Articles tagged with Primary Tumors
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A new study published in Oncotarget reveals a higher prevalence of germline BRCA1 and BRCA2 mutations in ovarian cancer patients from the Salento peninsula, with 28.6% having familial cases and 39.7% having sporadic cases. The study found that 29.8% of patients were carriers of BRCA1/2 mutation.
The review highlights how T cell metabolism influences their fate, particularly in response to pathogen infections and tumorigenesis. It explores the role of glucose, fatty acids, and amino acids in energy production and metabolic adaptation, which can contribute to T cell exhaustion.
A recent study by Pusan National University scientists discovered the crucial role of PKM gene and EPHA2 pathway in HNSCC development. The research highlights the importance of HPV infection status in shaping the tumor microenvironment, enabling precision medicine for targeted treatment.
Researchers at UCSF have identified AF1q as a universal biomarker for neuroblastoma, a highly aggressive and fatal form of childhood cancer. High-risk cases have a five-year survival rate of just 50%. The study found that silencing AF1q in neuroblastoma cells induces cell death and weakens tumor progression.
Researchers highlight difficulties in targeting metastatic tumors and propose two- and three-drug combinations to achieve effective tumor control. They also emphasize the need for simultaneous blocking of primary driving oncogene, evolving resistance mechanism, and secondary survival pathway.
Researchers identify a promising prognostic biomarker for lung cancer using circulating tumor DNA-based minimal residual disease detection. The study found that this method can effectively guide treatment decisions and predict recurrence risk, potentially modifying the lung cancer treatment paradigm.
Researchers have engineered T cells with a mutation found in malignant lymphoma cells, making them more than 100 times potent at killing cancer cells. The new approach shows promise against solid tumors and could provide long-term immunity against cancer.
Researchers used a novel microscopy technique to image human brain tissue with unprecedented detail, revealing new cells and structures previously invisible. The method could help diagnose tumors, generate more accurate prognoses, and guide treatment decisions.
A team of researchers from MIT and the Broad Institute developed two types of injectable molecules called 'priming agents' that can boost DNA levels in blood samples, allowing for earlier cancer diagnosis and more sensitive detection of tumor mutations. The approach could also help improve detection of cancer recurrence.
Researchers developed a new imaging technique to visualize the tumor microenvironment of glioblastoma, revealing insights into its pathology. The technique uses PET imaging with Carbon-11 acetate, tracking reactive astrocytes and distinguishing them from tumor cells.
A Stanford University study reveals that ENPP1 is produced by both cancer cells and healthy cells around tumors, with high levels linked to immunotherapy resistance and metastases. Researchers found that targeting ENPP1 could improve patient responses to existing medicines and help clinicians better predict patient outcomes
Researchers discuss recent advances in blood-based liquid biopsies for prostate cancer interrogation, highlighting key biomarkers like CTCs, ctDNA, and exosomes. The studies suggest that these approaches can aid in predicting tumor recurrence, improving treatment response, and evaluating prognosis.
Researchers discovered that Osteopontin induces mitochondrial biogenesis in deadherent breast tumor cells, which aids metastatic success. The study suggests a possible mechanism and targets for treating cancer metastasis by increasing ATP levels and mitochondrial mass.
Researchers found that carboxylic nanodiamonds blocked melanoma cells' ability to migrate and invade across membranes. Mice treated with these nanoparticles showed reduced or no tumor metastasis compared to untreated mice.
TTUHSC researchers received funding for pilot studies on photothermal tumor therapy, clear cell renal cell carcinoma, and colorectal cancer screening in underserved areas. The grants support the purchase of a cell sorter and address regional health disparities.
A phase 2 clinical trial found that serial blood tests can identify patients who benefit from additional immunotherapies, suggesting a potential early marker of treatment response. The study also showed that ctDNA analyses correlated with tumor size and survival, making it a promising strategy for guiding therapy.
Researchers discovered that fine-tuning mitochondrial energy production reduces melanoma tumor growth and enhances immune response in mice. The study reveals that manipulating mitochondrial electron transport increases expression of immune genes and makes tumor cells more visible to killer T cells.
A recent study from MIT found that measuring diversity of mutations within a tumor generates more accurate predictions of treatment success than overall mutation count. This discovery could help doctors identify patients who would benefit most from checkpoint blockade inhibitors.
Researchers from Shinshu University identified citrullination as a key mechanism in lung cancer metastasis. A novel CitFbg peptide was developed to block metastatic cell homing and reduce the risk of cancer spread.
Researchers developed an AI model called OncoNPC that can analyze genetic data to predict cancer type and origin. The model accurately classified at least 40% of tumors with unknown origin, leading to a 2.2-fold increase in eligible patients for targeted treatments.
Researchers investigated H3K27me3 expression patterns in pediatric brain tumors, finding a global loss of this epigenetic mark in diffused midline glioma (DMG). This loss was associated with high relapse rates and poor survival, highlighting the potential for targeting H3K27me3 as an epigenetically guided cancer therapy.
Researchers developed a new test that measures multiple characteristics of circulating tumour DNA to detect and localize multiple cancer types. The SPOT-MAS approach detected 73% of cancers with 97% accuracy, predicting the tissue of origin with 70% accuracy.
A new study found that cetuximab plus radiotherapy is an active treatment option for locally advanced cutaneous squamous cell skin cancer, with an objective response rate of 83.2%. The treatment was well-tolerated, with most patients experiencing mild acneiform skin rash or fatigue.
Three University Hospitals and Case Western Reserve University research teams received $50,000 Collaborative Science Pilot Awards to explore innovative research projects. The awards aim to increase competitiveness and capacity for major external funding opportunities in key areas such as cancer, brain health and genetics.
Researchers explore pyroptosis as a potential therapeutic approach for lung cancer treatment. The review highlights the dual role of pyroptosis in tumor progression and negative impact on normal cells. It suggests balancing the contradictory effects of pyroptosis to optimize clinical applications.
Researchers developed a novel endoscopic imaging system with a bioinspired sensor that can detect multiple fluorescent probes, enabling more accurate fluorescence-guided cancer surgery. The system showed improved spatial resolution and sensitivity in detecting tumors, paving the way for the adoption of multi-tracer FGS.
Researchers developed a novel combination therapy that eradicates tumors in select patients, with prolonged survival rates. The therapy has shown promise in treating glioblastoma, a notoriously difficult-to-treat primary brain cancer.
A team of researchers has discovered that a naturally produced chemical in the body helps glioblastoma cells go unrecognized by the immune system. The findings could lead to the development of new and more effective treatments for this aggressive brain cancer.
Research discovers how cancer cells evade immune system detection and metastasize in the body. Pre-metastatic cells and exhausted CD8+ cells are identified as key players in this process. The study explores ways to target these pathways and activate immune responses to block metastasis.
This study of 690 patients with early-stage breast cancer found racial disparities in pathological complete response to neoadjuvant chemotherapy, affecting survival outcomes. Racial disparities varied across different breast cancer subtypes and highlight the importance of understanding tumor biology.
A Phase II trial led by researchers from the University of Texas MD Anderson Cancer Center demonstrated that adding ipilimumab to a neoadjuvant combination of nivolumab plus platinum-based chemotherapy resulted in a major pathologic response in half of all treated patients with early-stage non-small cell lung cancer. The treatment also...
Researchers at Garvan Institute of Medical Research found that introducing bacteria to a tumor's microenvironment triggers an immune response, activating neutrophils to destroy tumors in animal models. This breakthrough therapy targets neutrophils to improve cancer treatment outcomes.
Researchers found that primary cancer tumors have a sluggish conversion of nutrients to usable cellular energy, conserving energy for growth and metastasis. The discovery has vast implications for anti-cancer strategies, directing attention to slow energy metabolism.
A team of researchers from Korea and USA identified the importance of lipid homeostasis in overcoming brain cancer radioresistance. They found that regulating diacylglycerol kinase B and diacylglycerol acyltransferase 1 could potentially sensitize brain cancer cells to radiotherapy, offering a new treatment strategy.
Researchers found that lncRNA MVIH is overexpressed in cervical cancer tumors and associated with younger age, lymph node metastasis, tumor invasion depth, and squamous cell type. This suggests its potential as a diagnostic biomarker for cervical cancer.
Researchers discovered three essential amino acids - leucine, valine, and tryptophan - as potential metabolic biomarkers for HCC. The study used metabolomics to analyze the differences in tumor and non-tumor tissue metabolomes, revealing striking differences that could aid in diagnosis.
Researchers at UNIGE have discovered a way to overcome resistance to chemotherapy in colorectal cancer, using an optimized combination of tyrosine kinase inhibitors. This breakthrough opens up new avenues for developing targeted therapies that can effectively treat patients with low five-year survival rates.
The analysis found that inadequate margin widths may result in higher risks of distant recurrence and breast cancer mortality, as well as increased local recurrence. The researchers recommend a minimum tumour free distance of 1mm from the margin for optimal oncological outcomes.
Research reveals that tumor cells form temporary structures to avoid destruction by the immune system. The findings suggest that timed inhibition of relevant signaling pathways is necessary alongside immunotherapy to prevent tumor resistance.
A cross-sectional study of over 25,000 adults found that approximately 70% of identified adrenal tumors were nonfunctioning, regardless of participant's age. The prevalence of adrenal tumors increased with age, from 0.2% in young adults to 3.2% in older adults.
Researchers have made significant breakthroughs in understanding the molecular mechanisms of supratentorial ependymoma, a rare and aggressive form of childhood brain cancer. By targeting the Hedgehog signaling pathway and primary cilia formation, scientists discovered new potential treatments that overcame resistance to existing drugs.
The ECOG-ACRIN Cancer Research Group presented promising trial results at ASCO 2022, including an 8-year survival rate in the CHAARTED prostate trial. The research also explored outcomes by tobacco use in head and neck studies, shedding light on cancer treatment effectiveness.
A team of biologists identified a protein involved in the spread of breast cancer to bones. The discovery confirms the importance of cellular plasticity during the metastatic process and could lead to new treatments. ZEB1, a protein that increases cell plasticity, was found to direct cells with metastatic characteristics to bones.
Researchers at Weill Cornell Medicine discovered that cancer cells suppress a key enzyme in propionate metabolism, increasing production of methylmalonic acid (MMA) and causing cells to become more aggressive. This metabolic change may hold the key to understanding how tumors metastasize and developing novel therapies.
Adding immunotherapy to chemotherapy before surgery reduced the risk of recurrence and death in lung cancer patients by 37%, according to a phase III trial. The treatment also led to a nearly twelvefold increase in pathological complete response, with 24% of patients achieving no active cancer remaining when the tumor was removed.
A study found that 12% of recurrent ductal carcinoma in situ (DCIS) cases were new primary lesions unrelated to the original tumor. These findings suggest that genetic biomarkers for predicting recurrence may not be effective for all patients.
Researchers at UNIGE find that near-death experience in primary tumors triggers pro-metastatic states in cells, leading to metastasis. These 'PAME' cells reprogram themselves and trigger a cytokine storm, forming new tumors.
Researchers developed nanoparticles that activate key cancer fighters by driving up immunity at the tumor site, improving interactions with antibody therapies. The technique left six of 10 mice with lymphoma tumor-free and was effective in melanoma when combined with existing immune response amplifiers.
A diet rich in palmitic acid makes tumor cells more aggressive and increases their metastatic capacity, a process that is responsible for 90% of cancer deaths. Exposure to palmitic acid leads to permanent epigenetic modifications in tumor cells, allowing them to conserve metastatic capacity even after the fatty acid is removed.
Children in UK and Ireland diagnosed with larger kidney cancers, leading to late diagnosis and potential poorer outcomes. A call for frontline healthcare workers to be trained in paediatric medicine has been made to improve early detection.
Researchers from UPV/EHU and Biocruces pathologists use game theory to study tumor cell interactions, finding that higher cell diversity may be beneficial for patients. This approach reveals the importance of collective stability in tumor cells' pursuit of better environments.
Eosinophils, a type of white blood cell, play a crucial role in destroying malignant tumors by recruiting T-cells and releasing destructive proteins. The study, published in Cancer Research, reveals that eosinophils combat cancer effectively but require the help of T-cells to do so.
A study reveals nearly 30% of breast cancer patients convert to HER2-low status, offering potential treatment opportunities for hard-to-treat tumours. The findings also suggest that HER2-low expression is more frequent in hormone receptor-positive tumours.
Researchers developed a system to deliver nucleotide-based drugs more effectively into primary tumor tissue and bone metastases, improving their clinical efficacy. The study found that iRGD-liposomes significantly enhanced the ability of antisense oligonucleotides to inhibit prostate cancer growth and prolong tumor suppression.
A study characterized genomic and neoantigen evolution between primary and first recurrence tumors in 23 HNSCC patients, identifying shared genes with predicted neoantigens. Patients with these shared neoantigens tend to have increased duration of survival with disease.
Researchers presented two radiation oncology trials that aimed to improve local tumor control in NSCLC patients. One trial found no significant difference in 2-year local-regional tumor progression-free rates between adaptive and standard radiation therapy arms, while another study demonstrated excellent local control rates with dose e...
A study investigated the correlation between ADC parameters, Ki-67 expression, and clinical outcomes in PCNSL patients. In immunocompetent patients, ADC histogram analysis predicted tumor proliferation and survival. However, in HIV-positive patients, ADC values showed limited utility in predicting clinical outcomes.
Researchers assessed CEACAM5 expression in breast cancer subtypes using immunohistochemistry, finding a high correlation between primary tumor and lymph node status. Expression of CEACAM5 also predicted different clinical outcomes depending on molecular subtypes, suggesting its potential role as a clinically relevant marker.
A new study reveals that lymph node and distant metastases develop through different evolutionary mechanisms, with lymph nodes being a genetically highly diverse group. This suggests that metastasis formation in locoregional lymph nodes is comparatively easy and can be achieved by many cells, whereas dissemination to and outgrowth in d...
This review article discusses the features of challenging cold tumors and potential approaches to transform them into hot tumors, which are more responsive to immunotherapy. The authors summarize current strategies for enhancing T cell trafficking and discuss the limitations of existing immunotherapeutic approaches.