity may limit the applicability of trial results to the general population and affect access to new therapies.
A study published in JAMA Neurology found that long-term exposure to space can cause brain damage in cosmonauts. The research analyzed five Russian male cosmonauts who spent an average of 169 days in space, showing significant increases in biomarkers for brain cell damage upon their return to Earth.
Researchers found that clot-busting drugs rarely cause aneurysms to rupture after a stroke. For people with larger saccular aneurysms, additional consideration should be taken regarding treatment to minimize risk of aneurysm rupture.