Articles tagged with Signaling Complexes
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers introduced an innovative ML model for classifying faults in SRF cavities, utilizing historical data and expert insights to enhance operational stability. The system achieved high accuracy and efficiency, facilitating long-term trend analysis and proactive maintenance strategies.
A University of Ottawa-led study reveals that serotonin neurons are connected and interact with each other, controlling serotonin release in specific regions of the brain. This complex system has implications for understanding decision-making and developing targeted therapeutics for mood disorders.
A team at HZB developed a method using photo-voltage to detect individual and local spin states of defects in diamonds. This could lead to more compact designs of quantum sensors. The research uses nitrogen vacancy centres, which can be manipulated with microwaves.
A team of researchers from Télécom Paris and Politecnico di Milano has developed a system of optical micro-antennas integrated into a programmable photonic chip, which can adapt in real time to restore chaotic signals. This innovation paves the way for chaos-based encryption for secure high-speed communication in hostile environments.
The POSTECH research team developed a smartphone-type OLED panel that can transform its shape while functioning as a speaker, maintaining ultra-thin flexibility. The panel uses electrically driven piezoelectric polymer actuators to achieve complex forms without mechanical hinges or motors.
Researchers have experimentally confirmed complex synchronisation patterns in oscillatory systems, including leaf-like structures and gaps representing unsynchronised states. This breakthrough builds on previous studies using breathing-soliton lasers to explore nonlinear dynamics.
Scientists found that parts of human chromosomes have evolved rapidly to enable complex brain development in humans. However, this acceleration may also lead to neurodevelopmental disorders like autism. The study used artificial neurons derived from human and chimpanzee cell lines.
Researchers have developed microcomb technology to miniaturize optical atomic clock systems, offering significant benefits for navigation, autonomous vehicles, and geo-data monitoring. The new system uses integrated photonics to integrate optical components on tiny photonic chips, reducing size and weight.
Researchers at Incheon National University have pioneered a novel resonant tuning rectifier (RTR) for parallel compensated receivers in wireless power transfer. The RTR enhances efficiency via dynamic frequency adaptation, reducing circuit impedance and minimizing interference with other devices.
Researchers at Incheon National University have developed a new AI-powered solution to improve high-speed users' connectivity in 5G and 6G networks. The method significantly reduces errors and improves data reliability by prioritizing key parameters such as angles and delays.
Researchers at Chalmers University of Technology have developed a unique method for encoding natural touch sensations via specific microstimulation patterns in implantable electrodes. This allows individuals with spinal cord injuries to feel tactile edges, shapes, curvatures and movements, enabling them to control a bionic arm with the...
Researchers designed metallo-supramolecular complexes that selectively bind to MPXV mRNA G4, modulating A5L protein expression and immune response activation. These findings highlight the significance of G4s in viral immunodominant protein expression and offer potential avenues for developing antiviral therapeutics.
Researchers developed a miniaturized all-fiber photoacoustic spectrometer for intravascular gas detection, achieving detection limits of 9 ppb and response times as quick as 18 milliseconds. The system detects trace gases at the ppb level and analyzes nanoliter-sized samples with millisecond response times.
Researchers discovered a novel platinum complex that targets androgen receptor signaling, inhibiting cell growth and survival in prostate cancer cells. The complex, 5-H-Y, showed stronger cytotoxic effects than cisplatin with minimal toxicity, offering a promising approach to treating advanced prostate cancer.
Engineered yeast cells can form cooperative groups that perform complex tasks and self-regulate in response to external signals. This approach enables precise production of therapeutic compounds, reducing waste and increasing treatment efficacy.
A new study finds that individuals with autism spectrum disorder have an increased dynamic range in their neuronal response, resulting in a more detailed but slower response to changes. This increase enables accurate encoding of details but comes at the expense of faster adaptation.
Researchers create system to manipulate cell behavior using 'crowd control' technique, enabling predictable patterns and structures. Cell density plays key role in guiding cellular development, offering potential for medical applications such as tissue engineering and organ regeneration.
A new PACT system offers rapid imaging of living organisms, enabling the tracking of whole-body dynamics and disease progression. The system achieves spatial resolution of approximately 212 micrometers and enables the visualization of oxygen saturation across complex biological systems.
Scientists have identified a novel molecular mechanism underlying brain cell communication, regulating excitatory synapse maturation and contributing to anxiety disorders. The study reveals the TrkC-PTPσ complex governs synaptic protein phosphorylation, leading to abnormal synapse organization and behavioral defects in mice.
Researchers from King's College London have created a new kind of compact circuit that enables robots to receive complex instructions without electricity. This breakthrough could enable the creation of robots with more complex AI-powered software and improve their social awareness and dexterity.
Researchers have discovered Flickering Gamma-Ray Flashes (FGFs), a phenomenon that could be the missing link between Terrestrial Gamma-ray Flashes and gamma-ray glows. Studies reveal dynamic gamma-ray emissions in tropical thunderclouds, challenging previous assumptions about these events.
A research team has developed a simplified synthesis method for organic fluorophores using formaldehyde, reducing molecular size and increasing atomic efficiency. The new technique can also be applied to in vivo environments, showing promise for life sciences research and diagnostics applications.
Researchers found that sustained neck exertions alter the cervical spine's curvature, leading to muscle fatigue and increased risk of neck pain. The study provides new insights into the mechanical changes that occur in the spine and muscles when performing repetitive tasks.
A new study using manifold learning and signal processing techniques identifies a significant correlation between adolescent brain activity and mental health symptoms. The approach, called exogenous PHATE, combines brain activation data with environmental variables to improve detection of existing symptoms and predict future ones.
A new study reveals that fasting helps regenerate and heal intestinal injuries, but also increases the risk of developing early-stage intestinal tumors in mice. The researchers identified a pathway enabling this enhanced regeneration, which is activated during refeeding after fasting.
A team of researchers has demonstrated a novel way of storing and releasing X-ray pulses at the single photon level, enabling future X-ray quantum technologies. This breakthrough uses nuclear ensembles to create long-lived quantum memories with improved coherence times.
A recent study revealed that specific bacteria produce a carbohydrate compound that induces settlement and metamorphosis in larvae of the warm-water tubeworm Hydroides elegans. This process, known as biofouling, can coat ship hulls and propellers, causing significant economic damage.
Researchers at Ben-Gurion University's PAI Lab developed groundbreaking multifunctional material-sensors that emulate natural systems, advancing Physical AI. The sensors can process diverse signals concurrently through ions and electrons, enabling versatile and lifelike interactions in fields like robotics and healthcare.
Researchers have developed a new photonic chip that can process, transmit and reconstruct images in nanoseconds, eliminating optical-electronic conversions. This technology holds promise for revolutionizing edge intelligence in machine vision applications.
The CCR4-NOT complex plays a crucial role in regulating RNA metabolism and stress response in C. elegans, compromising stress resistance and decreasing lifespan when depleted of subunits. This study highlights an important new role for the CCR4-NOT complex in normal aging and longevity.
Researchers discovered that command-like DNs in fruit flies recruit additional networks of neurons to orchestrate complex behaviors. The study shows that these networks work together to produce coordinated actions, transforming the way we understand brain signals and behavior.
A recent study discovered a critical brain signal mediated by dopamine and its 'D2' receptors that plays a crucial role in timing actions. The research team used novel imaging techniques to observe this activity before self-timed presses, finding a gradual increase in brain signals about half a second prior.
A new Bayesian inference framework reduces data size by over 80% while achieving accurate modeling and control of optical power evolution. The approach enables simultaneous exploitation and exploration of a data space to identify suitable candidates for autonomous driving optical networks.
The study suggests that memory plays a pivotal role in shaping consciousness, contrasting the idea that computer-based Information Theory provides a sufficient framework for understanding neural memory. The researchers propose a novel perspective that memory underpins consciousness, introducing the concept of a "brain cloud" to illustr...
Researchers assessed swimming performance and survival under stress to evaluate the effects of three compounds on health and lifespan in Caenorhabditis. The study found complex relationships among median lifespan, oxidative stress resistance, thermotolerance, and mobility vigor.
A new study from Israel found that nearly 1 in 5 adults with congenital heart disease developed an abnormal heart rhythm during a five-year study. Those who developed arrhythmias had twice the risk of early death and increased hospitalization rates compared to those without irregular heart rhythms.
Researchers have developed a method to differentiate human pluripotent stem cells into cell populations that form patterns resembling the facial primordium. This allows for the creation of an in vitro model to study early facial development and potential treatments for craniofacial disorders.
A Mediterranean marine worm has evolved massive eyes, rivaling those of mammals, to see in the dark. The worms use their exceptional vision to detect bioluminescent signals and may have a secret language through light communication.
A team of researchers from Tokyo Institute of Technology identified the molecular mechanisms involved in synaptic communication using Drosophila. They found that Side-IV/Beat-IIb immunoglobulin superfamily protein molecules play a crucial role in inducing synapse formation and regulating preferential signaling among neuron pairs.
Researchers at Kyoto University have discovered a signal protein called ERK that plays an active role in causing growing lung tissue to curve. This finding reveals a previously unknown regulatory system governing the development of intricate branching patterns in mouse lungs.
Research finds companies prioritize price and self-disclosures over third-party verified sustainability claims, raising questions about greenwashing. Buyers value disclosed information and its update frequency, but are not willing to pay premium for reliability.
The T2oFu method offers a new approach to quantitative phase and polarization-sensitive tomography, enabling high-contrast images of muscle fibers with implications for diagnosing skeletal myopathies. The technique has been successfully tested on heart tissue samples with cardiac amyloidosis, providing promising results.
Researchers deciphered a novel process helping viruses choose to be nasty or friendly to their host bacteria. Phages use the bacterial immune system to make decisions, activating violent mode when necessary.
Scientists have created a way to correct distorted light patterns in real time without needing to reapply the same distortion. This method uses nonlinear optics and exploits difference frequency generation to produce an aberration-free output beam.
Researchers discovered that two types of TORC1 complexes in yeast play unique roles in cellular responses to stress and lifespan regulation. The study's findings provide new insights into molecular evolution, cellular signaling pathways, and age-related diseases, offering promising avenues for human health advancements.
A study published in BMC Geriatrics uses in-vehicle sensors to detect anomalous driving behavior indicative of cognitive impairment in older adults. The system analyzes driving patterns, facial expressions, and eye movement to identify early signs of dementia.
Scientists have discovered that the bat brainstem processes echolocation and communication calls differently, with a stronger response to less frequent calls due to better neural synchronization. The findings may also be relevant to medical applications in humans, such as understanding diseases like ADHD or schizophrenia.
Researchers have defined what a premature aging disease is and developed tools to diagnose progeria patients, allowing them to identify new syndromes. The study also identified correlations between progeroid syndromes and other conditions, providing a significant step forward in understanding premature aging.
A study by University of Alabama at Birmingham researchers discovered that protons are the primary signals transmitting tactile sensations from Merkel cells to nerves. Protons bind to ASIC receptors on nerve endings, triggering an influx of sodium ions that propagate action potentials up the nerve towards the brain.
A novel mechanism for splicing human short introns has been discovered using the SAP30BP-RBM17 complex. The researchers confirmed that the established pre-mRNA splicing mechanism cannot work in a subset of human short introns.
Researchers from Concordia University explore risks of cyberattacks faced by offshore wind farms with VSC-HVDC connections. These attacks could lead to false information, electrical disturbances, and potential transmission of amplified oscillations through the main power grid.
A team of scientists has identified a previously unrecognized control point in DNA repair processes, which could lead to novel cancer therapies by inhibiting the repair of damaged cancer cells. The newly discovered GSE1-CoREST complex contains three enzymes that control DNA repair and may form the basis for improved cancer treatments.
Researchers provide new insights into STING's function in innate immunity, revealing its role as a scaffold that activates TBK1. They also found that cholesterol plays a crucial role in STING clustering and activation, offering a potential target for treating diseases associated with STING inflammation.
A team of scientists used functional near-infrared spectroscopy (fNIRS) to measure brain activity in two key visual regions, the lateral occipital complex (LOC) and fusiform face area (FFA). The study found that fNIRS successfully measured LOC activity but had limitations in detecting FFA activity due to its depth. This research has th...
A new study finds that complex and unfamiliar sentences generate stronger responses in the brain's language processing centers. Sentences with higher surprisal and linguistic complexity evoke more activation, while extremely simple or nonsensical sequences elicit little response.
A new study has identified three genes, MANBA, TNFRSF13B, and EEF1A1, as crucial in the regulation of IgG galactosylation, a trait associated with ageing. The research used GWAS to analyze IgG glycosylation phenotypes in a large sample size, increasing the understanding of this complex posttranslational modification.
Researchers leverage AI to analyze healthcare data and identify new targets for effective therapies and accelerate drug development in aging research. AI can tailor cancer treatment more precisely to individual patients' unique aging profiles, optimizing treatment outcomes and minimizing risks.
Researchers create biphasic gel iontronics that mimic neural networks, enabling diverse ionic signal transmission. The system is capable of regulating cardiac electrical activity and converting electronic signals into bioionic signals.
Researchers at EMBL Grenoble have obtained the first structure of p38α being activated by MKK6, opening up new directions for developing drugs to stop cytokine storms. The inflammatory response is triggered by a series of kinases, and inactivating p38α could prevent inflammation from occurring.
Researchers at the University of California - Santa Barbara have developed a method that enables high-quality imaging of still objects with only WiFi signals. The technique uses Keller cones to trace edges of objects and has successfully imaged the English alphabet through walls, a task previously deemed too difficult for WiFi.