Research on how the brain is built and how it governs body and behavior. Covers neural circuits, sleep, sensory systems, brain structure, and the brain-body connection.
A UCL-led research team has identified an anti-viral gene that increases the risk of both Alzheimer's disease and severe Covid-19. The study found that a specific variant of the OAS1 gene amplifies inflammation in the brain, highlighting the importance of the immune system in both conditions.
Researchers at WVU will explore how a specific enzyme protects the brain from stroke effects and aging. Their findings may indicate a potential target for medications improving brain blood vessel function after a stroke.
Researchers analyzed genetic expression profiles of developing brain cells, finding that early tissue holds a pre-set map that develops into the cerebral cortex's characteristic topography. A new method for predicting cell fate has also been established, using chromatin structure to determine lineage before gene expression is possible.
Scientists have developed an improved technique to trace brain connections between neurons in zebrafish using vesicular stomatitis virus (VSV), enabling the visualization of connected neurons up to five days after infection. This breakthrough could provide insights into brain network connectivity repair after injury or disease.
Researchers identify 116 types of cells in the primary motor cortex, a significant step towards creating a comprehensive brain atlas. The findings aim to understand how neural networks control movement and cognition, and could lead to new therapies for neurologic and neuropsychiatric diseases.
Researchers at the Sainsbury Wellcome Centre have discovered a new brain circuit that enables mice to override their instincts based on previous experience. The ventral lateral geniculate nucleus (vLGN) inhibits threat reactions when animals feel safe, but activates them when danger is perceived.
A study by University of South Florida Health researchers suggests that fenchol, a natural compound in basil, can help reduce neurotoxic amyloid-beta in the brain. Fenchol stimulates FFAR2 signaling, reducing senescent neuronal cells and increasing Aβ degradation.
Researchers found that a cancer chemotherapy drug can restore memory and cognitive function in mice with Alzheimer’s disease by inhibiting blood vessel growth. The study suggests repurposing approved anti-cancer drugs as treatments for Alzheimer’s disease, potentially shortening clinical development time.
A Dartmouth study found that individuals who experienced higher levels of stress on a given day had lower social interaction the following day. The research used mobile phone sensing data from 99 undergraduate students and showed that stress predicted less social interaction, but not the other way around.
A new study found that ketone supplements enhanced blood flow to the brain and improved aspects of cognitive function, such as working memory and processing speed, in adults with obesity. This suggests that ketone supplements may be a novel therapeutic strategy for protecting and improving brain health in people with obesity.
A groundbreaking study will follow 7,500 pregnant women and their infants across the US to understand healthy brain development. The five-year study aims to provide a comprehensive picture of normal variability in brain development and identify factors that pose the greatest risk.
Researchers used neuroscientific theories to develop a decision-making model that predicts pedestrian road-crossing decisions. The model shows that pedestrians add up sensory data before crossing, helping autonomous vehicles communicate more effectively with pedestrians.
Researchers analyzed idle thoughts for 10 minutes to capture patterns of thinking, revealing a link between ruminative thinking and depression. Participants who scored high on a rumination questionnaire experienced negative thoughts that lasted longer than positive thoughts.
The researchers will develop techniques to analyze the joint growth of the brain and cranium using MRI scans, helping clinicians better assess and diagnose developmental disorders. The project has the potential to provide invaluable insights into healthy child development, enabling early detection and effective treatment.
Researchers found that people living at high altitudes have a lower risk of stroke and stroke-related death. The study suggests that adaptation to low oxygen conditions may help protect against stroke damage. A protective window between 2,000 and 3,500 meters was identified, with less protection seen above this altitude.
A meta-analysis of tDCS studies found that applying tDCS during tasks improved reaction times, particularly in learning and memory tasks and executive function/complex attention tasks. The improvement was more pronounced in older individuals, suggesting that tDCS may increase with age.
A recent study published in Frontiers in Immunology found that opioids can control gut immune responses, reduce colonic inflammation, and even promote the growth of regulatory T cells. The findings suggest that KNT-127 could be a promising therapeutic option for inflammatory bowel disease.
The Buck Institute has been awarded a $14.3 million grant from the NIH to study cellular senescence, a hallmark of aging, as a driver of Alzheimer's disease and other age-related dementias. Researchers will investigate new mechanisms that can be developed into interventions to treat patients.
Researchers discovered zebrafish neurons that monitor prediction errors to efficiently avoid danger, creating a 'hazard map' in the brain. This study sheds light on brain circuits shared across vertebrates, including humans.
Researchers at Rice University and the US Army are developing a portable skullcap that analyzes cerebrospinal fluid flow during sleep to clear metabolic waste. The goal is to noninvasively measure and modulate brain health in soldiers, potentially treating sleep disorders in real time.
A team of researchers at the Marine Biological Laboratory has developed a system called HySyn, which uses neuropeptides from Hydra to synthetically reconnect neural circuits in the C. elegans brain. This allows for the creation of an artificial synapse that rewires a behavioral circuit, enabling the worm to communicate more effectively.
A new study found that schizophrenia is associated with a loss of excitation but an increase in inhibition, resulting in hallucinations. The researchers used EEG data from 107 participants to demonstrate decreased synaptic gain, which may guide pharmacological and neurostimulation treatments.
A new study published in Current Biology reveals that visually impaired babies primarily use touch to respond to stimuli, while sighted babies rely more on auditory cues. The research suggests that both senses will be crucial in designing tools to aid their development.
Researchers used mice to demonstrate that acquired knowledge is stored in early visual areas of the brain, highlighting the widespread storage of semantic memories. The study showed that part of category knowledge is already present in the visual cortex.
A pioneering EEG test has shown high effectiveness in detecting small changes in brain waves associated with memory recall. The passive test could lead to earlier diagnosis and treatment of Alzheimer's disease, potentially improving patient outcomes.
Researchers at RIKEN Cluster for Pioneering Research have found that Kleefstra syndrome, a genetic disorder leading to intellectual disability, can be reversed after birth. Postnatal treatment with artificially induced GLP production resulted in improved brain and behavioral symptoms.
A common blood test could identify patients with schizophrenia at high risk for cardiovascular disease, enabling early intervention. Elevated white blood cell counts are suspected to be a signal, and a large-scale analysis of over 20,000 patients will examine its associations.
Scientists discovered a protein, IL13Ra2, that promotes brain metastases in breast cancer patients. High levels of this protein are associated with poor survival rates. Researchers aim to develop targeted therapies for this specific population.
Researchers discover brain forms a single motor plan to optimize task performance despite uncertainty, upending decades-old theory of motor averaging. The study used experiments and computational modeling to demonstrate the brain's ability to generate an optimal action choice under uncertain conditions.
Researchers found that subjects' heart rates synchronized even when listening to a story alone, as long as they were paying attention. This synchronization was predictive of conscious processing of the narrative, and had implications for understanding mindfulness and the brain-body connection.
A study found that microgravity significantly impacts P-glycoprotein expression and function in rats, with higher levels of P-gp expression in long-term microgravity exposure. The researchers identified 26 proteins interacting with P-gp, which regulated ATP hydrolysis-coupled transmembrane transport and other functions.
A new study found that cognitive control plays a significant role in determining whether individuals cheat or not. Participants who tended towards honesty were more likely to cheat, while those with a moral inclination towards dishonesty were more likely to remain honest. This suggests that cognitive control can override moral impulses...
Research from Dartmouth College reveals that making and breaking eye contact during conversations can create a dynamic balance between shared attention and individual expression. Pupillary synchrony decreases after eye contact breaks, allowing for creativity and new thoughts, while also signaling shared understanding.
A new study found that electroconvulsive therapy (ECT) significantly reduces deaths by suicide among older adults with depression in the months following hospitalization. The therapy may also improve overall health and cognitive functioning.
Researchers found that ribociclib achieved pharmacologically-relevant concentrations in tumor tissue, while everolimus showed minimal penetration. The combination is promising for brain cancer treatment and could lead to new therapeutic drug combinations.
Researchers surveyed 4,324 people with Parkinson's and found that many are unaware of all seven compensation strategies, but most who tried them reported positive effects. The study suggests a 'one-size-fits-all' approach doesn't work, emphasizing the need for personalized education on available strategies.
A recent study at Drexel University found that virtual reality art therapy can reduce prefrontal cortex activation, promoting relaxation and flow. The study also showed differences in brain function between creative self-expression and rote tracing tasks.
Researchers at Eötvös Loránd University discovered that dogs exhibit attachment behaviors similar to human infants, responding positively to their owner's speech. The study found that the reward center of a dog's brain is more sensitive to its owner's voice compared to a familiar person's praise.
Researchers developed a new AI algorithm called 'basis profile curve identification' to simplify comparisons between effects of electrical stimulation on the brain. The algorithm may help understand which brain regions interact with each other, guiding placement of electrodes for treating network brain diseases.
A team of neuroscientists at the Beckman Institute developed safety standards for multiband EEG-fMRI imaging, reducing heating risks and maintaining data quality. By establishing protocols to mitigate artifacts, they enabled the use of accelerated fMRI sequences with EEG recordings.
The new molecular device has exceptional memory reconfigurability, allowing for enhanced computational power and speed. It can be reconfigured using voltage to embed different computational tasks, making it a potential game-changer in edge computing and applications with limited power resources.
A recent study discovered a connection between the brain's opioid system and food craving triggered by external stimuli. The researchers found that individuals with fewer opioid receptors were more likely to overeat in response to appetizing food, suggesting the opioid system as a potential target for anti-obesity drugs.
The CAPTIVA trial will enroll 1,683 patients with symptomatic intracranial arterial stenosis and determine if two new prospective therapies are more effective than aspirin plus clopidogrel at reducing the risk of a second stroke. Intensive medical management and lifestyle modifications will also be provided to all patients.
A new study demonstrates that temporarily anesthetizing the retina of the non-amblyopic eye can lastingly improve vision in the amblyopic eye even after the critical period. The approach has shown promising results in two different mammal species, offering a potential pathway for a new and more effective treatment for amblyopia.
Researchers at the University of Arizona Health Sciences are investigating the biological complexities of Alzheimer's disease in women during midlife aging. The study aims to reveal transformations in the brain that lead to greater risk of Alzheimer's, with a focus on the menopausal transition.
A recent study by Mount Sinai researchers discovered that certain neurons in the brain's decision-making centers monitor body-state dynamics and hijack the decision-making process during intense states of arousal. This suggests that changes in heart rate and other bodily responses can impact the brain's ability to make rational decisions.
Researchers reviewed 79 studies on neurocognitive impairments and brain abnormalities associated with nonfatal opioid overdoses in humans. The findings suggest a link between overdose, cognitive impairment, and brain changes, which could influence attention span, memory, and executive function.
Researchers from HSE Centre for Language and Brain compared expressive and receptive language abilities in Russian-speaking children with ASD. The study shows that there is no single expressive-receptive language pattern in children with ASD, but the difference depends on linguistic level.
Researchers discovered that a brain area traditionally thought to specialize in old habits also plays a role in learning new actions. The study found that the dorsolateral striatum is involved in consolidating action learning immediately after the new action has been learned.
The Cleveland Alzheimer’s Disease Research Center will receive funding to accelerate research on Alzheimer’s disease and related dementias. The center aims to develop individualized treatment approaches for individuals with aging-associated brain disorders.
Researchers found that astrocytes carrying the AD-associated APOE4 gene released more cholesterol, leading to increased beta-amyloid production in neurons. This study suggests modulating brain cholesterol could be a potential treatment option for Alzheimer's disease.
Georgia State University researcher Vince Calhoun has received a $3.5 million grant to develop new methods for capturing dynamic connectivity in the brain and identifying biomarkers for early detection of Alzheimer's disease. The researchers aim to analyze real-time connectivity patterns to predict future cognitive decline.
Researchers have developed a dye-free method to visualize blood flow in the brain, allowing for detailed mapping of small capillaries and assessing blood flow rates. The technique has potential applications in understanding cardiovascular diseases, tumor growth, and targeted drug delivery.
A new study suggests that a treatment for canine glioblastoma may also be effective in humans, with some dogs experiencing significant tumor shrinkage. The treatment uses an immunotherapy drug called STING agonist, which induced a robust immune response against cancer cells.
Researchers identified physical binding sites for cholesterol in GIRK channels, which play a role in neurodegenerative diseases. The study provides structural insights into how cholesterol alters channel function, paving the way for drug development.
A new study suggests that existing drugs for multiple sclerosis may not be effective due to toxic blood leaks in the brain. Researchers have identified a promising alternative treatment option that could improve myelin repair, even in the presence of these harmful elements.
A new study from University of California - San Diego suggests that protein deposits in the retina and brain may be a sign of Alzheimer's disease risk. Retinal imaging may potentially serve as an early biomarker for detecting AD risk, offering a non-invasive alternative to traditional brain scans.
A recent study found that regular physical exercise modulates iron homeostasis in both the brain and skeletal muscle of mice with Alzheimer's disease. The results suggest that IL-6 is a key modulator of hepcidin in exercise-induced brain iron modulation, which may help explain why exercise is beneficial for AD prevention or treatment.
Researchers at WashU Medicine have identified two antibodies that protect animals from disease caused by alphaviruses, which could form the basis of treatments or serve as a template for a universal vaccine. The antibodies worked against all tested alphaviruses and prevented arthritis and brain infections in animals.
Researchers developed a novel detector system using superconducting nanowire single-photon detectors to measure cerebral blood flow. The SNSPD-DCS system showed significant improvement in signal-to-noise ratio compared to conventional SPAD-based DCS, allowing for clearer detection of arterial pulses.