Articles tagged with Blood Plasma
The study used LC-HRMS/MS to identify two main metabolites of Nitroproston in rat plasma: 1,3-GDN and PGE2. In human whole blood, Nitroproston biodegradation rate was the slowest, occurring more rapidly in whole blood. This suggests that metabolism is mainly associated with RBC fractions.
A study of US hospital inpatient discharges from 1993 to 2014 found a decrease in red blood cell and plasma transfusions between 2011 and 2014. This trend may be attributed to the implementation of restrictive transfusion practices aimed at improving patient outcomes and conserving blood.
Researchers have created an engineered form of ADAMTS-13 (BAX 930) to restore the missing enzyme in patients with congenital thrombotic thrombocytopenic purpura (TTP), a rare and life-threatening blood disease. The therapy was found to be safe and effective, with no allergic reactions or serious adverse events.
Researchers identified a protein, TIMP2, that had the same effect when injected into older mice. The findings could lead to new treatments for age-associated declines in mental ability.
A study from Massachusetts General Hospital found that a widely adopted blood transfusion practice may not benefit patients without traumatic injuries and may even be harmful. The practice, which involves giving patients more plasma than red blood cells during massive transfusions, was previously studied only in trauma patients.
Researchers at Joslin Diabetes Center have discovered a potential way to reduce complications from blood clot removal during stroke treatment. By targeting the plasma kallikrein protein, they aim to increase the efficacy of tissue plasminogen activator (tPA) therapy while minimizing bleeding and swelling.
Researchers at Nagoya University developed a cold plasma-activated Ringer's solution that exhibits anti-tumor effects, attributed to the lactate component. The solution triggers cell death through increased intracellular hydrogen peroxide levels, suggesting a potential specific tumor therapy.
Scientists at Tohoku University found that discharge plasma increases calcium ion influx through TRP channels, triggering cell activities like gene transfection and wound healing. This breakthrough may contribute to developing more efficient plasma medicine treatments.
A new method using proton nuclear magnetic resonance (H-NMR) of blood plasma identifies unique metabolic biomarkers for early and late-stage lung cancer. The technique correctly classifies 78% of patients and 92% of controls, showing promise as a complementary tool to improve lung cancer screening.
Researchers at the University of Cincinnati have discovered that a human cancer-causing gene called DEK can be detected in the plasma of head and neck cancer patients. High levels of DEK may indicate better outcomes for patients, while low levels are associated with advanced cancers.
A new technology uses oscillating electric fields to isolate drug-delivery nanoparticles from blood, overcoming traditional separation methods' limitations. The device can recover nanoparticles in various processes and monitor their interaction with blood proteins.
Researchers developed a bacterium-based biosensor that can detect zinc levels in blood samples, providing an inexpensive way to assess nutritional deficiencies. The test uses color changes to indicate zinc levels, making it visible without specialized equipment.
A new plasma protocol effectively treats trauma patients quicker in ERs by delivering thawed plasma within 10 minutes of arrival. This approach improves outcomes for victims with massive bleeding and reduces wastage of frozen plasma.
Researchers are investigating whether plasma from Ebola survivors can help treat patients with the disease. The study aims to determine if protective antibodies in the plasma can be used safely to reduce deaths in current and future outbreaks.
The 2013 guidelines recommend delivering universal donor plasma to critically injured patients as part of optimized treatment with red blood cell transfusions. This approach can be consistently implemented and rapidly delivered in high-volume trauma centers without excessive wastage.
A Michigan State University study found that most people are willing to donate bodily samples for medical research, but this willingness drops when specific projects are mentioned. The study suggests that biobanks should rethink their consent processes and be more transparent about the research they support.
A research team led by the University of Liverpool is testing the safety and efficacy of using Ebola survivors' blood to treat patients in West Africa. The study aims to reduce deaths from the outbreak by finding a safe and effective therapy.
Researchers developed a new protein biomarker test platform that can accurately measure multiple proteins indicative of diseases like graft-versus-host disease. The test uses aqueous two-phase systems and no washing steps, enabling simultaneous measurement of multiple diagnostic proteins.
A new plasma thermogram test has been developed by researchers at the University of Louisville, indicating the presence or absence of cervical cancer. The test measures unique protein signatures in blood plasma, providing a non-invasive alternative to traditional Pap smear screening.
Researchers at the University of Illinois have determined the amino acid digestibility of five blood products produced in the US to provide swine producers with guidance for formulating diets. The study found that spray-dried blood products were good sources of amino acids, while flash-dried products had lower digestibility.
Researchers found a reliable D-dimer plasma level threshold for detecting venous thromboembolism after craniotomy, indicating high sensitivity and specificity. A postoperative D-dimer threshold of 2 mg/L is proposed, with higher levels associated with pulmonary embolism.
A randomized trial found that a 1:1:1 blood transfusion protocol is feasible but associated with higher waste of plasma. The study suggests that widespread adoption may lead to significant resource and safety implications due to the scarcity of plasma.
Researchers analyzed cerebrospinal fluid and plasma samples from patients with no cognitive decline, mild cognitive impairment, and Alzheimer's disease. They detected significant changes in metabolic pathways related to mitochondrial function, validating blood as a reliable source for biomarker development.
Researchers have developed a new solid form of bioactive plasma-based biomaterials that can promote healing at sites of tissue injury. These materials, known as PBMs, are easier to work with, inexpensive to produce, and safe to use.
Dr. Michael Keidar is researching ways to cut human tissue more efficiently using plasma technology, which could minimize the need for blood transfusions during surgery. His goal is to understand the physics of plasma interaction with living tissue and develop new devices that can safely and effectively cut through human tissues.
Researchers at Saarland University and the University of Pennsylvania have discovered that blood plasma is a non-Newtonian fluid that forms threads and exhibits viscoelastic properties, influencing blood flow into narrow capillaries. This study may improve computer simulations of vascular pathological processes.
Researchers analyzed blood plasma samples from mice to identify protein traits associated with genetic markers, paving the way for diagnostic and therapeutic targets
A new study provides clear procedures for collecting and analyzing microRNAs, significantly improving diagnostic accuracy. Researchers developed measures to overcome interfering activities and improved the sensitivity of miRNA detection by up to 30-fold, enabling faithful quantitation of miRNA abundance in body fluids.
Researchers at UC Berkeley have discovered that ionized plasmas can kill bacteria in water for up to a week, making it a potential cheap and effective sterilizer for developing countries. The plasma-generated molecules create a cocktail of highly reactive chemicals that attack and destroy microbes.
A CU-Boulder study finds that fatty acids circulating in python bloodstreams promote healthy heart growth, with no evidence of fat deposition in the heart. The researchers also saw an increase in the activity of a key enzyme protecting the heart from damage.
The new instrument, developed at UCSB, can detect nanoparticles in fluid at rates of up to half a million particles per second. It measures the volume of each nanoparticle for rapid and precise size analysis of complex mixtures.
The American Academy of Neurology recommends using plasma exchange to treat people with severe relapses in multiple sclerosis (MS) and related diseases, as well as those with certain kinds of nerve disorders known as neuropathies. Plasma exchange has been found effective for treating severe flares in relapsing forms of MS.
PlasmaButton therapy offers a new treatment option for benign prostatic hyperplasia (BPH), with benefits including excellent tissue ablation, minimal patient morbidity, and ease of use. The technology provides a virtually bloodless procedure, reducing complications such as urinary tract infections and renal failure.
A study found that higher concentrations of clusterin protein in plasma are associated with the development and severity of Alzheimer's disease. Clusterin levels were also linked to rapid cognitive decline, brain atrophy, and increased amyloid-beta accumulation.
New research reveals that high doses of caffeine increase muscle power and endurance during sub-maximal activities, such as everyday tasks or running a marathon. The study's findings have implications for the use of caffeine in sports to enhance performance, although caffeine remains unlisted by the World Anti-Doping Agency.
Researchers observed that early blood flow begins all at once in zebrafish embryos, involving hundreds of cells. Red blood cells initially stick to the vessel wall before releasing themselves with a protease enzyme called ADAM8.
A recent commentary in the Canadian Medical Association Journal highlights inappropriate uses of frozen plasma, with 45% to 48% of audited transfusions found to be misuse. Experts recommend introducing measures to promote alternative use and screen orders against guidelines to improve practice.
A retrospective study of Red Cross donor and hospital data found that patients receiving female-donor plasma had better lung function, reduced risk of death within 30 days of surgery, and longer hospital stays compared to those who received male-donor plasma.
A new study from the University of Warwick found that high levels of selenium are associated with increased cholesterol levels. The research team discovered a 10% increase in non-HDL cholesterol levels and an 8% total cholesterol level increase, which can lead to heart disease. The study highlights the importance of moderate selenium i...
Researchers describe a potential new therapeutic approach for diabetic retinopathy using ASP-440, a protease plasma kallikrein inhibitor. The study showed significant reductions in retinal vascular permeability and blood pressure in rodents, suggesting promising results for treating the condition.
The Integrated Blood-Barcode Chip (IBBC) is a revolutionary diagnostic tool that measures protein concentrations from just a pinprick of blood. The device offers a significant improvement over traditional laboratory tests, reducing costs and time by orders of magnitude.
A low-cost egg-beater-based centrifuge can separate plasma from blood in minutes, used to detect deadly infectious diseases common in developing countries. The device requires no training or electricity and can be sterilized with boiling water.
Research reveals T tube patients with duodenal-biliary reflux, sphincter of Oddi hypomotility, and abnormal gastrointestinal hormone secretion. The disorder may cause recurrence of gallstones.
Research highlights the importance of diet, statins, and genetic factors in cholesterol regulation and cardiovascular health. Studies have shown that low HDL-C levels are strongly associated with an increased risk of CAD, and genetic mutations can affect HDL-C production.
Researchers at Tufts University identified groups with inadequate vitamin B6 status, including women of reproductive age and smokers. The study found a significant link between oral contraceptive use and low plasma pyridoxal 5'- phosphate levels.
Researchers at Duke University Medical Center analyzed 8,300 heart surgery patients and found no association between transfused female plasma and adverse outcomes, even a potential protective effect.
Researchers at the University of Warwick have discovered a link between vitamin B1 deficiency and vascular problems in diabetic patients. The study found that type 1 and type 2 diabetic patients had significantly lower levels of thiamine in their blood plasma, which may contribute to microvascular and macrovascular complications.
Scientists have developed a method to rapidly separate blood plasma without moving parts, leveraging the phenomenon of tea leaves accumulating at the center of a stirred teacup. This technique could significantly speed up medical tests, such as cholesterol level checks and glucose testing for diabetics.
The Australia-US Free Trade Agreement could lead to a decline in Australia's blood safety standards if plasma fractionation is opened up to overseas tender. The move could also affect products in other countries, including New Zealand, which may be forced into 'piggy-backing' with new arrangements.
A new artificial preservative has increased the storage period of blood platelets to 7 days, reducing the need for frequent transfusions and lowering the risk of adverse reactions. This innovation could have significant global implications for patients in critical need of platelet transfusions.
Hematologists say coagulation-factor concentrates from plasma are now deemed safe from most infectious agents, but challenges from new agents remain. Recombinant products offer a risk-free alternative, but safety studies have not definitively made the case for either.
Researchers found high HCV rates among former plasma/blood donors and villagers who received blood transfusions. Unhygienic plasma donation and blood transfusion are strong risk factors for HCV infection in rural central China.
The study suggests that different patterns of tissue damage in MS patients require different treatment approaches. Plasma exchange treatment was found to be most helpful for severe attacks in patients with pattern II MS lesions, which contain large quantities of immunoglobulins and complement activation.
Researchers at Pacific Northwest National Laboratory have identified a vast array of 4,000 distinctive proteins in human blood plasma, surpassing previous reports by 10 times. This significant advance paves the way for the early detection of cancer and other diseases.
HUPO scientists have created a master proteomics database from human blood plasma, which will help answer key questions about protein identification and analysis. The project's long-term goals include identifying all protein constituents of human blood plasma and determining variation across populations.
Researchers found that taking vitamin E supplements with food, especially those containing fat, increases its bioavailability. The study suggests that people may not be getting enough vitamin E from their low-fat diets.
IVIg is the preferred treatment for Guillain-Barré Syndrome due to its ease of use and lower complication rate compared to plasma exchange. Early treatment within two weeks of symptom onset improves chances for a better outcome.
Guideline suggests that early treatment with IVIg or plasma exchange can be beneficial for adults and children with severe, early Guillain-Barré syndrome. These treatments have been found to be equally effective in treating the condition.
A new study found that current low-dose oral contraceptives significantly increase plasma concentrations of C-reactive protein (CRP), an inflammatory biomarker associated with cardiovascular disease. CRP levels were two times higher among OC users than non-users, regardless of diet assignment or phase of the menstrual cycle.
Researchers have successfully treated a patient with TTP, a rare blood disorder affecting 3,000 Americans annually, by suppressing the immune system. The treatment involves using immunosuppressive drugs, which target the underlying problem of the immune system attacking its own tissues.